Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair

DNA Repair

Volumn 12, Issue 10, 2013, Pages 856-863

  German, Peter ^a   Szaniszlo, Peter ^a   Hajas, Gyorgy ^a   Radak, Zsolt ^a   Bacsi, Attila ^a   Hazra, Tapas K ^a,b   Hegde, Muralidhar L ^a   Ba, Xueqing ^a   Boldogh, Istvan ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Base excision repair; Cell signaling; Ogg1

Indexed keywords

8 HYDROXYGUANINE; DNA GLYCOSYLTRANSFERASE; DNA GLYCOSYLTRANSFERASE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PROTEIN RAF1; RAF PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA DAMAGE; EXCISION REPAIR; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; TEMPERATURE SENSITIVITY;

BASE EXCISION REPAIR; CELL SIGNALING; OGG1;

CELL LINE; DNA GLYCOSYLASES; DNA REPAIR; GENE EXPRESSION REGULATION; GUANINE; HELA CELLS; HUMANS; OXIDATIVE STRESS; PHOSPHORYLATION; RAS PROTEINS; SIGNAL TRANSDUCTION; U937 CELLS;

EID: 84885376540     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2013.06.006     Document Type: Article

References (46)

1. Nishimura S. Involvement of mammalian OGG1(MMH) in excision of the 8-hydroxyguanine residue in DNA. Free Radic. Biol. Med. 2002, 32:813-821.
2. Shigenaga M.K., Hagen T.M., Ames B.N. Oxidative damage and mitochondrial decay in aging. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:10771-10778.
3. David S.S., O'Shea V.L., Kundu S. Base-excision repair of oxidative DNA damage. Nature 2007, 447:941-950.
4. Markesbery W.R., Lovell M.A. DNA oxidation in Alzheimer's disease. Antioxid. Redox Signal 2006, 8:2039-2045.
5. Svoboda P., Maekawa M., Kawai K., Tominaga T., Savela K., Kasai H. Urinary 8-hydroxyguanine may be a better marker of oxidative stress than 8-hydroxydeoxyguanosine in relation to the life spans of various species. Antioxid. Redox Signal 2006, 8:985-992.
6. Bruner S.D., Norman D.P., Verdine G.L. Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA. Nature 2000, 403:859-866.
7. Mitra S., Hazra T.K., Roy R., Ikeda S., Biswas T., Lock J., Boldogh I., Izumi T. Complexities of DNA base excision repair in mammalian cells. Mol. Cells 1997, 7:305-312.
8. Dizdaroglu M. Base-excision repair of oxidative DNA damage by DNA glycosylases. Mutat. Res. 2005, 591:45-59.
9. Perillo B., Ombra M.N., Bertoni A., Cuozzo C., Sacchetti S., Sasso A., Chiariotti L., Malorni A., Abbondanza C., Avvedimento E.V. DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression. Science 2008, 319:202-206.
10. Amente S., Bertoni A., Morano A., Lania L., Avvedimento E.V., Majello B. LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription. Oncogene 2011, 29:3691-3702.
11. Dantzer F., Luna L., Bjoras M., Seeberg E. Human OGG1 undergoes serine phosphorylation and associates with the nuclear matrix and mitotic chromatin in vivo. Nucleic Acids Res. 2002, 30:2349-2357.
12. Conlon K.A., Zharkov D.O., Berrios M. Cell cycle regulation of the murine 8-oxoguanine DNA glycosylase (mOGG1): mOGG1 associates with microtubules during interphase and mitosis. DNA Repair (Amst.) 2004, 3:1601-1615.
13. Boldogh I., Hajas G., Aguilera-Aguirre L., Hegde M.L., Radak Z., Bacsi A., Sur S., Hazra T.K., Mitra S. Activation of ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine. J. Biol. Chem. 2012, 287:20769-20773.
14. Hajas G., Bacsi A., Aguilera-Aguirre L., Hegde M.L., Tapas K.H., Sur S., Radak Z., Ba X., Boldogh I. 8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1. Free Radic. Biol. Med. 2013, (Epub ahead of print).
15. Hill J.W., Evans M.K. A novel R229Q OGG1 polymorphism results in a thermolabile enzyme that sensitizes KG-1 leukemia cells to DNA damaging agents. Cancer Detect. Prev. 2007, 31:237-243.
16. Saito H., Hammond A.T., Moses R.E. The effect of low oxygen tension on the in vitro-replicative life span of human diploid fibroblast cells and their transformed derivatives. Exp. Cell Res. 1995, 217:272-279.
17. Sung H.J., Ma W., Starost M.F., Lago C.U., Lim P.K., Sack M.N., Kang J.G., Wang P.Y., Hwang P.M. Ambient oxygen promotes tumorigenesis. PLoS ONE 2011, 6:e19785.
18. Ballal R., Cheema A., Ahmad W., Rosen E.M., Saha T. Fluorescent oligonucleotides can serve as suitable alternatives to radiolabeled oligonucleotides. J. Biomol. Tech. 2009, 20:190-194.
19. Bhakat K.K., Mokkapati S.K., Boldogh I., Hazra T.K., Mitra S. Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo. Mol. Cell. Biol. 2006, 26:1654-1665.
20. Taylor S.J., Resnick R.J., Shalloway D. Nonradioactive determination of Ras-GTP levels using activated ras interaction assay. Methods Enzymol. 2001, 333:333-342.
21. Bacsi A., Aguilera-Aguirre L., Szczesny B., Radak Z., Hazra T.K., Sur S., Ba X., Boldogh I. Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation. DNA Repair (Amst.) 2012, 12:18-26.
22. Smith C.C., O'Donovan M.R., Martin E.A. hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII. Mutagenesis 2006, 21:185-190.
23. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001, 25:402-408.
24. Aguilera-Aguirre L., Bacsi A., Saavedra-Molina A., Kurosky A., Sur S., Boldogh I. Mitochondrial dysfunction increases allergic airway inflammation. J. Immunol. 2009, 183:5379-5387.
25. Hyun J.W., Choi J.Y., Zeng H.H., Lee Y.S., Kim H.S., Yoon S.H., Chung M.H. Leukemic cell line, KG-1 has a functional loss of hOGG1 enzyme due to a point mutation and 8-hydroxydeoxyguanosine can kill KG-1. Oncogene 2000, 19:4476-4479.
26. Berges C., Naujokat C., Tinapp S., Wieczorek H., Hoh A., Sadeghi M., Opelz G., Daniel V. A cell line model for the differentiation of human dendritic cells. Biochem. Biophys. Res. Commun. 2005, 333:896-907.
27. D'Autreaux B., Toledano M.B. ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat. Rev. Mol. Cell Biol. 2007, 8:813-824.
28. Heo J. Redox control of GTPases: from molecular mechanisms to functional significance in health and disease. Antioxid. Redox Signal 2011, 14:689-724.
29. Hill J.W., Evans M.K. Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase. Nucleic Acids Res. 2006, 34:1620-1632.
30. de Souza-Pinto N.C., Hogue B.A., Bohr V.A. DNA repair and aging in mouse liver: 8-oxodG glycosylase activity increase in mitochondrial but not in nuclear extracts. Free Radic. Biol. Med. 2001, 30:916-923.
31. Hazra T.K., Izumi T., Boldogh I., Imhoff B., Kow Y.W., Jaruga P., Dizdaroglu M., Mitra S. Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:3523-3528.
32. Hazra T.K., Kow Y.W., Hatahet Z., Imhoff B., Boldogh I., Mokkapati S.K., Mitra S., Izumi T. Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions. J. Biol. Chem. 2002, 277:30417-30420.
33. Buday L., Downward J. Many faces of Ras activation. Biochim. Biophys. Acta 2008, 1786:178-187.
34. Bourne H.R., Sanders D.A., McCormick F. The GTPase superfamily: a conserved switch for diverse cell functions. Nature 1990, 348:125-132.
35. Boriack-Sjodin P.A., Margarit S.M., Bar-Sagi D., Kuriyan J. The structural basis of the activation of Ras by Sos. Nature 1998, 394:337-343.
36. Scheffzek K., Ahmadian M.R., Kabsch W., Wiesmuller L., Lautwein A., Schmitz F., Wittinghofer A. The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 1997, 277:333-338.
37. Chan E.Y., Stang S.L., Bottorff D.A., Stone J.C. Hypothermic stress leads to activation of Ras-Erk signaling. J. Clin. Invest. 1999, 103:1337-1344.
38. Satoh T., Fantl W.J., Escobedo J.A., Williams L.T., Kaziro Y. Platelet-derived growth factor receptor mediates activation of Ras through different signaling pathways in different cell types. Mol. Cell. Biol. 1993, 13:3706-3713.
39. Mitra S. DNA glycosylases: specificity and mechanisms. Prog. Nucleic Acid Res. Mol. Biol. 2001, 68:189-192.
40. Izumi T., Wiederhold L.R., Roy G., Roy R., Jaiswal A., Bhakat K.K., Mitra S., Hazra T.K. Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage. Toxicology 2003, 193:43-65.
41. Markus T.Z., Daube S.S., Naaman R., Fleming A.M., Muller J.G., Burrows C.J. Electronic structure of DNA - unique properties of 8-oxoguanosine. J. Am. Chem. Soc. 2009, 131:89-95.
42. Block C., Janknecht R., Herrmann C., Nassar N., Wittinghofer A. Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo. Nat. Struct. Biol. 1996, 3:244-251.
43. Kyriakis J.M., App H., Zhang X.F., Banerjee P., Brautigan D.L., Rapp U.R., Avruch J. Raf-1 activates MAP kinase-kinase. Nature 1992, 358:417-421.
44. Rodier F., Coppe J.P., Patil C.K., Hoeijmakers W.A., Munoz D.P., Raza S.R., Freund A., Campeau E., Davalos A.R., Campisi J. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat. Cell Biol. 2009, 11:973-979.
45. Chan S.W., Dedon P.C. The biological and metabolic fates of endogenous DNA damage products. J. Nucleic Acids 2010, 2010:929047.
46. Mabley J.G., Pacher P., Deb A., Wallace R., Elder R.H., Szabo C. Potential role for 8-oxoguanine DNA glycosylase in regulating inflammation. FASEB J. 2005, 19:290-292.