Semi-synthesis and biological evaluation of 1,2,3-triazole-based podophyllotoxin congeners as potent antitumor agents inducing apoptosis in HepG2 cells

Archiv der Pharmazie

Volumn 345, Issue 12, 2012, Pages 945-956

  Chen, Jinying ^a   Ma, Liang ^a   Zhang, Ronghong ^a   Tang, Jie ^b   Lai, Huijun ^b   Wang, Jun ^a   Wang, Guangcheng ^a   Xu, Qinyuan ^a   Chen, Tao ^a   Peng, Fei ^a   Qiu, Jingxiang ^a   Liang, Xiaolin ^a   Cao, Dong ^a   Ran, Yan ^a   Peng, Aihua ^a   Wei, Yuquan ^a   Chen, Lijuan ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Antitumor activity; Cell cycle; Docking study; G2 M phase; Podophyllotoxin congeners

Indexed keywords

4BETA (4 ARYL) 1,2,3 TRIAZOLE 1 YL)PODOPHYLLOTOXIN; 4BETA [[4 ((1,1' BIPHENYL)4 YLOXY)METHYL] 1H 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [[4 ((3,4 DIMETHOXYPHENYL)THIO)METHYL] 1H 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [[4 ((4 (3,4 DIMETHOXYPHENYL)ACRYLOYL) 2 METHOXYPHENOXY)METHYL] 1H 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [[4 ((4 METHOXYPHENYL)THIO)METHYL] 1H 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [[4 (4 (3 (4 FLUOROPHENYL)ACRYLOYL) 2 METHOXYPHENOXY)METHYL] 1H 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [[4 (BENZO[D][1,3]DIOXOL 5 YLOXY)METHYL] 1H 1,2,3 TRIAZOL 1 YL] 4 DESOXYPODOPHYLLOTOXIN; ADENOSINE TRIPHOSPHATASE; ANTINEOPLASTIC AGENT; ETOPOSIDE; PODOPHYLLOTOXIN DERIVATIVE; TENIPOSIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN HEPG2; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MOLECULAR DOCKING; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CLICK CHEMISTRY; DRUG SCREENING ASSAYS, ANTITUMOR; HEP G2 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; PODOPHYLLOTOXIN; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84870510528     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201100438     Document Type: Article

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