-
1
-
-
0032227694
-
Enzymology of nitric oxide synthases
-
Hemmens B., and Mayer B. Enzymology of nitric oxide synthases. Methods Mol. Biol. 100 (1998) 1-32
-
(1998)
Methods Mol. Biol.
, vol.100
, pp. 1-32
-
-
Hemmens, B.1
Mayer, B.2
-
2
-
-
0025802065
-
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase
-
Bredt D.S., Hwang P.M., Glatt C.E., Lowenstein C., Reed R.R., and Snyder S.H. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 351 (1991) 714-718
-
(1991)
Nature
, vol.351
, pp. 714-718
-
-
Bredt, D.S.1
Hwang, P.M.2
Glatt, C.E.3
Lowenstein, C.4
Reed, R.R.5
Snyder, S.H.6
-
3
-
-
0028902552
-
Nitric oxide synthases: properties and catalytic mechanism
-
Griffith O.W., and Stuehr D.J. Nitric oxide synthases: properties and catalytic mechanism. Annu. Rev. Physiol. 57 (1995) 707-736
-
(1995)
Annu. Rev. Physiol.
, vol.57
, pp. 707-736
-
-
Griffith, O.W.1
Stuehr, D.J.2
-
4
-
-
0028270719
-
Regulation of biosynthesis of nitric oxide
-
Nathan C., and Xie Q.W. Regulation of biosynthesis of nitric oxide. J. Biol. Chem. 269 (1994) 13725-13728
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 13725-13728
-
-
Nathan, C.1
Xie, Q.W.2
-
5
-
-
0030988217
-
Structure-function aspects in the nitric oxide synthases
-
Stuehr D.J. Structure-function aspects in the nitric oxide synthases. Annu. Rev. Pharmacol. Toxicol. 37 (1997) 339-359
-
(1997)
Annu. Rev. Pharmacol. Toxicol.
, vol.37
, pp. 339-359
-
-
Stuehr, D.J.1
-
6
-
-
0035425503
-
Nitric oxide synthases: structure, function and inhibition
-
Alderton W.K., Cooper C.E., and Knowles R.G. Nitric oxide synthases: structure, function and inhibition. Biochem. J. 357 (2001) 593-615
-
(2001)
Biochem. J.
, vol.357
, pp. 593-615
-
-
Alderton, W.K.1
Cooper, C.E.2
Knowles, R.G.3
-
7
-
-
0026569273
-
Cloning and characterization of inducible nitric oxide synthase from mouse macrophages
-
Xie Q.W., Cho H.J., Calaycay J., Mumford R.A., Swiderek K.M., Lee T.D., Ding A., Troso T., and Nathan C. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256 (1992) 225-228
-
(1992)
Science
, vol.256
, pp. 225-228
-
-
Xie, Q.W.1
Cho, H.J.2
Calaycay, J.3
Mumford, R.A.4
Swiderek, K.M.5
Lee, T.D.6
Ding, A.7
Troso, T.8
Nathan, C.9
-
9
-
-
0033567065
-
Enzymatic function of nitric oxide synthases
-
Andrew P.J., and Mayer B. Enzymatic function of nitric oxide synthases. Cardiovasc. Res. 43 (1999) 521-531
-
(1999)
Cardiovasc. Res.
, vol.43
, pp. 521-531
-
-
Andrew, P.J.1
Mayer, B.2
-
10
-
-
0026480755
-
Identification of inducible calmodulin-dependent nitric oxide synthase in the liver of rats
-
Iida S., Ohshima H., Oguchi S., Hata T., Suzuki H., Kawasaki H., and Esumi H. Identification of inducible calmodulin-dependent nitric oxide synthase in the liver of rats. J. Biol. Chem. 267 (1992) 25385-25388
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 25385-25388
-
-
Iida, S.1
Ohshima, H.2
Oguchi, S.3
Hata, T.4
Suzuki, H.5
Kawasaki, H.6
Esumi, H.7
-
11
-
-
0026492442
-
Glucocorticoids do not affect the induction of a novel calcium-dependent nitric oxide synthase in rabbit chondrocytes
-
Palmer R.M., Andrews T., Foxwell N.A., and Moncada S. Glucocorticoids do not affect the induction of a novel calcium-dependent nitric oxide synthase in rabbit chondrocytes. Biochem. Biophys. Res. Commun. 188 (1992) 209-215
-
(1992)
Biochem. Biophys. Res. Commun.
, vol.188
, pp. 209-215
-
-
Palmer, R.M.1
Andrews, T.2
Foxwell, N.A.3
Moncada, S.4
-
12
-
-
0026336186
-
Human colorectal adenocarcinoma cells: differential nitric oxide synthesis determines their ability to aggregate platelets
-
Radomski M.W., Jenkins D.C., Holmes L., and Moncada S. Human colorectal adenocarcinoma cells: differential nitric oxide synthesis determines their ability to aggregate platelets. Cancer Res. 51 (1991) 6073-6078
-
(1991)
Cancer Res.
, vol.51
, pp. 6073-6078
-
-
Radomski, M.W.1
Jenkins, D.C.2
Holmes, L.3
Moncada, S.4
-
13
-
-
0033546410
-
Interaction of interferon regulatory factor-1 and nuclear factor kappaB during activation of inducible nitric oxide synthase transcription
-
Saura M., Zaragoza C., Bao C., McMillan A., and Lowenstein C.J. Interaction of interferon regulatory factor-1 and nuclear factor kappaB during activation of inducible nitric oxide synthase transcription. J. Mol. Biol. 289 (1999) 459-471
-
(1999)
J. Mol. Biol.
, vol.289
, pp. 459-471
-
-
Saura, M.1
Zaragoza, C.2
Bao, C.3
McMillan, A.4
Lowenstein, C.J.5
-
14
-
-
0028106830
-
Role of interferon regulatory factor 1 in induction of nitric oxide synthase
-
Martin E., Nathan C., and Xie Q.W. Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J. Exp. Med. 180 (1994) 977-984
-
(1994)
J. Exp. Med.
, vol.180
, pp. 977-984
-
-
Martin, E.1
Nathan, C.2
Xie, Q.W.3
-
15
-
-
0028348307
-
Requirement for transcription factor IRF-1 in NO synthase induction in macrophages
-
Kamijo R., Harada H., Matsuyama T., Bosland M., Gerecitano J., Shapiro D., Le J., Koh S.I., Kimura T., Green S.J., et al. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science 263 (1994) 1612-1615
-
(1994)
Science
, vol.263
, pp. 1612-1615
-
-
Kamijo, R.1
Harada, H.2
Matsuyama, T.3
Bosland, M.4
Gerecitano, J.5
Shapiro, D.6
Le, J.7
Koh, S.I.8
Kimura, T.9
Green, S.J.10
-
16
-
-
0035328635
-
Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis
-
Tendler D.S., Bao C., Wang T., Huang E.L., Ratovitski E.A., Pardoll D.A., and Lowenstein C.J. Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis. Cancer Res. 61 (2001) 3682-3688
-
(2001)
Cancer Res.
, vol.61
, pp. 3682-3688
-
-
Tendler, D.S.1
Bao, C.2
Wang, T.3
Huang, E.L.4
Ratovitski, E.A.5
Pardoll, D.A.6
Lowenstein, C.J.7
-
17
-
-
0025328583
-
Hypoxic fractions of human tumors xenografted into mice: a review
-
Rockwell S., and Moulder J.E. Hypoxic fractions of human tumors xenografted into mice: a review. Int. J. Radiat. Oncol. Biol. Phys. 19 (1990) 197-202
-
(1990)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.19
, pp. 197-202
-
-
Rockwell, S.1
Moulder, J.E.2
-
18
-
-
0025968029
-
Measurement of tumor hypoxia by invasive and non-invasive procedures: a review of recent clinical studies
-
Chapman J.D. Measurement of tumor hypoxia by invasive and non-invasive procedures: a review of recent clinical studies. Radiother. Oncol. 20 Suppl. 1 (1991) 13-19
-
(1991)
Radiother. Oncol.
, vol.20
, Issue.SUPPL. 1
, pp. 13-19
-
-
Chapman, J.D.1
-
19
-
-
0028786601
-
A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
-
Melillo G., Musso T., Sica A., Taylor L.S., Cox G.W., and Varesio L. A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J. Exp. Med. 182 (1995) 1683-1693
-
(1995)
J. Exp. Med.
, vol.182
, pp. 1683-1693
-
-
Melillo, G.1
Musso, T.2
Sica, A.3
Taylor, L.S.4
Cox, G.W.5
Varesio, L.6
-
20
-
-
0028873889
-
Expression of nitric oxide synthase in human central nervous system tumors
-
Cobbs C.S., Brenman J.E., Aldape K.D., Bredt D.S., and Israel M.A. Expression of nitric oxide synthase in human central nervous system tumors. Cancer Res. 55 (1995) 727-730
-
(1995)
Cancer Res.
, vol.55
, pp. 727-730
-
-
Cobbs, C.S.1
Brenman, J.E.2
Aldape, K.D.3
Bredt, D.S.4
Israel, M.A.5
-
21
-
-
0032522754
-
Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer
-
Gallo O., Masini E., Morbidelli L., Franchi A., Fini-Storchi I., Vergari W.A., and Ziche M. Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer. J. Natl. Cancer Inst. 90 (1998) 587-596
-
(1998)
J. Natl. Cancer Inst.
, vol.90
, pp. 587-596
-
-
Gallo, O.1
Masini, E.2
Morbidelli, L.3
Franchi, A.4
Fini-Storchi, I.5
Vergari, W.A.6
Ziche, M.7
-
22
-
-
0033074477
-
Inducible nitric oxide synthase with transitional cell carcinoma of the bladder
-
Swana H.S., Smith S.D., Perrotta P.L., Saito N., Wheeler M.A., and Weiss R.M. Inducible nitric oxide synthase with transitional cell carcinoma of the bladder. J. Urol. 161 (1999) 630-634
-
(1999)
J. Urol.
, vol.161
, pp. 630-634
-
-
Swana, H.S.1
Smith, S.D.2
Perrotta, P.L.3
Saito, N.4
Wheeler, M.A.5
Weiss, R.M.6
-
23
-
-
0036679421
-
Relationship between the expression of iNOS,VEGF,tumor angiogenesis and gastric cancer
-
Song Z.J., Gong P., and Wu Y.E. Relationship between the expression of iNOS,VEGF,tumor angiogenesis and gastric cancer. World J. Gastroenterol. 8 (2002) 591-595
-
(2002)
World J. Gastroenterol.
, vol.8
, pp. 591-595
-
-
Song, Z.J.1
Gong, P.2
Wu, Y.E.3
-
24
-
-
0035403857
-
Nitric oxide synthase as a marker in colorectal carcinoma
-
Lagares-Garcia J.A., Moore R.A., Collier B., Heggere M., Diaz F., and Qian F. Nitric oxide synthase as a marker in colorectal carcinoma. Am. Surg. 67 (2001) 709-713
-
(2001)
Am. Surg.
, vol.67
, pp. 709-713
-
-
Lagares-Garcia, J.A.1
Moore, R.A.2
Collier, B.3
Heggere, M.4
Diaz, F.5
Qian, F.6
-
25
-
-
0029024521
-
Nitric oxide synthase activity in human breast cancer
-
Thomsen L.L., Miles D.W., Happerfield L., Bobrow L.G., Knowles R.G., and Moncada S. Nitric oxide synthase activity in human breast cancer. Br. J. Cancer 72 (1995) 41-44
-
(1995)
Br. J. Cancer
, vol.72
, pp. 41-44
-
-
Thomsen, L.L.1
Miles, D.W.2
Happerfield, L.3
Bobrow, L.G.4
Knowles, R.G.5
Moncada, S.6
-
26
-
-
0037033141
-
17beta-Oestradiol treatment modulates nitric oxide synthase activity in MDA231 tumour with implications on growth and radiation response
-
Chinje E.C., Williams K.J., Telfer B.A., Wood P.J., van der Kogel A.J., and Stratford I.J. 17beta-Oestradiol treatment modulates nitric oxide synthase activity in MDA231 tumour with implications on growth and radiation response. Br. J. Cancer 86 (2002) 136-142
-
(2002)
Br. J. Cancer
, vol.86
, pp. 136-142
-
-
Chinje, E.C.1
Williams, K.J.2
Telfer, B.A.3
Wood, P.J.4
van der Kogel, A.J.5
Stratford, I.J.6
-
27
-
-
0025765456
-
Cell inactivation and cell cycle inhibition as induced by extreme hypoxia: the possible role of cell cycle arrest as a protection against hypoxia-induced lethal damage
-
Amellem O., and Pettersen E.O. Cell inactivation and cell cycle inhibition as induced by extreme hypoxia: the possible role of cell cycle arrest as a protection against hypoxia-induced lethal damage. Cell Prolif. 24 (1991) 127-141
-
(1991)
Cell Prolif.
, vol.24
, pp. 127-141
-
-
Amellem, O.1
Pettersen, E.O.2
-
28
-
-
0028603270
-
The influence of microenvironmental factors during cancer therapy
-
Durand R.E. The influence of microenvironmental factors during cancer therapy. In Vivo 8 (1994) 691-702
-
(1994)
In Vivo
, vol.8
, pp. 691-702
-
-
Durand, R.E.1
-
29
-
-
1842833128
-
Tumor physiology and resistance to chemotherapy: repopulation and drug penetration
-
Davis A.J., and Tannock I.F. Tumor physiology and resistance to chemotherapy: repopulation and drug penetration. Cancer Treat. Res. 112 (2002) 1-26
-
(2002)
Cancer Treat. Res.
, vol.112
, pp. 1-26
-
-
Davis, A.J.1
Tannock, I.F.2
-
30
-
-
0037096732
-
Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene
-
Comerford K.M., Wallace T.J., Karhausen J., Louis N.A., Montalto M.C., and Colgan S.P. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res. 62 (2002) 3387-3394
-
(2002)
Cancer Res.
, vol.62
, pp. 3387-3394
-
-
Comerford, K.M.1
Wallace, T.J.2
Karhausen, J.3
Louis, N.A.4
Montalto, M.C.5
Colgan, S.P.6
-
31
-
-
0028307739
-
Hypoxia and drug resistance
-
Teicher B.A. Hypoxia and drug resistance. Cancer Metastasis Rev. 13 (1994) 139-168
-
(1994)
Cancer Metastasis Rev.
, vol.13
, pp. 139-168
-
-
Teicher, B.A.1
-
32
-
-
12144287046
-
Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance
-
Erler J.T., Cawthorne C.J., Williams K.J., Koritzinsky M., Wouters B.G., Wilson C., Miller C., Demonacos C., Stratford I.J., and Dive C. Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Mol. Cell Biol. 24 (2004) 2875-2889
-
(2004)
Mol. Cell Biol.
, vol.24
, pp. 2875-2889
-
-
Erler, J.T.1
Cawthorne, C.J.2
Williams, K.J.3
Koritzinsky, M.4
Wouters, B.G.5
Wilson, C.6
Miller, C.7
Demonacos, C.8
Stratford, I.J.9
Dive, C.10
-
33
-
-
33846697957
-
Hypoxia-induced genetic instability--a calculated mechanism underlying tumor progression
-
Huang L.E., Bindra R.S., Glazer P.M., and Harris A.L. Hypoxia-induced genetic instability--a calculated mechanism underlying tumor progression. J. Mol. Med. 85 (2007) 139-148
-
(2007)
J. Mol. Med.
, vol.85
, pp. 139-148
-
-
Huang, L.E.1
Bindra, R.S.2
Glazer, P.M.3
Harris, A.L.4
-
34
-
-
84960987950
-
The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
-
Gray L.H., Conger A.D., Ebert M., Hornsey S., and Scott O.C. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br. J. Radiol. 26 (1953) 638-648
-
(1953)
Br. J. Radiol.
, vol.26
, pp. 638-648
-
-
Gray, L.H.1
Conger, A.D.2
Ebert, M.3
Hornsey, S.4
Scott, O.C.5
-
35
-
-
2942590732
-
Exploiting tumour hypoxia in cancer treatment
-
Brown J.M., and Wilson W.R. Exploiting tumour hypoxia in cancer treatment. Nat. Rev. Cancer 4 (2004) 437-447
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 437-447
-
-
Brown, J.M.1
Wilson, W.R.2
-
36
-
-
0033405294
-
The hypoxic cell: a target for selective cancer therapy-eighteenth Bruce F. Cain Memorial Award lecture
-
Brown J.M. The hypoxic cell: a target for selective cancer therapy-eighteenth Bruce F. Cain Memorial Award lecture. Cancer Res. 59 (1999) 5863-5870
-
(1999)
Cancer Res.
, vol.59
, pp. 5863-5870
-
-
Brown, J.M.1
-
37
-
-
0030742027
-
Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck
-
Brizel D.M., Sibley G.S., Prosnitz L.R., Scher R.L., and Dewhirst M.W. Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int. J. Radiat. Oncol. Biol. Phys. 38 (1997) 285-289
-
(1997)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.38
, pp. 285-289
-
-
Brizel, D.M.1
Sibley, G.S.2
Prosnitz, L.R.3
Scher, R.L.4
Dewhirst, M.W.5
-
38
-
-
0031716020
-
Oxygenation predicts radiation response and survival in patients with cervix cancer
-
Fyles A.W., Milosevic M., Wong R., Kavanagh M.C., Pintilie M., Sun A., Chapman W., Levin W., Manchul L., Keane T.J., and Hill R.P. Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother. Oncol. 48 (1998) 149-156
-
(1998)
Radiother. Oncol.
, vol.48
, pp. 149-156
-
-
Fyles, A.W.1
Milosevic, M.2
Wong, R.3
Kavanagh, M.C.4
Pintilie, M.5
Sun, A.6
Chapman, W.7
Levin, W.8
Manchul, L.9
Keane, T.J.10
Hill, R.P.11
-
39
-
-
0032585864
-
Intratumoral pO2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix
-
Knocke T.H., Weitmann H.D., Feldmann H.J., Selzer E., and Potter R. Intratumoral pO2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix. Radiother. Oncol. 53 (1999) 99-104
-
(1999)
Radiother. Oncol.
, vol.53
, pp. 99-104
-
-
Knocke, T.H.1
Weitmann, H.D.2
Feldmann, H.J.3
Selzer, E.4
Potter, R.5
-
40
-
-
0032708195
-
Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome
-
Brizel D.M., Dodge R.K., Clough R.W., and Dewhirst M.W. Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome. Radiother. Oncol. 53 (1999) 113-117
-
(1999)
Radiother. Oncol.
, vol.53
, pp. 113-117
-
-
Brizel, D.M.1
Dodge, R.K.2
Clough, R.W.3
Dewhirst, M.W.4
-
41
-
-
0015451983
-
Potential bioreductive alkylating agents. 1. Benzoquinone derivatives
-
Lin A.J., Cosby L.A., Shansky C.W., and Sartorelli A.C. Potential bioreductive alkylating agents. 1. Benzoquinone derivatives. J. Med. Chem. 15 (1972) 1247-1252
-
(1972)
J. Med. Chem.
, vol.15
, pp. 1247-1252
-
-
Lin, A.J.1
Cosby, L.A.2
Shansky, C.W.3
Sartorelli, A.C.4
-
44
-
-
0035904930
-
Bioreductive and gene therapy approaches to hypoxic diseases
-
Jaffar M., Williams K.J., and Stratford I.J. Bioreductive and gene therapy approaches to hypoxic diseases. Adv. Drug Deliv. Rev. 53 (2001) 217-228
-
(2001)
Adv. Drug Deliv. Rev.
, vol.53
, pp. 217-228
-
-
Jaffar, M.1
Williams, K.J.2
Stratford, I.J.3
-
45
-
-
0022493495
-
SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells
-
Zeman E.M., Brown J.M., Lemmon M.J., Hirst V.K., and Lee W.W. SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells. Int. J. Radiat. Oncol. Biol. Phys. 12 (1986) 1239-1242
-
(1986)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.12
, pp. 1239-1242
-
-
Zeman, E.M.1
Brown, J.M.2
Lemmon, M.J.3
Hirst, V.K.4
Lee, W.W.5
-
46
-
-
0027288316
-
SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours
-
Brown J.M. SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours. Br. J. Cancer 67 (1993) 1163-1170
-
(1993)
Br. J. Cancer
, vol.67
, pp. 1163-1170
-
-
Brown, J.M.1
-
47
-
-
0020556148
-
Activity of Mitomycin C for Aerobic and Hypoxic Cells in Vitro and in Vivo
-
Rauth A.M., Mohindra J.K., and Tannock I.F. Activity of Mitomycin C for Aerobic and Hypoxic Cells in Vitro and in Vivo. Cancer Res. 43 (1983) 4154-4158
-
(1983)
Cancer Res.
, vol.43
, pp. 4154-4158
-
-
Rauth, A.M.1
Mohindra, J.K.2
Tannock, I.F.3
-
48
-
-
0019995383
-
Mitomycin-C as a prototype bioreductive alkylating agent: in vitro studies of metabolism and cytotoxicity
-
Rockwell S., Kennedy K.A., and Sartorelli A.C. Mitomycin-C as a prototype bioreductive alkylating agent: in vitro studies of metabolism and cytotoxicity. Int. J. Radiat. Oncol. Biol. Phys. 8 (1982) 753-755
-
(1982)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.8
, pp. 753-755
-
-
Rockwell, S.1
Kennedy, K.A.2
Sartorelli, A.C.3
-
49
-
-
0023689603
-
Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity
-
Baker M.A., Zeman E.M., Hirst V.K., and Brown J.M. Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity. Cancer Res. 48 (1988) 5947-5952
-
(1988)
Cancer Res.
, vol.48
, pp. 5947-5952
-
-
Baker, M.A.1
Zeman, E.M.2
Hirst, V.K.3
Brown, J.M.4
-
50
-
-
0037105653
-
Tirapazamine: a hypoxia-activated topoisomerase II poison
-
Peters K.B., and Brown J.M. Tirapazamine: a hypoxia-activated topoisomerase II poison. Cancer Res. 62 (2002) 5248-5253
-
(2002)
Cancer Res.
, vol.62
, pp. 5248-5253
-
-
Peters, K.B.1
Brown, J.M.2
-
51
-
-
0030692717
-
Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069
-
Patterson A.V., Saunders M.P., Chinje E.C., Talbot D.C., Harris A.L., and Strafford I.J. Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069. Br. J. Cancer 76 (1997) 1338-1347
-
(1997)
Br. J. Cancer
, vol.76
, pp. 1338-1347
-
-
Patterson, A.V.1
Saunders, M.P.2
Chinje, E.C.3
Talbot, D.C.4
Harris, A.L.5
Strafford, I.J.6
-
52
-
-
0033561524
-
Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents
-
Garner A.P., Paine M.J., Rodriguez-Crespo I., Chinje E.C., Ortiz De M.P., Stratford I.J., Tew D.G., and Wolf C.R. Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents. Cancer Res. 59 (1999) 1929-1934
-
(1999)
Cancer Res.
, vol.59
, pp. 1929-1934
-
-
Garner, A.P.1
Paine, M.J.2
Rodriguez-Crespo, I.3
Chinje, E.C.4
Ortiz De, M.P.5
Stratford, I.J.6
Tew, D.G.7
Wolf, C.R.8
-
53
-
-
0038779269
-
Non-nuclear localized human NOSII enhances the bioactivation and toxicity of tirapazamine (SR4233) in vitro
-
Chinje E.C., Cowen R.L., Feng J., Sharma S.P., Wind N.S., Harris A.L., and Stratford I.J. Non-nuclear localized human NOSII enhances the bioactivation and toxicity of tirapazamine (SR4233) in vitro. Mol. Pharmacol. 63 (2003) 1248-1255
-
(2003)
Mol. Pharmacol.
, vol.63
, pp. 1248-1255
-
-
Chinje, E.C.1
Cowen, R.L.2
Feng, J.3
Sharma, S.P.4
Wind, N.S.5
Harris, A.L.6
Stratford, I.J.7
-
54
-
-
0033967539
-
NADPH:cytochrome c (P450) reductase activates tirapazamine (SR4233) to restore hypoxic and oxic cytotoxicity in an aerobic resistant derivative of the A549 lung cancer cell line
-
Saunders M.P., Patterson A.V., Chinje E.C., Harris A.L., and Stratford I.J. NADPH:cytochrome c (P450) reductase activates tirapazamine (SR4233) to restore hypoxic and oxic cytotoxicity in an aerobic resistant derivative of the A549 lung cancer cell line. Br. J. Cancer 82 (2000) 651-656
-
(2000)
Br. J. Cancer
, vol.82
, pp. 651-656
-
-
Saunders, M.P.1
Patterson, A.V.2
Chinje, E.C.3
Harris, A.L.4
Stratford, I.J.5
-
55
-
-
84965808588
-
Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin
-
Dorie M.J., and Brown J.M. Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin. Cancer Res. 53 (1993) 4633-4636
-
(1993)
Cancer Res.
, vol.53
, pp. 4633-4636
-
-
Dorie, M.J.1
Brown, J.M.2
-
56
-
-
0031829934
-
Potentiation of cisplatin activity by the bioreductive agent tirapazamine
-
Siemann D.W., and Hinchman C.A. Potentiation of cisplatin activity by the bioreductive agent tirapazamine. Radiother. Oncol. 47 (1998) 215-220
-
(1998)
Radiother. Oncol.
, vol.47
, pp. 215-220
-
-
Siemann, D.W.1
Hinchman, C.A.2
-
57
-
-
0031023702
-
Modification of the antitumor activity of chemotherapeutic drugs by the hypoxic cytotoxic agent tirapazamine
-
Dorie M.J., and Brown J.M. Modification of the antitumor activity of chemotherapeutic drugs by the hypoxic cytotoxic agent tirapazamine. Cancer Chemother. Pharmacol. 39 (1997) 361-366
-
(1997)
Cancer Chemother. Pharmacol.
, vol.39
, pp. 361-366
-
-
Dorie, M.J.1
Brown, J.M.2
-
58
-
-
35548961829
-
Tirapazamine: from bench to clinical trials
-
Marcu L., and Olver I. Tirapazamine: from bench to clinical trials. Curr. Clin. Pharmacol. 1 (2006) 71-79
-
(2006)
Curr. Clin. Pharmacol.
, vol.1
, pp. 71-79
-
-
Marcu, L.1
Olver, I.2
-
59
-
-
16644377045
-
Tirapazamine, Cisplatin, and Radiation versus Fluorouracil, Cisplatin, and Radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02)
-
Rischin D., Peters L., Fisher R., Macann A., Denham J., Poulsen M., Jackson M., Kenny L., Penniment M., Corry J., Lamb D., and McClure B. Tirapazamine, Cisplatin, and Radiation versus Fluorouracil, Cisplatin, and Radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02). J. Clin. Oncol. 23 (2005) 79-87
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 79-87
-
-
Rischin, D.1
Peters, L.2
Fisher, R.3
Macann, A.4
Denham, J.5
Poulsen, M.6
Jackson, M.7
Kenny, L.8
Penniment, M.9
Corry, J.10
Lamb, D.11
McClure, B.12
-
60
-
-
0027220811
-
Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: a new class of bioreductive agent
-
Patterson L.H. Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: a new class of bioreductive agent. Cancer Metastasis Rev. 12 (1993) 119-134
-
(1993)
Cancer Metastasis Rev.
, vol.12
, pp. 119-134
-
-
Patterson, L.H.1
-
61
-
-
0034543132
-
AQ4N: a new approach to hypoxia-activated cancer chemotherapy
-
Patterson L.H., and McKeown S.R. AQ4N: a new approach to hypoxia-activated cancer chemotherapy. Br. J. Cancer 83 (2000) 1589-1593
-
(2000)
Br. J. Cancer
, vol.83
, pp. 1589-1593
-
-
Patterson, L.H.1
McKeown, S.R.2
-
62
-
-
0029935930
-
Tertiary amine N-oxides as bioreductive drugs: DACA N-oxide, nitracrine N-oxide and AQ4N
-
Wilson W.R., Denny W.A., Pullen S.M., Thompson K.M., Li A.E., Patterson L.H., and Lee H.H. Tertiary amine N-oxides as bioreductive drugs: DACA N-oxide, nitracrine N-oxide and AQ4N. Br. J. Cancer Suppl. 27 (1996) S43-S47
-
(1996)
Br. J. Cancer Suppl.
, vol.27
-
-
Wilson, W.R.1
Denny, W.A.2
Pullen, S.M.3
Thompson, K.M.4
Li, A.E.5
Patterson, L.H.6
Lee, H.H.7
-
63
-
-
0031040944
-
DNA topoisomerase II-dependent cytotoxicity of alkylaminoanthraquinones and their N-oxides
-
Smith P.J., Blunt N.J., Desnoyers R., Giles Y., and Patterson L.H. DNA topoisomerase II-dependent cytotoxicity of alkylaminoanthraquinones and their N-oxides. Cancer Chemother. Pharmacol. 39 (1997) 455-461
-
(1997)
Cancer Chemother. Pharmacol.
, vol.39
, pp. 455-461
-
-
Smith, P.J.1
Blunt, N.J.2
Desnoyers, R.3
Giles, Y.4
Patterson, L.H.5
-
64
-
-
0031019255
-
Flow cytometric analysis and confocal imaging of anticancer alkylaminoanthraquinones and their N-oxides in intact human cells using 647-nm krypton laser excitation
-
Smith P.J., Desnoyers R., Blunt N., Giles Y., Patterson L.H., and Watson J.V. Flow cytometric analysis and confocal imaging of anticancer alkylaminoanthraquinones and their N-oxides in intact human cells using 647-nm krypton laser excitation. Cytometry 27 (1997) 43-53
-
(1997)
Cytometry
, vol.27
, pp. 43-53
-
-
Smith, P.J.1
Desnoyers, R.2
Blunt, N.3
Giles, Y.4
Patterson, L.H.5
Watson, J.V.6
-
66
-
-
0001665005
-
Effect of nitric oxide on the radiosensitivity of bacteria
-
Howard-Flanders P. Effect of nitric oxide on the radiosensitivity of bacteria. Nature 180 (1957) 1191-1192
-
(1957)
Nature
, vol.180
, pp. 1191-1192
-
-
Howard-Flanders, P.1
-
67
-
-
0942264753
-
Effect of nitric oxide on the radiosensitivity of tumour cells
-
Gray L.H., Green F.O., and Hawes C.A. Effect of nitric oxide on the radiosensitivity of tumour cells. Nature 182 (1958) 952-953
-
(1958)
Nature
, vol.182
, pp. 952-953
-
-
Gray, L.H.1
Green, F.O.2
Hawes, C.A.3
-
68
-
-
0000734568
-
Effect of oxygen and nitric oxide on the radio-sensitivity of human cells in tissue culture
-
Dewey D.L. Effect of oxygen and nitric oxide on the radio-sensitivity of human cells in tissue culture. Nature 186 (1960) 780-782
-
(1960)
Nature
, vol.186
, pp. 780-782
-
-
Dewey, D.L.1
-
69
-
-
0029990646
-
Radiation sensitisation by nitric oxide releasing agents
-
Mitchell J.B., Cook J.A., Krishna M.C., DeGraff W., Gamson J., Fisher J., Christodoulou D., and Wink D.A. Radiation sensitisation by nitric oxide releasing agents. Br. J. Cancer Suppl. 27 (1996) S181-S184
-
(1996)
Br. J. Cancer Suppl.
, vol.27
-
-
Mitchell, J.B.1
Cook, J.A.2
Krishna, M.C.3
DeGraff, W.4
Gamson, J.5
Fisher, J.6
Christodoulou, D.7
Wink, D.A.8
-
70
-
-
0031742539
-
Redox generation of nitric oxide to radiosensitize hypoxic cells
-
Mitchell J.B., DeGraff W., Kim S., Cook J.A., Gamson J., Christodoulou D., Feelisch M., and Wink D.A. Redox generation of nitric oxide to radiosensitize hypoxic cells. Int. J. Radiat. Oncol. Biol. Phys. 42 (1998) 795-798
-
(1998)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.42
, pp. 795-798
-
-
Mitchell, J.B.1
DeGraff, W.2
Kim, S.3
Cook, J.A.4
Gamson, J.5
Christodoulou, D.6
Feelisch, M.7
Wink, D.A.8
-
71
-
-
0027145634
-
Hypoxic mammalian cell radiosensitization by nitric oxide
-
Mitchell J.B., Wink D.A., DeGraff W., Gamson J., Keefer L.K., and Krishna M.C. Hypoxic mammalian cell radiosensitization by nitric oxide. Cancer Res. 53 (1993) 5845-5848
-
(1993)
Cancer Res.
, vol.53
, pp. 5845-5848
-
-
Mitchell, J.B.1
Wink, D.A.2
DeGraff, W.3
Gamson, J.4
Keefer, L.K.5
Krishna, M.C.6
-
73
-
-
34249676952
-
Radiosensitization by nitric oxide at low radiation doses
-
Wardman P., Rothkamm K., Folkes L.K., Woodcock M., and Johnston P.J. Radiosensitization by nitric oxide at low radiation doses. Radiat. Res. 167 (2007) 475-484
-
(2007)
Radiat. Res.
, vol.167
, pp. 475-484
-
-
Wardman, P.1
Rothkamm, K.2
Folkes, L.K.3
Woodcock, M.4
Johnston, P.J.5
-
74
-
-
0026730797
-
Mechanisms of action of the organic nitrates in the treatment of myocardial ischemia
-
Abrams J. Mechanisms of action of the organic nitrates in the treatment of myocardial ischemia. Am. J. Cardiol. 70 (1992) 30B-42B
-
(1992)
Am. J. Cardiol.
, vol.70
-
-
Abrams, J.1
-
75
-
-
0029133824
-
The response of tumour vasculature to angiotensin II revealed by its systemic and local administration to 'tissue-isolated' tumours
-
Tozer G.M., and Shaffi K.M. The response of tumour vasculature to angiotensin II revealed by its systemic and local administration to 'tissue-isolated' tumours. Br. J. Cancer 72 (1995) 595-600
-
(1995)
Br. J. Cancer
, vol.72
, pp. 595-600
-
-
Tozer, G.M.1
Shaffi, K.M.2
-
76
-
-
0030811240
-
Effects of diethylamine/nitric oxide on blood perfusion and oxygenation in the R3230Ac mammary carcinoma
-
Shan S.Q., Rosner G.L., Braun R.D., Hahn J., Pearce C., and Dewhirst M.W. Effects of diethylamine/nitric oxide on blood perfusion and oxygenation in the R3230Ac mammary carcinoma. Br. J. Cancer 76 (1997) 429-437
-
(1997)
Br. J. Cancer
, vol.76
, pp. 429-437
-
-
Shan, S.Q.1
Rosner, G.L.2
Braun, R.D.3
Hahn, J.4
Pearce, C.5
Dewhirst, M.W.6
-
77
-
-
0034267721
-
Changes in tumor oxygenation/perfusion induced by the no donor, isosorbide dinitrate, in comparison with carbogen: monitoring by EPR and MRI
-
Jordan B.F., Misson P., Demeure R., Baudelet C., Beghein N., and Gallez B. Changes in tumor oxygenation/perfusion induced by the no donor, isosorbide dinitrate, in comparison with carbogen: monitoring by EPR and MRI. Int. J. Radiat. Oncol. Biol. Phys. 48 (2000) 565-570
-
(2000)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.48
, pp. 565-570
-
-
Jordan, B.F.1
Misson, P.2
Demeure, R.3
Baudelet, C.4
Beghein, N.5
Gallez, B.6
-
78
-
-
0036884118
-
Modulation of the tumor vasculature functionality by ionizing radiation accounts for tumor radiosensitization and promotes gene delivery
-
Sonveaux P., Dessy C., Brouet A., Jordan B.F., Gregoire V., Gallez B., Balligand J.L., and Feron O. Modulation of the tumor vasculature functionality by ionizing radiation accounts for tumor radiosensitization and promotes gene delivery. FASEB J. 16 (2002) 1979-1981
-
(2002)
FASEB J.
, vol.16
, pp. 1979-1981
-
-
Sonveaux, P.1
Dessy, C.2
Brouet, A.3
Jordan, B.F.4
Gregoire, V.5
Gallez, B.6
Balligand, J.L.7
Feron, O.8
-
79
-
-
0032535681
-
Activation of inducible nitric oxide synthase results in nitric oxide-mediated radiosensitization of hypoxic EMT-6 tumor cells
-
Janssens M.Y., Van den Berge D.L., Verovski V.N., Monsaert C., and Storme G.A. Activation of inducible nitric oxide synthase results in nitric oxide-mediated radiosensitization of hypoxic EMT-6 tumor cells. Cancer Res. 58 (1998) 5646-5648
-
(1998)
Cancer Res.
, vol.58
, pp. 5646-5648
-
-
Janssens, M.Y.1
Van den Berge, D.L.2
Verovski, V.N.3
Monsaert, C.4
Storme, G.A.5
-
80
-
-
0036727090
-
Mechanisms and management of toxicities associated with high-dose interferon alfa-2b therapy
-
Kirkwood J.M., Bender C., Agarwala S., Tarhini A., Shipe-Spotloe J., Smelko B., Donnelly S., and Stover L. Mechanisms and management of toxicities associated with high-dose interferon alfa-2b therapy. J. Clin. Oncol. 20 (2002) 3703-3718
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 3703-3718
-
-
Kirkwood, J.M.1
Bender, C.2
Agarwala, S.3
Tarhini, A.4
Shipe-Spotloe, J.5
Smelko, B.6
Donnelly, S.7
Stover, L.8
-
81
-
-
1242338769
-
Adenoviral gene transfer of the human inducible nitric oxide synthase gene enhances the radiation response of human colorectal cancer associated with alterations in tumor vascularity
-
Wang Z., Cook T., Alber S., Liu K., Kovesdi I., Watkins S.K., Vodovotz Y., Billiar T.R., and Blumberg D. Adenoviral gene transfer of the human inducible nitric oxide synthase gene enhances the radiation response of human colorectal cancer associated with alterations in tumor vascularity. Cancer Res. 64 (2004) 1386-1395
-
(2004)
Cancer Res.
, vol.64
, pp. 1386-1395
-
-
Wang, Z.1
Cook, T.2
Alber, S.3
Liu, K.4
Kovesdi, I.5
Watkins, S.K.6
Vodovotz, Y.7
Billiar, T.R.8
Blumberg, D.9
-
82
-
-
0033673457
-
Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides
-
Palmer L.A., Gaston B., and Johns R.A. Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides. Mol. Pharmacol. 58 (2000) 1197-1203
-
(2000)
Mol. Pharmacol.
, vol.58
, pp. 1197-1203
-
-
Palmer, L.A.1
Gaston, B.2
Johns, R.A.3
-
83
-
-
0034638623
-
Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway
-
Sandau K.B., Faus H.G., and Brune B. Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway. Biochem. Biophys. Res. Commun. 278 (2000) 263-267
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.278
, pp. 263-267
-
-
Sandau, K.B.1
Faus, H.G.2
Brune, B.3
-
84
-
-
0035864361
-
Accumulation of HIF-1alpha under the influence of nitric oxide
-
Sandau K.B., Fandrey J., and Brune B. Accumulation of HIF-1alpha under the influence of nitric oxide. Blood 97 (2001) 1009-1015
-
(2001)
Blood
, vol.97
, pp. 1009-1015
-
-
Sandau, K.B.1
Fandrey, J.2
Brune, B.3
-
85
-
-
0042469448
-
Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases
-
Metzen E., Zhou J., Jelkmann W., Fandrey J., and Brune B. Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases. Mol. Biol. Cell 14 (2003) 3470-3481
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 3470-3481
-
-
Metzen, E.1
Zhou, J.2
Jelkmann, W.3
Fandrey, J.4
Brune, B.5
-
86
-
-
0032560504
-
Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia
-
Sogawa K., Numayama-Tsuruta K., Ema M., Abe M., Abe H., and Fujii-Kuriyama Y. Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia. Proc. Natl. Acad. Sci. USA 95 (1998) 7368-7373
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 7368-7373
-
-
Sogawa, K.1
Numayama-Tsuruta, K.2
Ema, M.3
Abe, M.4
Abe, H.5
Fujii-Kuriyama, Y.6
-
87
-
-
0033605676
-
Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling
-
Huang L.E., Willmore W.G., Gu J., Goldberg M.A., and Bunn H.F. Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling. J. Biol. Chem. 274 (1999) 9038-9044
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 9038-9044
-
-
Huang, L.E.1
Willmore, W.G.2
Gu, J.3
Goldberg, M.A.4
Bunn, H.F.5
-
89
-
-
0036089548
-
Role of nitric oxide in the regulation of HIF-1alpha expression during hypoxia
-
Agani F.H., Puchowicz M., Chavez J.C., Pichiule P., and LaManna J. Role of nitric oxide in the regulation of HIF-1alpha expression during hypoxia. Am. J. Physiol. Cell Physiol. 283 (2002) C178-C186
-
(2002)
Am. J. Physiol. Cell Physiol.
, vol.283
-
-
Agani, F.H.1
Puchowicz, M.2
Chavez, J.C.3
Pichiule, P.4
LaManna, J.5
-
90
-
-
0036382929
-
Effects of nitric oxide donors on vascular endothelial growth factor gene induction
-
Kimura H., Ogura T., Kurashima Y., Weisz A., and Esumi H. Effects of nitric oxide donors on vascular endothelial growth factor gene induction. Biochem. Biophys. Res. Commun. 296 (2002) 976-982
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.296
, pp. 976-982
-
-
Kimura, H.1
Ogura, T.2
Kurashima, Y.3
Weisz, A.4
Esumi, H.5
-
91
-
-
0346027211
-
Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways
-
Mateo J., Garcia-Lecea M., Cadenas S., Hernandez C., and Moncada S. Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways. Biochem. J. 376 (2003) 537-544
-
(2003)
Biochem. J.
, vol.376
, pp. 537-544
-
-
Mateo, J.1
Garcia-Lecea, M.2
Cadenas, S.3
Hernandez, C.4
Moncada, S.5
-
92
-
-
0036513249
-
Does nitric oxide modulate mitochondrial energy generation and apoptosis?
-
Moncada S., and Erusalimsky J.D. Does nitric oxide modulate mitochondrial energy generation and apoptosis?. Nat. Rev. Mol. Cell Biol. 3 (2002) 214-220
-
(2002)
Nat. Rev. Mol. Cell Biol.
, vol.3
, pp. 214-220
-
-
Moncada, S.1
Erusalimsky, J.D.2
-
93
-
-
0348134741
-
Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha
-
Hagen T., Taylor C.T., Lam F., and Moncada S. Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha. Science 302 (2003) 1975-1978
-
(2003)
Science
, vol.302
, pp. 1975-1978
-
-
Hagen, T.1
Taylor, C.T.2
Lam, F.3
Moncada, S.4
-
94
-
-
34047272690
-
Regulation of HIF-1alpha stability through S-nitrosylation
-
Li F., Sonveaux P., Rabbani Z.N., Liu S., Yan B., Huang Q., Vujaskovic Z., Dewhirst M.W., and Li C.Y. Regulation of HIF-1alpha stability through S-nitrosylation. Mol. Cell 26 (2007) 63-74
-
(2007)
Mol. Cell
, vol.26
, pp. 63-74
-
-
Li, F.1
Sonveaux, P.2
Rabbani, Z.N.3
Liu, S.4
Yan, B.5
Huang, Q.6
Vujaskovic, Z.7
Dewhirst, M.W.8
Li, C.Y.9
-
95
-
-
2342611976
-
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules
-
Moeller B.J., Cao Y., Li C.Y., and Dewhirst M.W. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5 (2004) 429-441
-
(2004)
Cancer Cell
, vol.5
, pp. 429-441
-
-
Moeller, B.J.1
Cao, Y.2
Li, C.Y.3
Dewhirst, M.W.4
-
96
-
-
23644453277
-
Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity
-
Moeller B.J., Dreher M.R., Rabbani Z.N., Schroeder T., Cao Y., Li C.Y., and Dewhirst M.W. Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell 8 (2005) 99-110
-
(2005)
Cancer Cell
, vol.8
, pp. 99-110
-
-
Moeller, B.J.1
Dreher, M.R.2
Rabbani, Z.N.3
Schroeder, T.4
Cao, Y.5
Li, C.Y.6
Dewhirst, M.W.7
-
97
-
-
8544229943
-
Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha
-
Zhang X., Kon T., Wang H., Li F., Huang Q., Rabbani Z.N., Kirkpatrick J.P., Vujaskovic Z., Dewhirst M.W., and Li C.Y. Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha. Cancer Res. 64 (2004) 8139-8142
-
(2004)
Cancer Res.
, vol.64
, pp. 8139-8142
-
-
Zhang, X.1
Kon, T.2
Wang, H.3
Li, F.4
Huang, Q.5
Rabbani, Z.N.6
Kirkpatrick, J.P.7
Vujaskovic, Z.8
Dewhirst, M.W.9
Li, C.Y.10
-
98
-
-
20944449117
-
Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1
-
Williams K.J., Telfer B.A., Xenaki D., Sheridan M.R., Desbaillets I., Peters H.J., Honess D., Harris A.L., Dachs G.U., van der Kogel A., and Stratford I.J. Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1. Radiother. Oncol. 75 (2005) 89-98
-
(2005)
Radiother. Oncol.
, vol.75
, pp. 89-98
-
-
Williams, K.J.1
Telfer, B.A.2
Xenaki, D.3
Sheridan, M.R.4
Desbaillets, I.5
Peters, H.J.6
Honess, D.7
Harris, A.L.8
Dachs, G.U.9
van der Kogel, A.10
Stratford, I.J.11
-
99
-
-
0035866771
-
Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy
-
Geng L., Donnelly E., McMahon G., Lin P.C., Sierra-Rivera E., Oshinka H., and Hallahan D.E. Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy. Cancer Res. 61 (2001) 2413-2419
-
(2001)
Cancer Res.
, vol.61
, pp. 2413-2419
-
-
Geng, L.1
Donnelly, E.2
McMahon, G.3
Lin, P.C.4
Sierra-Rivera, E.5
Oshinka, H.6
Hallahan, D.E.7
-
100
-
-
0035132923
-
Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts
-
Kozin S.V., Boucher Y., Hicklin D.J., Bohlen P., Jain R.K., and Suit H.D. Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts. Cancer Res. 61 (2001) 39-44
-
(2001)
Cancer Res.
, vol.61
, pp. 39-44
-
-
Kozin, S.V.1
Boucher, Y.2
Hicklin, D.J.3
Bohlen, P.4
Jain, R.K.5
Suit, H.D.6
-
101
-
-
0036145292
-
The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation
-
Ning S., Laird D., Cherrington J.M., and Knox S.J. The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation. Radiat. Res. 157 (2002) 45-51
-
(2002)
Radiat. Res.
, vol.157
, pp. 45-51
-
-
Ning, S.1
Laird, D.2
Cherrington, J.M.3
Knox, S.J.4
-
102
-
-
34547103992
-
Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment
-
Moeller B.J., Richardson R.A., and Dewhirst M.W. Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment. Cancer Metastasis Rev. 26 (2007) 241-248
-
(2007)
Cancer Metastasis Rev.
, vol.26
, pp. 241-248
-
-
Moeller, B.J.1
Richardson, R.A.2
Dewhirst, M.W.3
-
104
-
-
0027231742
-
Nitric oxide-mediated apoptosis in murine peritoneal macrophages
-
Albina J.E., Cui S., Mateo R.B., and Reichner J.S. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. J. Immunol. 150 (1993) 5080-5085
-
(1993)
J. Immunol.
, vol.150
, pp. 5080-5085
-
-
Albina, J.E.1
Cui, S.2
Mateo, R.B.3
Reichner, J.S.4
-
106
-
-
0034899785
-
Transcription factors p53 and HIF-1alpha as targets of nitric oxide
-
Brune B., von Knethen A., and Sandau K.B. Transcription factors p53 and HIF-1alpha as targets of nitric oxide. Cell. Signal. 13 (2001) 525-533
-
(2001)
Cell. Signal.
, vol.13
, pp. 525-533
-
-
Brune, B.1
von Knethen, A.2
Sandau, K.B.3
-
107
-
-
0034280568
-
Gene therapy of rat medullary thyroid cancer by naked nitric oxide synthase II DNA injection
-
Soler M.N., Bobe P., Benihoud K., Lemaire G., Roos B.A., and Lausson S. Gene therapy of rat medullary thyroid cancer by naked nitric oxide synthase II DNA injection. J. Gene Med. 2 (2000) 344-352
-
(2000)
J. Gene Med.
, vol.2
, pp. 344-352
-
-
Soler, M.N.1
Bobe, P.2
Benihoud, K.3
Lemaire, G.4
Roos, B.A.5
Lausson, S.6
-
108
-
-
85047697705
-
Tumour cell radiosensitization using constitutive (CMV) and radiation inducible (WAF1) promoters to drive the iNOS gene: a novel suicide gene therapy
-
Worthington J., Robson T., O'Keeffe M., and Hirst D.G. Tumour cell radiosensitization using constitutive (CMV) and radiation inducible (WAF1) promoters to drive the iNOS gene: a novel suicide gene therapy. Gene Ther. 9 (2002) 263-269
-
(2002)
Gene Ther.
, vol.9
, pp. 263-269
-
-
Worthington, J.1
Robson, T.2
O'Keeffe, M.3
Hirst, D.G.4
-
109
-
-
3242798679
-
Use of the radiation-inducible WAF1 promoter to drive iNOS gene therapy as a novel anti-cancer treatment
-
Worthington J., McCarthy H.O., Barrett E., Adams C., Robson T., and Hirst D.G. Use of the radiation-inducible WAF1 promoter to drive iNOS gene therapy as a novel anti-cancer treatment. J. Gene Med. 6 (2004) 673-680
-
(2004)
J. Gene Med.
, vol.6
, pp. 673-680
-
-
Worthington, J.1
McCarthy, H.O.2
Barrett, E.3
Adams, C.4
Robson, T.5
Hirst, D.G.6
-
110
-
-
20844449408
-
Nitric oxide synthase II suppresses the growth and metastasis of human cancer regardless of its up-regulation of protumor factors
-
Le X., Wei D., Huang S., Lancaster Jr. J.R., and Xie K. Nitric oxide synthase II suppresses the growth and metastasis of human cancer regardless of its up-regulation of protumor factors. Proc. Natl. Acad. Sci. USA 102 (2005) 8758-8763
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 8758-8763
-
-
Le, X.1
Wei, D.2
Huang, S.3
Lancaster Jr., J.R.4
Xie, K.5
-
111
-
-
47049126494
-
-
R.L. Cowen, S. Singh, E.C. Chinje, R. Al-Assah, P. Harris, C. Dunk, I.J. Stratford, Adenoviral delivery of inducible nitric oxide synthase (NOSII) enhances AQ4N/radiation cytotoxicity within hypoxic tumor cells, AACR Meeting Abstracts, 2005 (2005) 314-a.
-
R.L. Cowen, S. Singh, E.C. Chinje, R. Al-Assah, P. Harris, C. Dunk, I.J. Stratford, Adenoviral delivery of inducible nitric oxide synthase (NOSII) enhances AQ4N/radiation cytotoxicity within hypoxic tumor cells, AACR Meeting Abstracts, 2005 (2005) 314-a.
-
-
-
-
112
-
-
1242271216
-
Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: reversing tumor radioresistance and effecting cure
-
Cowen R.L., Williams K.J., Chinje E.C., Jaffar M., Sheppard F.C., Telfer B.A., Wind N.S., and Stratford I.J. Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: reversing tumor radioresistance and effecting cure. Cancer Res. 64 (2004) 1396-1402
-
(2004)
Cancer Res.
, vol.64
, pp. 1396-1402
-
-
Cowen, R.L.1
Williams, K.J.2
Chinje, E.C.3
Jaffar, M.4
Sheppard, F.C.5
Telfer, B.A.6
Wind, N.S.7
Stratford, I.J.8
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