FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression

Development

Volumn 131, Issue 16, 2004, Pages 3885-3896

  Brent, Ava E ^a   Tabin, Clifford J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Erm; Ets; FGF; Pea3; Scleraxis; Sclerotome; Somite; Syndetome; Tendon

Indexed keywords

FIBROBLAST GROWTH FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ERM; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR ETS 2; TRANSCRIPTION FACTOR PEA3; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CARTILAGE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MOLECULAR CLONING; MOLECULAR MECHANICS; MUSCLE; MYOTOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SOMITE; STEM CELL; TENDON; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; AVIAN PROTEINS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CHICK EMBRYO; DNA-BINDING PROTEINS; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; SIGNAL TRANSDUCTION; SOMITES; TENDONS; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 4544261800     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.01275     Document Type: Article

References (44)

1. Aoyama, H. and Asamoto, K. (2000). The developmental fate of the rostral/caudal half of a somite for vertebra and rib formation: experimental confirmation of the resegmentation theory using chick-quail chimeras. Mech. Dev. 99, 71-82.
2. Bagnall, K. M., Higgins, S. J. and Sanders, E. J. (1988). The contribution made by a single somite to the vertebral column: experimental evidence in support of resegmentation using the chick-quail chimaera model. Development 103, 69-85.
3. Bojovic, B. B. and Hassell, J. A. (2001). The PEA3 Ets transcription factor comprises multiple domains that regulate transactivation and DNA binding. J. Biol. Chem. 276, 4509-4521.
4. Brand-Saberi, B. and Christ, B. (2000). Evolution and development of distinct cell lineages derived from somites. Curr. Top. Dev. Biol. 48, 1-42
5. Brent, A. E. and Tabin, C. J. (2002). Developmental regulation of somite derivatives: muscle, cartilage and tendon. Curr. Opin. Genet. Dev. 12, 548-557.
6. Brent, A. E., Schweitzer, R. and Tabin, C. J. (2003). A somitic compartment of tendon progenitors. Cell 113, 235-248.
7. Chambers, D. and Mason, I. (2000). Expression of sprouty2 during early development of the chick embryo is coincident with known sites of FGF signalling. Mech. Dev. 91, 361-364.
8. Corson, L. B., Yamanaka, Y., Lai, K. M. and Rossant, J. (2003). Spatial and temporal patterns of ERK signaling during mouse embryogenesis. Development 130, 4527-4537.
9. Cserjesi, P., Brown, D., Ligon, K. L., Lyons, G. E., Copeland, N. G., Gilbert, D. J., Jenkins, N. A. and Olson, E. N. (1995). Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis. Development 121, 1099-1110.
10. Dickinson, R. J., Eblaghie, M. C., Keyse, S. M. and Morriss-Kay, G. M. (2002). Expression of the ERK-specific MAP kinase phosphatase PYST1/MKP3 in mouse embryos during morphogenesis and early organogenesis. Mech. Dev. 113, 193-196.
11. Dockter, J. L. and Ordahl, C. P. (1998). Determination of sclerotome to the cartilage fate. Development 125, 2113-2124.
12. Dubrulle, J., McGrew, M. J. and Pourquie, O. (2001). FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hex gene activation. Cell 106, 219-232.
13. Eblaghie, M. C., Lunn, J. S., Dickinson, R. J., Munsterberg, A. E., Sanz-Ezquerro, J. J., Farrell, E. R., Mathers, J., Keyse, S. M., Storey, K. and Tickle, C. (2003). Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos. Curr. Biol. 13, 1009-1018.
14. Firnberg, N. and Neubuser, A. (2002). FGF signaling regulates expression of Tbx2, Erm, Pea3, and Pax3 in the early nasal region. Dev. Biol. 247, 237-250.
15. Fraidenraich, D., Iwahori, A., Rudnicki, M. and Basilico, C. (2000). Activation of fgf4 gene expression in the myotomes is regulated by myogenic bHLH factors and by sonic hedgehog. Dev. Biol. 225, 392-406.
16. Furthauer, M., Lin, W., Ang, S. L., Thisse, B. and Thisse, C. (2002). Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling. Nat. Cell Biol. 4, 170-174.
17. Grass, S., Arnold, H. H. and Braun, T. (1996). Alterations in somite patterning of Myf-5-deficient mice: a possible role for FGF-4 and FGF-6. Development 122, 141-150.
18. Hacohen, N., Kramer, S., Sutherland, D., Hiromi, Y. and Krasnow, M. A. (1998). sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell 92, 253-263.
19. Hamburger, V. and Hamilton, H. L. (1951). A series of normal stages in the development of the chick embryo. J. Morphol. 88, 49-92.
20. Huang, R., Zhi, Q., Neubuser, A., Muller, T. S., Brand-Saberi, B., Christ, B. and Wilting, J. (1996). Function of somite and somitocoele cells in the formation of the vertebral motion segment in avian embryos. Acta Anat. 155, 231-241.
21. Huang, R., Zhi, Q., Brand-Saberi, B. and Christ, B. (2000). New experimental evidence for somite resegmentation. Anat. Embryol. 202, 195-200.
22. Huang, R., Stolte, D., Kurz, H., Ehehalt, F., Cann, G. M., Stockdale, F. E., Patel, K. and Christ, B. (2003). Ventral axial organs regulate expression of myotomal Fgf-8 that influences rib development. Dev. Biol. 255, 30-47.
23. Itoh, N., Mima, T. and Mikawa, T. (1996). Loss of fibroblast growth factor receptors is necessary for terminal differentiation of embryonic limb muscle. Development 122, 291-300.
24. Janknecht, R., Monte, D., Baert, J. L. and de Launoit, Y. (1996). The ETS-related transcription factor ERM is a nuclear target of signaling cascades involving MAPK and PKA. Oncogene 13, 1745-1754.
25. Kahane, N., Cinnamon, Y., Bachelet, I. and Kalcheim, C. (2001). The third wave of myotome colonization by mitotically competent progenitors: regulating the balance between differentiation and proliferation during muscle development. Development 128, 2187-2198.
26. Kawakami, Y., Rodriguez-Leon, J., Koth, C. M., Buscher, D., Itoh, T., Raya, A., Ng, J. K., Esteban, C. R., Takahashi, S., Henrique, D. et al. (2003). MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb. Nat. Cell Biol. 5, 513-519.
27. Logan, M. and Tabin, C. (1998). Targeted gene misexpression in chick limb buds using avian replication-competent retroviruses. Methods 14, 407-420.
28. Mailleux, A. A., Tefft, D., Ndiaye, D., Itoh, N., Thiery, J. P., Warburton, D. and Bellusci, S. (2001). Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis. Mech. Dev. 102, 81-94.
29. Marics, I., Padilla, F., Guillemot, J. F., Scaal, M. and Marcelle, C. (2002). FGFR4 signaling is a necessary step in limb muscle differentiation. Development 129, 4559-4569.
30. Minowada, G., Jarvis, L. A., Chi, C. L., Neubuser, A., Sun, X., Hacohen, N., Krasnow, M. A. and Martin, G. R. (1999). Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. Development 126, 4465-4475.
31. Morgan, B. A. and Fekete, D. M. (1996). Manipulating gene expression with replication-competent retroviruses. Methods Cell Biol. 51, 185-218.
32. Munchberg, S. R. and Steinbeisser, H. (1999). The Xenopus Ets transcription factor XER81 is a target of the FGF signaling pathway. Mech. Dev. 80, 53-65.
33. O'Hagan, R. C., Tozer, R. G., Symons, M., McCormick, F. and Hassell, J. A. (1996). The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades. Oncogene 13, 1323-1333.
34. Ozaki, K., Kadomoto, R., Asato, K., Tanimura, S., Itoh, N. and Kohno, M. (2001). ERK pathway positively regulates the expression of Sprouty genes. Biochem. Biophys. Res. Commun. 285, 1084-1088.
35. Palmeirim, I., Henrique, D., Ish-Horowicz, D. and Pourquie, O. (1997). Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis. Cell 91, 639-648.
36. Paratore, C., Brugnoli, G., Lee, H. Y., Suter, U. and Sommer, L. (2002). The role of the Ets domain transcription factor Erm in modulating differentiation of neural crest stem cells. Dev. Biol. 250, 168-180.
37. Raible, F. and Brand, M. (2001). Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signaling during early zebrafish development. Mech. Dev. 107, 105-117.
38. Roehl, H. and Nusslein-Volhard, C. (2001). Zebrafish pea3 and erm are general targets of FGF8 signaling. Curr. Biol. 11, 503-507.
39. Schweitzer, R., Chyung, J. H., Murtaugh, L. C., Brent, A. E., Rosen, V., Olson, E. N., Lassar, A. and Tabin, C. J. (2001). Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments. Development 128, 3855-3866.
40. Sharrocks, A. D., Brown, A. L., Ling, Y. and Yates, P. R. (1997). The ETS-domain transcription factor family. Int. J. Biochem. Cell Biol. 29, 1371-1387.
41. Shepherd, T. G., Kockeritz, L., Szrajber, M. R., Muller, W. J. and Hassell, J. A. (2001). The pea3 subfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis. Curr. Biol. 11, 1739-1748.
42. Stolte, D., Huang, R. and Christ, B. (2002). Spatial and temporal pattern of Fgf-8 expression during chicken development. Anat. Embryol. 205, 1-6.
43. Tsang, M., Friesel, R., Kudoh, T. and Dawid, I. B. (2002). Identification of Sef, a novel modulator of FGF signalling. Nat. Cell Biol. 4, 165-169.
44. Williams, B. A. and Ordahl, C. P. (1997). Emergence of determined myotome precursor cells in the somite. Development 124, 4983-4997.