Transcription factors Mesp2 and Paraxis have critical roles in axial musculoskeletal formation

Developmental Dynamics

Volumn 236, Issue 6, 2007, Pages 1484-1494

  Takahashi, Yu ^a   Takagi, Atsuya ^a   Hiraoka, Shuichi ^b   Koseki, Haruhiko ^b   Kanno, Jun ^a   Rawls, Alan ^c   Saga, Yumiko ^d  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b RIKEN YOKOHAMA INSTITUTE   (Japan)

^c ARIZONA STATE UNIVERSITY   (United States)

^d NATIONAL INSTITUTE OF GENETICS   (Japan)

Author keywords

bHLH factor; Pax genes; Sclerotome; Somitogenesis; Vertebra

Indexed keywords

BAPX1 PROTEIN; HELIX LOOP HELIX PROTEIN; MESP2 PROTEIN; NKX3.1 PROTEIN; PARAXIS PROTEIN; PAX1 PROTEIN; PROTEIN UNCX4.1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX3; TRANSCRIPTION FACTOR PAX9; UNCLASSIFIED DRUG;

ARTICLE; CELL LINEAGE; CHONDROGENESIS; EMBRYO SEGMENTATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HYPOPLASIA; MESODERM; MOLECULAR INTERACTION; MUSCLE DEVELOPMENT; MUSCULOSKELETAL SYSTEM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SCLEROTOME; SKELETON; SOMITE; SPINE; TISSUE DIFFERENTIATION; TWO HYBRID SYSTEM; VERTEBRA BODY;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BODY PATTERNING; CELL DIFFERENTIATION; CELL POLARITY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE REGULATORY NETWORKS; MICE; MICE, TRANSGENIC; MUSCLE, SKELETAL; PAIRED BOX TRANSCRIPTION FACTORS; PROTEIN BINDING; SOMITES;

MUS;

EID: 34250629987     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.21178     Document Type: Article

References (42)

1. Barnes GL, Alexander PG, Hsu CW, Mariani BD, Tuan RS. 1997. Cloning and characterization of chicken Paraxis: a regulator of paraxial mesoderm development and somite formation. Dev Biol 189:95-111.
2. Bettenhausen B, Hrabe de Angelis M, Simon D, Guenet JL, Gossler A. 1995. Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Development 121:2407-2418.
3. Bi W, Deng JM, Zhang Z, Behringer RR, de Crombrugghe B. 1999. Sox9 is required for cartilage formation. Nat Genet 22:85-89.
4. Brent AE, Schweitzer R, Tabin CJ. 2003. A somitic compartment of tendon progenitors. Cell 113:235-248.
5. Burgess R, Cserjesi P, Ligon KL, Olson EN. 1995. Paraxis: a basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites. Dev Biol 168:296-306.
6. Burgess R, Rawls A, Brown D, Bradley A, Olson EN. 1996. Requirement of the paraxis gene for somite formation and musculoskeletal patterning. Nature 384:570-573.
7. Bussen M, Petry M, Schuster-Gossler K, Leitges M, Gossler A, Kispert A. 2004. The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Genes Dev 18:1209-1221.
8. Cserjesi P, Brown D, Ligon KL, Lyons GE, Copeland NG, Gilbert DJ, Jenkins NA, Olson EN. 1995. Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis. Development 121:1099-1110.
9. Fan CM, Tessier-Lavigne M. 1994. Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog. Cell 79:1175-1186.
10. Fields S, Bartel PL. 2001. The two-hybrid system. A personal view. Methods Mol Biol 177:3-8.
11. Johnson RL, Laufer E, Riddle RD, Tabin C. 1994. Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites. Cell 79:1165-1173.
12. Johnson J, Rhee J, Parsons SM, Brown D, Olson EN, Rawls A. 2001. The anterior/posterior polarity of somites is disrupted in paraxis-deficient mice. Dev Biol 229:176-187.
13. Jostes B, Walther C, Gruss P. 1990. The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system. Mech Dev 33:27-37.
14. Kitajima S, Takagi A, Inoue T, Saga Y. 2000. MesP1 and MesP2 are essential for the development of cardiac mesoderm. Development 127:3215-3226.
15. Leitges M, Neidhardt L, Haenig B, Herrmann BG, Kispert A. 2000. The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column. Development 127:2259-2267.
16. Lettice LA, Purdie LA, Carlson GJ, Kilanowski F, Dorin J, Hill RE. 1999. The mouse bagpipe gene controls development of axial skeleton, skull, and spleen. Proc Natl Acad Sci U S A 96:9695-9700.
17. Mansouri A, Yokota Y, Wehr R, Copeland NG, Jenkins NA, Gruss P. 1997. Paired-related murine homeobox gene expressed in the developing sclerotome, kidney, and nervous system. Dev Dyn 210:53-65.
18. Mansouri A, Voss AK, Thomas T, Yokota Y, Gruss P. 2000. Uncx4.1 is required for the formation of the pedicles and proximal ribs and acts upstream of Pax9. Development 127:2251-2258.
19. Maroto M, Reshef R, Munsterberg AE, Koester S, Goulding M, Lassar AB. 1997. Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissue. Cell 89:139-148.
20. Morimoto M, Kiso M, Sasaki N, Saga Y. 2006. Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis. Dev Biol 300:687-698.
21. Nakajima Y, Morimoto M, Takahashi Y, Koseki H, Saga Y. 2006. Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2. Development 133:2517-2525.
22. Neidhardt LM, Kispert A, Herrmann BG. 1997. A mouse gene of the paired-related homeobox class expressed in the caudal somite compartment and in the developing vertebral column, kidney and nervous system. Dev Genes Evol 207:330-339.
23. Neubuser A, Koseki H, Balling R. 1995. Characterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1. Dev Biol 170:701-716.
24. Peters H, Wilm B, Sakai N, Imai K, Maas R, Balling R. 1999. Pax1 and Pax9 synergistically regulate vertebral column development. Development 126:5399-5408.
25. Pourquie O. 2003. Vertebrate somitogenesis: a novel paradigm for animal segmentation? Int J Dev Biol 47:597-603.
26. Rodrigo I, Hill RE, Balling R, Munsterberg A, Imai K. 2003. Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome. Development 130:473-482.
27. Saga Y, Hata N, Koseki H, Taketo MM. 1997. Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes Dev 11:1827-1839.
28. Sassoon D, Lyons G, Wright WE, Lin V, Lassar A, Weintraub H, Buckingham M. 1989. Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis. Nature 341:303-307.
29. Schnittger S, Rao W, Deutsch U, Gruss P, Balling R, Hansmann I. 1992. Pax1, a member of the paired box-containing class of developmental control genes, is mapped to human chromosome 20p11.2 by in situ hybridization (ISH and FISH). Genomics 14:740-744.
30. Tajbakhsh S, Rocancourt D, Cossu G, Buckingham M. 1997. Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD. Cell 89:127-138.
31. Takahashi Y, Koizumi K, Takagi A, Kitajima S, Inoue T, Koseki H, Saga Y. 2000. Mesp2 initiates somite segmentation through the Notch signalling pathway. Nat Genet 25:390-396.
32. Takahashi Y, Inoue T, Gossler A, Saga Y. 2003. Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involve-ment of Psen1 are essential for rostrocaudal patterning of somites. Development 130:4259-4268.
33. Takahashi Y, Kitajima S, Inoue T, Kanno J, Saga Y. 2005. Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites. Development 132:787-796.
34. Tribioli C, Lufkin T. 1999. The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen. Development 126:5699-5711.
35. Tribioli C, Frasch M, Lufkin T. 1997. Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton. Mech Dev 65:145-162.
36. Tseng HT, Jamrich M. 2004. Identification and developmental expression of Xenopus paraxis. Int J Dev Biol 48:1155-1158.
37. Vojtek AB, Hollenberg SM, Cooper JA. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74:205-214.
38. Williams BA, Ordahl CP. 1994. Pax-3 expression in segmental mesoderm marks early stages in myogenic cell specification. Development 120:785-796.
39. Wilm B, Dahl E, Peters H, Balling R, Imai K. 1998. Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency. Proc Natl Acad Sci U S A 95:8692-8697.
40. Wilson-Rawls J, Hurt CR, Parsons SM, Rawls A. 1999. Differential regulation of epaxial and hypaxial muscle development by paraxis. Development 126:5217-5229.
41. Wright E, Hargrave MR, Christiansen J, Cooper L, Kun J, Evans T, Gangadharan U, Greenfield A, Koopman P. 1995. The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos. Nat Genet 9:15-20.
42. Zeng L, Kempf H, Murtaugh LC, Sato ME, Lassar AB. 2002. Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis. Genes Dev 16:1990-2005.