Fruits and Vegetables

Food Hypersensitivity: Diagnosing and Managing Food Allergies and Intolerance

Volumn , Issue , 2009, Pages 147-165

  Skypala, Isabel ^a,b  

^a ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Apples, causing fruit allergy in Europe; Fruits and vegetables; Main allergens, involving in OAS, occurring in plant defence system and profilin families; Oral allergy syndrome (OAS); Plant defence system, containing pathogenesis related (PR) proteins; Prolamin superfamily, including cereal prolamins, seed storage proteins and nsLTPs; Thaumatin like proteins (TLPs)

Indexed keywords

EID: 84886154108     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781444312119.ch7     Document Type: Chapter

References (103)

1. Breiteneder H, Mills ENC. Molecular properties of food allergens. J Allergy Clin Immunol 2005;115:14-23.
2. Mari A, Ballmer-Weber BK, Veiths S. The oral allergy syndrome: improved diagnostic and treatment methods. Curr Opin Allergy Clin Immunol 2005;5:267-73.
3. Pastorello EA, Ortalani C. Oral allergy syndrome. In: Metcalfe DD, Sampson HJ, Simon RA, eds. Food Allergy: Adverse Reactions to Foods and Food Additives. Oxford: Blackwell, 2003: 425-37.
4. Eriksson NE, Formaren H, Svenonius E. Food hypersensitivity in patients with pollen allergy. Allergy 1982;37:437-43.
5. Steinke M, Fiocchi A, Kirchlechner V et al. Perceived food allergy in children in 10 European nations: a randomised telephone survey. Int Arch Allergy Immunol 2007;143:290-5.
6. Zuberbier T, Edenharter G, Worm M et al. Prevalence of adverse reactions to food in Germany: a population study. Allergy 2004;59:338-45.
7. Eriksson NE, Möller C, Werner S et al. Self-reported food hypersensitivity in Sweden, Denmark, Estonia, Lithuania and Russia. J Investig Allergol Clin Immunol 2004;14:70-9.
8. Cuesta-Herranz J, Lazaro M, de las Heras M et al. Peach allergy pattern: experience in 70 patients. Allergy 1998;53:78-82.
9. Ballmer-Weber B, Wüthrich B, Wangorsch A et al. Carrot allergy: double-blinded, placebo-controlled food challenge and identification of allergens. J Allergy Clin Immunol 2001;108:301-7.
10. Ballmer-Weber BK, Vieths S, Luttkopf D, Heuschmann P, Wüthrich B. Celery allergy confirmed by double-blind, placebo-controlled food challenge. J Allergy Clin Immunol 2000;106:373-8.
11. Lucas JSA, Lewis SA, Hourihane J. Kiwi fruit allergy: a review. Pediatr Allergy Immunol 2003;14:420-8.
12. Alemán A, Sastre J, Quirce S, et al. Allergy to kiwi: a double-blind, placebo-controlled food challenge study in patients from a birch-free area. J Allergy Clin Immunol 2004;113:543-50.
13. Sicherer SH, Sampson HA. Food allergy. J Allergy Clin Immunol 2006;117:S470-5.
14. Falcäo H, Lunet N, Lopes C, Barros H. Food hypersensitivity in Portuguese adults. Eur J Clin Nutr 2004;58:1621-5.
15. Osterballe M, Hansen TK, Mortz CG, Høst A, Bindslev-Jensen C. The prevalence of food hypersensitivity in an unselected population of children and adults. Pediatr Allergy Immunol 2005;16:567-73.
16. Vierk KA, Koehler KM, Fein SB, Street DA. Prevalence of self-reported food allergy in American adults and use of food labels. J Allergy Clin Immunol 2007;119:1504-10.
17. Venter C, Pereira B, Voigt K et al. Prevalence and cumulative incidence of food hypersens-itivity in the first three years of life. Allergy 2008;63:354-9.
18. Pereira B, Venter C, Grundy J et al. Prevalence of sensitization to food allergens, reported adverse reaction to foods, food avoidance, and food hypersensitivity among teenagers. J Allergy Clin Immunol 2005;116:884-92.
19. Schäfer T, Böhler E, Ruhdorfer S et al. Epidemiology of food allergy/food intolerance in adults: associations with other manifestations of atopy. Allergy 2001;56:1172-9.
20. Hoffmann-Sommergruber K, Radauer C. Bet v 1-homologous allergens. In: Mills ENC, Shewry PR, eds. Plant Food Allergens. Oxford: Blackwell, 2004: 125-40.
21. Dreborg S. Allergy in pollen-sensitive patients. Ann Allergy 1988;64:41.
22. Veiths S, Scheurer S, Ballmer-Weber B. Current understanding of cross-reactivity of food allergens and pollen. Ann N Y Acad Sci 2002;964:47-68.
23. Bauchau V, Durham SR. Prevalence and rate of diagnosis of allergic rhinitis in Europe. Eur Respir J 2004;24:758-64.
24. Mothes N, Westritschnig K, Valenta R. Tree pollen allergens. In: Lockey RF, Bukantz S, Bousquet J, eds. Allergens and Allergen Immunotherapy. New York, NY: Informa Health Care, 2004: 165-84.
25. Royal College of Physicians Working Party. Allergy: the Unmet Need. London: Royal College of Physicians, 2003.
26. Breiteneder H, Radauer C. A classification of plant food allergens J Allergy Clin Immunol 2004;113:821-30.
27. Radauer C, Breiteneder H. Evolutionary biology of plant food allergens. J Allergy Clin Immunol 2007;120:518-25.
28. Vaughan JG, Geissler CA. The New Oxford Book of Food Plants. Oxford: Oxford University Press, 1997.
29. Radauer C, Hoffmann-Sommergruber K. Profilins. In: Mills ENC, Shewry PR, eds. Plant Food Allergens. Oxford: Blackwell, 2004: 105-24.
30. Breiteneder H. Thaumatin-like proteins: a new family of pollen and fruit allergens. Allergy 2004;59:479-81.
31. Salcedo G, Sanchez-Monge R, Diaz-Perales A, Garcia-Casado G, Barber D. Plant non-specific lipid transfer proteins as food and pollen allergens. Clin Exp Allergy 2004;34:1336-41.
32. Asero R, Mistrello G, Roncarolo D, Amato S. Relationship between peach lipid transfer protein specific IgE levels and hypersensitivity to non-Rosaceae vegetable foods in patients allergic to lipid transfer protein. Ann Allergy Asthma Immunol 2004;92:268-72.
33. Fernández-Rivas M, Bolhaar S, González-Moncebo E et al. Apple allergy across Europe: how allergen sensitisation profiles determine the clinical expression of allergies to plant foods. J Allergy Clin Immunol 2006;118:481-8.
34. Kalogeromitros DC, Makris MP, Gregoriou SG et al. Grape anaphylaxis: a study of 11 adult onset cases. Allergy Asthma Proc 2005;26:53-8.
35. Schad SG, Trcka J, Vieths S et al. Wine anaphylaxis in a German patient: IgE-mediated allergy against a lipid transfer protein of grapes. Int Arch Allergy Immunol 2005;136:159-64.
36. Lucas JSA, Nieuwenhuizen NJ, Atkinson RG et al. Kiwifruit allergy: actinidin is not a major allergen in the United Kingdom. Clin Exp Allergy 2007;37:1340-8.
37. André F, André C, Colin L, Cacaraci F, Cavagna S. Role of new allergens consumption in the increased incidence of food sensitization in France. Toxicology 1994;92:77-83.
38. Ballmer-Weber BK, Hoffmann A, Wüthrich B et al. Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked celery in patients with celery allergy. Allergy 2002;57:228-35.
39. San Miguel-Moncín M, Krail M, Scheurer S et al. Lettuce anaphylaxis: identification of a lipid transfer protein as the major allergen. Allergy 2003;58:511-17.
40. Palacín A, Cumplido J, Figueroa J et al. Cabbage lipid transfer protein Bra o 3 is a major allergen responsible for cross-reactivity between plant foods and pollens. J Allergy Clin Immunol 2007;6:1423-9.
41. De Swert LFA, Cadot P, Ceuppens JL. Diagnosis and natural course of allergy to cooked potatoes in children. Allergy 2007;62:750-7.
42. Egger M, Mutschlechner S, Wopfner N et al. Pollen-food syndromes associated with weed pollinosis: an update from the molecular point of view. Allergy 2006;61:461-76.
43. Ma S, Sicherer SC, Nowark-Wegrzyn A. A survey on the management of pollen-food allergy syndrome in allergy practices. J Allergy Clin Immunol 2003;112:784-8.
44. Breiteneder H, Ebner C. Molecular and biochemical classifications of plant-derived food allergens. J Allergy Clinn Immunol 2000;106:27-36.
45. Sampson H. Update on food allergy. J Allergy Clin Immunol 2004;113:805-19.
46. Bohle B. The impact of pollen-related food allergens on pollen allergy. Allergy 2007;62:3-10.
47. Mills ENC, Jenkins JA, Shewry PR. The role of common properties in determining plant food protein allergenicity. In: Mills ENC, Shewry PR, eds. Plant Food Allergens. Oxford: Blackwell, 2004: 158-70.
48. Osterballe M, Hansen TK, Mortz CG, Bindslev-Jensen C. The clinical relevance of sensitisa-tion to pollen-related fruits and vegetables in unselected pollen-sensitised adults. Allergy 2005;60:218-25.
49. Mortz CG, Andersen KE, Bindeslev-Jensen C. Prevalence of peanut sensitisation and the association to pollen sensitisation in a cohort of unselected adolescents: the Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis (TOACS). Pediatr Allergy Immunol 2005;16:501-6.
50. Emberlin JC. Grass, tree and weed pollens. In: Kay AB, ed. Allergy and Allergic Diseases. Oxford: Blackwell, 1997: 835-57.
51. Enrique E, Cisteró-Bahima A, Bartolomé B et al. Platanus acerifolia pollinosis and food allergy. Allergy 2002;75:351-6.
52. Hugues B, Didierlaurent A, Charpin D. Cross-reactivity between cypress pollen and peach: a report of seven cases. Allergy 2006;61:1241-3.
53. Asero R. Birch and ragweed pollenosis of Milan: a model to investigate the effects of exposure to 2 new airborne allergens. Allergy 2002;57:1063-6.
54. Wagner S, Breiteneder H. The latex-fruit syndrome. Biochem Soc Trans 2002;30:935-40.
55. Jarolim E, Rumpold H, Endler AT et al. IgE and IgG antibodies of patients with allergy to birch pollen as tools to define the allergen profile of Betula verrucosa. Allergy 1989;44:385-95.
56. Hoffmann-Sommergruber K. Plant allergens and pathogenisis-related proteins. What do they have in common? Int Arch Allergy Immunol 2000;122:155-66.
57. Rodriguez-Perez R, Crespo J, Rodruigez J, Salcedo G. Profilin is a relevant melon allergen susceptible to pepsin digestion in patients with oral allergy syndrome. J Allergy Clin Immunol 2003;111:634-9.
58. Asero R. Plant food allergies: a suggested approach to allergen-resolved diagnosis in the clinical practice by identifying easily available sensitisation markers. Int Arch Allergy Immunol 2005;138:1-11.
59. van Ree RM, Fernandez-Rivas M, Cuevas M, van Wijngaarden M, Aalberse RC. Pollen-related allergy to peach and apple: an important role for profilin. J Allergy Clin Immunol. 1995;95:726-34.
60. van Ree R, Aalberse RC. Pollen vegetable food cross-reactivity: serological and clinical relevance of cross-reactive IgE. J Clin Immunoassay 1993;16:124-30.
61. Ortolani C, Ispano M, Pastorello E, Bigi A, Ansaloni R. The oral allergy syndrome. Ann Allergy 1988;61:47-52.
62. Etesamifar M, Wüthrich B. IgE-vermittelte Nahrungsmittelallergie bei 383 Patienten unter Berücksichigung des oralen Allergie-Syndroms. Allergologie 1998;21:451-7.
63. Jensen-Jarolim E, Leitner A, Hirschwehr R et al. Characterization of allergens in Apiaceae spices: anise, fennel, coriander and cumin. Clin Exp Allergy 1997;27:1299-306.
64. Moneret-Vautrin DA, Morisset M, Lemerdy P, Croizier A, Kanny G. Food allergy and IgE sensitization caused by spices: CICBAA data (based on 589 cases of food allergy). Allerg Immunol (Paris) 2002;34:135-40.
65. Chiu AM, Zacharisen MC. Anaphylaxis to dill. Ann Allergy Asthma Immunol 2000;84:559-60.
66. Bock SA. Anaphylaxis to coriander: a sleuthing story. J Allergy Clin Immunol 1993;91:1232-3.
67. Kleiber-Janke T, Crameri R, Scheurer S, Veiths S, Becker WM. Patient-tailored cloning of allergens by phage display: peanut (Arachis hypogaea) profilin, a food allergen derived from a rare mRNA. J Chromatogr B Biomed Sci Appl 2001;756:295-305.
68. Mittag D, Akkerdass J, Ballmer-Weber B et al. Ara h 8, a Bet v 1-homologous allergen from peanut, is a major allergen in patients with combined birch pollen and peanut allergy. J Allergy Clin Immunol 2004;114:1410-17.
69. Pastorello EA, Vieths S, Pravettoni V et al. Identification of hazelnut major allergens in sensitive patients with positive double-blind, placebo-controlled food challenge results. J Allergy Clin Immunol 2002;109:563-70.
70. Raulf-Heimsoth M, Rihs HP, Rozynek P et al. Quantitative analysis of immunoglobulin E reactivity profiles in patients allergic or sensitised to natural rubber latex (Hevea brasiliensis) Clin Exp Allergy 2007;37:1657-67.
71. Wagner S, Breiteneder H. Hevea brasiliensis latex allergens: current panel and clinical relevance. Int Arch Allergy Immunol 2005;136:90-7.
72. Ibero M, Castilio M, Pineda F. Allergy to cassava: a new allergenic food with cross-reactivity to latex. J Investig Allergol Clin Immunol 2007;17:409-12.
73. Pereira C, Tavares B, Loureiro G, Lundberg M, Chieira C. Turnip and zucchini: new foods in the latex-fruit syndrome. Allergy 2007;62:452-3.
74. Ho MHK, Hill DJ. White button mushroom food hypersensitivity in a child. J Paediatr Child Health 2006;42:555-6.
75. Senti G, Leser C, Lundberg M, Wüthrich B. Allergic asthma to shiitake and oyster mushroom. Allergy 2000;55:975-6.
76. Aalto-Korte K, Susitaival P, Kaminska R, Mäkinen-Kiljunen S. Occupational protein contact dermatitis from shiitake mushroom and demonstration of shiitake-specific immunoglobulin E. Contact Dermatitis 2005;53:211-13.
77. Levy AM, Kita H, Phillips SF et al. Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms. J Allergy Clin Immunol 1998;101:613-20.
78. Dauby PAL, Whisman BA, Hagan L Cross-reactivity between raw mushroom and molds in a patient with oral allergy syndrome. Ann Allergy Asthma Immunol 2002;89:319-21.
79. Herrera I, Moneo I, Caballero ML et al. Food allergy to spinach and mushroom. Allergy 2002;57:261-2.
80. Koivikko A, Savolainen J. Mushroom allergy. Allergy 1988;43:1-10.
81. Helbling A, Gayer F, Pichler WJ, Brander KA. Mushroom (Basidiomycete) allergy: diagnosis established by skin test and nasal challenge. J Allergy Clin Immunol 1998;102:853-8.
82. Airola K, Petman L, Mäkinen-Kiljunen S. Clustered sensitivity to fungi: anaphylactic reactions caused by ingestive allergy to yeasts. Ann Allergy Asthma Immunol 2006;97:294-7.
83. Fernandez-Rivas M, Miles S. Food allergies: clinical and psychosocial perspectives. In: Mills ENC, Shewry PR, eds. Plant Food Allergens. Oxford: Blackwell, 2004: 1-23.
84. Schimek EM, Zwölfer B, Brize P et al. Gastrointestinal digestion of Bet v 1-homologous food allergens destroys their mediator-releasing, but not T-cell activating, capacity. J Allergy Clin Immunol 2005;116:1327-33.
85. Bohle B, Zwölfer B, Heratizadeh A et al. Cooking birch pollen-related food: divergent consequences for IgE-and T cell-mediated reactivity in vitro and in vivo. J Allergy Clin Immunol 2006;118:242-9.
86. Dreborg S, Foucard T. Allergy to apple, carrot and potato in children with birch pollen allergy. Allergy 1983;38:167-72.
87. Helm RM. Food allergy: in-vivo diagnostics including challenge. Curr Opin Allergy Clin Immunol 2001;1:255-9.
88. Anhøj C, Backer V, Nolte H. Diagnostic evaluation of grass-and birch-allergic patients with oral allergy syndrome. Allergy 2001;56:548-52.
89. Ortolani C, Ispano M, Pastorello EA, Ansaloni R, Magri GC. Comparison of results of skin prick tests (with fresh foods and commercial food extracts) and RAST in 100 patients with oral allergy syndrome. J Allergy Clin Immunol 1989;83:683-90.
90. Sicherer SH. Clinical implications of cross-reactive food allergens. J Allergy Clin Immunol 2001;108:881-90.
91. Crespo JF, Rodriguez J, James JM et al. Reactivity to potential cross-reactive foods in fruit-allergic patients: implications for prescribing food avoidance. Allergy 2002;57:946-9.
92. Fernandez-Rivas M, Cuevas M. Peels of Rosaceae fruits have a higher allergenicity than pulps. Clin Exp Allergy 1999;29:1239-47.
93. Bindslev-Jensen C, Ballmer-Webber BK, Bengtsson U et al. Standardisation of food challenges in patients with immediate reactions to foods: position paper from the European Academy of Allergology and Clinical Immunology. Allergy 2004;59:690-7.
94. Asero R, Massironi F, Velati C. Detection of prognostic factors for oral allergy syndrome in patients with birch pollen hypersensitivity. J Allergy Clin Immunol 1996;2:611-16.
95. Sloan D, Sheffer A. Oral allergy syndrome. Allergy Asthma Proc 2001;22:321-5.
96. Veiths S, Jankiewicz A, Schöning B, Aulepp H. Apple allergy: the IgE-binding potency of apple strains is related to the occurrence of the 18-kDa allergen. Allergy 1994;49:262-71.
97. Carnés J, Ferrer A, Fernández-Caldas E. Allergenicity of 10 different apple varieties. Ann Allergy Asthma Immunol 2006;96:564-70.
98. Sancho AI, Foxall R, Browne T et al. Effect of postharvest storage on the expression of the apple allergen Mal d 1. J Agric Food Chem 2006;54:5917-23.
99. Assero R. How long does the effect of birch pollen injection SIT on apple allergy last? Allergy 2003;58:435-8.
100. Hansen KS, Khinchi MS, Skov PS et al. Food allergy to apple and specific immunotherapy with birch pollen. Mol Nutr Food Res 2004;48:441-8.
101. Bucher X, Pichier WJ, Dahinden CA, Heibling A. Effect of tree pollen specific subcutaneous immunotherapy on the oral allergy syndrome to apple and hazelnut. Allergy 2004;59:1272-6.
102. Kinaciyan T, Jahn-Schmid B, Radakovics A et al. Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1. J Allergy Clin Immunol 2007;119:937-43.
103. des Roches A, Paradis L, Paradis J, Singer S. Food allergy as a new risk factor for scurvy. Allergy 2006;61:1487-8.