mTOR inactivation by ROS-JNK-p53 pathway plays an essential role in Psedolaric acid B induced autophagy-dependent senescence in murine fibrosarcoma L929 cells

European Journal of Pharmacology

Volumn 715, Issue 1-3, 2013, Pages 76-88

  Qi, Min ^a   Zhou, Haiyan ^a   Fan, Simiao ^a   Li, Zhao ^a   Yao, Guodong ^a   Tashiro, Shin Ichi ^b   Onodera, Satoshi ^b   Xia, Mingyu ^a   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Autophagy; MTOR inactivation; Pseudolaric acid B; ROS JNK p53 pathway; Senescence

Indexed keywords

GROWTH FACTOR; HETERODIMER; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P16; PROTEIN P19; PROTEIN P21; PROTEIN P53; PSEUDOLARIC ACID B; REACTIVE OXYGEN METABOLITE; RETINOBLASTOMA PROTEIN; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TUBERIN;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL FATE; CELL STRAIN; CELL STRAIN L929; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; FIBROSARCOMA; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SARCOMA CELL; SENESCENCE; SIGNAL TRANSDUCTION;

AUTOPHAGY; MTOR INACTIVATION; PSEUDOLARIC ACID B; ROS-JNK-P53 PATHWAY; SENESCENCE;

ANIMALS; AUTOPHAGY; CELL AGING; CELL LINE, TUMOR; DITERPENES; FEEDBACK, PHYSIOLOGICAL; FIBROSARCOMA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICE; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84885479865     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.05.051     Document Type: Article

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