메뉴 건너뛰기




Volumn 28, Issue 3, 2008, Pages 294-302

In vitro approaches to evaluate palytoxin-induced toxicity and cell death in intestinal cells

Author keywords

Apoptosis; Caco 2 cells; Caspases; Cell death; F actin; Mitochondrial membrane potential; Palytoxin

Indexed keywords

CASPASE; DNA; F ACTIN; LACTATE DEHYDROGENASE; PALYTOXIN; PROPIDIUM IODIDE;

EID: 42049098814     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1278     Document Type: Article
Times cited : (26)

References (56)
  • 1
    • 1842451620 scopus 로고    scopus 로고
    • Death without caspases, caspases without death
    • Abraham MC, Shaham S. 2004. Death without caspases, caspases without death. Trends Cell Biol. 14: 184-193.
    • (2004) Trends Cell Biol , vol.14 , pp. 184-193
    • Abraham, M.C.1    Shaham, S.2
  • 2
    • 29044446498 scopus 로고    scopus 로고
    • Actin cytoskeleton of rabbit intestinal cells is a target for potent marine phycotoxins
    • Ares IR, Louzao MC, Vieytes AR, Yasumoto T, Botana LA. 2005. Actin cytoskeleton of rabbit intestinal cells is a target for potent marine phycotoxins. J. Exp. Biol. 208: 4345-4354.
    • (2005) J. Exp. Biol , vol.208 , pp. 4345-4354
    • Ares, I.R.1    Louzao, M.C.2    Vieytes, A.R.3    Yasumoto, T.4    Botana, L.A.5
  • 3
    • 1842736450 scopus 로고    scopus 로고
    • Large diameter of palytoxin-induced Na/K pump channels and modulation of palytoxin interaction by Na/K pump ligands
    • Artigas P, Gadsby DC. 2004. Large diameter of palytoxin-induced Na/K pump channels and modulation of palytoxin interaction by Na/K pump ligands. J. Gen. Physiol. 123: 357-376.
    • (2004) J. Gen. Physiol , vol.123 , pp. 357-376
    • Artigas, P.1    Gadsby, D.C.2
  • 4
    • 0025823502 scopus 로고
    • The protein phosphatase inhibitor okadaic acid induces morphological-changes typical of apoptosis in mammalian-cells
    • Boe R, Gjertsen BT, Vintermyr OK, Houge G, Lanotte M, Doskeland SO. 1991. The protein phosphatase inhibitor okadaic acid induces morphological-changes typical of apoptosis in mammalian-cells. Exp. Cell Res. 195: 237-246.
    • (1991) Exp. Cell Res , vol.195 , pp. 237-246
    • Boe, R.1    Gjertsen, B.T.2    Vintermyr, O.K.3    Houge, G.4    Lanotte, M.5    Doskeland, S.O.6
  • 5
    • 0033786442 scopus 로고    scopus 로고
    • Apoptosis: Overview and signal transduction pathways
    • Bredesen DE. 2000. Apoptosis: overview and signal transduction pathways. J. Neurotrauma 17: 801-810.
    • (2000) J. Neurotrauma , vol.17 , pp. 801-810
    • Bredesen, D.E.1
  • 6
    • 1542366546 scopus 로고    scopus 로고
    • Caspase-8 activation initiates okadaic acid-induced apoptosis in neuroblastoma
    • Villalba A, Reguera B, Romalde JL, Beiras R eds, Consellería de Pesca e Asuntos Marítimos da Xunta de Galicia and Intergovernmental Oceanographic Commission of UNESCO: Santiago de Compostela;
    • Cabado AG, Leira F, Vieites JM, Vieytes M, Botana LM. 2003. Caspase-8 activation initiates okadaic acid-induced apoptosis in neuroblastoma. In Molluscan Shellfish Safety, Villalba A, Reguera B, Romalde JL, Beiras R (eds). Consellería de Pesca e Asuntos Marítimos da Xunta de Galicia and Intergovernmental Oceanographic Commission of UNESCO: Santiago de Compostela; 107-117.
    • (2003) Molluscan Shellfish Safety , pp. 107-117
    • Cabado, A.G.1    Leira, F.2    Vieites, J.M.3    Vieytes, M.4    Botana, L.M.5
  • 7
    • 1542283580 scopus 로고    scopus 로고
    • Cytoskeletal disruption is the key factor that triggers apoptosis in okadaic acid-treated neuroblastoma cells
    • Cabado AG, Leira F, Vieytes M, Vieites JM, Botana LM. 2004. Cytoskeletal disruption is the key factor that triggers apoptosis in okadaic acid-treated neuroblastoma cells. Arch. Toxicol. 78: 74-85.
    • (2004) Arch. Toxicol , vol.78 , pp. 74-85
    • Cabado, A.G.1    Leira, F.2    Vieytes, M.3    Vieites, J.M.4    Botana, L.M.5
  • 8
    • 0030093869 scopus 로고    scopus 로고
    • Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor staurosporine is attenuated by isoquinolinesulfonamides H-7, H-8, and H-9
    • Cagnoli CM, Kharlamov E, Atabay C, Uz T, Manev H. 1996. Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor staurosporine is attenuated by isoquinolinesulfonamides H-7, H-8, and H-9. J. Mol. Neurosci. 7: 65-76.
    • (1996) J. Mol. Neurosci , vol.7 , pp. 65-76
    • Cagnoli, C.M.1    Kharlamov, E.2    Atabay, C.3    Uz, T.4    Manev, H.5
  • 9
    • 0034006893 scopus 로고    scopus 로고
    • Study on the cytotoxicity of microcystin-LR on cultured cells
    • Chong MWK, Gu KD, Lam PKS, Yang M, Fong WF. 2000. Study on the cytotoxicity of microcystin-LR on cultured cells. Chemosphere 41: 143-147.
    • (2000) Chemosphere , vol.41 , pp. 143-147
    • Chong, M.W.K.1    Gu, K.D.2    Lam, P.K.S.3    Yang, M.4    Fong, W.F.5
  • 10
    • 18344418298 scopus 로고    scopus 로고
    • Recent advances in the study of epigenetics effects induced by the phycotoxin okadaic acid
    • Creppy EE, Traoré A, Baudrimont I, Cascante M, Carratú M-R. 2002. Recent advances in the study of epigenetics effects induced by the phycotoxin okadaic acid. Toxicol. In Vitro 181: 433-439.
    • (2002) Toxicol. In Vitro , vol.181 , pp. 433-439
    • Creppy, E.E.1    Traoré, A.2    Baudrimont, I.3    Cascante, M.4    Carratú, M.-R.5
  • 11
    • 0028593362 scopus 로고
    • Characterization of a renal epithelial cell model of apoptosis using okadaic acid and the NRK-52E cell line
    • Davis MA, Smith MW, Chang SH, Trump BF. 1994. Characterization of a renal epithelial cell model of apoptosis using okadaic acid and the NRK-52E cell line. Toxicol. Pathol. 22: 595-605.
    • (1994) Toxicol. Pathol , vol.22 , pp. 595-605
    • Davis, M.A.1    Smith, M.W.2    Chang, S.H.3    Trump, B.F.4
  • 12
    • 0034284637 scopus 로고    scopus 로고
    • Mitochondria as the central control point of apoptosis
    • Desagher S, Martinou JC. 2000. Mitochondria as the central control point of apoptosis. Trends Cell Biol. 10: 369-377.
    • (2000) Trends Cell Biol , vol.10 , pp. 369-377
    • Desagher, S.1    Martinou, J.C.2
  • 14
    • 0032932789 scopus 로고    scopus 로고
    • Unique features of the okadaic acid activity class of tumour promoters
    • Fujiki H, Suganuma M. 1999. Unique features of the okadaic acid activity class of tumour promoters. J. Cancer Res. Clin. Oncol. 125: 150-155.
    • (1999) J. Cancer Res. Clin. Oncol , vol.125 , pp. 150-155
    • Fujiki, H.1    Suganuma, M.2
  • 15
    • 0022965231 scopus 로고
    • Palytoxin is a non-12-O-tetradecanoylphorbol-13-acetate type tumour promoter in two-stage mouse skin carcinogenesis
    • Fujiki H, Suganuma M, Nakayasu M, Hakii H, Horiuchi T, Takayama S, Sugimura T. 1986. Palytoxin is a non-12-O-tetradecanoylphorbol-13-acetate type tumour promoter in two-stage mouse skin carcinogenesis. Carcinogenesis 7: 707-710.
    • (1986) Carcinogenesis , vol.7 , pp. 707-710
    • Fujiki, H.1    Suganuma, M.2    Nakayasu, M.3    Hakii, H.4    Horiuchi, T.5    Takayama, S.6    Sugimura, T.7
  • 16
    • 0033231590 scopus 로고    scopus 로고
    • Distribution and sequestration of palytoxin in coral reef animals
    • Gleibs S, Mebs D. 1999. Distribution and sequestration of palytoxin in coral reef animals. Toxicon 37: 1521-1527.
    • (1999) Toxicon , vol.37 , pp. 1521-1527
    • Gleibs, S.1    Mebs, D.2
  • 17
    • 0036145152 scopus 로고    scopus 로고
    • Okadaic acid stimulates apoptosis through expression of Fas receptor and Fas ligand in human oral squamous carcinoma cells
    • Goto K, Fukuda J, Haneji T. 2002. Okadaic acid stimulates apoptosis through expression of Fas receptor and Fas ligand in human oral squamous carcinoma cells. Oral Oncol. 38: 16-22.
    • (2002) Oral Oncol , vol.38 , pp. 16-22
    • Goto, K.1    Fukuda, J.2    Haneji, T.3
  • 18
    • 0036016923 scopus 로고    scopus 로고
    • Molecular mechanisms of detachment-induced apoptosis-anoikis
    • Grossman J. 2002. Molecular mechanisms of detachment-induced apoptosis-anoikis. Apoptosis 7: 247-260.
    • (2002) Apoptosis , vol.7 , pp. 247-260
    • Grossman, J.1
  • 19
  • 20
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO. 2000. The biochemistry of apoptosis. Nature 407: 770-776.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 22
    • 0030998806 scopus 로고    scopus 로고
    • Effects of repeated injections of palytoxin on lymphoid tissues in mice
    • Ito E, Ohkusu M, Terao K, Yasumoto T. 1997. Effects of repeated injections of palytoxin on lymphoid tissues in mice. Toxicon 35: 679-688.
    • (1997) Toxicon , vol.35 , pp. 679-688
    • Ito, E.1    Ohkusu, M.2    Terao, K.3    Yasumoto, T.4
  • 24
    • 0036217324 scopus 로고    scopus 로고
    • Biochemical and morphological events during okadaic acid-induced apoptosis of Tsc2-null ERC-18 cell line
    • Kolb TM, Chang SH, Davis MA. 2002. Biochemical and morphological events during okadaic acid-induced apoptosis of Tsc2-null ERC-18 cell line. Toxicol. Pathol. 30: 235-246.
    • (2002) Toxicol. Pathol , vol.30 , pp. 235-246
    • Kolb, T.M.1    Chang, S.H.2    Davis, M.A.3
  • 25
    • 24344433292 scopus 로고    scopus 로고
    • Collapse of mitochondrial membrane potential and caspases activation are early events in okadaic acid-treated Caco-2 cells
    • Lago J, Santaclara F, Vieites JM, Cabado AG. 2005. Collapse of mitochondrial membrane potential and caspases activation are early events in okadaic acid-treated Caco-2 cells. Toxicon 46: 579-586.
    • (2005) Toxicon , vol.46 , pp. 579-586
    • Lago, J.1    Santaclara, F.2    Vieites, J.M.3    Cabado, A.G.4
  • 26
    • 42049086985 scopus 로고    scopus 로고
    • Comparison between cytotoxic effects induced by PTX-2 in vitro in two human cell lines
    • Lamas C, Valverde I, Lago J, Vieites JM, Cabado AG. 2006a. Comparison between cytotoxic effects induced by PTX-2 in vitro in two human cell lines. Egypt. J. Nat. Toxins. 3: 1-16.
    • (2006) Egypt. J. Nat. Toxins , vol.3 , pp. 1-16
    • Lamas, C.1    Valverde, I.2    Lago, J.3    Vieites, J.M.4    Cabado, A.G.5
  • 27
    • 42049094213 scopus 로고    scopus 로고
    • In vitro evaluation of apoptotic markers triggered by PTX-2 in Caco-2 and neuroblastoma cells
    • Lamas C, Valverde I, Lago J, Vieites JM, Cabado AG. 2006b. In vitro evaluation of apoptotic markers triggered by PTX-2 in Caco-2 and neuroblastoma cells. Egypt. J. Nat. Toxins. 3: 17-33.
    • (2006) Egypt. J. Nat. Toxins , vol.3 , pp. 17-33
    • Lamas, C.1    Valverde, I.2    Lago, J.3    Vieites, J.M.4    Cabado, A.G.5
  • 28
    • 33244492464 scopus 로고    scopus 로고
    • Genotoxicity of the marine toxin okadaic acid, in human Caco-2 cells and in mice gut cells
    • Le Hegarat L, Jacquin AG, Bazin E, Fessard V. 2006. Genotoxicity of the marine toxin okadaic acid, in human Caco-2 cells and in mice gut cells. Environ. Toxicol. 21: 55-64.
    • (2006) Environ. Toxicol , vol.21 , pp. 55-64
    • Le Hegarat, L.1    Jacquin, A.G.2    Bazin, E.3    Fessard, V.4
  • 29
    • 0034826704 scopus 로고    scopus 로고
    • Study of cytoskeletal changes induced by okadaic acid in BE(2)-M17 cells by means of a quantitative fluorimetric microplate assay
    • Leira F, Alvarez C, Vieites JM, Vieytes MR, Botana LM. 2001. Study of cytoskeletal changes induced by okadaic acid in BE(2)-M17 cells by means of a quantitative fluorimetric microplate assay. Toxicol. In Vitro 15: 277-282.
    • (2001) Toxicol. In Vitro , vol.15 , pp. 277-282
    • Leira, F.1    Alvarez, C.2    Vieites, J.M.3    Vieytes, M.R.4    Botana, L.M.5
  • 30
    • 0036151289 scopus 로고    scopus 로고
    • Characterization of distinct apoptotic changes induced by okadaic acid and yessotoxin in the BE(2)-M17 neuroblastoma cell line
    • Leira F, Alvarez C, Vieites JM, Vieytes MR, Botana LM. 2002. Characterization of distinct apoptotic changes induced by okadaic acid and yessotoxin in the BE(2)-M17 neuroblastoma cell line. Toxicol. In Vitro 16: 23-31.
    • (2002) Toxicol. In Vitro , vol.16 , pp. 23-31
    • Leira, F.1    Alvarez, C.2    Vieites, J.M.3    Vieytes, M.R.4    Botana, L.M.5
  • 31
    • 0035018838 scopus 로고    scopus 로고
    • Apoptotic events induced by the phosphatase inhibitor okadaic acid in normal human lung fibroblasts
    • Leira F, Vieites JM, Vieytes MR, Botana LM. 2001. Apoptotic events induced by the phosphatase inhibitor okadaic acid in normal human lung fibroblasts. Toxicol. In Vitro 15: 199-208.
    • (2001) Toxicol. In Vitro , vol.15 , pp. 199-208
    • Leira, F.1    Vieites, J.M.2    Vieytes, M.R.3    Botana, L.M.4
  • 32
    • 11144302536 scopus 로고    scopus 로고
    • First evidence of palytoxin analogues from an Ostreopsis mascarenensis (Dinophyceae) benthic bloom in Southwestern Indian Ocean
    • Lenoir S, Ten-Hage L, Turquet J, Quod JP, Bernard C, Hennion MC. 2004. First evidence of palytoxin analogues from an Ostreopsis mascarenensis (Dinophyceae) benthic bloom in Southwestern Indian Ocean. J. Phycol. 40: 1042-1051.
    • (2004) J. Phycol , vol.40 , pp. 1042-1051
    • Lenoir, S.1    Ten-Hage, L.2    Turquet, J.3    Quod, J.P.4    Bernard, C.5    Hennion, M.C.6
  • 33
    • 0034954056 scopus 로고    scopus 로고
    • Caspase-3 is actively involved in okadaic acid-induced lens epithelial cell apoptosis
    • Li DWC, Xiang H, Mao YW, Wang J, Fass U, Zhang XY, Xu C. 2001. Caspase-3 is actively involved in okadaic acid-induced lens epithelial cell apoptosis. Exp. Cell Res. 266: 279-291.
    • (2001) Exp. Cell Res , vol.266 , pp. 279-291
    • Li, D.W.C.1    Xiang, H.2    Mao, Y.W.3    Wang, J.4    Fass, U.5    Zhang, X.Y.6    Xu, C.7
  • 34
    • 0032732969 scopus 로고    scopus 로고
    • Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin
    • Li SN, Wattenberg EV. 1999. Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin. Toxicol. Appl. Pharmacol. 160: 109-119.
    • (1999) Toxicol. Appl. Pharmacol , vol.160 , pp. 109-119
    • Li, S.N.1    Wattenberg, E.V.2
  • 35
    • 0036271756 scopus 로고    scopus 로고
    • Paralytic shell-fish poisoning toxins in France linked to a human-introduced strain of Alexandrium catenella from the western Pacific: Evidence from DNA and toxin analysis
    • Lilly EL, Kulis DM, Gentien P, Anderson DM. 2002. Paralytic shell-fish poisoning toxins in France linked to a human-introduced strain of Alexandrium catenella from the western Pacific: evidence from DNA and toxin analysis. J. Plankton Res. 24: 443-452.
    • (2002) J. Plankton Res , vol.24 , pp. 443-452
    • Lilly, E.L.1    Kulis, D.M.2    Gentien, P.3    Anderson, D.M.4
  • 36
    • 0035663968 scopus 로고    scopus 로고
    • Possible introduction of alien phytoplankton via shipping ballast water: A South African perspective
    • Marangoni C, Pienaar RN, Sym SD. 2001. Possible introduction of alien phytoplankton via shipping ballast water: A South African perspective. S. Afr. J. Bot. 67: 465-474.
    • (2001) S. Afr. J. Bot , vol.67 , pp. 465-474
    • Marangoni, C.1    Pienaar, R.N.2    Sym, S.D.3
  • 37
    • 0032400774 scopus 로고    scopus 로고
    • The cyanobacterial toxin, microcystin-LR, can induce apoptosis in a variety of cell types
    • McDermott CM, Nho CW, Howard W, Holton B. 1998. The cyanobacterial toxin, microcystin-LR, can induce apoptosis in a variety of cell types. Toxicon 36: 1981-1996.
    • (1998) Toxicon , vol.36 , pp. 1981-1996
    • McDermott, C.M.1    Nho, C.W.2    Howard, W.3    Holton, B.4
  • 38
    • 0015245199 scopus 로고
    • Palytoxin - new marine toxin from a Coelenterate
    • Moore RE, Scheuer PJ. 1971. Palytoxin - new marine toxin from a Coelenterate. Science 172: 495-498.
    • (1971) Science , vol.172 , pp. 495-498
    • Moore, R.E.1    Scheuer, P.J.2
  • 39
    • 0031080389 scopus 로고    scopus 로고
    • The protein phosphatase inhibitor okadaic acid and calyculin A induces apoptosis in human osteoblastic cells
    • Morimoto Y, Ohba T, Kobayashi S, Haneji T. 1997. The protein phosphatase inhibitor okadaic acid and calyculin A induces apoptosis in human osteoblastic cells. Exp. Cell Res. 230: 181-186.
    • (1997) Exp. Cell Res , vol.230 , pp. 181-186
    • Morimoto, Y.1    Ohba, T.2    Kobayashi, S.3    Haneji, T.4
  • 42
    • 0032450575 scopus 로고    scopus 로고
    • Evaluation of the use of two human cell lines for okadaic acid and DTX-1 determination by cytotoxicity assays and damage characterization
    • Oteri G, Stammati A, Zampaglioni F, Zucco F. 1998. Evaluation of the use of two human cell lines for okadaic acid and DTX-1 determination by cytotoxicity assays and damage characterization. Nat. Toxins 6: 197-209.
    • (1998) Nat. Toxins , vol.6 , pp. 197-209
    • Oteri, G.1    Stammati, A.2    Zampaglioni, F.3    Zucco, F.4
  • 43
    • 4344595996 scopus 로고    scopus 로고
    • Okadaic acid stimulates caspase-like activities and induces apoptosis of cultured rat mesangial cells
    • Parameswaran N, Spielman WS, Brooks DP, Nambi P. 2004. Okadaic acid stimulates caspase-like activities and induces apoptosis of cultured rat mesangial cells. Mol. Cell. Biochem. 260: 7-11.
    • (2004) Mol. Cell. Biochem , vol.260 , pp. 7-11
    • Parameswaran, N.1    Spielman, W.S.2    Brooks, D.P.3    Nambi, P.4
  • 44
    • 33750549155 scopus 로고    scopus 로고
    • Cytotoxic effects of BADGE (Bisphenol A Diglicidy-Ether) and BFDGE (Bisfenol F Diglicidyl-Ether) on Caco-2 cells
    • Ramilo G, Valverde I, Lago J, Vieites JM, Cabado AG. 2006. Cytotoxic effects of BADGE (Bisphenol A Diglicidy-Ether) and BFDGE (Bisfenol F Diglicidyl-Ether) on Caco-2 cells. Arch. Toxicol. 80: 748-755.
    • (2006) Arch. Toxicol , vol.80 , pp. 748-755
    • Ramilo, G.1    Valverde, I.2    Lago, J.3    Vieites, J.M.4    Cabado, A.G.5
  • 45
    • 0033801430 scopus 로고    scopus 로고
    • Toxic marine epiphytic dinoflagellates, Ostreopsis siamensis and Coolia monotis (Dinophyceae), in New Zealand
    • Rhodes L, Adamson J, Suzuki T, Briggs L, Garthwaite I. 2000. Toxic marine epiphytic dinoflagellates, Ostreopsis siamensis and Coolia monotis (Dinophyceae), in New Zealand. N. Z. J. Mar. Freshw. Res. 34: 371-383.
    • (2000) N. Z. J. Mar. Freshw. Res , vol.34 , pp. 371-383
    • Rhodes, L.1    Adamson, J.2    Suzuki, T.3    Briggs, L.4    Garthwaite, I.5
  • 46
    • 0242416621 scopus 로고    scopus 로고
    • Uptake of palytoxin-like compounds by shellfish fed Ostreopsis siamensis (Dinophyceae)
    • Rhodes L, Towers N, Briggs L, Munday R, Adamson J. 2002. Uptake of palytoxin-like compounds by shellfish fed Ostreopsis siamensis (Dinophyceae). N. Z. J. Mar. Freshw. Res. 36: 631-636.
    • (2002) N. Z. J. Mar. Freshw. Res , vol.36 , pp. 631-636
    • Rhodes, L.1    Towers, N.2    Briggs, L.3    Munday, R.4    Adamson, J.5
  • 47
    • 0032544721 scopus 로고    scopus 로고
    • Okadaic acid-induced apoptosis of HL60 leukemia cells is preceded by destabilization of bcl-2 mRNA and downregulation of bcl-2 protein
    • Riordan FA, Foroni L, Hoffbrand AV, Mehta AB, Wickremasinghe RG. 1998. Okadaic acid-induced apoptosis of HL60 leukemia cells is preceded by destabilization of bcl-2 mRNA and downregulation of bcl-2 protein. FEBS Lett. 435: 195-198.
    • (1998) FEBS Lett , vol.435 , pp. 195-198
    • Riordan, F.A.1    Foroni, L.2    Hoffbrand, A.V.3    Mehta, A.B.4    Wickremasinghe, R.G.5
  • 48
    • 0037470827 scopus 로고    scopus 로고
    • Palytoxin-induced increase in cytosolic free calcium in mouse spleen cells
    • Satoh E, Ishii T, Nishimura M. 2003. Palytoxin-induced increase in cytosolic free calcium in mouse spleen cells. Eur. J. Pharmacol. 465: 9-13.
    • (2003) Eur. J. Pharmacol , vol.465 , pp. 9-13
    • Satoh, E.1    Ishii, T.2    Nishimura, M.3
  • 50
    • 25144443171 scopus 로고    scopus 로고
    • Cytotoxic actions of palytoxin on aortic smooth muscle cells in culture
    • Sheridan RE, Deshpande SS, Adler M. 2005. Cytotoxic actions of palytoxin on aortic smooth muscle cells in culture. J. Appl. Toxicol. 25: 365-373.
    • (2005) J. Appl. Toxicol , vol.25 , pp. 365-373
    • Sheridan, R.E.1    Deshpande, S.S.2    Adler, M.3
  • 51
    • 0036351423 scopus 로고    scopus 로고
    • Loss of cell anchorage triggers apoptosis (anoikis) in primary mouse hepatocytes
    • Smets FN, Chen YM, Wang LJ, Soriano HE. 2002. Loss of cell anchorage triggers apoptosis (anoikis) in primary mouse hepatocytes. Mol. Genet. Metab. 75: 344-352.
    • (2002) Mol. Genet. Metab , vol.75 , pp. 344-352
    • Smets, F.N.1    Chen, Y.M.2    Wang, L.J.3    Soriano, H.E.4
  • 52
    • 0032829103 scopus 로고    scopus 로고
    • New anti-actin drugs in the study of the organization and function of the actin cytoskeleton
    • Spector I, Braet F, Shochet NR, Bubb MR. 1999. New anti-actin drugs in the study of the organization and function of the actin cytoskeleton. Microsc. Res. Tech. 47: 18-37.
    • (1999) Microsc. Res. Tech , vol.47 , pp. 18-37
    • Spector, I.1    Braet, F.2    Shochet, N.R.3    Bubb, M.R.4
  • 54
    • 42049087852 scopus 로고    scopus 로고
    • Neuroblastoma cells a cell model to study BADGE (Bisphenol A diglycidyl-ether) and BFDGE (Bisphenol F diglycidyl-ether) toxicity
    • Nova Science: New York
    • Valverde I, Lago J, Vieites JM, Cabado AG. 2007. Neuroblastoma cells a cell model to study BADGE (Bisphenol A diglycidyl-ether) and BFDGE (Bisphenol F diglycidyl-ether) toxicity. In Neuroblastoma Cells. Nova Science: New York.
    • (2007) Neuroblastoma Cells
    • Valverde, I.1    Lago, J.2    Vieites, J.M.3    Cabado, A.G.4
  • 56
    • 4043182010 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic Ras
    • Warmka JK, Mauro LJ, Wattenberg EV. 2004. Mitogen-activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic Ras. J. Biol. Chem. 279: 33085-33092.
    • (2004) J. Biol. Chem , vol.279 , pp. 33085-33092
    • Warmka, J.K.1    Mauro, L.J.2    Wattenberg, E.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.