Synthesis and biological evaluation of new 4β-anilino- and 4β-imido-substituted podophyllotoxin congeners

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 22, 2005, Pages 6218-6225

  Kamal, Ahmed ^a   Gayatri, N Lakshmi ^a   Rajasekhar Reddy, D ^a   Murali Mohan Reddy, P S ^a   Arifuddin, M ^a   Dastidar, Sunanda G ^b   Kondapi, Anand K ^c   Rajkumar, M ^c  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b RANBAXY RESEARCH LABORATORIES   (India)

^c UNIVERSITY OF HYDERABAD   (India)

Author keywords

DNA topoisomerase II; Etoposide; Podophyllotoxin; Substituted 2 aminobenzophenone

Indexed keywords

2'' DEOXY 2'' (DIMETHYLAMINO)ETOPOSIDE; 4' O NOR 4BETA 1'' [2'' (2 CHLOROBENZOYL) 4'' CHLOROANILINO] 4 DESOXYPODOPHYLLOTOXIN; 4' O NOR 4BETA 1'' [2'' (2 FLUOROBENZOYL) 4'' CHLOROANILINO] 4 DESOXYPODOPHYLLOTOXIN; 4' O NOR 4BETA 1'' [2'' (BENZOYL) 4'' CHLOROANILINO] 4 DESOXYPODOPHYLLOTOXIN; 4' O NOR 4BETA 1'' [2'' (BENZOYL) 4'' NITROANILINO] 4 DESOXYPODOPHYLLOTOXIN; 4' O NOR 4BETA 1'' [2'' (BENZOYL)ANILINO] 4 DESOXYPODOPHYLLOTOXIN; 4' O NOR 4BETA PHTHALIMIDO 4 DESOXYPODOPHYLLOTOXIN; 4' O NOR 4BETA SUCCINIMIDO 4 DESOXYPODOPHYLLOTOXIN; 4BETA 1'' [2'' (2 CHLOROBENZOYL) 4'' CHLOROANILINO] 4 DESOXYPODOPHYLLOTOXIN; 4BETA 1'' [2'' (2 FLUOROBENZOYL) 4'' CHLOROANILINO] 4 DESOXYPODOPHYLLOTOXIN; 4BETA 1'' [2'' (BENZOYL) 4 NITROANILINO] 4 DESOXYPODOPHYLLOTOXIN; 4BETA 1'' [2'' (BENZOYL) 4'' CHLOROANILINO] 4 DESOXYPODOPHYLLOTOXIN; 4BETA 1'' [2'' (BENZOYL)ANILINO] 4 DESOXYPODOPHYLLOTOXIN; 4BETA NAPHTHALIMIDO 4 DESOXYPODOPHYLLOTOXIN; 4BETA PHTHALIMIDO 4 DESOXYPODOPHYLLOTOXIN; 4BETA SUCCINIMIDO 4 DESOXYPODOPHYLLOTOXIN; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE INHIBITOR; ETOPOSIDE; ETOPOSIDE DERIVATIVE; PODOPHYLLOTOXIN DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; EMBRYO; ENZYME INHIBITION; HUMAN; HUMAN CELL;

ANILINE COMPOUNDS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IMIDES; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PODOPHYLLOTOXIN; PRODRUGS;

EID: 25844514216     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.06.032     Document Type: Article

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