A novel R229Q OGG1 polymorphism results in a thermolabile enzyme that sensitizes KG-1 leukemia cells to DNA damaging agents

Cancer Detection and Prevention

Volumn 31, Issue 3, 2007, Pages 237-243

  Hill, Jeff W ^a   Evans, Michele K ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

8 Oxoguanine; KG 1; Leukemia; OGG1; Polymorphism; R229Q

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; 8 OXOGUANINE DNA GLYCOSYLASE; ANTINEOPLASTIC AGENT; DNA; DNA GLYCOSYLTRANSFERASE; MENADIONE; NUCLEOSIDE; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA DAMAGE; DRUG SENSITIZATION; ENZYME ACTIVITY; ENZYME STABILITY; GENE EXPRESSION; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; IONIZING RADIATION; LEUKEMIA CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; RADIOSENSITIZATION; STATISTICAL SIGNIFICANCE; TEMPERATURE DEPENDENCE; THERMOSTABILITY;

ALLELES; AMINO ACID SUBSTITUTION; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DEOXYGUANOSINE; DNA DAMAGE; DNA GLYCOSYLASES; GENE EXPRESSION; GUANINE; HEAT; HUMANS; LEUKEMIA; POLYMORPHISM, GENETIC; RADIATION, IONIZING; VITAMIN K 3; VITAMINS;

EID: 34547844148     PISSN: 0361090X     EISSN: 15251500     Source Type: Journal    
DOI: 10.1016/j.cdp.2007.05.001     Document Type: Article

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