Synthesis and evaluation of new quinazolone derivatives of nalidixic acid as potential antibacterial and antifungal agents

European Journal of Medicinal Chemistry

Volumn 41, Issue 2, 2006, Pages 256-262

  Grover, Gaurav ^a   Kini, Suvarna G ^b  

^a Clinical Research and Medical Services   (India)

^b MANIPAL COLLEGE OF PHARMACEUTICAL SCIENCES   (India)

Author keywords

Aeromonas hydrophila; Candida albicans; Coagulase negative Staphylococcus; Iodo quinazolinone derivative of nalidixic acid (IQN); Nalidixic acid hydrazide (NAH); Proteus vulgaris; Quinazolinone derivative of nalidixic acid (QN); Streptococcus pyogenes

Indexed keywords

6 IODO BENZOXAZINE; 6 NITRO BENZOXAZINE; ACENANTHRANIL; ACETIC ANHYDRIDE; AGAR; ALCOHOL; ANTHRANILIC ACID; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; BENZOXAZINE DERIVATIVE; CHLORIDE; ESTER DERIVATIVE; HYDRAZINE; METHANOL; METHYL ESTER; NALIDIXIC ACID; NALIDIXIC ACID HYDRAZIDE; NALIDIXOYL CHLORIDE; NITRIC ACID; QUINAZOLINONE DERIVATIVE; SULFURIC ACID; THIONYL CHLORIDE; UNCLASSIFIED DRUG;

ACYLATION; ADDITION REACTION; AEROMONAS HYDROPHILA; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CANDIDA; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONTROLLED STUDY; DIARRHEA; DILUTION; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROBACTERIACEAE; IMMUNE DEFICIENCY; INFRARED SPECTROSCOPY; LABORATORY; NITRATION; NONHUMAN; OPPORTUNISTIC INFECTION; PROTEUS VULGARIS; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOCOCCUS PYOGENES; TEMPERATURE MEASUREMENT;

ADULT; AMPICILLIN; ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CHILD; HUMANS; MICROBIAL SENSITIVITY TESTS; NALIDIXIC ACID; QUINAZOLINES; SPECTRUM ANALYSIS; STREPTOCOCCUS PYOGENES; URINARY TRACT INFECTIONS;

EID: 33644944329     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.09.002     Document Type: Article

References (14)

1. R. Albrecht Development of antibacterial agents of the nalidixic acid type Prog. Drug Res. 21 1977 9 104
2. American Medical Association-Drug Evaluations-Fifth Edition, (1747-1749).
3. Goodmann and Gilmann, Text Book of Pharmacology, Sixth Edition, (1120-1121).
4. P.Y. Shirodkar, and M. Vartak Meghna Synthesis, biological evaluation and QSAR evaluation of Mannic bases of 6-nitro-quinazolones Indian J. Heterocyclic Chem. 9 2000 239 240
5. V.K. Pandey, D. Misra, and A. Shukla Synthesis and antiviral activity if 2-aryl-5-[3′-2′-methyl-6:8 substituted-quinazolyl)-phenyl], pyrazoles Indian Drugs 31 11 1994 532 536
6. N.C. Desai, B.R. Shah, J.J. Bhatt, H.H. Patel, N.K. Undavia, P.B. Trivedi, and V. Narayanan Synthesis of 2,3-disubstituted-3,1-quinazolin-4 (4H)-ones as potential anticancer and anti-HIV agents Indian J. Chem. 34B 1995 201 208
7. L.M. Werbel, E.F. Elslager, and L.S. Newton J. Heterocyclic Chem. 1987 24
8. N.B. Patel, and J.D. Lilakar Synthesis of new substituted-4-(3H)- quinazolinones and their antibacterial activity Indian J. Heterocyclic Chem. 11 2001 85 86
9. R. Ashok Antimicrobials in Laboratory Medicine 2000 B. I. Churchill Livingstone 62 70
10. G. Gaurav, and S.G. Kini Synthesis and Evaluation of certain new 1,3,4-oxadiazole derivatives of Nalidixic acid moiety as potential Antifungal and Antibacterial agents Indian J. Heterocyclic Chem. 12 3 2003 289 290 (Jan-March)
11. S. Parmar Surendra, and R.C. Arora Some 2,3,6,8-tetrasubstituted quinazolone hydrazides as monoamine oxidase inhibitors European J. Org. Chem. 10 1967 1182 1183
12. K.R. Desai, and N.M. Naik Reactive disperse dyes: synthesis of sulphonylazido group reactive disperse dyes and their application on nylon and polyester fibres J. Indian Chem. Soc. 66 1989 495 496
13. S.G. Abdel-Hamide Synthesis of some new quinazoline derivatives Indian J. Hetrocyclic Chem. 10 2000 59 64
14. A. Waheed, and S.A. Khan Synthesis of certain substituted 1,2 Pyrazolines from nalidixic acid as Antibacterial and Analgesic agents Indian J. Hetrocyclic Chem. 11 2001 59 62 (July-Sept.)