메뉴 건너뛰기




Volumn 19, Issue 38, 2013, Pages 6398-6407

New insights in bilirubin metabolism and their clinical implications

Author keywords

ABCC2; Hereditary jaundice; Hyperbilirubinemia; Organic anion transporting polypeptide 1B1; Organic anion transporting polypeptide 1B3; UGT1A1

Indexed keywords

BILIRUBIN GLUCURONIDE; COPROPORPHYRIN; GLUCURONOSYLTRANSFERASE 1A1; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B1; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B3; UNCLASSIFIED DRUG;

EID: 84885600167     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i38.6398     Document Type: Review
Times cited : (149)

References (143)
  • 1
  • 2
    • 0000523238 scopus 로고
    • On the origin of bile pigment in normal man
    • [PMID: 15422003]
    • London IM, West R, Shemin D, Rittenberg D. On the origin of bile pigment in normal man. J Biol Chem 1950; 184: 351-358 [PMID: 15422003]
    • (1950) J Biol Chem , vol.184 , pp. 351-358
    • London, I.M.1    West, R.2    Shemin, D.3    Rittenberg, D.4
  • 3
    • 0014608853 scopus 로고
    • Studies of bilirubin kinetics in normal adults
    • [PMID: 5824077 DOI: 10.1172/JCI106184]
    • Berk PD, Howe RB, Bloomer JR, Berlin NI. Studies of bilirubin kinetics in normal adults. J Clin Invest 1969; 48: 2176-2190 [PMID: 5824077 DOI: 10.1172/JCI106184]
    • (1969) J Clin Invest , vol.48 , pp. 2176-2190
    • Berk, P.D.1    Howe, R.B.2    Bloomer, J.R.3    Berlin, N.I.4
  • 4
    • 0014348401 scopus 로고
    • The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase
    • [PMID: 4386763]
    • Tenhunen R, Marver HS, Schmid R. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA 1968; 61: 748-755 [PMID: 4386763]
    • (1968) Proc Natl Acad Sci USA , vol.61 , pp. 748-755
    • Tenhunen, R.1    Marver, H.S.2    Schmid, R.3
  • 5
    • 0011325753 scopus 로고
    • The identification of direct-reacting bilirubin as bilirubin glucuronide
    • [PMID: 13502349]
    • Schmid R. The identification of direct-reacting bilirubin as bilirubin glucuronide. J Biol Chem 1957; 229: 881-888 [PMID: 13502349]
    • (1957) J Biol Chem , vol.229 , pp. 881-888
    • Schmid, R.1
  • 6
    • 0002679775 scopus 로고
    • Direct-reacting bilirubin, bilirubin glucuronide, in serum, bile and urine
    • [PMID: 13337353 DOI: 10.1126/science.124.3211.76]
    • Schmid R. Direct-reacting bilirubin, bilirubin glucuronide, in serum, bile and urine. Science 1956; 124: 76-77 [PMID: 13337353 DOI: 10.1126/science.124.3211.76]
    • (1956) Science , vol.124 , pp. 76-77
    • Schmid, R.1
  • 7
    • 0017353725 scopus 로고
    • Purification and properties of microsomal UDP-glucuronosyltransferase from rat liver
    • [PMID: 402364]
    • Gorski JP, Kasper CB. Purification and properties of microsomal UDP-glucuronosyltransferase from rat liver. J Biol Chem 1977; 252: 1336-1343 [PMID: 402364]
    • (1977) J Biol Chem , vol.252 , pp. 1336-1343
    • Gorski, J.P.1    Kasper, C.B.2
  • 8
    • 0017685171 scopus 로고
    • Purification of UDP-glucuronyltransferase from untreated rat liver
    • [PMID: 406146 DOI: 10.1016/0014-5793(77)80283-4]
    • Burchell B. Purification of UDP-glucuronyltransferase from untreated rat liver. FEBS Lett 1977; 78: 101-104 [PMID: 406146 DOI: 10.1016/0014-5793(77)80283-4]
    • (1977) FEBS Lett , vol.78 , pp. 101-104
    • Burchell, B.1
  • 9
    • 0035209568 scopus 로고    scopus 로고
    • The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism
    • [PMID: 11768770 DOI: 10.1081/DMR-120000653]
    • Fisher MB, Paine MF, Strelevitz TJ, Wrighton SA. The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism. Drug Metab Rev 2001; 33: 273-297 [PMID: 11768770 DOI: 10.1081/DMR-120000653]
    • (2001) Drug Metab Rev , vol.33 , pp. 273-297
    • Fisher, M.B.1    Paine, M.F.2    Strelevitz, T.J.3    Wrighton, S.A.4
  • 10
    • 0033003747 scopus 로고    scopus 로고
    • Supplement of liver enzyme by intestinal and kidney transplants in congenitally enzyme-deficient rat
    • [PMID: 10188835]
    • Kokudo N, Takahashi S, Sugitani K, Okazaki T, Nozawa M. Supplement of liver enzyme by intestinal and kidney transplants in congenitally enzyme-deficient rat. Microsurgery 1999; 19: 103-107 [PMID: 10188835]
    • (1999) Microsurgery , vol.19 , pp. 103-107
    • Kokudo, N.1    Takahashi, S.2    Sugitani, K.3    Okazaki, T.4    Nozawa, M.5
  • 11
    • 30144437158 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferases: Gene structures of UGT1 and UGT2 families
    • [PMID: 16399340 DOI: 10.1016/ S0076-6879(05)00001-7]
    • Owens IS, Basu NK, Banerjee R. UDP-glucuronosyltransferases: gene structures of UGT1 and UGT2 families. Methods Enzymol 2005; 400: 1-22 [PMID: 16399340 DOI: 10.1016/ S0076-6879(05)00001-7]
    • (2005) Methods Enzymol , vol.400 , pp. 1-22
    • Owens, I.S.1    Basu, N.K.2    Banerjee, R.3
  • 12
    • 3543024020 scopus 로고
    • Identification and purification of mutiple forms of UDP-glucuronosyltransferase
    • Burchell B. Identification and purification of mutiple forms of UDP-glucuronosyltransferase. Rev Biochem Toxicol 1981; 3: 1
    • (1981) Rev Biochem Toxicol , vol.3 , pp. 1
    • Burchell, B.1
  • 13
    • 0022627563 scopus 로고
    • Isolation and characterization of multiple forms of rat liver UDP-glucuronate glucuronosyltransferase
    • [PMID: 3085655]
    • Roy Chowdhury J, Roy Chowdhury N, Falany CN, Tephly TR, Arias IM. Isolation and characterization of multiple forms of rat liver UDP-glucuronate glucuronosyltransferase. Biochem J 1986; 233: 827-837 [PMID: 3085655]
    • (1986) Biochem J , vol.233 , pp. 827-837
    • Roy Chowdhury, J.1    Roy Chowdhury, N.2    Falany, C.N.3    Tephly, T.R.4    Arias, I.M.5
  • 14
    • 0041725049 scopus 로고    scopus 로고
    • The structure and function of the UDP-glucuronosyltransferase gene family
    • [PMID: 9327909 DOI: 10.1016/S1054-3589(08)60758-9]
    • Burchell B, Brierley CH, Monaghan G, Clarke DJ. The structure and function of the UDP-glucuronosyltransferase gene family. Adv Pharmacol 1998; 42: 335-338 [PMID: 9327909 DOI: 10.1016/S1054-3589(08)60758-9]
    • (1998) Adv Pharmacol , vol.42 , pp. 335-338
    • Burchell, B.1    Brierley, C.H.2    Monaghan, G.3    Clarke, D.J.4
  • 15
    • 0034128936 scopus 로고    scopus 로고
    • Human UDP-glucuronosyltransferases: Metabolism, expression, and disease
    • [PMID: 10836148 DOI: 10.1146/annurev.pharmtox.40.1.581]
    • Tukey RH, Strassburg CP. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 2000; 40: 581-616 [PMID: 10836148 DOI: 10.1146/annurev.pharmtox.40.1.581]
    • (2000) Annu Rev Pharmacol Toxicol , vol.40 , pp. 581-616
    • Tukey, R.H.1    Strassburg, C.P.2
  • 16
    • 0036137072 scopus 로고    scopus 로고
    • Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats
    • [PMID: 11752103]
    • Cherrington NJ, Hartley DP, Li N, Johnson DR, Klaassen CD. Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. J Pharmacol Exp Ther 2002; 300: 97-104 [PMID: 11752103]
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 97-104
    • Cherrington, N.J.1    Hartley, D.P.2    Li, N.3    Johnson, D.R.4    Klaassen, C.D.5
  • 17
    • 0031392360 scopus 로고    scopus 로고
    • Molecular regulation of sinusoidal liver bile acid transporters during cholestasis
    • [PMID: 9626756]
    • Gartung C, Matern S. Molecular regulation of sinusoidal liver bile acid transporters during cholestasis. Yale J Biol Med 1997; 70: 355-363 [PMID: 9626756]
    • (1997) Yale J Biol Med , vol.70 , pp. 355-363
    • Gartung, C.1    Matern, S.2
  • 18
    • 77955300958 scopus 로고    scopus 로고
    • Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs
    • [PMID: 20644253 DOI: 10.1172/JCI42168]
    • van de Steeg E, Wagenaar E, van der Kruijssen CM, Burggraaff JE, de Waart DR, Elferink RP, Kenworthy KE, Schinkel AH. Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. J Clin Invest 2010; 120: 2942-2952 [PMID: 20644253 DOI: 10.1172/JCI42168]
    • (2010) J Clin Invest , vol.120 , pp. 2942-2952
    • van de Steeg, E.1    Wagenaar, E.2    van der Kruijssen, C.M.3    Burggraaff, J.E.4    de Waart, D.R.5    Elferink, R.P.6    Kenworthy, K.E.7    Schinkel, A.H.8
  • 19
    • 84856556484 scopus 로고    scopus 로고
    • Functions of OATP1A and 1B transporters in vivo: Insights from mouse models
    • [PMID: 22130008 DOI: 10.1016/j.tips.2011.10.005]
    • Iusuf D, van de Steeg E, Schinkel AH. Functions of OATP1A and 1B transporters in vivo: insights from mouse models. Trends Pharmacol Sci 2012; 33: 100-108 [PMID: 22130008 DOI: 10.1016/j.tips.2011.10.005]
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 100-108
    • Iusuf, D.1    van de Steeg, E.2    Schinkel, A.H.3
  • 20
    • 0034725617 scopus 로고    scopus 로고
    • Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide
    • [PMID: 10779507 DOI: 10.1074/jbc.M001448200]
    • König J, Cui Y, Nies AT, Keppler D. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J Biol Chem 2000; 275: 23161-23168 [PMID: 10779507 DOI: 10.1074/jbc.M001448200]
    • (2000) J Biol Chem , vol.275 , pp. 23161-23168
    • König, J.1    Cui, Y.2    Nies, A.T.3    Keppler, D.4
  • 21
    • 0037733365 scopus 로고    scopus 로고
    • A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
    • [PMID: 10644574]
    • König J, Cui Y, Nies AT, Keppler D. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am J Physiol Gastrointest Liver Physiol 2000; 278: G156-G164 [PMID: 10644574]
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.278
    • König, J.1    Cui, Y.2    Nies, A.T.3    Keppler, D.4
  • 22
    • 84867887941 scopus 로고    scopus 로고
    • Hepatocyte hopping of OATP1B substrates contributes to efficient hepatic detoxification
    • [PMID: 23010652 DOI: 10.1038/clpt.2012.143]
    • Iusuf D, van de Steeg E, Schinkel AH. Hepatocyte hopping of OATP1B substrates contributes to efficient hepatic detoxification. Clin Pharmacol Ther 2012; 92: 559-562 [PMID: 23010652 DOI: 10.1038/clpt.2012.143]
    • (2012) Clin Pharmacol Ther , vol.92 , pp. 559-562
    • Iusuf, D.1    van de Steeg, E.2    Schinkel, A.H.3
  • 23
    • 35549008848 scopus 로고    scopus 로고
    • OATP1B1 polymorphism is a major determinant of serum bilirubin level but not associated with rifampicin-mediated bilirubin elevation
    • [PMID: 17973861]
    • Zhang W, He YJ, Gan Z, Fan L, Li Q, Wang A, Liu ZQ, Deng S, Huang YF, Xu LY, Zhou HH. OATP1B1 polymorphism is a major determinant of serum bilirubin level but not associated with rifampicin-mediated bilirubin elevation. Clin Exp Pharmacol Physiol 2007; 34: 1240-1244 [PMID: 17973861]
    • (2007) Clin Exp Pharmacol Physiol , vol.34 , pp. 1240-1244
    • Zhang, W.1    He, Y.J.2    Gan, Z.3    Fan, L.4    Li, Q.5    Wang, A.6    Liu, Z.Q.7    Deng, S.8    Huang, Y.F.9    Xu, L.Y.10    Zhou, H.H.11
  • 25
    • 0037907742 scopus 로고    scopus 로고
    • Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placentamaternal liver tandem excretory pathway for foetal bilirubin
    • [PMID: 12568656]
    • Briz O, Serrano MA, MacIas RI, Gonzalez-Gallego J, Marin JJ. Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placentamaternal liver tandem excretory pathway for foetal bilirubin. Biochem J 2003; 371: 897-905 [PMID: 12568656]
    • (2003) Biochem J , vol.371 , pp. 897-905
    • Briz, O.1    Serrano, M.A.2    McIas, R.I.3    Gonzalez-Gallego, J.4    Marin, J.J.5
  • 26
    • 65649152315 scopus 로고    scopus 로고
    • Excretion of biliary compounds during intrauterine life
    • [PMID: 19230042 DOI: 10.3748/wjg.15.817]
    • Macias RI, Marin JJ, Serrano MA. Excretion of biliary compounds during intrauterine life. World J Gastroenterol 2009; 15: 817-828 [PMID: 19230042 DOI: 10.3748/wjg.15.817]
    • (2009) World J Gastroenterol , vol.15 , pp. 817-828
    • McIas, R.I.1    Marin, J.J.2    Serrano, M.A.3
  • 27
    • 0023132858 scopus 로고
    • Bilirubin is an antioxidant of possible physiological importance
    • [PMID: 3029864 DOI: 10.1126/science.3029864]
    • Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. Bilirubin is an antioxidant of possible physiological importance. Science 1987; 235: 1043-1046 [PMID: 3029864 DOI: 10.1126/science.3029864]
    • (1987) Science , vol.235 , pp. 1043-1046
    • Stocker, R.1    Yamamoto, Y.2    McDonagh, A.F.3    Glazer, A.N.4    Ames, B.N.5
  • 28
    • 0029129079 scopus 로고
    • Hyperbilirubinemia results in reduced oxidative injury in neonatal Gunn rats exposed to hyperoxia
    • [PMID: 7590389 DOI: 10.1016/089 1-5849(95)00032-S]
    • Dennery PA, McDonagh AF, Spitz DR, Rodgers PA, Stevenson DK. Hyperbilirubinemia results in reduced oxidative injury in neonatal Gunn rats exposed to hyperoxia. Free Radic Biol Med 1995; 19: 395-404 [PMID: 7590389 DOI: 10.1016/089 1-5849(95)00032-S]
    • (1995) Free Radic Biol Med , vol.19 , pp. 395-404
    • Dennery, P.A.1    McDonagh, A.F.2    Spitz, D.R.3    Rodgers, P.A.4    Stevenson, D.K.5
  • 29
    • 0033756130 scopus 로고    scopus 로고
    • Association of serum bilirubin concentration with risk of coronary artery disease
    • [PMID: 11067805]
    • Mayer M. Association of serum bilirubin concentration with risk of coronary artery disease. Clin Chem 2000; 46: 1723-1727 [PMID: 11067805]
    • (2000) Clin Chem , vol.46 , pp. 1723-1727
    • Mayer, M.1
  • 31
    • 78249277155 scopus 로고    scopus 로고
    • Genetic polymorphism in the conjugating enzyme UGT1A1 and the risk of head and neck cancer
    • [PMID: 21351260 DOI: 10.1002/ijc.25296]
    • Lacko M, Roelofs HM, Te Morsche RH, Voogd AC, Ophuis MB, Peters WH, Manni JJ. Genetic polymorphism in the conjugating enzyme UGT1A1 and the risk of head and neck cancer. Int J Cancer 2010; 127: 2815-2821 [PMID: 21351260 DOI: 10.1002/ijc.25296]
    • (2010) Int J Cancer , vol.127 , pp. 2815-2821
    • Lacko, M.1    Roelofs, H.M.2    Te Morsche, R.H.3    Voogd, A.C.4    Ophuis, M.B.5    Peters, W.H.6    Manni, J.J.7
  • 33
    • 4644344388 scopus 로고    scopus 로고
    • Unconjugated bilirubin induces apoptosis in colon cancer cells by triggering mitochondrial depolarization
    • [PMID: 15382069 DOI: 10.1002/ ijc.20418]
    • Keshavan P, Schwemberger SJ, Smith DL, Babcock GF, Zucker SD. Unconjugated bilirubin induces apoptosis in colon cancer cells by triggering mitochondrial depolarization. Int J Cancer 2004; 112: 433-445 [PMID: 15382069 DOI: 10.1002/ ijc.20418]
    • (2004) Int J Cancer , vol.112 , pp. 433-445
    • Keshavan, P.1    Schwemberger, S.J.2    Smith, D.L.3    Babcock, G.F.4    Zucker, S.D.5
  • 35
    • 0000210568 scopus 로고
    • Zur Kenntnis des ikterus neonatatorum, inbesondere der dabei auftreten den gehirnveranderungen
    • Schmorl G. Zur Kenntnis des ikterus neonatatorum, inbesondere der dabei auftreten den gehirnveranderungen. Verh Dtsch Ges Pathol 1903; 6: 109
    • (1903) Verh Dtsch Ges Pathol , vol.6 , pp. 109
    • Schmorl, G.1
  • 36
    • 0021955905 scopus 로고
    • Bilirubin toxicity in neural cell lines N115 and NBR10A
    • [PMID: 4047759]
    • Schiff D, Chan G, Poznansky MJ. Bilirubin toxicity in neural cell lines N115 and NBR10A. Pediatr Res 1985; 19: 908-911 [PMID: 4047759]
    • (1985) Pediatr Res , vol.19 , pp. 908-911
    • Schiff, D.1    Chan, G.2    Poznansky, M.J.3
  • 37
    • 0014670915 scopus 로고
    • Effects of bilirubin on mitochondrial reactions
    • [PMID: 4982202]
    • Mustafa MG, Cowger ML, King TE. Effects of bilirubin on mitochondrial reactions. J Biol Chem 1969; 244: 6403-6414 [PMID: 4982202]
    • (1969) J Biol Chem , vol.244 , pp. 6403-6414
    • Mustafa, M.G.1    Cowger, M.L.2    King, T.E.3
  • 38
    • 0014197871 scopus 로고
    • Oxidative phosphorylation in experimental bilirubin encephalopathy
    • [PMID: 6018655]
    • Diamond I, Schmid R. Oxidative phosphorylation in experimental bilirubin encephalopathy. Science 1967; 155: 1288-1289 [PMID: 6018655]
    • (1967) Science , vol.155 , pp. 1288-1289
    • Diamond, I.1    Schmid, R.2
  • 39
    • 84885608276 scopus 로고
    • Effect of bilirubin on some hydrolases
    • [PMID: 13835320]
    • Strumia E. [Effect of bilirubin on some hydrolases]. Boll Soc Ital Biol Sper 1959; 35: 2160-2162 [PMID: 13835320]
    • (1959) Boll Soc Ital Biol Sper , vol.35 , pp. 2160-2162
    • Strumia, E.1
  • 40
    • 0014010242 scopus 로고
    • Inhibition of hepatic alcohol dehydrogenase by bilirubin
    • [PMID: 5908133]
    • Flitman R, Worth MH. Inhibition of hepatic alcohol dehydrogenase by bilirubin. J Biol Chem 1966; 241: 669-672 [PMID: 5908133]
    • (1966) J Biol Chem , vol.241 , pp. 669-672
    • Flitman, R.1    Worth, M.H.2
  • 41
    • 0016422907 scopus 로고
    • Studies on cellular toxicity of bilirubin: Effect on the carbohydrate metabolism in the young rat brain
    • [DOI: 10.1016/0006-8993(75)90860-4]
    • Katoh R, Kashiwamata S, Niwa F. Studies on cellular toxicity of bilirubin: Effect on the carbohydrate metabolism in the young rat brain. Brain Res 1975; 83: 81-92 [DOI: 10.1016/0006-8993(75)90860-4]
    • (1975) Brain Res , vol.83 , pp. 81-92
    • Katoh, R.1    Kashiwamata, S.2    Niwa, F.3
  • 42
    • 0016374910 scopus 로고
    • Bilirubin encephalopathy: Effect on protein synthesis in the brain of the Gunn rat
    • [PMID: 4857425]
    • Greenfield S, Majumdar AP. Bilirubin encephalopathy: effect on protein synthesis in the brain of the Gunn rat. J Neurol Sci 1974; 22: 83-89 [PMID: 4857425]
    • (1974) J Neurol Sci , vol.22 , pp. 83-89
    • Greenfield, S.1    Majumdar, A.P.2
  • 43
    • 0016316585 scopus 로고
    • Bilirubin encephalopathy: Effect on RNA polymerase activity and chromatin template activity in the brain of the Gunn rat
    • [PMID: 4453356]
    • Majumdar AP. Bilirubin encephalopathy: effect on RNA polymerase activity and chromatin template activity in the brain of the Gunn rat. Neurobiology 1974; 4: 425-431 [PMID: 4453356]
    • (1974) Neurobiology , vol.4 , pp. 425-431
    • Majumdar, A.P.1
  • 44
    • 0042766885 scopus 로고    scopus 로고
    • Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis
    • [PMID: 12883478 DOI: 10.1053/jhep.2003.50317]
    • Geier A, Dietrich CG, Voigt S, Kim SK, Gerloff T, Kullak-Ublick GA, Lorenzen J, Matern S, Gartung C. Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis. Hepatology 2003; 38: 345-354 [PMID: 12883478 DOI: 10.1053/jhep.2003.50317]
    • (2003) Hepatology , vol.38 , pp. 345-354
    • Geier, A.1    Dietrich, C.G.2    Voigt, S.3    Kim, S.K.4    Gerloff, T.5    Kullak-Ublick, G.A.6    Lorenzen, J.7    Matern, S.8    Gartung, C.9
  • 45
    • 33847011377 scopus 로고    scopus 로고
    • Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration
    • [PMID: 17291602 DOI: 10.1016/ j.bbamcr.2006.04.014]
    • Geier A, Wagner M, Dietrich CG, Trauner M. Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration. Biochim Biophys Acta 2007; 1773: 283-308 [PMID: 17291602 DOI: 10.1016/ j.bbamcr.2006.04.014]
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 283-308
    • Geier, A.1    Wagner, M.2    Dietrich, C.G.3    Trauner, M.4
  • 46
    • 34548572892 scopus 로고    scopus 로고
    • Bile acid transporters: Structure, function, regulation and pathophysiological implications
    • [PMID: 17404808 DOI: 10.1007/ s11095-007-9289-1]
    • Alrefai WA, Gill RK. Bile acid transporters: structure, function, regulation and pathophysiological implications. Pharm Res 2007; 24: 1803-1823 [PMID: 17404808 DOI: 10.1007/ s11095-007-9289-1]
    • (2007) Pharm Res , vol.24 , pp. 1803-1823
    • Alrefai, W.A.1    Gill, R.K.2
  • 47
    • 0033753524 scopus 로고    scopus 로고
    • Genetic defects in hepatocanalicular transport
    • [PMID: 11076402 DOI: 10.1055/s-2000-9384]
    • Thompson R, Jansen PL. Genetic defects in hepatocanalicular transport. Semin Liver Dis 2000; 20: 365-372 [PMID: 11076402 DOI: 10.1055/s-2000-9384]
    • (2000) Semin Liver Dis , vol.20 , pp. 365-372
    • Thompson, R.1    Jansen, P.L.2
  • 48
    • 0033744558 scopus 로고    scopus 로고
    • Molecular alterations in hepatocyte transport mechanisms in acquired cholestatic liver disorders
    • [PMID: 11076403 DOI: 10.1055/ s-2000-9390]
    • Lee J, Boyer JL. Molecular alterations in hepatocyte transport mechanisms in acquired cholestatic liver disorders. Semin Liver Dis 2000; 20: 373-384 [PMID: 11076403 DOI: 10.1055/ s-2000-9390]
    • (2000) Semin Liver Dis , vol.20 , pp. 373-384
    • Lee, J.1    Boyer, J.L.2
  • 49
    • 0001130357 scopus 로고
    • Hereditary acholuric jaundice in a new mutant strain of rats
    • Gunn CH. Hereditary acholuric jaundice in a new mutant strain of rats. J Hered 1938; 29: 137-139
    • (1938) J Hered , vol.29 , pp. 137-139
    • Gunn, C.H.1
  • 51
    • 43149112558 scopus 로고    scopus 로고
    • Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease
    • [PMID: 18180294 DOI: 10.1074/jbc.M709244200]
    • Nguyen N, Bonzo JA, Chen S, Chouinard S, Kelner MJ, Hardiman G, Bélanger A, Tukey RH. Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease. J Biol Chem 2008; 283: 7901-7911 [PMID: 18180294 DOI: 10.1074/jbc.M709244200]
    • (2008) J Biol Chem , vol.283 , pp. 7901-7911
    • Nguyen, N.1    Bonzo, J.A.2    Chen, S.3    Chouinard, S.4    Kelner, M.J.5    Hardiman, G.6    Bélanger, A.7    Tukey, R.H.8
  • 53
    • 0021250793 scopus 로고
    • The effects of nutrition on unconjugated plasma bilirubin concentrations in squirrel monkeys
    • [PMID: 6724513 DOI: 10.1002/ hep.1840040318]
    • Portman OW, Alexander M, Cornelius CE, Chowdhury JR, Chowdhury NR, Arias IM. The effects of nutrition on unconjugated plasma bilirubin concentrations in squirrel monkeys. Hepatology 1984; 4: 454-460 [PMID: 6724513 DOI: 10.1002/ hep.1840040318]
    • (1984) Hepatology , vol.4 , pp. 454-460
    • Portman, O.W.1    Alexander, M.2    Cornelius, C.E.3    Chowdhury, J.R.4    Chowdhury, N.R.5    Arias, I.M.6
  • 54
    • 0027485073 scopus 로고
    • Preserved organic anion transport in mutant TRrats with a hepatobiliary secretion defect
    • [PMID: 8214066]
    • Jansen PL, van Klinken JW, van Gelder M, Ottenhoff R, Elferink RP. Preserved organic anion transport in mutant TRrats with a hepatobiliary secretion defect. Am J Physiol 1993; 265: G445-G452 [PMID: 8214066]
    • (1993) Am J Physiol , vol.265
    • Jansen, P.L.1    van Klinken, J.W.2    van Gelder, M.3    Ottenhoff, R.4    Elferink, R.P.5
  • 55
    • 0027992269 scopus 로고
    • Establishment of hyperbilirubinuria rat mutant--a new animal model for jaundice
    • [PMID: 8119341]
    • Kawaguchi A, Nozaki Y, Hosokawa S, Tagaya O, Mikami T, Wakabayashi T. [Establishment of hyperbilirubinuria rat mutant--a new animal model for jaundice]. Jikken Dobutsu 1994; 43: 37-44 [PMID: 8119341]
    • (1994) Jikken Dobutsu , vol.43 , pp. 37-44
    • Kawaguchi, A.1    Nozaki, Y.2    Hosokawa, S.3    Tagaya, O.4    Mikami, T.5    Wakabayashi, T.6
  • 57
    • 0037976648 scopus 로고
    • Hepatic pigmentation with photosensitivity: A Syndrome in corriedale sheep resembling dubin-johnson syndrome in man
    • [PMID: 14317604]
    • Cornelius CE, Arias IM, Osburn BI. Hepatic pigmentation with photosensitivity: A Syndrome in corriedale sheep resembling dubin-johnson syndrome in man. J Am Vet Med Assoc 1965; 146: 709-713 [PMID: 14317604]
    • (1965) J Am Vet Med Assoc , vol.146 , pp. 709-713
    • Cornelius, C.E.1    Arias, I.M.2    Osburn, B.I.3
  • 60
    • 0035029401 scopus 로고    scopus 로고
    • The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CA-R
    • [PMID: 11343253 DOI: 10.1053/jhep.2001.24172]
    • Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T. The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CA-R. Hepatology 2001; 33: 1232-1238 [PMID: 11343253 DOI: 10.1053/jhep.2001.24172]
    • (2001) Hepatology , vol.33 , pp. 1232-1238
    • Sugatani, J.1    Kojima, H.2    Ueda, A.3    Kakizaki, S.4    Yoshinari, K.5    Gong, Q.H.6    Owens, I.S.7    Negishi, M.8    Sueyoshi, T.9
  • 61
    • 0001438682 scopus 로고
    • Congenital familial nonhemolytic jaundice with kernicterus
    • [PMID: 12983120]
    • Crigler JF, Najjar VA. Congenital familial nonhemolytic jaundice with kernicterus. Pediatrics 1952; 10: 169-180 [PMID: 12983120]
    • (1952) Pediatrics , vol.10 , pp. 169-180
    • Crigler, J.F.1    Najjar, V.A.2
  • 62
    • 0026764632 scopus 로고
    • Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient
    • [PMID: 1634606 DOI: 10.1172/JCI115829]
    • Ritter JK, Yeatman MT, Ferreira P, Owens IS. Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient. J Clin Invest 1992; 90: 150-155 [PMID: 1634606 DOI: 10.1172/JCI115829]
    • (1992) J Clin Invest , vol.90 , pp. 150-155
    • Ritter, J.K.1    Yeatman, M.T.2    Ferreira, P.3    Owens, I.S.4
  • 63
    • 0032705521 scopus 로고    scopus 로고
    • Diagnosis and management of Crigler-Najjar syndrome
    • [PMID: 10603107 DOI: 10.1007/PL00014330]
    • Jansen PL. Diagnosis and management of Crigler-Najjar syndrome. Eur J Pediatr 1999; 158 Suppl 2: S89-S94 [PMID: 10603107 DOI: 10.1007/PL00014330]
    • (1999) Eur J Pediatr , vol.158 , Issue.SUPPL. 2
    • Jansen, P.L.1
  • 64
    • 0014942139 scopus 로고
    • Effective phototherapy in congenital nonobstructive, nonhemolytic jaundice
    • [PMID: 5411133 DOI: 10.1056/ NEJM197002122820709]
    • Karon M, Imach D, Schwartz A. Effective phototherapy in congenital nonobstructive, nonhemolytic jaundice. N Engl J Med 1970; 282: 377-380 [PMID: 5411133 DOI: 10.1056/ NEJM197002122820709]
    • (1970) N Engl J Med , vol.282 , pp. 377-380
    • Karon, M.1    Imach, D.2    Schwartz, A.3
  • 65
    • 0023137332 scopus 로고
    • Crigler-Najjar syndrome type I: Treatment by home phototherapy followed by orthotopic hepatic transplantation
    • [PMID: 3546653 DOI: 10.1016/S0022-3476(87)80510-3]
    • Shevell MI, Bernard B, Adelson JW, Doody DP, Laberge JM, Guttman FM. Crigler-Najjar syndrome type I: treatment by home phototherapy followed by orthotopic hepatic transplantation. J Pediatr 1987; 110: 429-431 [PMID: 3546653 DOI: 10.1016/S0022-3476(87)80510-3]
    • (1987) J Pediatr , vol.110 , pp. 429-431
    • Shevell, M.I.1    Bernard, B.2    Adelson, J.W.3    Doody, D.P.4    Laberge, J.M.5    Guttman, F.M.6
  • 67
    • 0017062465 scopus 로고
    • Hepatocellular transplantation for metabolic deficiencies: Decrease of plasms bilirubin in Gunn rats
    • [PMID: 818706 DOI: 10.1126/ science.818706]
    • Matas AJ, Sutherland DE, Steffes MW, Mauer SM, Sowe A, Simmons RL, Najarian JS. Hepatocellular transplantation for metabolic deficiencies: decrease of plasms bilirubin in Gunn rats. Science 1976; 192: 892-894 [PMID: 818706 DOI: 10.1126/ science.818706]
    • (1976) Science , vol.192 , pp. 892-894
    • Matas, A.J.1    Sutherland, D.E.2    Steffes, M.W.3    Mauer, S.M.4    Sowe, A.5    Simmons, R.L.6    Najarian, J.S.7
  • 68
    • 0029849639 scopus 로고    scopus 로고
    • Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long-term gene therapy in Gunn rats
    • [PMID: 8958229 DOI: 10.1172/JCI119085]
    • Ilan Y, Attavar P, Takahashi M, Davidson A, Horwitz MS, Guida J, Chowdhury NR, Chowdhury JR. Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long-term gene therapy in Gunn rats. J Clin Invest 1996; 98: 2640-2647 [PMID: 8958229 DOI: 10.1172/JCI119085]
    • (1996) J Clin Invest , vol.98 , pp. 2640-2647
    • Ilan, Y.1    Attavar, P.2    Takahashi, M.3    Davidson, A.4    Horwitz, M.S.5    Guida, J.6    Chowdhury, N.R.7    Chowdhury, J.R.8
  • 69
    • 0029970829 scopus 로고    scopus 로고
    • Long term correction of bilirubin-UDPglucuronosyltransferase deficiency in Gunn rats by administration of a recombinant adenovirus during the neonatal period
    • [PMID: 8900123 DOI: 10.1074/jbc.271.43.26536]
    • Takahashi M, Ilan Y, Chowdhury NR, Guida J, Horwitz M, Chowdhury JR. Long term correction of bilirubin-UDPglucuronosyltransferase deficiency in Gunn rats by administration of a recombinant adenovirus during the neonatal period. J Biol Chem 1996; 271: 26536-26542 [PMID: 8900123 DOI: 10.1074/jbc.271.43.26536]
    • (1996) J Biol Chem , vol.271 , pp. 26536-26542
    • Takahashi, M.1    Ilan, Y.2    Chowdhury, N.R.3    Guida, J.4    Horwitz, M.5    Chowdhury, J.R.6
  • 70
    • 0001400656 scopus 로고
    • Chronic unconjugated hyperbilirubinemia without overt signs of hemolysis in adolescents and adults
    • [PMID: 14013759 DOI: 10.1172/ JCI104682]
    • Arias IM. Chronic unconjugated hyperbilirubinemia without overt signs of hemolysis in adolescents and adults. J Clin Invest 1962; 41: 2233-2245 [PMID: 14013759 DOI: 10.1172/ JCI104682]
    • (1962) J Clin Invest , vol.41 , pp. 2233-2245
    • Arias, I.M.1
  • 71
    • 0016733807 scopus 로고
    • Prolonged survival in three brothers with severe type 2 Crigler-Najjar syndrome. Ultrastructural and metabolic studies
    • [PMID: 805737]
    • Gollan JL, Huang SN, Billing B, Sherlock S. Prolonged survival in three brothers with severe type 2 Crigler-Najjar syndrome. Ultrastructural and metabolic studies. Gastroenterology 1975; 68: 1543-1555 [PMID: 805737]
    • (1975) Gastroenterology , vol.68 , pp. 1543-1555
    • Gollan, J.L.1    Huang, S.N.2    Billing, B.3    Sherlock, S.4
  • 72
    • 0027524805 scopus 로고
    • Identification of an A-to-G missense mutation in exon 2 of the UGT1 gene complex that causes Crigler-Najjar syndrome type 2
    • [PMID: 8276413 DOI: 10.1006/ geno.1993.1451]
    • Moghrabi N, Clarke DJ, Boxer M, Burchell B. Identification of an A-to-G missense mutation in exon 2 of the UGT1 gene complex that causes Crigler-Najjar syndrome type 2. Genomics 1993; 18: 171-173 [PMID: 8276413 DOI: 10.1006/ geno.1993.1451]
    • (1993) Genomics , vol.18 , pp. 171-173
    • Moghrabi, N.1    Clarke, D.J.2    Boxer, M.3    Burchell, B.4
  • 73
    • 0015545331 scopus 로고
    • Inheritance of type 2 Crigler-Najjar hyperbilirubinaemia
    • [PMID: 4692254]
    • Hunter JO, Thompson RP, Dunn PM, Williams R. Inheritance of type 2 Crigler-Najjar hyperbilirubinaemia. Gut 1973; 14: 46-49 [PMID: 4692254]
    • (1973) Gut , vol.14 , pp. 46-49
    • Hunter, J.O.1    Thompson, R.P.2    Dunn, P.M.3    Williams, R.4
  • 74
    • 0024425404 scopus 로고
    • Crigler-Najjar type II disease inheritance: A family study
    • [PMID: 2515370 DOI: 10.1007/BF01799221]
    • Labrune P, Myara A, Hennion C, Gout JP, Trivin F, Odievre M. Crigler-Najjar type II disease inheritance: a family study. J Inherit Metab Dis 1989; 12: 302-306 [PMID: 2515370 DOI: 10.1007/BF01799221]
    • (1989) J Inherit Metab Dis , vol.12 , pp. 302-306
    • Labrune, P.1    Myara, A.2    Hennion, C.3    Gout, J.P.4    Trivin, F.5    Odievre, M.6
  • 75
    • 0028081366 scopus 로고
    • Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase
    • [PMID: 7989595 DOI: 10.1172/JCI117604]
    • Seppen J, Bosma PJ, Goldhoorn BG, Bakker CT, Chowdhury JR, Chowdhury NR, Jansen PL, Oude Elferink RP. Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase. J Clin Invest 1994; 94: 2385-2391 [PMID: 7989595 DOI: 10.1172/JCI117604]
    • (1994) J Clin Invest , vol.94 , pp. 2385-2391
    • Seppen, J.1    Bosma, P.J.2    Goldhoorn, B.G.3    Bakker, C.T.4    Chowdhury, J.R.5    Chowdhury, N.R.6    Jansen, P.L.7    Oude Elferink, R.P.8
  • 77
    • 0014199704 scopus 로고
    • Gilbert's disease and the bilirubin tolerance test
    • [PMID: 6017546]
    • Nixon JC, Monahan GJ. Gilbert's disease and the bilirubin tolerance test. Can Med Assoc J 1967; 96: 370-373 [PMID: 6017546]
    • (1967) Can Med Assoc J , vol.96 , pp. 370-373
    • Nixon, J.C.1    Monahan, G.J.2
  • 78
    • 0028827696 scopus 로고
    • Gilbert's syndrome--a legitimate genetic anomaly?
    • [PMID: 7565981 DOI: 10.1056/NEJM199511023331812]
    • Schmid R. Gilbert's syndrome--a legitimate genetic anomaly? N Engl J Med 1995; 333: 1217-1218 [PMID: 7565981 DOI: 10.1056/NEJM199511023331812]
    • (1995) N Engl J Med , vol.333 , pp. 1217-1218
    • Schmid, R.1
  • 79
    • 0019521749 scopus 로고
    • Diagnosis of Gilbert's syndrome. Reliability of the caloric restriction and phenobarbital stimulation tests
    • [PMID: 7323703]
    • Thomsen HF, Hardt F, Juhl E. Diagnosis of Gilbert's syndrome. Reliability of the caloric restriction and phenobarbital stimulation tests. Scand J Gastroenterol 1981; 16: 699-703 [PMID: 7323703]
    • (1981) Scand J Gastroenterol , vol.16 , pp. 699-703
    • Thomsen, H.F.1    Hardt, F.2    Juhl, E.3
  • 80
    • 0014971406 scopus 로고
    • Excess lipofuscin accumulation in constitutional hepatic dysfunction (Gilbert's syndrome). Light and electron microscopic observations
    • [PMID: 5538621]
    • Barth RF, Grimley PM, Berk PD, Bloomer JR, Howe RB. Excess lipofuscin accumulation in constitutional hepatic dysfunction (Gilbert's syndrome). Light and electron microscopic observations. Arch Pathol 1971; 91: 41-47 [PMID: 5538621]
    • (1971) Arch Pathol , vol.91 , pp. 41-47
    • Barth, R.F.1    Grimley, P.M.2    Berk, P.D.3    Bloomer, J.R.4    Howe, R.B.5
  • 81
    • 0018571969 scopus 로고
    • Gilbert's syndrome: Analytical subcellular fractionation of liver biopsy specimens. Enzyme activities, organelle pathology and evidence for subpopulations of the syndrome
    • [PMID: 391473 DOI: 10.1042/cs0570491]
    • Dawson J, Seymour CA, Peters TJ. Gilbert's syndrome: analytical subcellular fractionation of liver biopsy specimens. Enzyme activities, organelle pathology and evidence for subpopulations of the syndrome. Clin Sci (Lond) 1979; 57: 491-497 [PMID: 391473 DOI: 10.1042/cs0570491]
    • (1979) Clin Sci (Lond) , vol.57 , pp. 491-497
    • Dawson, J.1    Seymour, C.A.2    Peters, T.J.3
  • 82
    • 0014664802 scopus 로고
    • Hepatic bilirubin udp-glucuronyl transferase activity in liver disease and gilbert's syndrome
    • [PMID: 5770050 DOI: 10.1056/NEJM196906052802303]
    • Black M, Billing BH. Hepatic bilirubin udp-glucuronyl transferase activity in liver disease and gilbert's syndrome. N Engl J Med 1969; 280: 1266-1271 [PMID: 5770050 DOI: 10.1056/NEJM196906052802303]
    • (1969) N Engl J Med , vol.280 , pp. 1266-1271
    • Black, M.1    Billing, B.H.2
  • 83
    • 0016784220 scopus 로고
    • Population studies on Gilbert's syndrome
    • [PMID: 1142378]
    • Owens D, Evans J. Population studies on Gilbert's syndrome. J Med Genet 1975; 12: 152-156 [PMID: 1142378]
    • (1975) J Med Genet , vol.12 , pp. 152-156
    • Owens, D.1    Evans, J.2
  • 85
    • 34247597891 scopus 로고    scopus 로고
    • Molecular pathogenesis of Gilbert's syndrome: Decreased TATAbinding protein binding affinity of UGT1A1 gene promoter
    • [PMID: 17496722 DOI: 10.1097/FPC.0b013e328012d0da]
    • Hsieh TY, Shiu TY, Huang SM, Lin HH, Lee TC, Chen PJ, Chu HC, Chang WK, Jeng KS, Lai MM, Chao YC. Molecular pathogenesis of Gilbert's syndrome: decreased TATAbinding protein binding affinity of UGT1A1 gene promoter. Pharmacogenet Genomics 2007; 17: 229-236 [PMID: 17496722 DOI: 10.1097/FPC.0b013e328012d0da]
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 229-236
    • Hsieh, T.Y.1    Shiu, T.Y.2    Huang, S.M.3    Lin, H.H.4    Lee, T.C.5    Chen, P.J.6    Chu, H.C.7    Chang, W.K.8    Jeng, K.S.9    Lai, M.M.10    Chao, Y.C.11
  • 86
    • 0032847365 scopus 로고    scopus 로고
    • Molecular genetic basis of Gilbert's syndrome
    • [PMID: 10530490 DOI: 10.1046/j.1440-1746.1999.01984.x]
    • Burchell B, Hume R. Molecular genetic basis of Gilbert's syndrome. J Gastroenterol Hepatol 1999; 14: 960-966 [PMID: 10530490 DOI: 10.1046/j.1440-1746.1999.01984.x]
    • (1999) J Gastroenterol Hepatol , vol.14 , pp. 960-966
    • Burchell, B.1    Hume, R.2
  • 87
    • 0032493441 scopus 로고    scopus 로고
    • Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: A balanced polymorphism for regulation of bilirubin metabolism?
    • [PMID: 9653159]
    • Beutler E, Gelbart T, Demina A. Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? Proc Natl Acad Sci USA 1998; 95: 8170-8174 [PMID: 9653159]
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8170-8174
    • Beutler, E.1    Gelbart, T.2    Demina, A.3
  • 88
    • 0344083645 scopus 로고    scopus 로고
    • Haplotype structure of the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene and its relationship to serum total bilirubin concentration in a male Korean population
    • [PMID: 14633881 DOI: 10.1373/clinchem.2003.024174]
    • Ki CS, Lee KA, Lee SY, Kim HJ, Cho SS, Park JH, Cho S, Sohn KM, Kim JW. Haplotype structure of the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene and its relationship to serum total bilirubin concentration in a male Korean population. Clin Chem 2003; 49: 2078-2081 [PMID: 14633881 DOI: 10.1373/clinchem.2003.024174]
    • (2003) Clin Chem , vol.49 , pp. 2078-2081
    • Ki, C.S.1    Lee, K.A.2    Lee, S.Y.3    Kim, H.J.4    Cho, S.S.5    Park, J.H.6    Cho, S.7    Sohn, K.M.8    Kim, J.W.9
  • 89
    • 0031595660 scopus 로고    scopus 로고
    • The UGT1A1*28 allele is relatively rare in a Japanese population
    • [PMID: 9731723]
    • Ando Y, Chida M, Nakayama K, Saka H, Kamataki T. The UGT1A1*28 allele is relatively rare in a Japanese population. Pharmacogenetics 1998; 8: 357-360 [PMID: 9731723]
    • (1998) Pharmacogenetics , vol.8 , pp. 357-360
    • Ando, Y.1    Chida, M.2    Nakayama, K.3    Saka, H.4    Kamataki, T.5
  • 90
    • 4544326498 scopus 로고    scopus 로고
    • Genetic polymorphisms of bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese patients with Crigler-Najjar syndrome or Gilbert's syndrome as well as in healthy Japanese subjects
    • [PMID: 15304120 DOI: 10.1111/ j.1440-1746.2004.03370.x]
    • Takeuchi K, Kobayashi Y, Tamaki S, Ishihara T, Maruo Y, Araki J, Mifuji R, Itani T, Kuroda M, Sato H, Kaito M, Adachi Y. Genetic polymorphisms of bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese patients with Crigler-Najjar syndrome or Gilbert's syndrome as well as in healthy Japanese subjects. J Gastroenterol Hepatol 2004; 19: 1023-1028 [PMID: 15304120 DOI: 10.1111/ j.1440-1746.2004.03370.x]
    • (2004) J Gastroenterol Hepatol , vol.19 , pp. 1023-1028
    • Takeuchi, K.1    Kobayashi, Y.2    Tamaki, S.3    Ishihara, T.4    Maruo, Y.5    Araki, J.6    Mifuji, R.7    Itani, T.8    Kuroda, M.9    Sato, H.10    Kaito, M.11    Adachi, Y.12
  • 91
    • 34748822655 scopus 로고    scopus 로고
    • Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDPglucuronosyltransferase 1A substrates
    • [PMID: 18004206 DOI: 10.1097/ FPC.0b013e328256b1b6]
    • Udomuksorn W, Elliot DJ, Lewis BC, Mackenzie PI, Yoovathaworn K, Miners JO. Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDPglucuronosyltransferase 1A substrates. Pharmacogenet Genomics 2007; 17: 1017-1029 [PMID: 18004206 DOI: 10.1097/ FPC.0b013e328256b1b6]
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 1017-1029
    • Udomuksorn, W.1    Elliot, D.J.2    Lewis, B.C.3    McKenzie, P.I.4    Yoovathaworn, K.5    Miners, J.O.6
  • 92
    • 0033799997 scopus 로고    scopus 로고
    • Genetic lesions of bilirubin uridinediphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler-Najjar and Gilbert syndromes: Correlation of genotype to phenotype
    • [PMID: 11013440]
    • Kadakol A, Ghosh SS, Sappal BS, Sharma G, Chowdhury JR, Chowdhury NR. Genetic lesions of bilirubin uridinediphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler-Najjar and Gilbert syndromes: correlation of genotype to phenotype. Hum Mutat 2000; 16: 297-306 [PMID: 11013440]
    • (2000) Hum Mutat , vol.16 , pp. 297-306
    • Kadakol, A.1    Ghosh, S.S.2    Sappal, B.S.3    Sharma, G.4    Chowdhury, J.R.5    Chowdhury, N.R.6
  • 94
    • 0034324675 scopus 로고    scopus 로고
    • Prolonged unconjugated hyperbilirubinemia associated with breast milk and mutations of the bilirubin uridine diphosphate-glucuronosyltransferase gene
    • [PMID: 11061796]
    • Maruo Y, Nishizawa K, Sato H, Sawa H, Shimada M. Prolonged unconjugated hyperbilirubinemia associated with breast milk and mutations of the bilirubin uridine diphosphate-glucuronosyltransferase gene. Pediatrics 2000; 106: E59 [PMID: 11061796]
    • (2000) Pediatrics , vol.106
    • Maruo, Y.1    Nishizawa, K.2    Sato, H.3    Sawa, H.4    Shimada, M.5
  • 95
    • 0034654290 scopus 로고    scopus 로고
    • Drug-mediated toxicity caused by genetic deficiency of UDP-glucuronosyltransferases
    • [PMID: 10720749 DOI: 10.1016/S0378-4274(99)00209-X]
    • Burchell B, Soars M, Monaghan G, Cassidy A, Smith D, Ethell B. Drug-mediated toxicity caused by genetic deficiency of UDP-glucuronosyltransferases. Toxicol Lett 2000; 112-113: 333-340 [PMID: 10720749 DOI: 10.1016/S0378-4274(99)00209-X]
    • (2000) Toxicol Lett , vol.112-113 , pp. 333-340
    • Burchell, B.1    Soars, M.2    Monaghan, G.3    Cassidy, A.4    Smith, D.5    Ethell, B.6
  • 96
    • 15444367186 scopus 로고    scopus 로고
    • Polymorphism of UDP-glucuronosyltransferase and drug metabolism
    • [PMID: 15853761 DOI: 10.2174/1389200053586064]
    • Maruo Y, Iwai M, Mori A, Sato H, Takeuchi Y. Polymorphism of UDP-glucuronosyltransferase and drug metabolism. Curr Drug Metab 2005; 6: 91-99 [PMID: 15853761 DOI: 10.2174/1389200053586064]
    • (2005) Curr Drug Metab , vol.6 , pp. 91-99
    • Maruo, Y.1    Iwai, M.2    Mori, A.3    Sato, H.4    Takeuchi, Y.5
  • 99
    • 27544468948 scopus 로고    scopus 로고
    • In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation
    • [PMID: 16118329 DOI: 10.1124/dmd.105.005447]
    • Zhang D, Chando TJ, Everett DW, Patten CJ, Dehal SS, Humphreys WG. In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation. Drug Metab Dispos 2005; 33: 1729-1739 [PMID: 16118329 DOI: 10.1124/dmd.105.005447]
    • (2005) Drug Metab Dispos , vol.33 , pp. 1729-1739
    • Zhang, D.1    Chando, T.J.2    Everett, D.W.3    Patten, C.J.4    Dehal, S.S.5    Humphreys, W.G.6
  • 100
    • 0031661579 scopus 로고    scopus 로고
    • UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan
    • [PMID: 9789606]
    • Ando Y, Saka H, Asai G, Sugiura S, Shimokata K, Kamataki T. UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan. Ann Oncol 1998; 9: 845-847 [PMID: 9789606]
    • (1998) Ann Oncol , vol.9 , pp. 845-847
    • Ando, Y.1    Saka, H.2    Asai, G.3    Sugiura, S.4    Shimokata, K.5    Kamataki, T.6
  • 102
    • 48949119333 scopus 로고    scopus 로고
    • Pharmacogenetics of Gilbert's syndrome
    • [PMID: 18518849 DOI: 10.2217/14622416.9.6.703]
    • Strassburg CP. Pharmacogenetics of Gilbert's syndrome. Pharmacogenomics 2008; 9: 703-715 [PMID: 18518849 DOI: 10.2217/14622416.9.6.703]
    • (2008) Pharmacogenomics , vol.9 , pp. 703-715
    • Strassburg, C.P.1
  • 103
    • 0000552161 scopus 로고
    • Chronic idiopathic jaundice with unidentified pigment in liver cells; a new clinicopathologic entity with a report of 12 cases
    • [PMID: 13193360]
    • Dubin IN, Johnson FB. Chronic idiopathic jaundice with unidentified pigment in liver cells; a new clinicopathologic entity with a report of 12 cases. Medicine (Baltimore) 1954; 33: 155-197 [PMID: 13193360]
    • (1954) Medicine (Baltimore) , vol.33 , pp. 155-197
    • Dubin, I.N.1    Johnson, F.B.2
  • 104
    • 0001414260 scopus 로고
    • Persistent non-hemolytic hyperbilirubinemia associated with lipochrome-like pigment in liver cells: Report of four cases
    • [PMID: 13208040]
    • Sprinz H, Nelson RS. Persistent non-hemolytic hyperbilirubinemia associated with lipochrome-like pigment in liver cells: report of four cases. Ann Intern Med 1954; 41: 952-962 [PMID: 13208040]
    • (1954) Ann Intern Med , vol.41 , pp. 952-962
    • Sprinz, H.1    Nelson, R.S.2
  • 105
    • 0014859813 scopus 로고
    • Dubin-Johnson syndrome in Israel. I. Clinical, laboratory, and genetic aspects of 101 cases
    • [PMID: 5532959]
    • Shani M, Seligsohn U, Gilon E, Sheba C, Adam A. Dubin-Johnson syndrome in Israel. I. Clinical, laboratory, and genetic aspects of 101 cases. Q J Med 1970; 39: 549-567 [PMID: 5532959]
    • (1970) Q J Med , vol.39 , pp. 549-567
    • Shani, M.1    Seligsohn, U.2    Gilon, E.3    Sheba, C.4    Adam, A.5
  • 106
    • 0015536255 scopus 로고
    • Hepatic handling of unconjugated dyes in the Dubin-Johnson syndrome
    • [PMID: 4683844]
    • Erlinger S, Dhumeaux D, Desjeux JF, Benhamou JP. Hepatic handling of unconjugated dyes in the Dubin-Johnson syndrome. Gastroenterology 1973; 64: 106-110 [PMID: 4683844]
    • (1973) Gastroenterology , vol.64 , pp. 106-110
    • Erlinger, S.1    Dhumeaux, D.2    Desjeux, J.F.3    Benhamou, J.P.4
  • 107
    • 0023556512 scopus 로고
    • Further evidence that the pigment in the Dubin-Johnson syndrome is not melanin
    • [PMID: 2853343 DOI: 10.1111/ j.1600-0749.1987.tb00392.x]
    • Swartz HM, Chen K, Roth JA. Further evidence that the pigment in the Dubin-Johnson syndrome is not melanin. Pigment Cell Res 1987; 1: 69-75 [PMID: 2853343 DOI: 10.1111/ j.1600-0749.1987.tb00392.x]
    • (1987) Pigment Cell Res , vol.1 , pp. 69-75
    • Swartz, H.M.1    Chen, K.2    Roth, J.A.3
  • 108
    • 6944248075 scopus 로고
    • Hepatitis with resulting mobilization of hepatic pigment in a patient with dubinjohnson syndrome
    • [PMID: 14234683]
    • Hunter FM, Sparks RD, Flinner RL. Hepatitis with resulting mobilization of hepatic pigment in a patient with dubinjohnson syndrome. Gastroenterology 1964; 47: 631-635 [PMID: 14234683]
    • (1964) Gastroenterology , vol.47 , pp. 631-635
    • Hunter, F.M.1    Sparks, R.D.2    Flinner, R.L.3
  • 109
    • 0020412911 scopus 로고
    • Clinicopathological studies of the Dubin-Johnson syndrome complicated with chronic hepatitis
    • [PMID: 7160601 DOI: 10.1007/BF02779135]
    • Watanabe S, Nishioka M, Kodama T, Ando K, Numa Y, Fukumoto Y, Okita K, Takemoto T, Mizuta M. Clinicopathological studies of the Dubin-Johnson syndrome complicated with chronic hepatitis. Gastroenterol Jpn 1982; 17: 576-584 [PMID: 7160601 DOI: 10.1007/BF02779135]
    • (1982) Gastroenterol Jpn , vol.17 , pp. 576-584
    • Watanabe, S.1    Nishioka, M.2    Kodama, T.3    Ando, K.4    Numa, Y.5    Fukumoto, Y.6    Okita, K.7    Takemoto, T.8    Mizuta, M.9
  • 110
    • 0029986408 scopus 로고    scopus 로고
    • Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome
    • [PMID: 8621134 DOI: 10.1053/jhep.1996.v23.pm0008621134]
    • Kartenbeck J, Leuschner U, Mayer R, Keppler D. Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome. Hepatology 1996; 23: 1061-1066 [PMID: 8621134 DOI: 10.1053/jhep.1996.v23.pm0008621134]
    • (1996) Hepatology , vol.23 , pp. 1061-1066
    • Kartenbeck, J.1    Leuschner, U.2    Mayer, R.3    Keppler, D.4
  • 111
    • 0029981430 scopus 로고    scopus 로고
    • Congenital jaundice in rats with a mutation in a multidrug resistanceassociated protein gene
    • [PMID: 8599091 DOI: 10.1126/science.271.5252.1126]
    • Paulusma CC, Bosma PJ, Zaman GJ, Bakker CT, Otter M, Scheffer GL, Scheper RJ, Borst P, Oude Elferink RP. Congenital jaundice in rats with a mutation in a multidrug resistanceassociated protein gene. Science 1996; 271: 1126-1128 [PMID: 8599091 DOI: 10.1126/science.271.5252.1126]
    • (1996) Science , vol.271 , pp. 1126-1128
    • Paulusma, C.C.1    Bosma, P.J.2    Zaman, G.J.3    Bakker, C.T.4    Otter, M.5    Scheffer, G.L.6    Scheper, R.J.7    Borst, P.8    Oude Elferink, R.P.9
  • 113
    • 6844250107 scopus 로고    scopus 로고
    • Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome
    • [PMID: 9425227 DOI: 10.1093/hmg/7.2.203]
    • Wada M, Toh S, Taniguchi K, Nakamura T, Uchiumi T, Kohno K, Yoshida I, Kimura A, Sakisaka S, Adachi Y, Kuwano M. Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome. Hum Mol Genet 1998; 7: 203-207 [PMID: 9425227 DOI: 10.1093/hmg/7.2.203]
    • (1998) Hum Mol Genet , vol.7 , pp. 203-207
    • Wada, M.1    Toh, S.2    Taniguchi, K.3    Nakamura, T.4    Uchiumi, T.5    Kohno, K.6    Yoshida, I.7    Kimura, A.8    Sakisaka, S.9    Adachi, Y.10    Kuwano, M.11
  • 114
    • 0033361943 scopus 로고    scopus 로고
    • Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome
    • [PMID: 10053008 DOI: 10.1086/302292]
    • Toh S, Wada M, Uchiumi T, Inokuchi A, Makino Y, Horie Y, Adachi Y, Sakisaka S, Kuwano M. Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome. Am J Hum Genet 1999; 64: 739-746 [PMID: 10053008 DOI: 10.1086/302292]
    • (1999) Am J Hum Genet , vol.64 , pp. 739-746
    • Toh, S.1    Wada, M.2    Uchiumi, T.3    Inokuchi, A.4    Makino, Y.5    Horie, Y.6    Adachi, Y.7    Sakisaka, S.8    Kuwano, M.9
  • 115
    • 0032501054 scopus 로고    scopus 로고
    • Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatinresistant cancer cells with decreased ATP-dependent drug transport
    • [PMID: 9813153 DOI: 10.1006/bbrc.1998.9546]
    • Uchiumi T, Hinoshita E, Haga S, Nakamura T, Tanaka T, Toh S, Furukawa M, Kawabe T, Wada M, Kagotani K, Okumura K, Kohno K, Akiyama S, Kuwano M. Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatinresistant cancer cells with decreased ATP-dependent drug transport. Biochem Biophys Res Commun 1998; 252: 103-110 [PMID: 9813153 DOI: 10.1006/bbrc.1998.9546]
    • (1998) Biochem Biophys Res Commun , vol.252 , pp. 103-110
    • Uchiumi, T.1    Hinoshita, E.2    Haga, S.3    Nakamura, T.4    Tanaka, T.5    Toh, S.6    Furukawa, M.7    Kawabe, T.8    Wada, M.9    Kagotani, K.10    Okumura, K.11    Kohno, K.12    Akiyama, S.13    Kuwano, M.14
  • 117
    • 38349126398 scopus 로고    scopus 로고
    • Involvement of Mrp2 (Abcc2) in biliary excretion of moxifloxacin and its metabolites in the isolated perfused rat liver
    • [PMID: 18088505 DOI: 10.1211/jpp.60.1.0007]
    • Ahmed S, Vo NT, Thalhammer T, Thalhammer F, Gattringer KB, Jäger W. Involvement of Mrp2 (Abcc2) in biliary excretion of moxifloxacin and its metabolites in the isolated perfused rat liver. J Pharm Pharmacol 2008; 60: 55-62 [PMID: 18088505 DOI: 10.1211/jpp.60.1.0007]
    • (2008) J Pharm Pharmacol , vol.60 , pp. 55-62
    • Ahmed, S.1    Vo, N.T.2    Thalhammer, T.3    Thalhammer, F.4    Gattringer, K.B.5    Jäger, W.6
  • 118
    • 44949184483 scopus 로고    scopus 로고
    • Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)
    • [PMID: 18457386 DOI: 10.1021/jm7015683]
    • Pedersen JM, Matsson P, Bergström CA, Norinder U, Hoogstraate J, Artursson P. Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). J Med Chem 2008; 51: 3275-3287 [PMID: 18457386 DOI: 10.1021/jm7015683]
    • (2008) J Med Chem , vol.51 , pp. 3275-3287
    • Pedersen, J.M.1    Matsson, P.2    Bergström, C.A.3    Norinder, U.4    Hoogstraate, J.5    Artursson, P.6
  • 119
    • 33846418041 scopus 로고    scopus 로고
    • Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition
    • [PMID: 16863439 DOI: 10.1517/17425255.2.3.351]
    • Jedlitschky G, Hoffmann U, Kroemer HK. Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition. Expert Opin Drug Metab Toxicol 2006; 2: 351-366 [PMID: 16863439 DOI: 10.1517/17425255.2.3.351]
    • (2006) Expert Opin Drug Metab Toxicol , vol.2 , pp. 351-366
    • Jedlitschky, G.1    Hoffmann, U.2    Kroemer, H.K.3
  • 120
    • 53349117254 scopus 로고    scopus 로고
    • Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development
    • [PMID: 18691054 DOI: 10.2174/092986708785132870]
    • Zhou SF, Wang LL, Di YM, Xue CC, Duan W, Li CG, Li Y. Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development. Curr Med Chem 2008; 15: 1981-2039 [PMID: 18691054 DOI: 10.2174/092986708785132870]
    • (2008) Curr Med Chem , vol.15 , pp. 1981-2039
    • Zhou, S.F.1    Wang, L.L.2    Di, Y.M.3    Xue, C.C.4    Duan, W.5    Li, C.G.6    Li, Y.7
  • 121
    • 22344450518 scopus 로고    scopus 로고
    • Dual hereditary jaundice: Simultaneous occurrence of mutations causing Gilbert's and Dubin-Johnson syndrome
    • [PMID: 16012956 DOI: 10.1053/j.gastro.2004.10.009]
    • Cebecauerova D, Jirasek T, Budisova L, Mandys V, Volf V, Novotna Z, Subhanova I, Hrebicek M, Elleder M, Jirsa M. Dual hereditary jaundice: simultaneous occurrence of mutations causing Gilbert's and Dubin-Johnson syndrome. Gastroenterology 2005; 129: 315-320 [PMID: 16012956 DOI: 10.1053/j.gastro.2004.10.009]
    • (2005) Gastroenterology , vol.129 , pp. 315-320
    • Cebecauerova, D.1    Jirasek, T.2    Budisova, L.3    Mandys, V.4    Volf, V.5    Novotna, Z.6    Subhanova, I.7    Hrebicek, M.8    Elleder, M.9    Jirsa, M.10
  • 122
    • 0142033403 scopus 로고
    • Familial non-hemolytic jaundice with direct van den Bergh reaction
    • Rotor B, Manahan L, Florentin A. Familial non-hemolytic jaundice with direct van den Bergh reaction. Acta medica Philippina 1948; 5: 37-49
    • (1948) Acta medica Philippina , vol.5 , pp. 37-49
    • Rotor, B.1    Manahan, L.2    Florentin, A.3
  • 123
    • 0017287180 scopus 로고
    • Rotor's syndrome. A distinct inheritable pathophysiologic entity
    • [PMID: 766621 DOI: 10.1016/0002-934 3(76)90426-5]
    • Wolkoff AW, Wolpert E, Pascasio FN, Arias IM. Rotor's syndrome. A distinct inheritable pathophysiologic entity. Am J Med 1976; 60: 173-179 [PMID: 766621 DOI: 10.1016/0002-934 3(76)90426-5]
    • (1976) Am J Med , vol.60 , pp. 173-179
    • Wolkoff, A.W.1    Wolpert, E.2    Pascasio, F.N.3    Arias, I.M.4
  • 124
    • 0017360711 scopus 로고
    • Abnormal sulfobromophthalein metabolism in Rotor's syndrome and obligate heterozygotes
    • [PMID: 850521 DOI: 10.1056/NEJM197705122961907]
    • Wolpert E, Pascasio FM, Wolkoff AW, Arias IM. Abnormal sulfobromophthalein metabolism in Rotor's syndrome and obligate heterozygotes. N Engl J Med 1977; 296: 1099-1101 [PMID: 850521 DOI: 10.1056/NEJM197705122961907]
    • (1977) N Engl J Med , vol.296 , pp. 1099-1101
    • Wolpert, E.1    Pascasio, F.M.2    Wolkoff, A.W.3    Arias, I.M.4
  • 126
    • 70350048926 scopus 로고    scopus 로고
    • Impact of OATP transporters on pharmacokinetics
    • [PMID: 19785645 DOI: 10.1111/j.1476-5381.2009.00430.x]
    • Kalliokoski A, Niemi M. Impact of OATP transporters on pharmacokinetics. Br J Pharmacol 2009; 158: 693-705 [PMID: 19785645 DOI: 10.1111/j.1476-5381.2009.00430.x]
    • (2009) Br J Pharmacol , vol.158 , pp. 693-705
    • Kalliokoski, A.1    Niemi, M.2
  • 127
    • 56549086849 scopus 로고    scopus 로고
    • The effect of SLCO1B1 polymorphism on repaglinide pharmacokinetics persists over a wide dose range
    • [PMID: 18823304 DOI: 10.1111/ j.1365-2125.2008.03287.x]
    • Kalliokoski A, Neuvonen M, Neuvonen PJ, Niemi M. The effect of SLCO1B1 polymorphism on repaglinide pharmacokinetics persists over a wide dose range. Br J Clin Pharmacol 2008; 66: 818-825 [PMID: 18823304 DOI: 10.1111/ j.1365-2125.2008.03287.x]
    • (2008) Br J Clin Pharmacol , vol.66 , pp. 818-825
    • Kalliokoski, A.1    Neuvonen, M.2    Neuvonen, P.J.3    Niemi, M.4
  • 128
    • 79953901458 scopus 로고    scopus 로고
    • Organic anion transporting polypeptide 1B1: A genetically polymorphic transporter of major importance for hepatic drug uptake
    • [PMID: 21245207 DOI: 10.1124/pr.110.002857]
    • Niemi M, Pasanen MK, Neuvonen PJ. Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev 2011; 63: 157-181 [PMID: 21245207 DOI: 10.1124/pr.110.002857]
    • (2011) Pharmacol Rev , vol.63 , pp. 157-181
    • Niemi, M.1    Pasanen, M.K.2    Neuvonen, P.J.3
  • 130
    • 0032798666 scopus 로고    scopus 로고
    • New molecular aspects of cholestatic liver diseases
    • [PMID: 10458013]
    • Trauner M, Fickert P, Stauber RE. [New molecular aspects of cholestatic liver diseases]. Z Gastroenterol 1999; 37: 639-647 [PMID: 10458013]
    • (1999) Z Gastroenterol , vol.37 , pp. 639-647
    • Trauner, M.1    Fickert, P.2    Stauber, R.E.3
  • 131
    • 25444530047 scopus 로고    scopus 로고
    • Transcriptional regulation of hepatobiliary transport systems in health and disease: Implications for a rationale approach to the treatment of intrahepatic cholestasis
    • [PMID: 16010241]
    • Wagner M, Trauner M. Transcriptional regulation of hepatobiliary transport systems in health and disease: implications for a rationale approach to the treatment of intrahepatic cholestasis. Ann Hepatol 2005; 4: 77-99 [PMID: 16010241]
    • (2005) Ann Hepatol , vol.4 , pp. 77-99
    • Wagner, M.1    Trauner, M.2
  • 132
    • 0242690430 scopus 로고    scopus 로고
    • Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis
    • [PMID: 14568249 DOI: 10.1016/S0168-8278(03)00410-0]
    • Kojima H, Nies AT, König J, Hagmann W, Spring H, Uemura M, Fukui H, Keppler D. Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis. J Hepatol 2003; 39: 693-702 [PMID: 14568249 DOI: 10.1016/S0168-8278(03)00410-0]
    • (2003) J Hepatol , vol.39 , pp. 693-702
    • Kojima, H.1    Nies, A.T.2    König, J.3    Hagmann, W.4    Spring, H.5    Uemura, M.6    Fukui, H.7    Keppler, D.8
  • 133
    • 0013138711 scopus 로고    scopus 로고
    • Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis
    • [PMID: 12763363 DOI: 10.1016/S0168-8278(03)00096-5]
    • Zollner G, Fickert P, Silbert D, Fuchsbichler A, Marschall HU, Zatloukal K, Denk H, Trauner M. Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis. J Hepatol 2003; 38: 717-727 [PMID: 12763363 DOI: 10.1016/S0168-8278(03)00096-5]
    • (2003) J Hepatol , vol.38 , pp. 717-727
    • Zollner, G.1    Fickert, P.2    Silbert, D.3    Fuchsbichler, A.4    Marschall, H.U.5    Zatloukal, K.6    Denk, H.7    Trauner, M.8
  • 134
    • 1542619640 scopus 로고    scopus 로고
    • BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis
    • [PMID: 14999697 DOI: 10.1002/hep.20159]
    • Pauli-Magnus C, Kerb R, Fattinger K, Lang T, Anwald B, Kullak-Ublick GA, Beuers U, Meier PJ. BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis. Hepatology 2004; 39: 779-791 [PMID: 14999697 DOI: 10.1002/hep.20159]
    • (2004) Hepatology , vol.39 , pp. 779-791
    • Pauli-Magnus, C.1    Kerb, R.2    Fattinger, K.3    Lang, T.4    Anwald, B.5    Kullak-Ublick, G.A.6    Beuers, U.7    Meier, P.J.8
  • 135
    • 84855970257 scopus 로고    scopus 로고
    • Hepatobiliary membrane transporters in primary biliary cirrhosis
    • [PMID: 22175826 DOI: 10.1111/j.1872-034X.2011.00912.x]
    • Takeyama Y, Sakisaka S. Hepatobiliary membrane transporters in primary biliary cirrhosis. Hepatol Res 2012; 42: 120-130 [PMID: 22175826 DOI: 10.1111/j.1872-034X.2011.00912.x]
    • (2012) Hepatol Res , vol.42 , pp. 120-130
    • Takeyama, Y.1    Sakisaka, S.2
  • 136
    • 45849103909 scopus 로고    scopus 로고
    • Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia
    • [PMID: 18327154 DOI: 10.1203/ PDR.0b013e318170a6b5]
    • Chen HL, Liu YJ, Chen HL, Wu SH, Ni YH, Ho MC, Lai HS, Hsu WM, Hsu HY, Tseng HC, Jeng YM, Chang MH. Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia. Pediatr Res 2008; 63: 667-673 [PMID: 18327154 DOI: 10.1203/ PDR.0b013e318170a6b5]
    • (2008) Pediatr Res , vol.63 , pp. 667-673
    • Chen, H.L.1    Liu, Y.J.2    Chen, H.L.3    Wu, S.H.4    Ni, Y.H.5    Ho, M.C.6    Lai, H.S.7    Hsu, W.M.8    Hsu, H.Y.9    Tseng, H.C.10    Jeng, Y.M.11    Chang, M.H.12
  • 137
    • 0034916717 scopus 로고    scopus 로고
    • Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis
    • [PMID: 11454187 DOI: 10.1034/j.1600-0676.2001.021004247.x]
    • Oswald M, Kullak-Ublick GA, Paumgartner G, Beuers U. Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis. Liver 2001; 21: 247-253 [PMID: 11454187 DOI: 10.1034/j.1600-0676.2001.021004247.x]
    • (2001) Liver , vol.21 , pp. 247-253
    • Oswald, M.1    Kullak-Ublick, G.A.2    Paumgartner, G.3    Beuers, U.4
  • 138
    • 15244342411 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferases and clinical drug-drug interactions
    • [PMID: 15781124]
    • Kiang TK, Ensom MH, Chang TK. UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacol Ther 2005; 106: 97-132 [PMID: 15781124]
    • (2005) Pharmacol Ther , vol.106 , pp. 97-132
    • Kiang, T.K.1    Ensom, M.H.2    Chang, T.K.3
  • 139
    • 84857092984 scopus 로고    scopus 로고
    • OATPs, OATs and OCTs: The organic anion and cation transporters of the SLCO and SLC22A gene superfamilies
    • [PMID: 22013971 DOI: 10.1111/j.1476-5381.2011.01724.x]
    • Roth M, Obaidat A, Hagenbuch B. OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies. Br J Pharmacol 2012; 165: 1260-1287 [PMID: 22013971 DOI: 10.1111/j.1476-5381.2011.01724.x]
    • (2012) Br J Pharmacol , vol.165 , pp. 1260-1287
    • Roth, M.1    Obaidat, A.2    Hagenbuch, B.3
  • 140
    • 84861494749 scopus 로고    scopus 로고
    • Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): Influence of protein expression on drug-drug interactions
    • [PMID: 22541068 DOI: 10.1021/jm300212s]
    • Karlgren M, Vildhede A, Norinder U, Wisniewski JR, Kimoto E, Lai Y, Haglund U, Artursson P. Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. J Med Chem 2012; 55: 4740-4763 [PMID: 22541068 DOI: 10.1021/jm300212s]
    • (2012) J Med Chem , vol.55 , pp. 4740-4763
    • Karlgren, M.1    Vildhede, A.2    Norinder, U.3    Wisniewski, J.R.4    Kimoto, E.5    Lai, Y.6    Haglund, U.7    Artursson, P.8
  • 141
    • 79959935821 scopus 로고    scopus 로고
    • Clinical importance of OATP1B1 and OATP1B3 in drug-drug interactions
    • [PMID: 21297316 DOI: 10.2133/dmpk]
    • Shitara Y. Clinical importance of OATP1B1 and OATP1B3 in drug-drug interactions. Drug Metab Pharmacokinet 2011; 26: 220-227 [PMID: 21297316 DOI: 10.2133/dmpk]
    • (2011) Drug Metab Pharmacokinet , vol.26 , pp. 220-227
    • Shitara, Y.1
  • 142
    • 77649235131 scopus 로고    scopus 로고
    • Pharmacogenetics of membrane transporters: An update on current approaches
    • [PMID: 19950006 DOI: 10.1007/s12033-009-9220-6]
    • Sissung TM, Baum CE, Kirkland CT, Gao R, Gardner ER, Figg WD. Pharmacogenetics of membrane transporters: an update on current approaches. Mol Biotechnol 2010; 44: 152-167 [PMID: 19950006 DOI: 10.1007/s12033-009-9220-6]
    • (2010) Mol Biotechnol , vol.44 , pp. 152-167
    • Sissung, T.M.1    Baum, C.E.2    Kirkland, C.T.3    Gao, R.4    Gardner, E.R.5    Figg, W.D.6
  • 143
    • 27744463332 scopus 로고    scopus 로고
    • Pharmacogenetics/genomics and personalized medicine
    • Spec No. 2, [PMID: 16244319]
    • Sadée W, Dai Z. Pharmacogenetics/genomics and personalized medicine. Hum Mol Genet 2005; 14 Spec No. 2: R207-R214 [PMID: 16244319]
    • (2005) Hum Mol Genet , vol.14
    • Sadée, W.1    Dai, Z.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.