The cytoskeleton, a structure that is susceptible to the toxic mechanism activated by palytoxins in human excitable cells

FEBS Journal

Volumn 274, Issue 8, 2007, Pages 1991-2004

  Louzao, M Carmen ^a   Ares, Isabel R ^a   Vieytes, Mercedes R ^a   Valverde, Iago ^b   Vieites, Juan M ^b   Yasumoto, Takeshi ^c   Botana, Luis M ^a,d  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIVERSITY OF VIGO   (Spain)

^c JAPAN FOOD RESEARCH LABORATORIES   (Japan)

^d Facultad de Veterinaria   (Spain)

Author keywords

Actin cytoskeleton; Laser scanning cytometry; Membrane potential; Ostreocin D; Palytoxin

Indexed keywords

CALCIUM ION; OSTREOCIN D; PALYTOXIN; TOXIN; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ARTICLE; CALCIUM CELL LEVEL; CELL ADHESION; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE POTENTIAL; CELL STRUCTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSKELETON; CYTOTOXICITY; FLUORESCENCE; HUMAN; HUMAN CELL; ION TRANSPORT; LASER SCANNING CYTOMETRY; NEUROBLASTOMA CELL; PRIORITY JOURNAL; SPECTROFLUOROMETRY;

ACRYLAMIDES; ACTINS; BICYCLO COMPOUNDS, HETEROCYCLIC; CALCIUM; CELL LINE, TUMOR; CYTOSKELETON; HUMANS; NA(+)-K(+)-EXCHANGING ATPASE; PYRANS;

EID: 34247151646     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2007.05743.x     Document Type: Article

References (52)

1. Taniyama S, Arakawa O, Terada M, Nishio S, Takatani T, Mahmud Y & Noguchi T (2003) Ostreopsis sp., a possible origin of palytoxin (PTX) in parrotfish Scarus ovifrons. Toxicon 42, 29-33.
2. Onuma Y, Satake M, Ukena T, Roux J, Chanteau S, Rasolofonirina N, Ratsimaloto M, Naoki H & Yasumoto T (1999) Identification of putative palytoxin as the cause of clupeotoxism. Toxicon 37, 55-65.
3. Yasumoto T (2001) The chemistry and biological function of natural marine toxins. Chem Rec 1, 228-242.
4. Wiles JS, Vick JA & Christensen MK (1974) Toxicological evaluation of palytoxin in several animal species. Toxicon 12, 427-433.
5. Nakajima I, Oshima Y & Yasumoto T (1981) Toxicity of benthic dinoflagellates in Okinawa. Bull Jap Soc Sci Fish 47, 1029-1033.
6. Usami M, Satake M, Ishida S, Inoue A, Kan Y & Yasumoto T (1995) Palytoxin analogs from the dinoflagellates Ostreopsis siamensis. J Am Chem Soc 177, 5389-5390.
7. Contreras RG, Flores-Maldonado C, Lazaro A, Shoshani L, Flores-Benitez D, Larre I & Cereijido M (2004) Ouabain binding to Na+,K+-ATPase relaxes cell attachment and sends a specific signal (NACos) to the nucleus. J Membr Biol 198, 147-158.
8. Artigas P & Gadsby D (2003) Ion occlusion/deocclusion partial reactions in individual palytoxin-modified Na/K pumps. Ann NY Acad Sci 986, 116-126.
9. Warmka JK, Mauro LJ & Wattenberg EV (2004) Mitogen-activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic ras. J Biol Chem 279, 33085-33092.
10. Ikeda M, Mitani K & Ito K (1988) Palytoxin induces a nonselective cation channel in single ventricular cells of rat. Naunyn Schmiedebergs Arch Pharmacol 337, 591-593.
11. Van Renterghem C & Frelin C (1993) 3,4-Dichlorobenzamil-sensitive, monovalent cation channel induced by palytoxin in cultured aortic myocytes. Br J Pharmacol 109, 859-865.
12. Ishii K, Ikeda M & Ito K (1997) Characteristics of palytoxin-induced cation currents and Ca2+ mobilization in smooth muscle cells of rabbit portal vein. Naunyn Schmiedebergs Arch Pharmacol 355, 103-110.
13. Habermann E (1989) Palytoxin acts through Na+,K+-ATPase. Toxicon 27, 1171-1187.
14. Contreras RG, Shoshani L, Flores-Maldonado C, Lazaro A & Cereijido M (1999) Relationship between Na(+),K(+)-ATPase and cell attachment. J Cell Sci 112, 4223-4232.
15. Gumbiner BM (1996) Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 84, 345-357.
16. Chen H, Bernstein BW & Bamburg JR (2000) Regulating actin-filament dynamics in vivo. Trends Biochem Sci 25, 19-23.
17. 3H]norepinephrine release from a rat pheochromocytoma cell line. Mol Pharmacol 25, 379-383.
18. Satoh E & Nakazato Y (1991) Mode of action of palytoxin on the release of acetylcholine from rat cerebrocortical synaptosomes. J Neurochem 57, 1276-1280.
19. Ishii K, Ito KM, Uemura D & Ito K (1997) Possible mechanism of palytoxin-induced Ca++ mobilization in porcine coronary artery. J Pharmacol Exp Ther 281, 1077-1084.
20. Louzao MC, Vieytes MR, Baptista de Sousa JMV, Leira F & Botana LM (2001) A fluorimetric method based on changes in membrane potential for screening paralytic shellfish toxins in mussels. Anal Biochem 289, 246-250.
21. Mohr FC & Fewtrell C (1987) IgE receptor-mediated depolarization of rat basophilic leukemia cells measured with the fluorescent probe bis-oxonol. J Immunol 138, 1564-1570.
22. Louzao MC, Vieytes MR, Cabado AG, Baptista de Sousa JMV & Botana LM (2003) A fluorimetric microplate assay for detection and quantitation of toxins causing paralytic shellfish poisoning. Chem Res Toxicol 16, 433-438.
23. Louzao MC, Vieytes MR, Yasumoto T & Botana LM (2004) Detection of sodium channel activators by a rapid fluorimetric microplate assay. Chem Res Toxicol 17, 572-578.
24. Lipp P & Niggli E (1993) Ratiometric confocal Ca(2+)-measurements with visible wavelength indicators in isolated cardiac myocytes. Cell Calcium 14, 359-372.
25. Yip KP & Marsh DJ (1996) [Ca2+]i in rat afferent arteriole during constriction measured with confocal fluorescence microscopy. Am J Physiol Renal Physiol 271, F1004-F1011.
26. Budel S, Schuster A, Stergiopoulos N, Meister JJ & Beny JL (2001) Role of smooth muscle cells on endothelial cell cytosolic free calcium in porcine coronary arteries. Am J Physiol Heart Circ Physiol 281, H1156-H1162.
27. Guennoun S & Horisberger JD (2000) Structure of the 5th transmembrane segment of the Na,K-ATPase alpha subunit: a cysteine-scanning mutagenesis study. FEBS Lett 482, 144-148.
28. + exchange system. Neurosci Lett 130, 103-106.
29. Monroe JJ & Tashjian AH Jr (1995) Actions of palytoxin on Na+ and Ca2+ homeostasis in human osteoblast-like Saos-2 cells. Am J Physiol Cell Physiol 269, 582-589.
30. Lankford KL & Letourneau PC (1989) Evidence that calcium may control neurite outgrowth by regulating the stability of actin filaments. J Cell Biol 109, 1229-1243.
31. Yin HL & Stossel TP (1979) Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium-dependent regulatory protein. Nature 281, 583-586.
32. Puius YA, Mahoney NM & Almo SC (1998) The modular structure of actin-regulatory proteins. Curr Opin Cell Biol 10, 23-34.
33. Kockskamper J, Ahmmed G, Zima A, Sheehan K, Glitsch H & Blatter L (2004) Palytoxin disrupts cardiac excitation-contraction coupling through interactions with P-type ion pumps. Am J Physiol Cell Physiol 287, C527-C538.
34. Frelin C & Van Renterghem C (1995) Palytoxin. Recent electrophysiological and pharmacological evidence for several mechanisms of action. Gen Pharmacol 26, 33-37.
35. Amano K, Sato K, Hori M, Ozaki H & Karaki H (1997) Palytoxin-induced increase in endothelial Ca2+ concentration in the rabbit aortic valve. Naunyn Schmiedebergs Arch Pharmacol 355, 751-758.
36. Satoh E, Ishii T & Nishimura M (2003) Palytoxin-induced increase in cytosolic-free Ca(2+) in mouse spleen cells. Eur J Pharmacol 465, 9-13.
37. Ares IR, Louzao MC, Vieytes MR, Yasumoto T & Botana LM (2005) Actin cytoskeleton of rabbit intestinal cells is a target for potent marine phycotoxins. J Exp Biol 208, 4345-4354.
38. +-ATPase to growth-related genes in cardiac myocytes: the roles of ras and mitogen-activated protein kinases. J Biol Chem 273, 15249-15256.
39. +-ATPase. J Biol Chem 275, 27832-27837.
40. 2+ concentrations. J Biol Chem 275, 27838-27844.
41. +-ATPase as a signal transducer. Eur J Biochem 269, 2434-2439.
42. Fiorentini C, Matarrese P, Fattorossi A & Donelli G (1996) Okadaic acid induces changes in the organization of F-actin in intestinal cells. Toxicon 34, 937-945.
43. McCormack SA, Ray RM, Blanner PM & Johnson LR (1999) Polyamine depletion alters the relationship of F-actin, G-actin, and thymosin beta4 in migrating IEC-6 cells. Am J Physiol Cell Physiol 276, C459-C468.
44. Richelme F, Benoliel AM & Bongrand P (2000) Dynamic study of cell mechanical and structural responses to rapid changes of calcium level. Cell Motil Cytoskeleton 45, 93-105.
45. Ukena T, Satake M, Usami M, Oshima Y, Fujita T, Naoki H & Yasumoto T (2002) Structural confirmation of ostreocin-D by application of negative-ion fast-atom bombardment collision-induced dissociation tandem mass spectrometric methods. Rapid Commun Mass Spectrom 16, 2387-2393.
46. Denker SP & Barber DL (2002) Ion transport proteins anchor and regulate the cytoskeleton. Curr Opin Cell Biol 14, 214-220.
47. Denker SP, Huang DC, Orlowski J, Furthmayr H & Barber DL (2000) Direct binding of the Na-H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation. Mol Cell 6, 1425-1436.
48. Spector I, Braet F, Shochet N & Bubb M (1999) New anti-actin drugs in the study of the organization and function of the actin cytoskeleton. Microsc Res Tech 47, 18-37.
49. Leira F, Alvarez C, Vieites JM, Vieytes MR & Botana LM (2001) Study of cytoskeletal changes induced by okadaic acid in BE(2)-M17 cells by means of a quantitative fluorimetric microplate assay. Toxicol Vitro 15, 277-282.
50. Leira F, Cabado A, Vieytes M, Roman Y, Alfonso A, Botana L, Yasumoto T, Malaguti C & Rossini G (2002) Characterization of F-actin depolymerization as a major toxic event induced by pectenotoxin-6 in neuroblastoma cells. Biochem Pharmacol 63, 1979-1988.
51. Cabado AG, Leira F, Vieytes M, Vieites J & Botana L (2004) Cytoskeletal disruption is the key factor that triggers apoptosis in okadaic acid-treated neuroblastoma cells. Arch Toxicol 78, 74-85.
52. Cabado AG, Leira F, Vieites JM, Vieytes MR & Botana LM (2003) Caspase-8 activation iniciates okadaic acid-induced apoptosis in neuroblastoma. In Proceedings of the 4th International Conference on Molluscan Shellfish Safety (Villalba A, Reguera B, Romalde JL & Beiras R, eds), pp. 107-117. Consellerí a de Pesca e Asuntos Marítimos da Xunta de Galicia and IOC of UNESCO, Santiago de Compostela.