메뉴 건너뛰기




Volumn 405, Issue 26, 2013, Pages 8487-8503

Bioappearance and pharmacokinetics of bioactives upon coffee consumption

Author keywords

Bioappearance; Caffeine; Chlorogenic acids; Coffee; Trigonelline; UPLC HDMS

Indexed keywords

BIOAPPEARANCE; CHLOROGENIC ACIDS; INTERVENTION STUDIES; PHARMACOKINETIC PROFILES; PHARMACOKINETIC PROPERTIES; STATISTICAL DATA ANALYSIS; TRIGONELLINE; UPLC-HDMS;

EID: 84885428871     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-7288-0     Document Type: Article
Times cited : (88)

References (42)
  • 1
    • 58849083195 scopus 로고    scopus 로고
    • Midlife coffee and tea drinking and the risk of late-life dementia: A population-based CAIDE study
    • Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M (2009) Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study. J Alzheimer Dis 19:85-91
    • (2009) J Alzheimer Dis , vol.19 , pp. 85-91
    • Eskelinen, M.H.1    Ngandu, T.2    Tuomilehto, J.3    Soininen, H.4    Kivipelto, M.5
  • 2
    • 34247633571 scopus 로고    scopus 로고
    • Coffee consumption and risk of liver cancer: A meta-analysis
    • 10.1053/j.gastro.2007.03.044
    • Larsson SC, Wolk A (2007) Coffee consumption and risk of liver cancer: a meta-analysis. Gastroenterol 132:1740-1745
    • (2007) Gastroenterol , vol.132 , pp. 1740-1745
    • Larsson, S.C.1    Wolk, A.2
  • 4
    • 0033851408 scopus 로고    scopus 로고
    • Discriminate analysis of roasted coffee varieties for trigonelline, nicotinic acid and caffeine content
    • 10.1021/jf990702b 1:CAS:528:DC%2BD3cXks1WnsL0%3D
    • Casal S, Oliveira MBPP, Alves MR, Ferreira MA (2000) Discriminate analysis of roasted coffee varieties for trigonelline, nicotinic acid and caffeine content. J Agric Food Chem 48:3420-3424
    • (2000) J Agric Food Chem , vol.48 , pp. 3420-3424
    • Casal, S.1    Oliveira, M.2    Alves, M.R.3    Ferreira, M.A.4
  • 5
    • 76449106422 scopus 로고    scopus 로고
    • Measurement of the intracellular pH in human stomach cells: A novel approach to evaluate the gastric acid secretory potential of coffee beverages
    • 10.1021/jf903614d 1:CAS:528:DC%2BC3cXksFeitQ%3D%3D
    • Weiss C, Rubach M, Lang R, Seebach E, Blumberg S, Frank O, Hofmann T, Somoza V (2010) Measurement of the intracellular pH in human stomach cells: a novel approach to evaluate the gastric acid secretory potential of coffee beverages. J Agric Food Chem 58:1976-1985
    • (2010) J Agric Food Chem , vol.58 , pp. 1976-1985
    • Weiss, C.1    Rubach, M.2    Lang, R.3    Seebach, E.4    Blumberg, S.5    Frank, O.6    Hofmann, T.7    Somoza, V.8
  • 6
    • 77949834586 scopus 로고    scopus 로고
    • Quantitative studies on the influence of the bean roasting parameters and hot water percolation on the concentrations of bitter compounds in coffee brew
    • 10.1021/jf9044606 1:CAS:528:DC%2BC3cXitlakurY%3D
    • Blumberg S, Frank O, Hofmann T (2010) Quantitative studies on the influence of the bean roasting parameters and hot water percolation on the concentrations of bitter compounds in coffee brew. J Agric Food Chem 58:3720-3728
    • (2010) J Agric Food Chem , vol.58 , pp. 3720-3728
    • Blumberg, S.1    Frank, O.2    Hofmann, T.3
  • 7
    • 33748422943 scopus 로고    scopus 로고
    • Development of a Stable Isotope Dilution Analysis with LC-MS/MS detection for the quantitative analysis of di- and trihydroxybenzenes in foods and model systems
    • 10.1021/jf061118n 1:CAS:528:DC%2BD28XmslWhur4%3D
    • Lang R, Mueller C, Hofmann T (2006) Development of a Stable Isotope Dilution Analysis with LC-MS/MS detection for the quantitative analysis of di- and trihydroxybenzenes in foods and model systems. J Agric Food Chem 54:5755-5762
    • (2006) J Agric Food Chem , vol.54 , pp. 5755-5762
    • Lang, R.1    Mueller, C.2    Hofmann, T.3
  • 8
    • 58949096676 scopus 로고    scopus 로고
    • Quantitative Investigation of Trigonelline, Nicotinic Acid, and Nicotinamide in Foods, Urine, and Plasma by Means of LC-MS/MS and Stable Isotope Dilution Analysis
    • 10.1021/jf802838s 1:CAS:528:DC%2BD1cXhtlOiurvP
    • Lang R, Yagar EF, Eggers R, Hofmann T (2008) Quantitative Investigation of Trigonelline, Nicotinic Acid, and Nicotinamide in Foods, Urine, and Plasma by Means of LC-MS/MS and Stable Isotope Dilution Analysis. J Agric Food Chem 56:11114-11121
    • (2008) J Agric Food Chem , vol.56 , pp. 11114-11121
    • Lang, R.1    Yagar, E.F.2    Eggers, R.3    Hofmann, T.4
  • 9
    • 67650802353 scopus 로고    scopus 로고
    • Metabolite profiling of hydroxycinnamate derivatives in plasma and urine after the ingestion of coffee by humans: Identification of biomarkers of coffee consumption
    • 10.1124/dmd.109.028019 1:CAS:528:DC%2BD1MXps1ygtLg%3D
    • Stalmach A, Mullen W, Barron D, Uchida K, Yokota T, Cavin C, Steiling H, Williamson G, Crozier A (2009) Metabolite profiling of hydroxycinnamate derivatives in plasma and urine after the ingestion of coffee by humans: identification of biomarkers of coffee consumption. Drug metabol Dispos 37:1749-1758
    • (2009) Drug Metabol Dispos , vol.37 , pp. 1749-1758
    • Stalmach, A.1    Mullen, W.2    Barron, D.3    Uchida, K.4    Yokota, T.5    Cavin, C.6    Steiling, H.7    Williamson, G.8    Crozier, A.9
  • 10
    • 77950633375 scopus 로고    scopus 로고
    • Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy
    • 10.1016/j.abb.2010.03.005 1:CAS:528:DC%2BC3cXhtV2jurvJ
    • Stalmach A, Steiling H, Williamson G, Crozier A (2010) Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. Arch Biochem Biophys 501:98-105
    • (2010) Arch Biochem Biophys , vol.501 , pp. 98-105
    • Stalmach, A.1    Steiling, H.2    Williamson, G.3    Crozier, A.4
  • 11
    • 77958151737 scopus 로고    scopus 로고
    • In vitro and in vivo conjugation of dietary hydroxycinnamic acids by UDP-glucuronosyltransferase and sulfotransferases in humans
    • 10.1016/j.jnutbio.2009.09.001 1:CAS:528:DC%2BC3cXhtlenurnJ
    • Wong CC, Meinl W, Glat HR, Barron D, Stalmach A, Steiling H, Crozier A, Williamson G (2010) in vitro and in vivo conjugation of dietary hydroxycinnamic acids by UDP-glucuronosyltransferase and sulfotransferases in humans. J Nutr Biochem 21:1060-1068
    • (2010) J Nutr Biochem , vol.21 , pp. 1060-1068
    • Wong, C.C.1    Meinl, W.2    Glat, H.R.3    Barron, D.4    Stalmach, A.5    Steiling, H.6    Crozier, A.7    Williamson, G.8
  • 12
    • 79954610780 scopus 로고    scopus 로고
    • Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression
    • 10.1016/j.jnutbio.2010.03.011 1:CAS:528:DC%2BC3MXkvFaqur8%3D
    • Boettler U, Sommerfeld K, Volz N, Pahlke G, Teller N, Somoza V, Lang R, Hofmann T, Marko D (2011) Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression. J Nutr Biochem 22:426-440
    • (2011) J Nutr Biochem , vol.22 , pp. 426-440
    • Boettler, U.1    Sommerfeld, K.2    Volz, N.3    Pahlke, G.4    Teller, N.5    Somoza, V.6    Lang, R.7    Hofmann, T.8    Marko, D.9
  • 13
    • 84865394734 scopus 로고    scopus 로고
    • Activation of antioxidant response element (ARE)-dependent genes by roasted coffee extracts
    • 10.1039/c2fo30021d
    • Yazheng L, Kitts DD (2012) Activation of antioxidant response element (ARE)-dependent genes by roasted coffee extracts. Food Funct 9:950-954
    • (2012) Food Funct , vol.9 , pp. 950-954
    • Yazheng, L.1    Kitts, D.D.2
  • 14
    • 0014208934 scopus 로고
    • Hypoglycaemic effect of trigonelline
    • 10.1016/S0140-6736(67)90428-X
    • Mishkinsky J, Joseph B, Sulman FG (1967) Hypoglycaemic effect of trigonelline. Lancet 290:1311-1312
    • (1967) Lancet , vol.290 , pp. 1311-1312
    • Mishkinsky, J.1    Joseph, B.2    Sulman, F.G.3
  • 15
    • 67049159773 scopus 로고    scopus 로고
    • Anti-diabetic effects of pumpkin and its compounds, trigonelline and nicotinic acid, on Goto-Kakizaki rats
    • 10.1271/bbb.80805 1:CAS:528:DC%2BD1MXntFKjsL0%3D
    • Yoshinari O, Sato H, Igarashi K (2009) Anti-diabetic effects of pumpkin and its compounds, trigonelline and nicotinic acid, on Goto-Kakizaki rats. Biosci Biotechnol Biochem 73:1033-1041
    • (2009) Biosci Biotechnol Biochem , vol.73 , pp. 1033-1041
    • Yoshinari, O.1    Sato, H.2    Igarashi, K.3
  • 16
    • 66549126196 scopus 로고    scopus 로고
    • Acute effect of decaffeinated coffee and the major coffee components chlorogenic acids and trigonelline on glucose tolerance
    • 10.2337/dc09-0207
    • Van Dijk AE, Olthof MR, Meeuse JC, Seebus E, Heine RJ, van Dam RM (2009) Acute effect of decaffeinated coffee and the major coffee components chlorogenic acids and trigonelline on glucose tolerance. Diabetes Care 32:1023-1025
    • (2009) Diabetes Care , vol.32 , pp. 1023-1025
    • Van Dijk, A.E.1    Olthof, M.R.2    Meeuse, J.C.3    Seebus, E.4    Heine, R.J.5    Van Dam, R.M.6
  • 17
    • 0000323224 scopus 로고
    • Thermal behavior of trigonelline
    • 10.1111/j.1365-2621.1974.tb07357.x 1:CAS:528:DyaE2MXivFOr
    • Viani R, Horman I (1974) Thermal behavior of trigonelline. J Food Sci 39:1216-1217
    • (1974) J Food Sci , vol.39 , pp. 1216-1217
    • Viani, R.1    Horman, I.2
  • 18
    • 0037180986 scopus 로고    scopus 로고
    • Alkylpyridiniums. 1. Formation in model systems via thermal degradation of trigonelline
    • 10.1021/jf011234k 1:CAS:528:DC%2BD38XptVOlsw%3D%3D
    • Stadler RH, Varga N, Hau J, Vera FA, Welt DH (2002) Alkylpyridiniums. 1. Formation in model systems via thermal degradation of trigonelline. J Agric Food Chem 50:1192-1199
    • (2002) J Agric Food Chem , vol.50 , pp. 1192-1199
    • Stadler, R.H.1    Varga, N.2    Hau, J.3    Vera, F.A.4    Welt, D.H.5
  • 19
    • 84885427587 scopus 로고    scopus 로고
    • Identification of urinary and salivary biomarkers for coffee consumption
    • Toth S, Mussinan C (ed) Oxford Print Inc
    • Lang R, Wahl A, Stark T, Hofmann T (2012) Identification of urinary and salivary biomarkers for coffee consumption. In: Toth S, Mussinan C (ed) Recent Advances in the Analysis of Food and Flavors. Oxford Print Inc
    • (2012) Recent Advances in the Analysis of Food and Flavors
    • Lang, R.1    Wahl, A.2    Stark, T.3    Hofmann, T.4
  • 20
    • 76849097471 scopus 로고    scopus 로고
    • Development of a hydrophilic liquid interaction chromatography - Tandem mass spectroscopy based stable isotope dilution analysis and pharmacokinetic studies on bioactives pyridines in human plasma and urine after coffee consumption
    • 10.1021/ac902616k 1:CAS:528:DC%2BC3cXlslSiug%3D%3D
    • Lang R, Wahl A, Skurk T, Yagar EF, Schmiech L, Eggers R, Hauner H, Hofmann T (2010) Development of a hydrophilic liquid interaction chromatography - tandem mass spectroscopy based stable isotope dilution analysis and pharmacokinetic studies on bioactives pyridines in human plasma and urine after coffee consumption. Anal Chem 82:1486-1497
    • (2010) Anal Chem , vol.82 , pp. 1486-1497
    • Lang, R.1    Wahl, A.2    Skurk, T.3    Yagar, E.F.4    Schmiech, L.5    Eggers, R.6    Hauner, H.7    Hofmann, T.8
  • 21
    • 80155186901 scopus 로고    scopus 로고
    • Urinary N-methylpyridinium and trigonelline as candidate dietary biomarkers of coffee consumption
    • 10.1002/mnfr.201000656 1:CAS:528:DC%2BC3MXhsVShsr7I
    • Lang R, Wahl A, Stark T, Hofmann T (2011) Urinary N-methylpyridinium and trigonelline as candidate dietary biomarkers of coffee consumption. Mol Nutr Food Res 55:1613-1623
    • (2011) Mol Nutr Food Res , vol.55 , pp. 1613-1623
    • Lang, R.1    Wahl, A.2    Stark, T.3    Hofmann, T.4
  • 22
    • 0020683936 scopus 로고
    • The absolute bioavailability of caffeine in man
    • 10.1007/BF00613933
    • Blanchard J, Sawers SJA (1982) the absolute bioavailability of caffeine in man. Eur J Cin Pharmacol 24:93-98
    • (1982) Eur J Cin Pharmacol , vol.24 , pp. 93-98
    • Blanchard, J.1    Sawers, S.J.A.2
  • 23
    • 12844266117 scopus 로고    scopus 로고
    • The critical role of methionine 35 in Alzheimer's amyloid β-peptide (1-42)-induced oxidative stress and neurotoxicity
    • 10.1016/j.bbapap.2004.10.014 1:CAS:528:DC%2BD2MXmvFOrtA%3D%3D
    • Butterfield DA, Boyd-Kimball D (2005) The critical role of methionine 35 in Alzheimer's amyloid β-peptide (1-42)-induced oxidative stress and neurotoxicity. Biochim Biophys Acta 1703:149-156
    • (2005) Biochim Biophys Acta , vol.1703 , pp. 149-156
    • Butterfield, D.A.1    Boyd-Kimball, D.2
  • 24
    • 33750984544 scopus 로고    scopus 로고
    • Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain β-amyloid production
    • 10.1016/j.neuroscience.2006.07.021 1:CAS:528:DC%2BD28XhtFCjsb%2FF
    • Arendash GW, Schleif W, Rezai-Zadeh K, Jackson EK, Zacharia LC, Cracchiolo JR, Shippy D, Tan J (2006) Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain β-amyloid production. Neuroscience 142:941-952
    • (2006) Neuroscience , vol.142 , pp. 941-952
    • Arendash, G.W.1    Schleif, W.2    Rezai-Zadeh, K.3    Jackson, E.K.4    Zacharia, L.C.5    Cracchiolo, J.R.6    Shippy, D.7    Tan, J.8
  • 26
    • 79960742203 scopus 로고    scopus 로고
    • Caffeine synergizes with another coffee component to increase plasma GCSF: Linkage to cognitive benefits in Alzheimer's Mice
    • 1:CAS:528:DC%2BC3MXotlygtr8%3D
    • Cao C, Wang L, Lin X, Mamcarz M, Zhang C, Bai G, Nong J, Sussman S, Arendash G (2011) Caffeine synergizes with another coffee component to increase plasma GCSF: Linkage to cognitive benefits in Alzheimer's Mice. J Alzheimer's Disease 25:323-335
    • (2011) J Alzheimer's Disease , vol.25 , pp. 323-335
    • Cao, C.1    Wang, L.2    Lin, X.3    Mamcarz, M.4    Zhang, C.5    Bai, G.6    Nong, J.7    Sussman, S.8    Arendash, G.9
  • 28
    • 84857497814 scopus 로고    scopus 로고
    • Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-line pathology in trangenic mice
    • 10.1074/jbc.M111.294025 1:CAS:528:DC%2BC38Xisl2ksL4%3D
    • Mori T, Rezai-Zadeh K, Koyama N, Arendash GW, Yamaguchi H, Kakuda N, Horikoshi-Sakuraba Y, Tan J, Town T (2012) Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-line pathology in trangenic mice. J Biol Chem 287:6912-6927
    • (2012) J Biol Chem , vol.287 , pp. 6912-6927
    • Mori, T.1    Rezai-Zadeh, K.2    Koyama, N.3    Arendash, G.W.4    Yamaguchi, H.5    Kakuda, N.6    Horikoshi-Sakuraba, Y.7    Tan, J.8    Town, T.9
  • 29
    • 25444500410 scopus 로고    scopus 로고
    • Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice
    • 10.1523/JNEUROSCI.1521-05.2005 1:CAS:528:DC%2BD2MXhtVGls73F
    • Rezai-Zadeh K, Shytle D, Sun N, Mori T, Hou H, Jeanniton D, Ehrhart J, Townsend K, Zheng J, Morgan D, Hardy J, Town T, Tan J (2005) Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. J Neurosci 25:8807-8814
    • (2005) J Neurosci , vol.25 , pp. 8807-8814
    • Rezai-Zadeh, K.1    Shytle, D.2    Sun, N.3    Mori, T.4    Hou, H.5    Jeanniton, D.6    Ehrhart, J.7    Townsend, K.8    Zheng, J.9    Morgan, D.10    Hardy, J.11    Town, T.12    Tan, J.13
  • 30
    • 1242285059 scopus 로고    scopus 로고
    • Accelerated Koenigs-Knorr Glucuronidation of a Deactivated Nitrophenol: Unveiling the Role of Polyamine Additive 1,1,4,7,10,10- Hexamethyltriethylenetetramine1 through Design of Experiments
    • 10.1021/jo035285n 1:CAS:528:DC%2BD2cXksFChsg%3D%3D
    • Stazi F, Palmisano G, Turconi M, Clini S, Santagostino M (2004) Accelerated Koenigs-Knorr Glucuronidation of a Deactivated Nitrophenol: Unveiling the Role of Polyamine Additive 1,1,4,7,10,10- Hexamethyltriethylenetetramine1 through Design of Experiments. JOC 69:1097-1103
    • (2004) JOC , vol.69 , pp. 1097-1103
    • Stazi, F.1    Palmisano, G.2    Turconi, M.3    Clini, S.4    Santagostino, M.5
  • 31
    • 78049322870 scopus 로고    scopus 로고
    • First synthesis, characterization, and evidence for the presence of hydroxycinnamic acid sulfate and glucuronide conjugates in human biological fluids as a result of coffee consumption
    • 10.1039/c0ob00137f 1:CAS:528:DC%2BC3cXhtlentL7I
    • Fumeaux R, Menozzi-Smarrito C, Stalmach A, Munari C, Kraehenbuehl K, Steiling H, Crozier A, Williamson G, Barron G (2010) First synthesis, characterization, and evidence for the presence of hydroxycinnamic acid sulfate and glucuronide conjugates in human biological fluids as a result of coffee consumption. Org Biomol Chem 8:5199-5211
    • (2010) Org Biomol Chem , vol.8 , pp. 5199-5211
    • Fumeaux, R.1    Menozzi-Smarrito, C.2    Stalmach, A.3    Munari, C.4    Kraehenbuehl, K.5    Steiling, H.6    Crozier, A.7    Williamson, G.8    Barron, G.9
  • 32
    • 80054080818 scopus 로고    scopus 로고
    • Development of stable isotope dilution assays for ochratoxin A in blood samples
    • 10.1016/j.ab.2011.08.032 1:CAS:528:DC%2BC3MXhtlejtb%2FI
    • Korn M, Frank O, Hofmann T, Rychlik M (2011) development of stable isotope dilution assays for ochratoxin A in blood samples. Anal Biochem 419:88-94
    • (2011) Anal Biochem , vol.419 , pp. 88-94
    • Korn, M.1    Frank, O.2    Hofmann, T.3    Rychlik, M.4
  • 33
    • 84874608976 scopus 로고    scopus 로고
    • Development and application of a stable isotope dilution analysis for the quantitation of advanced glycation end products of creatinine in biofluids of type 2 diabetic patients and healthy volunteers
    • 10.1021/ac303684v
    • Kunert C, Skurk T, Frank O, Lang R, Hauner H, Hofmann T (2013) Development and application of a stable isotope dilution analysis for the quantitation of advanced glycation end products of creatinine in biofluids of type 2 diabetic patients and healthy volunteers. Anal Chem. doi: 10.1021/ac303684v
    • (2013) Anal Chem
    • Kunert, C.1    Skurk, T.2    Frank, O.3    Lang, R.4    Hauner, H.5    Hofmann, T.6
  • 34
    • 0842330578 scopus 로고    scopus 로고
    • Determination of urinary 13C-caffeine metabolites by liquid chromatography-mass spectrometry: The use of metabolic ratios to assess CYP1A2 activity
    • 10.1016/S0731-7085(03)00528-4 1:CAS:528:DC%2BD2cXptFaqtw%3D%3D
    • Caubet MS, Comte B, Brazier JL (2004) Determination of urinary 13C-caffeine metabolites by liquid chromatography-mass spectrometry: the use of metabolic ratios to assess CYP1A2 activity. J Pharm Biomed Analysis 34:379-389
    • (2004) J Pharm Biomed Analysis , vol.34 , pp. 379-389
    • Caubet, M.S.1    Comte, B.2    Brazier, J.L.3
  • 35
    • 33846505633 scopus 로고    scopus 로고
    • Quantitative precursor studies on di- and trihydroxybenzene formation during coffee roasting using "in bean" model experiments and stable isotope dilution analysis
    • 10.1021/jf062727y
    • Müller C, Lang R, Hofmann T (2006) Quantitative precursor studies on di- and trihydroxybenzene formation during coffee roasting using "in bean" model experiments and stable isotope dilution analysis. J Agric Food Chem 54:10086-10091
    • (2006) J Agric Food Chem , vol.54 , pp. 10086-10091
    • Müller, C.1    Lang, R.2    Hofmann, T.3
  • 36
    • 0032989507 scopus 로고    scopus 로고
    • Chlorogenic acids and other cinnamates - Nature, occurrence and dietary burden
    • 10.1002/(SICI)1097-0010(19990301)79:3<362: AID-JSFA256>3.0.CO;2-D 1:CAS:528:DyaK1MXitlOlsbg%3D
    • Clifford MN (1999) Chlorogenic acids and other cinnamates - nature, occurrence and dietary burden. J Sci Foods Agric 79:362-372
    • (1999) J Sci Foods Agric , vol.79 , pp. 362-372
    • Clifford, M.N.1
  • 38
    • 0242331098 scopus 로고    scopus 로고
    • Activity-guided identification of a chemopreventive compound in coffee beverage using in vitro and in vivo techniques
    • 10.1021/jf034750e 1:CAS:528:DC%2BD3sXnslaguro%3D
    • Somoza V, Lindenmeier M, Wenzel E, Frank O, Erbersdobler HF, Hofmann T (2003) Activity-guided identification of a chemopreventive compound in coffee beverage using in vitro and in vivo techniques. J Agric Food Chem 51:6861-6869
    • (2003) J Agric Food Chem , vol.51 , pp. 6861-6869
    • Somoza, V.1    Lindenmeier, M.2    Wenzel, E.3    Frank, O.4    Erbersdobler, H.F.5    Hofmann, T.6
  • 41
    • 34948823247 scopus 로고    scopus 로고
    • 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway
    • 10.1038/sj.bjp.0707383 1:CAS:528:DC%2BD2sXhtVWhsLzI
    • Chlopicki S, Swies J, Mogielnicki A, Buczko W, Bartus W, Lomnicka M, Adamus J, Gebicki J (2007) 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/ prostacyclin pathway. BJP 152:230-239
    • (2007) BJP , vol.152 , pp. 230-239
    • Chlopicki, S.1    Swies, J.2    Mogielnicki, A.3    Buczko, W.4    Bartus, W.5    Lomnicka, M.6    Adamus, J.7    Gebicki, J.8
  • 42
    • 0242347608 scopus 로고
    • N-Methyl-4-pyridone-5-carboxamide as a metabolite of nicotinic acid in man and monkey
    • 1:STN:280:DyaF3c%2FhtFKnsQ%3D%3D
    • Chang MLW, Johnson BC (1961) N-Methyl-4-pyridone-5-carboxamide as a metabolite of nicotinic acid in man and monkey. J Biol Chem 236:2096-2098
    • (1961) J Biol Chem , vol.236 , pp. 2096-2098
    • Chang, M.L.W.1    Johnson, B.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.