Molecular regulation of sinusoidal liver bile acid transporters during cholestasis

Yale Journal of Biology and Medicine

Volumn 70, Issue 4, 1997, Pages 355-363

  Gartung, Carsten ^a   Matern, Siegfried ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ANION; BICARBONATE; BILE ACID; BROMSULFOPHTHALEIN; CARRIER PROTEINS AND BINDING PROTEINS; CATION; CYTOKINE; ENDOTOXIN; ESTROGEN; ETHINYLESTRADIOL; GLUTATHIONE; MESSENGER RNA; SODIUM; STEROID; TAUROCHOLIC ACID;

CELL MEMBRANE; CHOLESTASIS; CONFERENCE PAPER; ENZYME ACTIVITY; HUMAN; INTRAHEPATIC BILE DUCT; ION TRANSPORT; LIVER; LIVER SINUSOID; NONHUMAN;

ANIMALS; ANION TRANSPORT PROTEINS; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; CHOLESTASIS; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HUMANS; HYDROXYSTEROID DEHYDROGENASES; LIVER; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NA(+)-K(+)-EXCHANGING ATPASE; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; RATS; SYMPORTERS;

EID: 0031392360     PISSN: 00440086     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (46)

1. Scharschmidt, B. Bile formation and cholestasis. In: Zakim, D. and Boyer, T.D., eds. Hepatology: A Textbook of Liver Disease. Philadelphia: W.B. Saunders; 1990, pp. 303-340.
2. i, cell volume, and bile secretion. Ann. Rev. Physiol. 54:415-438, 1992.
3. Vlahcevic, Z.R., Heuman, D.M., and Hylemon, P.B. Physiology and pathophysiology of enterohepatic circulation of bile acids. In: Zakim, D. and Boyer, T.D., eds. Hepatology: A Textbook of Liver Disease. Philadelphia: W.B. Saunders; 1990, pp. 344-371.
4. Suchy, F.J. Hepatocellular transport of bile acids. Sem. Liver Dis. 13:235-247, 1993.
5. Nathanson, M.H. and Boyer, J.L. Mechanisms and regulation of bile secretion. Hepatology 14:551-566, 1991.
6. Meier, P.J. Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile. Am. J. Physiol. 269:G801-G812, 1995.
7. Noè, B., Hagenbuch, B., Stieger, B., and Meier, P.J. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc. Natl. Acad. Sci. USA, 94:10346-10350, 1997.
8. +/bile acid cotransport system. Proc. Natl. Acad. Sci. USA 88:10629-10633, 1991.
9. +/bile acid cotransporter. J. Clin. Invest. 93:1326-1331, 1994.
10. +-bile acid cotransporter using peptide and fusion protein antibodies. Am. J. Physiol. 267:G637-G643, 1994.
11. +/taurocholate cotransporting polypeptide in rat liver. Gastroenterology. 107:1781-1787, 1994.
12. +-independent organic anion transporter. Proc. Natl. Acad. Sci. USA 91:133-137, 1994.
13. Kullak-Ublick, G.-A., Hagenbuch, B., Stieger, B., Wolkoff, A.W., and Meier, P.J. Functional characterization of the basolateral rat liver organic anion transporting polypeptide. Hepatology 20:411-416, 1994.
14. Bossuyt, R., Müller, M., Hagenbuch, B., and Meier, P.J. Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J. Pharmacol. Exp. Ther. 276:891-896, 1996.
15. Kullak-Ublick, G.A., Hagenbuch, B., Stieger, B., Schteingart, C.D., Hofmann, A.F., Wolkoff, A.W., and Meier, P.J. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 109:1274-1282, 1995.
16. Bossuyt, X., Muller, M., and Meier, P.J. Multispecific amphipathic substrate transport by an organic anion transporter of human liver. J. Hepatology 25:733-738,1996.
17. Kanai, N., Lu, R., Satriano, J.A., Bao, Y., Wolkoff, A.W., and Schuster, V.L. Identification and characterization of a prostaglandin transporter. Science 268:866-869, 1995.
18. Adachi, Y., Kobayashi, H., Kurumi, Y., Shouji, M., Kitano, M., and Yamamoto, T. ATP-dependent taurocholate transport by rat liver canalicular membrane vesicles. Hepatology 14:655-659, 1991.
19. Müller, M., Ishikawa, T., Berger, U., Klünemann, C., Lucka, L., Schreyer, A., Kannicht, C., Reutter, W., Kurz, G., and Keppler, D. ATP-dependent transport of taurocholate across the hepatocyte canalicular membrane mediated by a 110-kDa glycoprotein binding ATP and bile salts. J. Biol. Chem. 266:18920-18926, 1991.
20. Nishida, T., Gatmaitan, Z., Che, M., and Arias, I.M. Rat liver canalicular membrane vesicles contain an ATP-dependent bile acid transport system. Proc. Natl. Acad. Sci. USA 88:6590-6594, 1991.
21. Stieger, B., O'Neill, B., and Meier, P.J. ATP-dependent bile-salt transport in canalicular rat liver plasma membrane vesicles. Biochem. J. 284:67-74,1992.
22. Gerloff, T, Stieger, B., Hagenbuch, B., Landmann, L., and Meier, P.J. The sister p-glycoprotein of rat liver mediates ATP-dependent taurocholate transport. Hepatology 26:471A, 1997.
23. Oude Elferink, R.P.J., Meijer, D.K.F., Kuipers, F., Jansen, P.L.M., Groen, A.K., and Groothuis, G.M.M. Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport. Biochim. Biophys. Acta 1241:215-268, 1995.
24. Büchler, M., König, J., Brom, M., Kartenbeck, J., Spring, H., Horie, T., and Keppler, D. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, mrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutants rats. J. Biol. Chem. 271:15091-15098, 1996.
25. Paulusma, C.C., Bosma, P.J., Zaman, G.J.R., Bakker, C.T.M., Otter, M., Scheffer, G.L., Scheper, R.J., Borst, P., and Oude Elferink, R.P.J. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science 217:1126-1128, 1996.
26. Muller, M., Roelofson, H., and Jansen, P.L. Secretion of organic anions by hepatocytes: involvement of homologues of the multidrug resistance protein. Sem. Liver Dis. 16:211-220, 1996.
27. Kartenbeck, J., Leuschner, U., Mayer, R., and Keppler, D. Absence of the canalicular isoform of the mrp gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson Syndrome. Hepatology 23:1061-1066, 1996.
28. Paulusma, C.C., Kool, M., Bosma, P., Scheffer, G.L., Ter Borg, F., Scheper, R.J., Tytgat, G.N.J., Borst, P., Baas, F., and Oude Elferink, R.P.J. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. Hepatology 25:1539-1542, 1997.
29. Kast, C., Stieger, B., Winterhalter, K.H., and Meier, P.J. Hepatocellular transport of bile acids. Evidence for distinct subcellular localizations of electrogenic and ATP-dependent taurocholate transport in rat hepatocytes. J. Biol. Chem. 269:5179-5186, 1994.
30. Simon, F.R., Fortune, J., Iwahashi, M., Gartung, C., Wolkoff, A., and Sutherland, E. Ethinyl estradiol-induced cholestasis involves alterations in expression of liver sinusoidal membrane transporters. Am. J. Physiol. 34:G1043-G1052, 1996.
31. +-ATPase, membrane fluidity, and bile flow in rats with ethinyl estradiol-induced cholestasis. Hepatology 3:12-17, 1983.
32. Smith, D.J. and Gordon, E.R. Role of liver plasma membrane fluidity in the pathogenesis of estrogen-induced cholestasis. J. Lab. Clin. Med. 112:679-685, 1988.
33. Isaacson, Y. and Van Thiel, D.H. Increased membrane fluidity and cholestasis: associated but not linked consequences of estrogen treatment. J. Lab. Clin. Med. 112:663-666, 1988.
34. Vore, M. Estrogen cholestasis: membranes, metabolites, or receptors? Gastroenterology 93:643-649, 1987.
35. +-adenosinetriphosphastase by endotoxin: a possible mechanism for endotoxin-induced cholestasis. J. Infect. Dis. 136:583-587, 1977.
36. Moseley, R.H., Wang, W., Takeda, H., Lown, K., Shick, L., Ananthanarayanan, M., and Suchy, F.J. Effect of endotoxin on bile acid transport in rat liver: a potential model for sepsis-associated cholestasis. Am. J. Physiol. 271:G137-G146, 1996.
37. Green, R.M., Beier, D., and Gollan, J.L. Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology 111:193-198, 1996.
38. Salgia, R., Becker, J., and Sayeed, M. Altered membrane fluidity in rat hepatocytes during endotoxemic shock. Mol. Cell. Biochem. 121:143-148, 1993.
39. Gartung, C., Ananthanarayanan, M., Rahman, M.A., Schuele, S., Nundy, S., Soroka, C., Stolz, A., Suchy, F.J., and Boyer, J.L. Down-regulation of expression and function of the hepatic sodium-dependent bile acid cotransporter in extrahepatic cholestasis in the rat. Gastroenterology 110:199-209, 1996.
40. Green, R.M., Whiting, J.F., Rosenbluth, A.B., Beier, D., and Gollan, J.L. Interleukin-6 inhibits hepatocyte taurocholate uptake and sodium-potassium-adenosinetriphosphate activity. Am. J. Physiol. 267:G1094-G1100, 1994.
41. Shneider, B.L., Fox, V.L., Schwarz, K.B., Watson, C.L., Ananthanarayanan, M., Thevananther, S., Christie, D.M., Hardikar, W., Setchell, K.D.R., Mieli-Vergani, G., Suchy, F.J., and Mowat, A.P. Hepatic basolateral sodium-dependent-bile acid transporter expression in two unusual cases of hypercholanemia and in extrahepatic biliary atresia. Hepatology 25:1176-1183, 1997.
42. Gartung, C., Schuele, S., Schlosser, S.F., and Boyer, J.L. Expression of the rat liver Na+/taurocholate cotransporter is regulated in vivo by retention of biliary constituents, but not their depletion. Hepatology 25:284-290, 1997.
43. Karpen, S.J., Sun, A.-Q., Kudish, B., Hagenbuch, B., Meier, P.J., Ananthanarayanan, M., and Suchy, F.J. Multiple factors regulate the rat liver basolateral sodium-dependent bile acid Cotransporter gene promoter. J. Biol. Chem. 271:15211-15221, 1996.
44. +-dependent bile acid cotransporter gene promotor. Hepatology 22:318A, 1995.
45. Gartung, C., Trauner, M., Schlosser, S.F., Hagenbuch, B., Meier, P.J., and Boyer, J.L. Sodium-independent uptake of bile acids is unaffected by down-regulation of an organic anion transporter (oatp) in rat liver during cholestasis produced by common bile duct ligation. Hepatology 24:369A, 1996.
46. Trauner, M. Molecular alterations of canalicular transport systems in experimental models of cholestasis: possible functional correlations. Yale J. Biol. Med. 74:365-378, 1997.