Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death

Experimental and Molecular Medicine

Volumn 38, Issue 4, 2006, Pages 428-434

  Gong, Xianfeng ^a   Wang, Minwei ^a   Tashiro, Shin Ichi ^b   Onodera, Satoshi ^b   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; HeLa cells; JNK mitogen activated protein kinases; Protein kinase C; Pseudolaric acid B; Tumor suppressor protein p53

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CALPHOSTIN C; DNA FRAGMENT; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; PROTEIN P53; PSEUDOLARIC ACID B; STAUROSPORINE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STRUCTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVITY; HELA CELL; HUMAN; HUMAN CELL; INCUBATION TIME; NICK END LABELING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION; ANTINEOPLASTIC ACTIVITY; CELL CULTURE; CELL GROWTH; ENZYME ACTIVATION; GROWTH INHIBITION; WESTERN BLOTTING;

EID: 33748700418     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2006.50     Document Type: Article

References (25)

1. Waf1/Cip1 in protein kinase C Alpha-induced cell cycle progression. Mol Cell Biol 2000;20:4580-90
2. Brooks CL, Gu W. Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol 2003;15:164-71
3. Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, Pouyssegur J. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J 1999;18:664-74
4. Buschmann T, Potapova O, Bar-shira A, Ivanov VN, Fuchs SY, Henderson S, Fried VA, Minamoto T, Alarcon-vargas D, Pincus MR, Gaarde WA, Holbrook, NJ, Shiloh Y, Ronai Z. Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol Cell Biol 2001;21:2743-54
5. 2 induced an imbalance between mitogen-activated protein kinases and NF-κB that promotes apoptosis in macrophages. Mol Cell Biol 2003;23:1196-208
6. Comalada M, Xaus J, Valledor AF, Lopez-lopez C, Pennington DJ, Celada A. PKCε is involved in JNK activation that mediates LPS-induced TNF-α, which induces apoptosis in macrophages. Am J Physiol Cell Physiol 2003;285:1235-45
7. Cross TG, Scheel-Toellner D, Henriquez NV, Deacon E, Salmon M, Lord JM. Serine/Threonine protein kinases and apoptosis. Exp Cell Res 2000;256:34-41
8. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000;103:239-52
9. Fuchs SY, Adler V, Buschmann T, Yin ZM, Wu XW, Jones SN, Ronai Z. JNK targets p53 ubiquitination and degradation in nonstressed cells. Gene Dev 1998a;12:2658-63
10. Fuchs SY, Adler V, Pincus MR, Ronai Z. MEKK1/JNK signaling stabilizes and activates p53. Proc Natl Acad Sci 1998b;95:10541-6
11. Gong XF, Wang MW, Tashiro SI, Onodera S, Ikejima T. Pseudolaric acid B induces apoptosis through p53 and Bax/Bcl-2 pathways in human melanoma A375-S2 cells. Arch Pharm Res 2005;28:68-72
12. Gong XF, Wang MW, Wu Z, Tashiro SI, Onodera S, Ikejima T. Pseudolaric acid B induces apoptosis via activation of c-Jun N-terminal kinase and caspase-3 in HeLa cells. Exp Mol Med 2004;36:551-6
13. Haupt S, Berger M, Goldberg Z, Haupt Y. Apoptosis-the p53 network. J Cell Sci 2003;116:4077-85
14. Ip YT, Davis RJ. Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development. Curr Opin Cell Biol 1998;10:205-9.
15. Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK and p38 protein kinases. Science 2002;298:1911-2
16. Kowan KJ, Storey KB. Mitogen-activated protein kinase: new signaling pathways functioning in cellular responses to environmental stress. J Exp Biol 2003;206:1107-15
17. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997;88:323-31
18. Li E, Clark AM, Hufford CD. Antifungal evaluation of pseudolaric acid B, a major constituent of pseudolarix kaempferi. J Nat Prod 1995;58:57-67
19. Milne DM, Campbell LE, Campbell DG, Meek DW. p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-jun kinase, JNK1. J Biol Chem 1995;270:5511-6
20. Pan DJ, Li ZL, Hu CQ, Chen K, Chang JJ, Lee KH. The cytotoxic principles of Pseudolarix Kaempferi: pseudolaric acid-A and B and related derivatives. Planta Med 1990;56:383-5
21. Schaeffer HJ, Weber MJ. Mitogen-activated protein kinase: specific messages from ubiquitous messengers. Mol Cell Biol 1999;19:2435-44
22. Schonwasser DC, Marais RM, Marshall CJ, Parker PJ. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel and atypical protein kinase C isotype. Mol Cell Biol 1998;18:790-8
23. Wang WC, Lu RF, Zhao SX, Gu ZP. Comparison of early pregnancy-terminating effect and toxicity between pseudolaric acids A and B. Acta Pharmacol Sin 1988;9:445-8
24. Wang WC, Lu RF, Zhao SX, Zhu YZ. Antifertility effect of pseudolaric acid B. Acta Pharmacol Sin 1982;3:188-92
25. Werlen G, Jacinto E, Xia Y, Karin M. Calcineurin preferentially synergizes with PKC-θ to activate JNK and IL-2 promoter in T lymphocytes. EMBO J 1998;17:3101-11