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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 2, 2013, Pages 537-542

Discovery of a novel phenylethyl benzamide glucokinase activator for the treatment of type 2 diabetes mellitus

(9) Park, Kaapjoo a Lee, Byoung Moon a Kim, Young Hwan a Han, Taedong a Yi, Wonhui a Lee, Dong Hoon a Choi, Hyun Ho a Chong, Wonee a Lee, Chun Ho a

a Yuhan Research Institute (South Korea)

Author keywords

GKAs; Glucokinase; Glucokinase activator; OGTT; T2DM; Type 2 diabetes mellitus; YH GKA

Indexed keywords

6 [3 [2 (2,6 DIFLUOROPHENYL)ETHYL] 5 (2 METHOXY 1 METHYLETHOXY)BENZOYLAMINO]NICOTINIC ACID; ANTIDIABETIC AGENT; BENZAMIDE DERIVATIVE; CARBOXYPYRIDINE BENZAMIDE DERIVATIVE; ENZYME ACTIVATOR; GLUCOKINASE; GLUCOSE; HEXOKINASE; LIPID; METFORMIN; PYRAZOLE BENZAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; BINDING SITE; BODY WEIGHT; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISTRIBUTION VOLUME; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HORNER WADSWORTH EMMONS REACTION; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; IN VITRO STUDY; INSULIN RELEASE; LIPID BLOOD LEVEL; LIVER MICROSOME METABOLISM; MITSUNOBU REACTION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PHYSICAL CHEMISTRY;

ANIMALS; BENZAMIDES; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; DRUG DISCOVERY; ENZYME ACTIVATION; GLUCOKINASE; HUMANS; HYPOGLYCEMIC AGENTS; MICE; MICE, INBRED C57BL; MICE, OBESE; MOLECULAR STRUCTURE; PHENETHYLAMINES; PYRIDINES;

MUS;

EID: 84871717231 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.11.018 Document Type: Article

Times cited : (33)

References (22)

1
- 33845881411
- S.E. Kahn, R.L. Hull, and K.M. Utzschneider Nature 444 2006 840
- (2006) Nature , vol.444 , pp. 840
- Kahn, S.E.¹ Hull, R.L.² Utzschneider, K.M.³

2
- 79952944125
- 14th ed. Lippincott Williams & Wilkins Philadelphia, PA P 687
- H.E. Lebovitz Joslin's Diabetes Mellitus 14th ed. 2005 Lippincott Williams & Wilkins Philadelphia, PA P 687
- (2005) Joslin's Diabetes Mellitus
- Lebovitz, H.E.¹

3
- 42449159741
- E.C. Ralph, J. Thomson, J. Almaden, and S. Sun Biochemistry 47 2008 5028
- (2008) Biochemistry , vol.47 , pp. 5028
- Ralph, E.C.¹ Thomson, J.² Almaden, J.³ Sun, S.⁴

4
- 0030067124
- F.M. Matschinsky Diabetes 45 1996 223
- (1996) Diabetes , vol.45 , pp. 223
- Matschinsky, F.M.¹

5
- 33745150728
- W. Heredia, J. Thomson, D. Nettleton, and S. Sun Biochemistry 45 2006 7553
- (2006) Biochemistry , vol.45 , pp. 7553
- Heredia, W.¹ Thomson, J.² Nettleton, D.³ Sun, S.⁴

6
- 0031892853
- F.M. Matschinsky, B. Glaser, and M.A. Magnuson Diabetes 47 1998 307
- (1998) Diabetes , vol.47 , pp. 307
- Matschinsky, F.M.¹ Glaser, B.² Magnuson, M.A.³

7
- 84863115976
- J.A. Pfefferkorn, A. Guzman-Perez, J. Litchfield, R. Aiello, J.L. Treadway, J. Pattersen, M.L. Minich, K.J. Filipski, C.S. Jones, M. Tu, G. Aspnes, L. Sweet, S. Liras, and T.P. Rolph J. Med. Chem. 55 2012 1318
- (2012) J. Med. Chem. , vol.55 , pp. 1318
- Pfefferkorn, J.A.¹ Guzman-Perez, A.² Litchfield, J.³ Aiello, R.⁴ Treadway, J.L.⁵ Pattersen, J.⁶ Minich, M.L.⁷ Filipski, K.J.⁸ Jones, C.S.⁹ Tu, M.¹⁰ Aspnes, G.¹¹ Sweet, L.¹² Liras, S.¹³ Rolph, T.P.¹⁴

8
- 79951971018
- M.L. Massa, J.J. Gagliardino, and F. Francini Life 63 2011 1
- (2011) Life , vol.63 , pp. 1
- Massa, M.L.¹ Gagliardino, J.J.² Francini, F.³

9
- 70349641037
- G.R. Bebernitz, V. Beaulieu, B.A. Dale, R. Deacon, A. Duttaroy, J. Gao, M.S. Grondine, R.C. Gupta, M. Kakmak, M. Kavana, L.C. Kirman, J. Liang, W.M. Maniara, S. Munshi, S.S. Nadkarni, H.F. Schuster, T. Stams, I. Denny St, P.M. Taslimi, B. Vash, and S.L. Caplan J. Med. Chem. 52 2009 6142
- (2009) J. Med. Chem. , vol.52 , pp. 6142
- Bebernitz, G.R.¹ Beaulieu, V.² Dale, B.A.³ Deacon, R.⁴ Duttaroy, A.⁵ Gao, J.⁶ Grondine, M.S.⁷ Gupta, R.C.⁸ Kakmak, M.⁹ Kavana, M.¹⁰ Kirman, L.C.¹¹ Liang, J.¹² Maniara, W.M.¹³ Munshi, S.¹⁴ Nadkarni, S.S.¹⁵ Schuster, H.F.¹⁶ Stams, T.¹⁷ Denny St, I.¹⁸ Taslimi, P.M.¹⁹ Vash, B.²⁰ Caplan, S.L.²¹ more..

10
- 84930540987
- M.C.T. Fyfe, and M.J. Procter Drugs Future 34 2009 641
- (2009) Drugs Future , vol.34 , pp. 641
- Fyfe, M.C.T.¹ Procter, M.J.²

11
- 67349139275
- F. Matschinsky Nat. Rev. Drug Disc. 8 2009 399
- (2009) Nat. Rev. Drug Disc. , vol.8 , pp. 399
- Matschinsky, F.¹

12
- 76649144776
- T. Iino, N. Hashimoto, T. Hasegawa, M. Chiba, J. Eiki, and T. Nishimura Bioorg. Med. Chem. Lett. 20 2010 1619
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 1619
- Iino, T.¹ Hashimoto, N.² Hasegawa, T.³ Chiba, M.⁴ Eiki, J.⁵ Nishimura, T.⁶

13
- 77957566729
- A. Sidduri, J.S. Grimsby, W.L. Corbett, R. Sarabu, J.F. Grippo, J. Lou, R.F. Kester, M. Dvorozniak, L. Marcus, C. Spence, J.K. Racha, and D.J. Moore Bioorg. Med. Chem. Lett. 20 2010 5673
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 5673
- Sidduri, A.¹ Grimsby, J.S.² Corbett, W.L.³ Sarabu, R.⁴ Grippo, J.F.⁵ Lou, J.⁶ Kester, R.F.⁷ Dvorozniak, M.⁸ Marcus, L.⁹ Spence, C.¹⁰ Racha, J.K.¹¹ Moore, D.J.¹²

14
- 0037624071
- J. Grimsby, R. Sarabu, W.L. Corbett, N.E. Hayne, F.T. Bizzarro, J.W. Coffey, K.R. Guertin, D.W. Hilliard, R.F. Kester, P.E. Mahaney, L. Marcus, L.D. Qi, C.L. Soence, J. Tengi, M.A. Magnuson, C.A. Chu, M.T. Dvorozniak, F.M. Matschinsky, and J.F. Grippo Science 301 2003 370
- (2003) Science , vol.301 , pp. 370
- Grimsby, J.¹ Sarabu, R.² Corbett, W.L.³ Hayne, N.E.⁴ Bizzarro, F.T.⁵ Coffey, J.W.⁶ Guertin, K.R.⁷ Hilliard, D.W.⁸ Kester, R.F.⁹ Mahaney, P.E.¹⁰ Marcus, L.¹¹ Qi, L.D.¹² Soence, C.L.¹³ Tengi, J.¹⁴ Magnuson, M.A.¹⁵ Chu, C.A.¹⁶ Dvorozniak, M.T.¹⁷ Matschinsky, F.M.¹⁸ Grippo, J.F.¹⁹

15
- 84863174192
- R. Sarabu, J.W. Tilley, and J. Grimsby RSC Drug Discovery Ser. 4 2011 51
- (2011) RSC Drug Discovery Ser. , vol.4 , pp. 51
- Sarabu, R.¹ Tilley, J.W.² Grimsby, J.³

16
- 65349193384
- M. Mitsuya, K. Kamata, M. Bamba, H. Watanabe, Y. Sasaki, K. Sasaki, S. Ohyama, H. Hosaka, Y. Nagata, J. Eiki, and T. Nishimura Bioorg. Med. Chem. Lett. 19 2009 2718
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 2718
- Mitsuya, M.¹ Kamata, K.² Bamba, M.³ Watanabe, H.⁴ Sasaki, Y.⁵ Sasaki, K.⁶ Ohyama, S.⁷ Hosaka, H.⁸ Nagata, Y.⁹ Eiki, J.¹⁰ Nishimura, T.¹¹

17
- 79961133381
- M.J. Waring, C. Johnstone, D. McKerrecher, K.G. Pike, and G.R. Robb Med. Chem. Commun. 2 2011 775
- (2011) Med. Chem. Commun. , vol.2 , pp. 775
- Waring, M.J.¹ Johnstone, C.² McKerrecher, D.³ Pike, K.G.⁴ Robb, G.R.⁵

18
- 81555210580
- G.E. Meininger, R. Scott, R. Alba, Y. Shentu, E. Luo, H. Amin, M.J. Davies, K.D. Kaufman, and B.J. Goldstein Diabetes Care 34 2011 2560
- (2011) Diabetes Care , vol.34 , pp. 2560
- Meininger, G.E.¹ Scott, R.² Alba, R.³ Shentu, Y.⁴ Luo, E.⁵ Amin, H.⁶ Davies, M.J.⁷ Kaufman, K.D.⁸ Goldstein, B.J.⁹

19
- 79956067812
- K.G. Pike, J.V. Allen, P.W. Caulkett, D.S. Clarke, C.S. Donald, M.L. Fenwick, K.M. Johnson, C. Johnstone, D. McKerrecher, J.W. Rayner, R.P. Walker, and I. Wilson Bioorg. Med. Chem. Lett. 11 2011 3467
- (2011) Bioorg. Med. Chem. Lett. , vol.11 , pp. 3467
- Pike, K.G.¹ Allen, J.V.² Caulkett, P.W.³ Clarke, D.S.⁴ Donald, C.S.⁵ Fenwick, M.L.⁶ Johnson, K.M.⁷ Johnstone, C.⁸ McKerrecher, D.⁹ Rayner, J.W.¹⁰ Walker, R.P.¹¹ Wilson, I.¹²

20
- 79959308013
- M.S. Winzell, M. Coghlan, B. Leighton, G. Frangioudakis, D.M. Smith, L.H. Storlien, and B. Ahrén Eur. J. Pharmacol. 663 2011 80
- (2011) Eur. J. Pharmacol. , vol.663 , pp. 80
- Winzell, M.S.¹ Coghlan, M.² Leighton, B.³ Frangioudakis, G.⁴ Smith, D.M.⁵ Storlien, L.H.⁶ Ahrén, B.⁷

21
- 84871716343
- WO 2011/081280 A2
- Yi, W. -H.; Han, T. -D.; Lee, K. -Y.; Kim, Y. -H.; Jung, E. -H.; Lee, D. -H.; Park, Y. -H.; Min, K. -N.; Kim, J. -K.; Lee, B. -K. WO 2011/081280 A2, 2011.
- (2011)
- Yi, W.-H.¹ Han, T.-D.² Lee, K.-Y.³ Kim, Y.-H.⁴ Jung, E.-H.⁵ Lee, D.-H.⁶ Park, Y.-H.⁷ Min, K.-N.⁸ Kim, J.-K.⁹ Lee, B.-K.¹⁰

22
- 79959315409
- M.J. Waring, I.J. Brogan, M. Coghlan, C. Johnstone, H.B. Jones, B. Leighton, D. Mckerrecher, K.G. Pike, and G.R. Robb Med. Chem. Commun. 2 2011 771
- (2011) Med. Chem. Commun. , vol.2 , pp. 771
- Waring, M.J.¹ Brogan, I.J.² Coghlan, M.³ Johnstone, C.⁴ Jones, H.B.⁵ Leighton, B.⁶ McKerrecher, D.⁷ Pike, K.G.⁸ Robb, G.R.⁹

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