-
1
-
-
0035413614
-
Glycogen synthase kinase-3: properties, functions, and regulation
-
Ali, A., Hoeflich, K.P., and Woodgett, J.R. (2001). Glycogen synthase kinase-3: properties, functions, and regulation. Chem. Rev. 101, 2527-2540.
-
(2001)
Chem. Rev.
, vol.101
, pp. 2527-2540
-
-
Ali, A.1
Hoeflich, K.P.2
Woodgett, J.R.3
-
2
-
-
84859169877
-
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
-
Barretina, J., Caponigro, G., Stransky, N. et al. (2012). The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483, 603-607.
-
(2012)
Nature
, vol.483
, pp. 603-607
-
-
Barretina, J.1
Caponigro, G.2
Stransky, N.3
-
3
-
-
49549120607
-
GSK3beta inhibition promotes melanogenesis in mouse B16 melanoma cells and normal human melanocytes
-
Bellei, B., Flori, E., Izzo, E., Maresca, V., and Picardo, M. (2008). GSK3beta inhibition promotes melanogenesis in mouse B16 melanoma cells and normal human melanocytes. Cell. Signal. 20, 1750-1761.
-
(2008)
Cell. Signal.
, vol.20
, pp. 1750-1761
-
-
Bellei, B.1
Flori, E.2
Izzo, E.3
Maresca, V.4
Picardo, M.5
-
4
-
-
0242664588
-
Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418
-
Bhat, R., Xue, Y., Berg, S. et al. (2003). Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J. Biol. Chem. 278, 45937-45945.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 45937-45945
-
-
Bhat, R.1
Xue, Y.2
Berg, S.3
-
5
-
-
68349112682
-
Statistical methods for analysis of high-throughput RNA interference screens
-
Birmingham, A., Selfors, L.M., Forster, T. et al. (2009). Statistical methods for analysis of high-throughput RNA interference screens. Nat. Methods 6, 569-575.
-
(2009)
Nat. Methods
, vol.6
, pp. 569-575
-
-
Birmingham, A.1
Selfors, L.M.2
Forster, T.3
-
6
-
-
84865450022
-
Aurora B is regulated by the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway and is a valuable potential target in melanoma cells
-
Bonet, C., Giuliano, S., Ohanna, M., Bille, K., Allegra, M., Lacour, J.P., Bahadoran, P., Rocchi, S., Ballotti, R., and Bertolotto, C. (2012). Aurora B is regulated by the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway and is a valuable potential target in melanoma cells. J. Biol. Chem. 287, 29887-29898.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 29887-29898
-
-
Bonet, C.1
Giuliano, S.2
Ohanna, M.3
Bille, K.4
Allegra, M.5
Lacour, J.P.6
Bahadoran, P.7
Rocchi, S.8
Ballotti, R.9
Bertolotto, C.10
-
7
-
-
0034527287
-
Rational approach to the clinical protocol design for drug combinations: a review
-
Chang, T.T., and Chou, T.C. (2000). Rational approach to the clinical protocol design for drug combinations: a review. Acta. Paediatr. Taiwan 41, 294-302.
-
(2000)
Acta. Paediatr. Taiwan
, vol.41
, pp. 294-302
-
-
Chang, T.T.1
Chou, T.C.2
-
8
-
-
44849096481
-
Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development
-
Cheung, M., Sharma, A., Madhunapantula, S.V., and Robertson, G.P. (2008). Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development. Cancer Res. 68, 3429-3439.
-
(2008)
Cancer Res.
, vol.68
, pp. 3429-3439
-
-
Cheung, M.1
Sharma, A.2
Madhunapantula, S.V.3
Robertson, G.P.4
-
9
-
-
84864125580
-
Distinct expression and activity of GSK-3alpha and GSK-3beta in prostate cancer
-
Darrington, R.S., Campa, V.M., Walker, M.M., Bengoa-Vergniory, N., Gorrono-Etxebarria, I., Uysal-Onganer, P., Kawano, Y., Waxman, J., and Kypta, R.M. (2012). Distinct expression and activity of GSK-3alpha and GSK-3beta in prostate cancer. Int. J Caner 131, E872-883.
-
(2012)
Int. J Caner
, vol.131
-
-
Darrington, R.S.1
Campa, V.M.2
Walker, M.M.3
Bengoa-Vergniory, N.4
Gorrono-Etxebarria, I.5
Uysal-Onganer, P.6
Kawano, Y.7
Waxman, J.8
Kypta, R.M.9
-
10
-
-
84856890066
-
Resistance patterns with tyrosine kinase inhibitors in melanoma: new insights
-
Dummer, R., and Flaherty, K.T. (2012). Resistance patterns with tyrosine kinase inhibitors in melanoma: new insights. Curr. Opin. Oncol. 24, 150-154.
-
(2012)
Curr. Opin. Oncol.
, vol.24
, pp. 150-154
-
-
Dummer, R.1
Flaherty, K.T.2
-
11
-
-
77949373630
-
Multicentre study on standardisation of melanoma cell culture-an initiative of the German Melanoma Research Network
-
Eberle, J., Spangler, B., Becker, J.C. et al. (2010). Multicentre study on standardisation of melanoma cell culture-an initiative of the German Melanoma Research Network. Pigment Cell Melanoma Res. 23, 296-298.
-
(2010)
Pigment Cell Melanoma Res.
, vol.23
, pp. 296-298
-
-
Eberle, J.1
Spangler, B.2
Becker, J.C.3
-
12
-
-
73949083834
-
MEK1 mutations confer resistance to MEK and B-RAF inhibition
-
Emery, C.M., Vijayendran, K.G., Zipser, M.C. et al. (2009). MEK1 mutations confer resistance to MEK and B-RAF inhibition. Proc. Natl Acad. Sci. USA 106, 20411-20416.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 20411-20416
-
-
Emery, C.M.1
Vijayendran, K.G.2
Zipser, M.C.3
-
13
-
-
77950668281
-
High-throughput RNAi screening to dissect cellular pathways: a how-to guide
-
Falschlehner, C., Steinbrink, S., Erdmann, G., and Boutros, M. (2010). High-throughput RNAi screening to dissect cellular pathways: a how-to guide. Biotechnol. J. 5, 368-376.
-
(2010)
Biotechnol. J.
, vol.5
, pp. 368-376
-
-
Falschlehner, C.1
Steinbrink, S.2
Erdmann, G.3
Boutros, M.4
-
14
-
-
84868224906
-
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
-
Flaherty, K.T., Infante, J.R., Daud, A. et al. (2012). Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N. Engl. J. Med. 367, 1694-1703.
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 1694-1703
-
-
Flaherty, K.T.1
Infante, J.R.2
Daud, A.3
-
15
-
-
65649100104
-
Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development
-
Force, T., and Woodgett, J.R. (2009). Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development. J. Biol. Chem. 284, 9643-9647.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 9643-9647
-
-
Force, T.1
Woodgett, J.R.2
-
16
-
-
34447626493
-
Glycogen synthase kinase 3: a key regulator of cellular fate
-
Forde, J.E., and Dale, T.C. (2007). Glycogen synthase kinase 3: a key regulator of cellular fate. Cell. Mol. Life Sci. 64, 1930-1944.
-
(2007)
Cell. Mol. Life Sci.
, vol.64
, pp. 1930-1944
-
-
Forde, J.E.1
Dale, T.C.2
-
17
-
-
58149142955
-
Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells
-
Ganesan, A.K., Ho, H., Bodemann, B. et al. (2008). Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. PLoS Genet. 4, e1000298.
-
(2008)
PLoS Genet.
, vol.4
-
-
Ganesan, A.K.1
Ho, H.2
Bodemann, B.3
-
18
-
-
34247868174
-
Glycogen synthase kinase-3 beta; a new target in pancreatic cancer?
-
Garcea, G., Manson, M.M., Neal, C.P., Pattenden, C.J., Sutton, C.D., Dennison, A.R., and Berry, D.P. (2007). Glycogen synthase kinase-3 beta; a new target in pancreatic cancer? Curr. Cancer Drug Targets 7, 209-215.
-
(2007)
Curr. Cancer Drug Targets
, vol.7
, pp. 209-215
-
-
Garcea, G.1
Manson, M.M.2
Neal, C.P.3
Pattenden, C.J.4
Sutton, C.D.5
Dennison, A.R.6
Berry, D.P.7
-
19
-
-
77952542786
-
Lung cancer cell lines: useless artifacts or invaluable tools for medical science?
-
Gazdar, A.F., Gao, B., and Minna, J.D. (2010). Lung cancer cell lines: useless artifacts or invaluable tools for medical science? Lung Cancer 68, 309-318.
-
(2010)
Lung Cancer
, vol.68
, pp. 309-318
-
-
Gazdar, A.F.1
Gao, B.2
Minna, J.D.3
-
20
-
-
33847220364
-
Melanoma biology and new targeted therapy
-
Gray-Schopfer, V., Wellbrock, C., and Marais, R. (2007). Melanoma biology and new targeted therapy. Nature 445, 851-857.
-
(2007)
Nature
, vol.445
, pp. 851-857
-
-
Gray-Schopfer, V.1
Wellbrock, C.2
Marais, R.3
-
21
-
-
84862732834
-
Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations
-
Greger, J.G., Eastman, S.D., Zhang, V., Bleam, M.R., Hughes, A.M., Smitheman, K.N., Dickerson, S.H., Laquerre, S.G., Liu, L., and Gilmer, T.M. (2012). Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations. Mol. Cancer Ther. 11, 909-920.
-
(2012)
Mol. Cancer Ther.
, vol.11
, pp. 909-920
-
-
Greger, J.G.1
Eastman, S.D.2
Zhang, V.3
Bleam, M.R.4
Hughes, A.M.5
Smitheman, K.N.6
Dickerson, S.H.7
Laquerre, S.G.8
Liu, L.9
Gilmer, T.M.10
-
22
-
-
71549144773
-
Identification and functional validation of therapeutic targets for malignant melanoma
-
Gremel, G., Rafferty, M., Lau, T.Y., and Gallagher, W.M. (2009). Identification and functional validation of therapeutic targets for malignant melanoma. Crit. Rev. Oncol. Hematol. 72, 194-214.
-
(2009)
Crit. Rev. Oncol. Hematol.
, vol.72
, pp. 194-214
-
-
Gremel, G.1
Rafferty, M.2
Lau, T.Y.3
Gallagher, W.M.4
-
23
-
-
34247171828
-
GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN
-
Huang, W., Chang, H.Y., Fei, T., Wu, H., and Chen, Y.G. (2007). GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene 26, 2471-2482.
-
(2007)
Oncogene
, vol.26
, pp. 2471-2482
-
-
Huang, W.1
Chang, H.Y.2
Fei, T.3
Wu, H.4
Chen, Y.G.5
-
24
-
-
77955462823
-
KLF6 Gene and early melanoma development in a collagen I-rich extracellular environment
-
Huh, S.J., Chen, Y.L., Friedman, S.L., Liao, J., Huang, H.J., Cavenee, W.K., and Robertson, G.P. (2010). KLF6 Gene and early melanoma development in a collagen I-rich extracellular environment. J. Natl Cancer Inst. 102, 1131-1147.
-
(2010)
J. Natl Cancer Inst.
, vol.102
, pp. 1131-1147
-
-
Huh, S.J.1
Chen, Y.L.2
Friedman, S.L.3
Liao, J.4
Huang, H.J.5
Cavenee, W.K.6
Robertson, G.P.7
-
25
-
-
77954216113
-
Targeting the MAPK pathway in melanoma: why some approaches succeed and other fail
-
Inamdar, G.S., Madhunapantula, S.V., and Robertson, G.P. (2010). Targeting the MAPK pathway in melanoma: why some approaches succeed and other fail. Biochem. Pharmacol. 80, 624-637.
-
(2010)
Biochem. Pharmacol.
, vol.80
, pp. 624-637
-
-
Inamdar, G.S.1
Madhunapantula, S.V.2
Robertson, G.P.3
-
26
-
-
58249090328
-
Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization
-
Iorns, E., Lord, C.J., and Ashworth, A. (2009). Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization. Biochem. J. 417, 361-370.
-
(2009)
Biochem. J.
, vol.417
, pp. 361-370
-
-
Iorns, E.1
Lord, C.J.2
Ashworth, A.3
-
27
-
-
78650309875
-
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
-
Johannessen, C.M., Boehm, J.S., Kim, S.Y. et al. (2010). COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 468, 968-972.
-
(2010)
Nature
, vol.468
, pp. 968-972
-
-
Johannessen, C.M.1
Boehm, J.S.2
Kim, S.Y.3
-
28
-
-
84870515328
-
GSK3beta inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylation
-
John, J.K., Paraiso, K.H., Rebecca, V.W. et al. (2012). GSK3beta inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylation. J. Invest. Dermatol. 132, 2818-2827.
-
(2012)
J. Invest. Dermatol.
, vol.132
, pp. 2818-2827
-
-
John, J.K.1
Paraiso, K.H.2
Rebecca, V.W.3
-
29
-
-
56249128977
-
GSK3beta: a master switch and a promising target
-
Kannoji, A., Phukan, S., Sudher Babu, V., and Balaji, V.N. (2008). GSK3beta: a master switch and a promising target. Expert Opin. Ther. Targets 12, 1443-1455.
-
(2008)
Expert Opin. Ther. Targets
, vol.12
, pp. 1443-1455
-
-
Kannoji, A.1
Phukan, S.2
Sudher Babu, V.3
Balaji, V.N.4
-
31
-
-
53049093524
-
Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation
-
Kotliarova, S., Pastorino, S., Kovell, L.C. et al. (2008). Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation. Cancer Res. 68, 6643-6651.
-
(2008)
Cancer Res.
, vol.68
, pp. 6643-6651
-
-
Kotliarova, S.1
Pastorino, S.2
Kovell, L.C.3
-
32
-
-
0016738010
-
Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining
-
Krishan, A. (1975). Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J. Cell Biol. 66, 188-193.
-
(1975)
J. Cell Biol.
, vol.66
, pp. 188-193
-
-
Krishan, A.1
-
33
-
-
67449150231
-
Increasing burden of melanoma in the United States
-
Linos, E., Swetter, S.M., Cockburn, M.G., Colditz, G.A., and Clarke, C.A. (2009). Increasing burden of melanoma in the United States. J. Invest. Dermatol. 129, 1666-1674.
-
(2009)
J. Invest. Dermatol.
, vol.129
, pp. 1666-1674
-
-
Linos, E.1
Swetter, S.M.2
Cockburn, M.G.3
Colditz, G.A.4
Clarke, C.A.5
-
34
-
-
70449708980
-
Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel
-
Liu, C., Zhao, G., Liu, J., Ma, N., Chivukula, P., Perelman, L., Okada, K., Chen, Z., Gough, D., and Yu, L. (2009). Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel. J. Control. Release 140, 277-283.
-
(2009)
J. Control. Release
, vol.140
, pp. 277-283
-
-
Liu, C.1
Zhao, G.2
Liu, J.3
Ma, N.4
Chivukula, P.5
Perelman, L.6
Okada, K.7
Chen, Z.8
Gough, D.9
Yu, L.10
-
35
-
-
57349143530
-
Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy
-
Luo, J. (2009). Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy. Cancer Lett. 273, 194-200.
-
(2009)
Cancer Lett.
, vol.273
, pp. 194-200
-
-
Luo, J.1
-
36
-
-
39149133664
-
Is B-Raf a good therapeutic target for melanoma and other malignancies?
-
Madhunapantula, S.V., and Robertson, G.P. (2008). Is B-Raf a good therapeutic target for melanoma and other malignancies? Cancer Res. 68, 5-8.
-
(2008)
Cancer Res.
, vol.68
, pp. 5-8
-
-
Madhunapantula, S.V.1
Robertson, G.P.2
-
37
-
-
67749086812
-
The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma
-
Madhunapantula, S.V., and Robertson, G.P. (2009). The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma. Pigment Cell Melanoma Res. 22, 400-419.
-
(2009)
Pigment Cell Melanoma Res.
, vol.22
, pp. 400-419
-
-
Madhunapantula, S.V.1
Robertson, G.P.2
-
38
-
-
34248545489
-
PRAS40 deregulates apoptosis in malignant melanoma
-
Madhunapantula, S.V., Sharma, A., and Robertson, G.P. (2007). PRAS40 deregulates apoptosis in malignant melanoma. Cancer Res. 67, 3626-3636.
-
(2007)
Cancer Res.
, vol.67
, pp. 3626-3636
-
-
Madhunapantula, S.V.1
Sharma, A.2
Robertson, G.P.3
-
39
-
-
49849086366
-
PBIse, a novel selenium containing drug for the treatment of malignant melanoma
-
Madhunapantula, S.V., Desai, D., Sharma, A., Huh, S., Amin, S., and Robertson, G.P. (2008). PBIse, a novel selenium containing drug for the treatment of malignant melanoma. Mol. Cancer Ther. 7, 1297-1308.
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 1297-1308
-
-
Madhunapantula, S.V.1
Desai, D.2
Sharma, A.3
Huh, S.4
Amin, S.5
Robertson, G.P.6
-
40
-
-
84857389943
-
Targeting sphingosine kinase-1 to inhibit melanoma
-
Madhunapantula, S.V., Hengst, J., Gowda, R., Fox, T.E., Yun, J.K., and Robertson, G.P. (2012). Targeting sphingosine kinase-1 to inhibit melanoma. Pigment Cell Melanoma Res. 25, 259-274.
-
(2012)
Pigment Cell Melanoma Res.
, vol.25
, pp. 259-274
-
-
Madhunapantula, S.V.1
Hengst, J.2
Gowda, R.3
Fox, T.E.4
Yun, J.K.5
Robertson, G.P.6
-
41
-
-
66749130761
-
Glycogen synthase kinase-3 inhibition disrupts nuclear factor-kappaB activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapy
-
Mamaghani, S., Patel, S., and Hedley, D.W. (2009). Glycogen synthase kinase-3 inhibition disrupts nuclear factor-kappaB activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapy. BMC Cancer 9, 132.
-
(2009)
BMC Cancer
, vol.9
, pp. 132
-
-
Mamaghani, S.1
Patel, S.2
Hedley, D.W.3
-
42
-
-
37249011314
-
RNAi screening for therapeutic targets in human malignancies
-
Micklem, D.R., and Lorens, J.B. (2007). RNAi screening for therapeutic targets in human malignancies. Curr. Pharm. Biotechnol. 8, 337-343.
-
(2007)
Curr. Pharm. Biotechnol.
, vol.8
, pp. 337-343
-
-
Micklem, D.R.1
Lorens, J.B.2
-
43
-
-
78049483997
-
Glycogen synthase kinase-3beta: a prognostic marker and a potential therapeutic target in human bladder cancer
-
Naito, S., Bilim, V., Yuuki, K., Ugolkov, A., Motoyama, T., Nagaoka, A., Kato, T., and Tomita, Y. (2010). Glycogen synthase kinase-3beta: a prognostic marker and a potential therapeutic target in human bladder cancer. Clin. Cancer Res. 16, 5124-5132.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 5124-5132
-
-
Naito, S.1
Bilim, V.2
Yuuki, K.3
Ugolkov, A.4
Motoyama, T.5
Nagaoka, A.6
Kato, T.7
Tomita, Y.8
-
44
-
-
78650303507
-
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
-
Nazarian, R., Shi, H., Wang, Q. et al. (2010). Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 468, 973-977.
-
(2010)
Nature
, vol.468
, pp. 973-977
-
-
Nazarian, R.1
Shi, H.2
Wang, Q.3
-
45
-
-
79551691994
-
Melanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4
-
Nguyen, N., Sharma, A., Sharma, A.K., Desai, D., Huh, S.J., Amin, S., Meyers, C., and Robertson, G.P. (2011). Melanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4. Cancer Prev. Res. (Phila.) 4, 248-258.
-
(2011)
Cancer Prev. Res. (Phila.)
, vol.4
, pp. 248-258
-
-
Nguyen, N.1
Sharma, A.2
Sharma, A.K.3
Desai, D.4
Huh, S.J.5
Amin, S.6
Meyers, C.7
Robertson, G.P.8
-
46
-
-
33646795341
-
Targeting GSK-3: a promising approach for cancer therapy?
-
Ougolkov, A.V., and Billadeau, D.D. (2006). Targeting GSK-3: a promising approach for cancer therapy? Future Oncol. 2, 91-100.
-
(2006)
Future Oncol.
, vol.2
, pp. 91-100
-
-
Ougolkov, A.V.1
Billadeau, D.D.2
-
47
-
-
84857093928
-
Towards new therapeutic approaches for malignant melanoma
-
Pacheco, I., Buzea, C., and Tron, V. (2011). Towards new therapeutic approaches for malignant melanoma. Expert Rev. Mol. Med. 13, e33.
-
(2011)
Expert Rev. Mol. Med.
, vol.13
-
-
Pacheco, I.1
Buzea, C.2
Tron, V.3
-
48
-
-
38149102519
-
GSK-3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines
-
Panka, D.J., Cho, D.C., Atkins, M.B., and Mier, J.W. (2008). GSK-3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines. J. Biol. Chem. 283, 726-732.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 726-732
-
-
Panka, D.J.1
Cho, D.C.2
Atkins, M.B.3
Mier, J.W.4
-
49
-
-
67650569513
-
Glycogen synthase kinase 3: more than a namesake
-
Rayasam, G.V., Tulasi, V.K., Sodhi, R., Davis, J.A., and Ray, A. (2009). Glycogen synthase kinase 3: more than a namesake. Br. J. Pharmacol. 156, 885-898.
-
(2009)
Br. J. Pharmacol.
, vol.156
, pp. 885-898
-
-
Rayasam, G.V.1
Tulasi, V.K.2
Sodhi, R.3
Davis, J.A.4
Ray, A.5
-
50
-
-
0032483009
-
In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma
-
Robertson, G.P., Furnari, F.B., Miele, M.E., Glendening, M.J., Welch, D.R., Fountain, J.W., Lugo, T.G., Huang, H.J., and Cavenee, W.K. (1998). In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma. Proc. Natl Acad. Sci. USA 95, 9418-9423.
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 9418-9423
-
-
Robertson, G.P.1
Furnari, F.B.2
Miele, M.E.3
Glendening, M.J.4
Welch, D.R.5
Fountain, J.W.6
Lugo, T.G.7
Huang, H.J.8
Cavenee, W.K.9
-
51
-
-
79958776304
-
Inhibition of glycogen synthase kinase-3 increases the cytotoxicity of enzastaurin
-
Rovedo, M.A., Krett, N.L., and Rosen, S.T. (2011). Inhibition of glycogen synthase kinase-3 increases the cytotoxicity of enzastaurin. J. Invest. Dermatol. 131, 1442-1449.
-
(2011)
J. Invest. Dermatol.
, vol.131
, pp. 1442-1449
-
-
Rovedo, M.A.1
Krett, N.L.2
Rosen, S.T.3
-
52
-
-
34547782316
-
Inhibition of GSK-3 beta activity attenuates proliferation of human colon cancer cells in rodents
-
Shakoori, A., Mai, W., Miyashita, K., Yasumoto, K., Takahashi, Y., Ooi, A., Kawakami, K., and Minamoto, T. (2007). Inhibition of GSK-3 beta activity attenuates proliferation of human colon cancer cells in rodents. Cancer Sci. 98, 1388-1393.
-
(2007)
Cancer Sci.
, vol.98
, pp. 1388-1393
-
-
Shakoori, A.1
Mai, W.2
Miyashita, K.3
Yasumoto, K.4
Takahashi, Y.5
Ooi, A.6
Kawakami, K.7
Minamoto, T.8
-
53
-
-
77955757007
-
Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells
-
Shao, Y., and Aplin, A.E. (2010). Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells. Cancer Res. 70, 6670-6681.
-
(2010)
Cancer Res.
, vol.70
, pp. 6670-6681
-
-
Shao, Y.1
Aplin, A.E.2
-
54
-
-
16844362816
-
Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors
-
Sharma, A., Trivedi, N.R., Zimmerman, M.A., Tuveson, D.A., Smith, C.D., and Robertson, G.P. (2005). Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors. Cancer Res. 65, 2412-2421.
-
(2005)
Cancer Res.
, vol.65
, pp. 2412-2421
-
-
Sharma, A.1
Trivedi, N.R.2
Zimmerman, M.A.3
Tuveson, D.A.4
Smith, C.D.5
Robertson, G.P.6
-
55
-
-
63449115826
-
Targeting Akt3 signaling in malignant melanoma using isoselenocyanates
-
Sharma, A., Sharma, A.K., Madhunapantula, S.V., Desai, D., Huh, S.J., Mosca, P., Amin, S., and Robertson, G.P. (2009), Targeting Akt3 signaling in malignant melanoma using isoselenocyanates. Clin. Cancer Res. 15, 1674-1685.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 1674-1685
-
-
Sharma, A.1
Sharma, A.K.2
Madhunapantula, S.V.3
Desai, D.4
Huh, S.J.5
Mosca, P.6
Amin, S.7
Robertson, G.P.8
-
56
-
-
79960335679
-
The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model
-
Sharma, A.K., Kline, C.L., Berg, A., Amin, S., and Irby, R.B. (2011). The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model. Clin. Cancer Res. 17, 4474-4483.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 4474-4483
-
-
Sharma, A.K.1
Kline, C.L.2
Berg, A.3
Amin, S.4
Irby, R.B.5
-
57
-
-
84875148077
-
Identification of aurora kinase B and Wee1-like protein kinase as downstream targets of (V600E)B-RAF in melanoma
-
Sharma, A., Madhunapantula, S.V., Gowda, R., Berg, A., Neves, R.I., and Robertson, G.P. (2013). Identification of aurora kinase B and Wee1-like protein kinase as downstream targets of (V600E)B-RAF in melanoma. Am. J. Pathol. 182, 1151-1162.
-
(2013)
Am. J. Pathol.
, vol.182
, pp. 1151-1162
-
-
Sharma, A.1
Madhunapantula, S.V.2
Gowda, R.3
Berg, A.4
Neves, R.I.5
Robertson, G.P.6
-
58
-
-
84855792427
-
Cancer statistics, 2012
-
Siegel, R., Naishadham, D., and Jemal, A. (2012). Cancer statistics, 2012. CA Cancer J. Clin. 62, 10-29.
-
(2012)
CA Cancer J. Clin.
, vol.62
, pp. 10-29
-
-
Siegel, R.1
Naishadham, D.2
Jemal, A.3
-
59
-
-
84858262373
-
Cancers with increasing incidence trends in the United States: 1999 through 2008
-
Simard, E.P., Ward, E.M., Siegel, R., and Jemal, A. (2012). Cancers with increasing incidence trends in the United States: 1999 through 2008. CA Cancer J. Clin. 62, 118-128.
-
(2012)
CA Cancer J. Clin.
, vol.62
, pp. 118-128
-
-
Simard, E.P.1
Ward, E.M.2
Siegel, R.3
Jemal, A.4
-
60
-
-
33745075558
-
Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases
-
Smalley, K.S., Haass, N.K., Brafford, P.A., Lioni, M., Flaherty, K.T., and Herlyn, M. (2006). Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases. Mol. Cancer Ther. 5, 1136-1144.
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 1136-1144
-
-
Smalley, K.S.1
Haass, N.K.2
Brafford, P.A.3
Lioni, M.4
Flaherty, K.T.5
Herlyn, M.6
-
61
-
-
33846440113
-
An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells
-
Smalley, K.S., Contractor, R., Haass, N.K. et al. (2007). An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells. Cancer Res. 67, 209-217.
-
(2007)
Cancer Res.
, vol.67
, pp. 209-217
-
-
Smalley, K.S.1
Contractor, R.2
Haass, N.K.3
-
62
-
-
79951961755
-
Resistance to BRAF inhibition in melanomas
-
Solit, D.B., and Rosen, N. (2011). Resistance to BRAF inhibition in melanomas. N. Engl. J. Med. 364, 772-774.
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 772-774
-
-
Solit, D.B.1
Rosen, N.2
-
63
-
-
0038243115
-
Loss of PTEN promotes tumor development in malignant melanoma
-
Stahl, J.M., Cheung, M., Sharma, A., Trivedi, N.R., Shanmugam, S., and Robertson, G.P. (2003). Loss of PTEN promotes tumor development in malignant melanoma. Cancer Res. 63, 2881-2890.
-
(2003)
Cancer Res.
, vol.63
, pp. 2881-2890
-
-
Stahl, J.M.1
Cheung, M.2
Sharma, A.3
Trivedi, N.R.4
Shanmugam, S.5
Robertson, G.P.6
-
64
-
-
4944249733
-
Deregulated Akt3 activity promotes development of malignant melanoma
-
Stahl, J.M., Sharma, A., Cheung, M., Zimmerman, M., Cheng, J.Q., Bosenberg, M.W., Kester, M., Sandirasegarane, L., and Robertson, G.P. (2004). Deregulated Akt3 activity promotes development of malignant melanoma. Cancer Res. 64, 7002-7010.
-
(2004)
Cancer Res.
, vol.64
, pp. 7002-7010
-
-
Stahl, J.M.1
Sharma, A.2
Cheung, M.3
Zimmerman, M.4
Cheng, J.Q.5
Bosenberg, M.W.6
Kester, M.7
Sandirasegarane, L.8
Robertson, G.P.9
-
65
-
-
54849373400
-
Targeting V600EB-Raf and Akt3 using nanoliposomal-small interfering RNA inhibits cutaneous melanocytic lesion development
-
Tran, M.A., Gowda, R., Sharma, A., Park, E.J., Adair, J., Kester, M., Smith, N.B., and Robertson, G.P. (2008). Targeting V600EB-Raf and Akt3 using nanoliposomal-small interfering RNA inhibits cutaneous melanocytic lesion development. Cancer Res. 68, 7638-7649.
-
(2008)
Cancer Res.
, vol.68
, pp. 7638-7649
-
-
Tran, M.A.1
Gowda, R.2
Sharma, A.3
Park, E.J.4
Adair, J.5
Kester, M.6
Smith, N.B.7
Robertson, G.P.8
-
66
-
-
78650008177
-
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
-
Villanueva, J., Vultur, A., Lee, J.T. et al. (2010). Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell 18, 683-695.
-
(2010)
Cancer Cell
, vol.18
, pp. 683-695
-
-
Villanueva, J.1
Vultur, A.2
Lee, J.T.3
-
67
-
-
55249120170
-
Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy
-
Wang, Z., Smith, K.S., Murphy, M., Piloto, O., Somervaille, T.C., and Cleary, M.L. (2008). Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy. Nature 455, 1205-1209.
-
(2008)
Nature
, vol.455
, pp. 1205-1209
-
-
Wang, Z.1
Smith, K.S.2
Murphy, M.3
Piloto, O.4
Somervaille, T.C.5
Cleary, M.L.6
-
68
-
-
78651388423
-
Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo
-
Werzowa, J., Koehrer, S., Strommer, S., Cejka, D., Fuereder, T., Zebedin, E., and Wacheck, V. (2011). Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo. J. Invest. Dermatol. 131, 495-503.
-
(2011)
J. Invest. Dermatol.
, vol.131
, pp. 495-503
-
-
Werzowa, J.1
Koehrer, S.2
Strommer, S.3
Cejka, D.4
Fuereder, T.5
Zebedin, E.6
Wacheck, V.7
-
69
-
-
54249111455
-
Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer
-
Wilson, W. 3rd, and Baldwin, A.S. (2008). Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer. Cancer Res. 68, 8156-8163.
-
(2008)
Cancer Res.
, vol.68
, pp. 8156-8163
-
-
Wilson III, W.1
Baldwin, A.S.2
-
70
-
-
0029847565
-
Induction of apoptosis in prostatic tumor cell line DU145 by staurosporine, a potent inhibitor of protein kinases
-
Zhang, H., Hoang, T., Saeed, B., and Ng, S.C. (1996). Induction of apoptosis in prostatic tumor cell line DU145 by staurosporine, a potent inhibitor of protein kinases. Prostate 29, 69-76.
-
(1996)
Prostate
, vol.29
, pp. 69-76
-
-
Zhang, H.1
Hoang, T.2
Saeed, B.3
Ng, S.C.4
-
71
-
-
4444372444
-
Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways
-
Zhang, X.D., Gillespie, S.K., and Hersey, P. (2004). Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways. Mol. Cancer Ther. 3, 187-197.
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 187-197
-
-
Zhang, X.D.1
Gillespie, S.K.2
Hersey, P.3
|