P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK

Free Radical Research

Volumn 46, Issue 3, 2012, Pages 310-319

  Fan, Simiao ^a   Qi, Min ^a   Yu, Yang ^a   Li, Lihua ^a   Yao, Guodong ^a   Tashiro, Shin Ichi ^b   Onodera, Satoshi ^b   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

JNK; P53; PUMA; ROS; Silibinin

Indexed keywords

ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PIFITHRIN ALPHA; PROTEIN BAX; PROTEIN P53; PUMA PROTEIN; REACTIVE OXYGEN METABOLITE; SILIBININ;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PUMA; UPREGULATION;

ANTHRACENES; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BENZOTHIAZOLES; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HELA CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS; REACTIVE OXYGEN SPECIES; SILYMARIN; TOLUENE; TUMOR SUPPRESSOR PROTEIN P53; VULVAR NEOPLASMS;

EID: 84863142691     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2012.655244     Document Type: Article

References (33)

1. Haddad Y, Vallerand D, Brault A, Haddad PS. Antioxidant and hepatoprotective effects of silibinin in a rat model of nonalcoholic steatohepatitis. Evid Based Complement Alternat Med 2009. Available:http://ecam. oxfordjournals.org/cgi/reprint/nep164v1.pdf via the INTERNET.
2. Duan W, Jin X, Li Q, Tashiro S, Onodera S, Ikejima T. Silibinin induced autophagic and apoptotic cell death in HT1080 cells through a reactive oxygen species pathway. J Pharmacol Sci 2011;113:48-56.
3. Kim KW, Choi CH, Kim TH, Kwon CH, Woo JS, Kim YK. Silibinin inhibits glioma cell proliferation via Ca2+/ROS/MAPK-dependent mechanism in vitro and glioma tumor growth in vivo. Neurochem Res 2009;34:1479-1490.
4. Mira L, Silva M, Manso CF. Scavenging of reactive oxygen species by silibinin dihemisuccinate. Biochem Pharmacol 1994;48:753-759. (Pubitemid 24283845)
5. Fan S, Li L, Chen S, Yu Y, Qi M, Tashiro SI, et al. Silibinin induced-autophagic and apoptotic death is associated with ROS and RNS increase in HeLa cells. Free Radic Res 2011. [Epub ahead of print].
6. Duan WJ, Li QS, Xia MY, Tashiro S, Onodera S, Ikejima T. Silibinin activated p53 and induced autophagic death in human fibrosarcoma HT1080 cells via reactive oxygen spe-cies-p38 and c-Jun N-terminal kinase pathways. Biol Pharma-ceut Bull 2011;34:47-53.
7. Jiang YY, Huang H, Wang HJ, Wu D, Yang R, Tashiro S, et al. Interruption of mitochondrial complex IV activity and cytochrome c expression activated O2 ·-mediated cell survival in silibinin-treated human melanoma A375-S2 cells via IGF-1R-PI3K-Akt and IGF-1R-PLC y-PKC pathways. Eur J Pharmacol 2011;668:78-87.
8. Jiang YY, Yang R, Wang HJ, Huang H, Wu D, Tashiro SI, et al. Mechanism of autophagy induction and role of autophagy in antagonizing mitomycin C-induced cell apoptosis in silibinin treated human melanoma A375-S2 cells. Eur J Pharmacol 2011;668:78-87.
9. Wang HJ, Jiang YY, Wei XF, Huang H, Tashiro S, Onodera S, et al. Silibinin induces protective superoxide generation in human breast cancer MCF-7 cells. Free Radic Res 2010; 44:90-100.
10. Noh EM, Yi MS, Youn HJ, Lee BK, Lee YR, Han JH, et al. Silibinin enhances ultraviolet B-induced apoptosis in mcf-7 human breast cancer cells. J Breast Canc 2011;14:8-13.
11. Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med 2010;49:1603-1616.
12. Anna M. Puzio-Kuter. The Role of p53 in Metabolic Regulation. Gene Canc 2011;2:385-391.
13. Liu Z, Lu H, Shi H, Du Y, Yu J, Gu S. PUMA overexpression induces reactive oxygen species generation and proteasome-mediated stathmin degradation in colorectal cancer cells. Canc Res 2005;65:1647-1654. (Pubitemid 40478588)
14. Liu B, Chen Y, St Clair DK ROS and p53: a versatile partnership. Free Radic Biol Med 2008;44:1529-1535.
15. Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 2001;7:683-694. (Pubitemid 32706359)
16. Han J, Flemington C, Houghton AB, Gu Z, Zambetti GP, Lutz RJ, et al. Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci USA 2001;98:11318-11323. (Pubitemid 32928726)
17. Yu J, Zhang L. PUMA, a potent killer with or without p53. Oncogene 2008;27(Suppl 1):S71-S83.
18. Nagai H, Noguchi T, Takeda K. Pathophysiological roles of ASK1-MAP kinase signaling pathways. J Biochem Mol Biol 2007;40:1-6. (Pubitemid 46182728)
19. Chen K, Vita JA, Berk BC. c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation. J Biol Chem 2001;276:16045-16050.
20. Wu GS. Role of mitogen-activated protein kinase phos-phatases (MKPs) in cancer. Canc Metastasis Rev 2007;26: 579-585. (Pubitemid 350115109)
21. Kim EM, Yang HS, Kang SW, Ho JN, Lee SB, Um HD. Amplification of the gamma-irradiation-induced cell death pathway by reactive oxygen species in human U937 cells. Cell Signal 2008;20:916-924.
22. Park DJ, Nakamura H, Chumakov AM, Said JW, Miller CW, Chen DL, Koeffler HP. Transactivational and DNA binding abilities of endogenous p53 in p53 mutant cell lines. Onco-gene 1994;9:1899-1906. (Pubitemid 24194156)
23. Cheng CY, Su CC. Tanshinone IIA may inhibit the growth of small cell lung cancer H146 cells by up-regulating the Bax/Bcl-2 ratio and decreasing mitochondrial membrane potential. Mol Med Report 2010;3:645-650.
24. Komarov PG, Komarova EA, Kondratov RV, Christov-Tselkov K, Coon JS, Chernov MV. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 1999;285:1733-1737. (Pubitemid 29428873)
25. Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, Leisten JC. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 2001;98:13681-13686. (Pubitemid 33115958)
26. Chen Y, Gibson SB. Is mitochondrial generation of reactive oxygen species a trigger for autophagy? Autophagy 2008; 4:246-248. (Pubitemid 351231192)
27. Ricci JE, Gottlieb RA, Green DR. Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis. J Cell Biol 2003;160:65-75. (Pubitemid 36091717)
28. Thomas A, Giesler T, White E. p53 mediates bcl-2 phospho-rylation and apoptosis via activation of the Cdc42/JNK1 pathway. Oncogene 2000;19:5259-5269.
29. Kim JE, Jin DH, Lee SD, Hong SW, Shin JS, Lee SK. Vitamin C inhibits p53-induced replicative senescence through suppression of ROS production and p38 MAPK activity. Int J Mol Med 2008;22:651-655.
30. Shieh JM, Huang TF, Hung CF, Chou KH, Tsai YJ, Wu WB. Activation of c-Jun N-terminal kinase is essential for mito-chondrial membrane potential change and apoptosis induced by doxycycline in melanoma cells. Br J Pharmacol 2010; 160:1171-1184.
31. Yi L, Ji XX, Lin M, Tan H, Tang Y, Wen L, et al. Diallyl disulfide induces apoptosis in human leukemia HL-60 cells through activation of JNK mediated by reactive oxygen. Pharmazie 2010;65:693-698.
32. Liu H, Xiao Y, Xiong C, Wei A, Ruan J. Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species-mediated mitochondrial dysfunction and MAPK activation. Eur J Pharmacol 2011;654: 209-216.
33. Ashraf QM, Zanelli SA, Mishra OP, Delivoria-Papadopoulos M. Phosphorylation of Bcl-2 and Bax proteins during hypoxia in newborn piglets. Neurochem Res 2001;26:1-9. (Pubitemid 32428806)