Inhibition of Raf-MEK-ERK and Hypoxia pathways by Phyllanthus prevents metastasis in human lung (A549) cancer cell line

BMC Complementary and Alternative Medicine

Volumn 13, Issue , 2013, Pages

  Lee, Sau H ^a   Jaganath, Indu B ^b   Manikam, Rishya ^c   Sekaran, Shamala D ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b MALAYSIAN AGRICULTURAL RESEARCH AND DEVELOPMENT INSTITUTE MARDI   (Malaysia)

^c UNIVERSITY MALAYA MEDICAL CENTRE   (Malaysia)

Author keywords

Apoptosis; ERK1 2; HIF 1 ; Metastasis; Phyllanthus

Indexed keywords

ANTIMETASTATIC AGENT; CYCLINE; CYTOSKELETON PROTEIN; GELATINASE A; GELATINASE B; GLYCOLYTIC ENZYME; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MATRILYSIN; MAX PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MYC PROTEIN; NOTCH RECEPTOR; PHYLLANTHUS AMARUS EXTRACT; PHYLLANTHUS NIRURI EXTRACT; PHYLLANTHUS URINARIA EXTRACT; PHYLLANTHUS WATSONII EXTRACT; PLANT EXTRACT; PROTEIN BCL 2; PROTEIN P53; RAF PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULOTROPIN; WNT PROTEIN; ZINC FINGER PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CANCER CELL CULTURE; CELL CYCLE PHASE; CELL INVASION; CELL MOTILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HYPOXIA; INTRACELLULAR SIGNALING; LUNG CARCINOMA; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METASTASIS INHIBITION; PHYLLANTHUS; PHYLLANTHUS AMARUS; PHYLLANTHUS NIRURI; PHYLLANTHUS URINARIA; PHYLLANTHUS WATSONII; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSIENT TRANSFECTION; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING; ZYMOGRAPHY;

ANOXIA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUNG NEOPLASMS; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOPLASM METASTASIS; PHYLLANTHUS; PLANT EXTRACTS; PROTEOMICS; RAF KINASES; SIGNAL TRANSDUCTION;

EID: 84885510584     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-13-271     Document Type: Article

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