Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 7, 2005, Pages 1915-1917

  Cao, Sheng Li ^a   Feng, Yu Ping ^b   Jiang, Yu Yang ^b   Liu, Shi Ying ^b   Ding, Guo Yu ^b   Li, Run Tao ^c  

^a CAPITAL NORMAL UNIVERSITY   (China)

^b TSINGHUA UNIVERSITY   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

4(3H) Quinazolinone; Antitumor activity; Dithiocarbamate; K562 cells

Indexed keywords

(3,4 DIHYDRO 2 METHYL 4 OXOQUINAZOLIN 6 YL)METHYL 4 (4 FLUOROPHENYL) PIPERAZINE 1 CARBODITHIOATE; DITHIOCARBAMIC ACID; METHOTREXATE; QUINAZOLINE DERIVATIVE; RALTITREXED; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN K 562; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; LEUKEMIA CELL;

EID: 15044361072     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.01.083     Document Type: Article

References (14)

1. N.J. Curtin, and A.N. Hughes Lancet Oncol. 2 2001 298
2. P.R. Marsham, L.R. Hughes, A.L. Jackman, A.J. Hayter, J. Oldfield, J.M. Wardleworth, J.A.M. Bishop, B.M. O'Connor, and A.H. Calvert J. Med. Chem. 34 1991 1594
3. D. Cunningham, J. Zalcberg, J. Maroun, R. James, S. Clarke, T.S. Maughan, M. Vincent, J. Schulz, M.G. Baron, and T. Facchini Eur. J. Cancer 38 2002 478
4. V. Bavetsias, A.L. Jackman, R. Kimbell, W. Gibson, F.T. Boyle, and G.M.F. Bisset J. Med. Chem. 39 1996 73
5. S. Webber, C.A. Bartlett, T.J. Boritzki, J.A. Hilliard, E.F. Howland, A.L. Johnston, M. Kosa, S.A. Margosiak, C.A. Morse, and B.V. Shetty Cancer Chemother. Pharmacol. 37 1996 509
6. P.R. Marsham, J.M. Wardleworth, F.T. Boyle, L.F. Hennequin, R. Kimbell, M. Brown, and A.L. Jackman J. Med. Chem. 42 1999 3809
7. R.M. Moriarty, R.G. Mehta, and J. Liu Carcinogenesis 16 1995 399
8. C. Gerhauser, M. You, and J.M. Pezzuto Cancer Res. 57 1997 272
9. Li, R. T.; Cheng, T. M.; Cui, J. R. C. N. Patent 01118399.3, 2004
10. W. Guo, F.X. Ran, R.Q. Wang, J.R. Cui, R.T. Li, T.M. Cheng, and Z.M. Ge Chin. J. Clin. Pharmacol. Ther. 9 2004 59
11. S.L. Cao, and X.Q. Ma Huaxue Shiji 26 2004 27
12. R.T. Li, Z.M. Ge, T.M. Cheng, and M.S. Cai Chem. J. Chin. Univ. 20 1999 1897
13. Y.L. Niu, Y.Y. Jiang, S.L. Cao, W. Du, and Y.F. Zhao Chin. Sci. Bull. 48 2003 869
14. 2: C 58.86%, H 4.94%, N 13.07%. Found: C 58.84%, H 4.99%, N 12.93%