Expression patterns of chaperone proteins in cerebral cortex of the fetus with Down Syndrome: Dysregulation of T-complex protein 1

Journal of Neural Transmission, Supplement

Volumn , Issue 61, 2001, Pages 321-334

  Yoo, B C ^a   Fountoulakis, M ^b   Dierssen, M ^c   Lubec, G ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c HOSPITAL DURAN I REYNALS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; GLUCOSE REGULATED PROTEIN; HEAT SHOCK PROTEIN; PROTEIN DERIVATIVE; SYNAPSIN I; CHAPERONIN; HEAT SHOCK PROTEINS; T COMPLEX POLYPEPTIDE 1; T-COMPLEX POLYPEPTIDE-1;

ADULT; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN DYSFUNCTION; COMPLEX FORMATION; CONTROLLED STUDY; DOWN SYNDROME; FEMALE; FETUS; HUMAN; HUMAN TISSUE; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NEUROCHEMISTRY; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SECOND TRIMESTER PREGNANCY; STATISTICAL SIGNIFICANCE; TWO DIMENSIONAL GEL ELECTROPHORESIS; BIOSYNTHESIS; CONGENITAL MALFORMATION; GESTATIONAL AGE; METABOLISM; PATHOLOGY;

CEREBRAL CORTEX; CHAPERONINS; DOWN SYNDROME; FEMALE; FETUS; GESTATIONAL AGE; HEAT-SHOCK PROTEINS; HUMAN; MALE; MOLECULAR CHAPERONES; SUPPORT, NON-U.S. GOV'T;

EID: 0035233820     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6262-0_27     Document Type: Article

References (41)

1. Agashe VR, Hartl FU (2000) Roles of molecular chaperones in cytoplasmic protein folding. Semin Cell Dev Biol 11: 15-25
2. Berndt P, Hobohm U, Langen H (1999) Reliable automatic protein identification from matrix-assisted laser desorption/ionization mass spectrometric peptide fingerprints. Electrophoresis 20: 3521-3526
3. Brown CR, Doxsey SJ, Hong-Brown LQ, Martin RL, Welch WJ (1996) Molecular chaperones and the centrosome. A role for TCP-1 in microtubule nucleation. J Biol Chem 271: 824-832
4. Chen X, Sullivan DS, Huffaker TC (1994) Two yeast genes with similarity to TCP-1 are required for microtubule and actin function in vivo. Proc Natl Acad Sci USA 91: 9111-9115
5. Dittmar G, Schmidt G, Kopun M, Werner D (1997) Mapping of G2/M-phase prevalences of chaperon-encoding transcripts by means of a sensitive differential hybridization approach. Cell Biol Int 21: 383-391
6. Ellis RJ (2000) Moledular chaperones ten years. Introduction. Semin Cell Dev Biol 11: 1-5
7. Engidawork E, Balic N, Juranville J-F, Dierssen M, Lubec G (2001) Unaltered expression of Fas (CD95/APO-1), Caspase-3, Bcl-2 and Annexins in brains of fetal Down syndrome: evidence against increased apoptosis (this volume)
8. Fountoulakis M, Langen H (1997) Identification of proteins by matrix-assisted laser desorption ionization-mass spectrometry following in-gel digestion in low-salt, non-volatile buffer and simplified peptide recovery. Anal Biochem 250: 153-156
9. Gao Y, Thomas JO, Chow RL, Lee GH, Cowan NJ (1992) A cytoplasmic chaperonin that catalyzes beta-actin folding. Cell 69: 1043-1050
10. Gao Y, Vainberg IE, Chow RL, Cowan NJ (1993) Two cofactors and cytoplasmic chaperonin are required for the folding of alpha- and beta-tubulin. Mol Cell Biol 13: 2478-2485
11. Hartl FU (1996) Molecular chaperones in cellular protein folding. Nature 381: 571-579
12. Hori O, Matsumoto M, Kuwabara K, Maeda Y, Ueda H, Ohtsuki T, Kinoshita T, Ogawa S, Stern DM, Kamada T (1996) Exposure of astrocytes to hypoxia/reoxygenation enhances expression of glucose-regulated protein 78 facilitating astrocyte release of the neuroprotective cytokine interleukin 6. J Neurochem 66: 973-979
13. Iijima M, Shimizu H, Tanaka Y, Urushihara H (1998) A dictyostelium discoideum homologue to Tcp-1 is essential for growth and development. Gene 213(1-2): 101-106
14. Kouchi Z, Sorimachi H, Suzuki K, Ishiura S (1999) Proteasome inhibitors induce the association of Alzheimer's amyloid precursor protein with Hsc73. Biochem Biophys Res Commun 254: 804-810
15. Kubota H, Hynes G, Carne A, Ashworth A, Willison K (1994) Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin. Curr Biol 4: 89-99
16. Labudova O, Kitzmueller E, Rink H, Cairns N, Lubec G (1999) Increased phosphoglycerate kinase in the brains of patients with Down's syndrome but not with Alzheimer's disease. Clin Sci (Colch) 96: 279-285
17. Langen H, Roeder D, Juranville J-F, Fountoulakis M (1997) Effect of the protein application mode and the acrylamide concentration on the resolution of protein spots separated by two-dimensional gel electrophoresis. Electrophoresis 18: 2085-2090
18. Lewis VA, Hynes GM, Zheng D, Saibil H, Willison K (1992) T-complex polypeptide-1 is a subunit of a heteromeric particle in the eukaryotic cytosol. Nature 358: 249-252
19. Liou AK, Willison KR (1997) Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes. EMBO J 16: 4311-4316
20. Lubec G, Labudova O, Cairns N, Fountoulakis M (1999) Increased glyceraldehyde 3-phosphate dehydrogenase levels in the brain of patients with Down's syndrome. Neurosci Lett 260: 141-145
21. Mehlen P, Kretz-Remy C, Preville X, Arrigo AP (1996) Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death. EMBO J 15: 2695-2706
22. Melki R, Vainberg IE, Chow RL, Cowan NJ (1993) Chaperonin-mediated folding of vertebrate actin-related protein and gamma-tubulin. J Cell Biol 122: 1301-1310
23. Milner CM, Campbell RD (1990) Structure and expression of the three MHC-linked HSP70 genes. Immunogenetics 32: 242-251
24. Mosser DD, Caron AW, Bourget L, Denis-Larose C, Massie B (1997) Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol Cell Biol 17: 5317-5327
25. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B (2000) The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol 20: 7146-7159
26. Muchowski PJ, Schaffar G, Sittler A, Wanker EE, Hayer-Hartl MK, Hartl FU (2000) Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils. Proc Natl Acad Sci USA 97: 7841-7846
27. Nagy Z (1999) Mechanisms of neuronal death in Down's syndrome. J Neural Transm [Suppl] 57: 233-245
28. Reddy RK, Lu J, Lee AS (1999) The endoplasmic reticulum chaperone glycoprotein GRP94 with Ca(2+)-binding and antiapoptotic properties is a novel proteolytic target of calpain during etoposide-induced apoptosis. J Biol Chem 274: 28476-28483
29. Renkawek K, Voorter CE, Bosman GJ, van Workum FP, de Jong WW (1994) Expression of alpha B-crystallin in Alzheimer's disease. Acta Neuropathol (Berl) 87: 155-160
30. Rommelaere H, Van Troys M, Gao Y, Melki R, Cowan NJ, Vandekerckhove J, Ampe C (1993) Eukaryotic cytosolic chaperonin contains t-complex polypeptide 1 and seven related subunits. Proc Natl Acad Sci USA 90: 11975-11979
31. Roobol A, Carden MJ (1999) Subunits of the eukaryotic cytosolic chaperonin CCT do not always behave as components of a uniform hetero-oligomeric particle. Eur J Cell Biol 78: 21-32
32. Roobol A, Holmes FE, Hayes NV, Baines AJ, Carden MJ (1995) Cytoplasmic chaperonin complexes enter neurites developing in vitro and differ in subunit composition within single cells. J Cell Sci (Pt 4): 1477-1488
33. Roperch JP, Lethrone F, Prieur S, Piouffre L, Israeli D, Tuynder M, Nemani M, Pasturaud P, Gendron MC, Dausset J, Oren M, Amson RB, Telerman A (1999) SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1). Proc Natl Acad Sci USA 96: 8070-8073
34. Samali A, Cai J, Zhivotovsky B, Jones DP, Orrenius S (1999) Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells. EMBO J 18: 2040-2048
35. Shinohara H, Inaguma Y, Goto S, Inagaki T, Kato K (1993) Alpha B crystallin and HSP28 are enhanced in the cerebral cortex of patients with Alzheimer's disease. J Neurol Sci 119: 203-208
36. Ursic D, Culbertson MR (1991) The yeast homolog to mouse Tcp-1 affects microtubule-mediated processes. Mol Cell Biol 11: 2629-2640
37. Xanthoudakis S, Roy S, Rasper D, Hennessey T, Aubin Y, Cassady R, Tawa P, Ruel R, Rosen A, Nicholson DW (1999) Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis. EMBO J 18: 2049-2056
38. Yaffe MB, Farr GW, Miklos D, Horwich AL, Sternlicht ML, Sternlicht H (1992) TCP1 complex is a molecular chaperone in tubulin biogenesis. Nature 358: 245-248
39. Yang Y, Turner RS, Gaut JR (1998) The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Abeta40 and Abeta42 secretion. J Biol Chem 273: 25552-25555
40. Yoo BC, Vlkolinsky R, Engidawork E, Cairns N, Fountoulakis M, Lubec G (2001a) Differential expression of molecular chaperones in brain of patients with Down Syndrome. Electrophoresis 22: 1233-1241
41. Yoo BC, Kim SH, Cairns N, Fountoulakis M, Lubec G (2001b) Deranged expression of molecular chaperones in brains of patients with Alzheimer's disease. Biochem Biophys Res Commun 280(1): 249-258