Mitogen-activated protein kinases regulate palytoxin-induced calcium influx and cytotoxicity in cultured neurons

British Journal of Pharmacology

Volumn 152, Issue 2, 2007, Pages 256-266

  Vale, C ^a   Gomez Limia B ^a   Vieytes, M R ^a   Botana, L M ^a  

^a Facultad de Veterinaria   (Spain)

Author keywords

Calcium; Cerebellar granule cell; Cytotoxicity; ERK; MTT; Palytoxin; Protein kinase

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALCIUM; MARINE TOXIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PALYTOXIN; PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL CULTURE; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG BINDING; DRUG MECHANISM; ENZYME INHIBITION; GRANULE CELL; IMMUNOREACTIVITY; NERVE CELL; NEUROTOXICITY; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ACRYLAMIDES; ANIMALS; CALCIUM; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; CNIDARIAN VENOMS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; NEUROTOXINS; PROTEIN KINASE INHIBITORS;

EID: 34948890457     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707389     Document Type: Article

References (47)

1. Aizu E, Yamamoto S, Nakadate T, Kato R (1990). Differential effects of various skin tumor-promoting agents on prostaglandin E2 release from primary cultures of mouse epidermal cells. Eur J Pharmacol 182: 19-28.
2. Alcala AC, Alcala LC, Garth JS, Yasumura D, Yasumoto T (1988). Human fatality due to ingestion of the crab Demania reynaudii that contained a palytoxin-like toxin. Toxicon 26: 105-107.
3. Artigas P, Gadsby DC (2004). Large diameter of palytoxin-induced Na/K pump channels and modulation of palytoxin interaction by Na/K pump ligands. J Gen Physiol 123: 357-376.
4. Artigas P, Gadsby DC (2006). Ouabain affinity determining residues lie close to the Na/K pump ion pathway. Proc Natl Acad Sci USA 103: 12613-12618.
5. Battaini F, Pascale A (2005). Protein kinase C signal transduction regulation in physiological and pathological aging. Ann N Y Acad Sci 1057: 177-192.
6. Chu CT, Levinthal DJ, Kulich SM, Chalovich EM, DeFranco DB (2004). Oxidative neuronal injury. The dark side of ERK1/2. Eur J Biochem 271: 2060-2066.
7. Davis RJ (1994). MAPKs: new JNK expands the group. Trends Biochem Sci 19: 470-473.
8. Dent P, Reardon DB, Park JS, Bowers G, Logsdon C, Valerie K et al. (1999). Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death. Mol Biol Cell 10: 2493-2506.
9. Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR (1995). A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci USA 92: 7686-7689.
10. Fujiki H, Suganuma M, Nakayasu M, Hakii H, Horiuchi T, Takayama S et al. (1986). Palytoxin is a non-12-O-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesis. Carcinogenesis 7: 707-710.
11. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450.
12. Guerini D, Coletto L, Carafoli E (2005). Exporting calcium from cells. Cell Calcium 38: 281-289.
13. +-ATPase. Toxicon 27: 1171-1187.
14. Hetman M, Gozdz A (2004). Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. Eur J Biochem 271: 2050-2055.
15. Ito K, Urakawa N, Koike H (1982). Cardiovascular toxicity of palytoxin in anesthetized dogs. Arch Int Pharmacodyn Ther 258: 146-154.
16. Kelemen BR, Hsiao K, Goueli SA (2002). Selective in vivo inhibition of mitogen-activated protein kinase activation using cell-permeable peptides. J Biol Chem 277: 8741-8748.
17. Kodama AM, Hokama Y, Yasumoto T, Fukui M, Manea SJ, Sutherland N (1989). Clinical and laboratory findings implicating palytoxin as cause of ciguatera poisoning due to Decapterus macrosoma (mackerel). Toxicon 27: 1051-1053.
18. Kuroki DW, Minden A, Sanchez I, Wattenberg EV (1997). Regulation of a c-Jun amino-terminal kinase/stress-activated protein kinase cascade by a sodium-dependent signal transduction pathway. J Biol Chem 272: 23905-23911.
19. Li S, Wattenberg EV (1998). Differential activation of mitogen-activated protein kinases by palytoxin and ouabain, two ligands for the Na+,K+-ATPase. Toxicol Appl Pharmacol 151: 377-384.
20. Li S, Wattenberg EV (1999). Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin. Toxicol Appl Pharmacol 160: 109-119.
21. Luo Y, DeFranco DB (2006). Opposing roles for ERK1/2 in neuronal oxidative toxicity: distinct mechanisms of ERK1/2 action at early versus late phases of oxidative stress. J Biol Chem 281: 16436-16442.
22. +-ATPase to ERK1/2. J Biol Chem 276: 42050-42056.
23. Onuma Y, Satake M, Ukena T, Roux J, Chanteau S, Rasolofonirina N et al. (1999). Identification of putative palytoxin as the cause of clupeotoxism. Toxicon 37: 55-65.
24. Plourde D, Soltoff SP (2006). Ouabain potentiates the activation of ERK1/2 by carbachol in parotid gland epithelial cells; inhibition of ERK1/2 reduces Na(+)-K(+)-ATPase activity. Am J Physiol Cell Physiol 290: C702-C710.
25. Popp RL, Velasquez O, Bland J, Hughes P (2006). Characterization of protein kinase C isoforms in primary cultured cerebellar granule cells. Brain Res 1083: 70-84.
26. + influx into yeast cells expressing the mammalian sodium pump is due to the formation of a channel within the enzyme. Mol Pharmacol 49: 49-57.
27. Schaeffer HJ, Weber MJ (1999). Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol Cell Biol 19: 2435-2444.
28. + efflux from yeast cells expressing the mammalian sodium pump. Mol Pharmacol 45: 1132-1136.
29. Schousboe A, Meier E, Drejer J, Hertz L (1989). Preparation of primary cultures of mouse (rat) cerebellar granule cells. In: Shahar A, de Vellis J, Vernadakis A, Haber B (eds). A Dissection and Tissue Culture Manual of the Nervous System. Alan R Liss: New York, pp 203-206.
30. Simonian NA, Coyle JT (1996). Oxidative stress in neurodegenerative diseases. Annu Rev Pharmacol Toxicol 36: 83-106.
31. Spencer JP, Rice-Evans C, Williams RJ (2003). Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability. J Biol Chem 278: 34783-34793.
32. Sweatt JD (2001). The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J Neurochem 76: 1-10.
33. Thomas JA, Buchsbaum RN, Zimniak A, Racker E (1979). Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry 18: 2210-2218.
34. 2+]i in rat cardiac myocytes. Am J Physiol Heart Circ Physiol 281: H1899-H1907.
35. Tosteson MT (2000). Mechanism of action, pharmacology and toxicology. In: Botana LM (ed). Seafood and Freshwater Toxins. Marcel Dekker: New York-Basel, pp 549-566.
36. Vale C, Alfonso A, Sunol C, Vieytes MR, Botana LM (2006). Modulation of calcium entry and glutamate release in cultured cerebellar granule cells by palytoxin. J Neurosci Res 83: 1393-1406.
37. Vale C, Damgaard I, Sunol C, Rodriguez-Farre E, Schousboe A (1998). Cytotoxic action of lindane in cerebellar granule neurons is mediated by interaction with inducible GABA(B) receptors. J Neurosci Res 52: 286-294.
38. Vale C, Fonfria E, Bujons J, Messeguer A, Rodriguez-Farre E, Sunol C (2003). The organochlorine pesticides gamma-hexachlorocyclohexane (lindane), alpha-endosulfan and dieldrin differentially interact with GABA(A) and glycine-gated chloride channels in primary cultures of cerebellar granule cells. Neuroscience 117: 397-403.
39. Vale-Gonzalez C, Gomez-Limia B, Vieytes MR, Botana LM (2007). Effects of the marine phycotoxin palytoxin on neuronal pH in primary cultures of cerebellar granule cells. J Neurosci Res 85: 90-98.
40. Varming T, Drejer J, Frandsen A, Schousboe A (1996). Characterization of a chemical anoxia model in cerebellar granule neurons using sodium azide: protection by nifedipine and MK-801. J Neurosci Res 44: 40-46.
41. Warmka JK, Mauro LJ, Wattenberg EV (2004). Mitogen-activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic Ras. J Biol Chem 279: 33085-33092.
42. Warmka JK, Winston SE, Zeliadt NA, Wattenberg EV (2002). Extracellular signal-regulated kinase transmits palytoxin-stimulated signals leading to altered gene expression in mouse keratinocytes. Toxicol Appl Pharmacol 185: 8-17.
43. Wattenberg EV (2007). Palytoxin: Exploiting a novel skin tumor promoter to explore signal transduction and carcinogenesis. Am J Physiol Cell Physiol 292: C24-C32.
44. Wattenberg EV, Byron KL, Villereal ML, Fujiki H, Rosner MR (1989). Sodium as a mediator of non-phorbol tumor promoter action. Down-modulation of the epidermal growth factor receptor by palytoxin. J Biol Chem 264: 14668-14673.
45. Xie Z (2003). Molecular mechanisms of Na/K-ATPase-mediated signal transduction. Ann N Y Acad Sci 986: 497-503.
46. +-ATPase-mediated signal transduction: from protein interaction to cellular function. Mol Interv 3: 157-168.
47. Zeliadt NA, Warmka JK, Wattenberg EV (2003). Mitogen activated protein kinases selectively regulate palytoxin-stimulated gene expression in mouse keratinocytes. Toxicol Appl Pharmacol 192: 212-221.