The kinetic, mechanistic and cytomorphological effects of palytoxin in human intestinal cells (Caco-2) explain its lower-than-parenteral oral toxicity

FEBS Journal

Volumn 280, Issue 16, 2013, Pages 3906-3919

  Fernández, Diego A ^a   Louzao, M Carmen ^a   Vilariño, Natalia ^a   Espiña, Begoña ^a   Fraga, María ^a,b   Vieytes, Mercedes R ^a   Román, Albina ^c   Poli, Mark ^d   Botana, Luis M ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b INTERNATIONAL IBERIAN NANOTECHNOLOGY LABORATORY   (Portugal)

^c Unidad de Microscopía Electrõnica y Confocal   (Spain)

^d UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

Caco 2; intestinal permeability; occludin; palytoxin; trans epithelial electric resistance

Indexed keywords

OCCLUDIN; PALYTOXIN; ACRYLAMIDE DERIVATIVE; GASTROINTESTINAL AGENT; MARINE TOXIN; OCLN PROTEIN, HUMAN;

ARTICLE; CELL NUCLEUS MEMBRANE; CELL STRAIN CACO 2; CELL ULTRASTRUCTURE; CHROMATIN CONDENSATION; CONCENTRATION (PARAMETERS); CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; ELECTRIC RESISTANCE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE BRUSH BORDER; INTESTINE CELL; INTESTINE MUCOSA PERMEABILITY; PRIORITY JOURNAL; TIGHT JUNCTION; TRANSMISSION ELECTRON MICROSCOPY; CACO-2; CELL DIFFERENTIATION; CELL ORGANELLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; DRUG EFFECT; IMPEDANCE; INTESTINAL PERMEABILITY; KINETICS; METABOLISM; MICROVILLUS; MITOCHONDRION; OSMOLARITY; PERMEABILITY; TRANS-EPITHELIAL ELECTRIC RESISTANCE; ULTRASTRUCTURE;

CACO-2; INTESTINAL PERMEABILITY; OCCLUDIN; PALYTOXIN; TRANS-EPITHELIAL ELECTRIC RESISTANCE;

ACRYLAMIDES; CACO-2 CELLS; CELL DIFFERENTIATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; ELECTRIC IMPEDANCE; ENTEROCYTES; GASTROINTESTINAL AGENTS; HUMANS; KINETICS; MARINE TOXINS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MICROVILLI; MITOCHONDRIA; NUCLEAR ENVELOPE; OCCLUDIN; ORGANELLES; OSMOLAR CONCENTRATION; PERMEABILITY; TIGHT JUNCTIONS;

EID: 84885938283     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12390     Document Type: Article

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