메뉴 건너뛰기




Volumn 17, Issue 5, 2013, Pages 287-297

Pancreatic cancer genomes: Toward molecular subtyping and novel approaches to diagnosis and therapy

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

EID: 84885123394     PISSN: 11771062     EISSN: 11792000     Source Type: Journal    
DOI: 10.1007/s40291-013-0043-6     Document Type: Review
Times cited : (9)

References (106)
  • 2
    • 33751207530 scopus 로고    scopus 로고
    • Fourth Series, Fascicle 6 ed. AFIP Atlas of Tumor Pathology. Washington, D.C.: American Registry of Pathology
    • Hruban RH, Pitman MB, Klimstra DS. Tumors of the pancreas. Fourth Series, Fascicle 6 ed. AFIP Atlas of Tumor Pathology. Washington, D.C.: American Registry of Pathology; 2007.
    • (2007) Tumors of the Pancreas
    • Hruban, R.H.1    Pitman, M.B.2    Klimstra, D.S.3
  • 3
    • 0023735997 scopus 로고
    • KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas
    • 3047672 10.1093/nar/16.16.7773 1:CAS:528:DyaL1cXls1Crtr8%3D
    • Smit VT, Boot AJ, Smits AM, Fleuren GJ, Cornelisse CJ, Bos JL. KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas. Nucleic Acids Res. 1988;16(16):7773-82.
    • (1988) Nucleic Acids Res , vol.16 , Issue.16 , pp. 7773-7782
    • Smit, V.T.1    Boot, A.J.2    Smits, A.M.3    Fleuren, G.J.4    Cornelisse, C.J.5    Bos, J.L.6
  • 4
    • 0024292722 scopus 로고
    • Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
    • 2453289 10.1016/0092-8674(88)90571-5 1:CAS:528:DyaL1cXksV2nsbs%3D
    • Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 1988;53(4):549-54.
    • (1988) Cell , vol.53 , Issue.4 , pp. 549-554
    • Almoguera, C.1    Shibata, D.2    Forrester, K.3    Martin, J.4    Arnheim, N.5    Perucho, M.6
  • 5
    • 0029125820 scopus 로고
    • K-ras mutation and pancreatic adenocarcinoma
    • 7594765 1:CAS:528:DyaK2MXosF2gtrc%3D
    • Caldas C, Kern SE. K-ras mutation and pancreatic adenocarcinoma. Int J Pancreatol. 1995;18(1):1-6.
    • (1995) Int J Pancreatol , vol.18 , Issue.1 , pp. 1-6
    • Caldas, C.1    Kern, S.E.2
  • 6
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • 10.1126/science.1164368 18772397 10.1126/science.1164368 1:CAS:528:DC%2BD1cXhtFCrtLrL
    • Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008;321(5897):1801-6. doi: 10.1126/science.1164368.
    • (2008) Science , vol.321 , Issue.5897 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3    Lin, J.C.4    Leary, R.J.5    Angenendt, P.6
  • 7
    • 0028268635 scopus 로고
    • K-ras and p53 gene mutations in pancreatic cancer: Ductal and nonductal tumors progress through different genetic lesions
    • 8137263 1:CAS:528:DyaK2cXitFCjtb8%3D
    • Pellegata NS, Sessa F, Renault B, Bonato M, Leone BE, Solcia E, et al. K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions. Cancer Res. 1994;54(6):1556-60.
    • (1994) Cancer Res , vol.54 , Issue.6 , pp. 1556-1560
    • Pellegata, N.S.1    Sessa, F.2    Renault, B.3    Bonato, M.4    Leone, B.E.5    Solcia, E.6
  • 8
    • 0027733796 scopus 로고
    • K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization
    • 8342602 1:STN:280:DyaK3szktlaisA%3D%3D
    • Hruban RH, van Mansfeld AD, Offerhaus GJ, van Weering DH, Allison DC, Goodman SN, et al. K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol. 1993;143(2):545-54.
    • (1993) Am J Pathol , vol.143 , Issue.2 , pp. 545-554
    • Hruban, R.H.1    Van Mansfeld, A.D.2    Offerhaus, G.J.3    Van Weering, D.H.4    Allison, D.C.5    Goodman, S.N.6
  • 9
    • 41749100127 scopus 로고    scopus 로고
    • Pancreatic cancer
    • 10.1146/annurev.pathmechdis.3.121806.154305 18039136 10.1146/annurev. pathmechdis.3.121806.154305 1:CAS:528:DC%2BD1cXjsFers7Y%3D
    • Maitra A, Hruban RH. Pancreatic cancer. Annu Rev Pathol. 2008;3:157-88. doi: 10.1146/annurev.pathmechdis.3.121806.154305.
    • (2008) Annu Rev Pathol , vol.3 , pp. 157-188
    • Maitra, A.1    Hruban, R.H.2
  • 10
    • 26444580829 scopus 로고    scopus 로고
    • Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma
    • 10.1186/1471-230x-5-22 15985168 10.1186/1471-230X-5-22
    • Attri J, Srinivasan R, Majumdar S, Radotra BD, Wig J. Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma. BMC Gastroenterol. 2005;5:22. doi: 10.1186/1471-230x-5-22.
    • (2005) BMC Gastroenterol , vol.5 , pp. 22
    • Attri, J.1    Srinivasan, R.2    Majumdar, S.3    Radotra, B.D.4    Wig, J.5
  • 11
    • 0028059330 scopus 로고
    • Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
    • 10.1038/ng0994-27 7726912 10.1038/ng0994-27 1:CAS:528:DyaK2cXmtVajsL0%3D
    • Caldas C, Hahn SA, da Costa LT, Redston MS, Schutte M, Seymour AB, et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet. 1994;8(1):27-32. doi: 10.1038/ng0994-27.
    • (1994) Nat Genet , vol.8 , Issue.1 , pp. 27-32
    • Caldas, C.1    Hahn, S.A.2    Da Costa, L.T.3    Redston, M.S.4    Schutte, M.5    Seymour, A.B.6
  • 12
    • 16944367477 scopus 로고    scopus 로고
    • Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas
    • 9242437 1:CAS:528:DyaK2sXkvFKru78%3D
    • Schutte M, Hruban RH, Geradts J, Maynard R, Hilgers W, Rabindran SK, et al. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res. 1997;57(15):3126-30.
    • (1997) Cancer Res , vol.57 , Issue.15 , pp. 3126-3130
    • Schutte, M.1    Hruban, R.H.2    Geradts, J.3    Maynard, R.4    Hilgers, W.5    Rabindran, S.K.6
  • 14
    • 0030593038 scopus 로고    scopus 로고
    • DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
    • 8553070 10.1126/science.271.5247.350 1:CAS:528:DyaK28XlsFartg%3D%3D
    • Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science. 1996;271(5247):350-3.
    • (1996) Science , vol.271 , Issue.5247 , pp. 350-353
    • Hahn, S.A.1    Schutte, M.2    Hoque, A.T.3    Moskaluk, C.A.4    Da Costa, L.T.5    Rozenblum, E.6
  • 15
    • 13444274253 scopus 로고    scopus 로고
    • Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: A meta-analysis
    • 10.1593/neo.04445 15720814 10.1593/neo.04445
    • Lohr M, Kloppel G, Maisonneuve P, Lowenfels AB, Luttges J. Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis. Neoplasia. 2005;7(1):17-23. doi: 10.1593/neo.04445.
    • (2005) Neoplasia , vol.7 , Issue.1 , pp. 17-23
    • Lohr, M.1    Kloppel, G.2    Maisonneuve, P.3    Lowenfels, A.B.4    Luttges, J.5
  • 16
    • 0033842724 scopus 로고    scopus 로고
    • BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: Evidence and implications
    • 10.1016/s0002-9440(10)65047-x 10793087 10.1016/S0002-9440(10)65047-X 1:CAS:528:DC%2BD3cXjslKksrc%3D
    • Goggins M, Hruban RH, Kern SE. BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implications. Am J Pathol. 2000;156(5):1767-71. doi: 10.1016/s0002-9440(10)65047-x.
    • (2000) Am J Pathol , vol.156 , Issue.5 , pp. 1767-1771
    • Goggins, M.1    Hruban, R.H.2    Kern, S.E.3
  • 17
    • 0030988302 scopus 로고    scopus 로고
    • P16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma
    • 9187111 1:CAS:528:DyaK2sXjslGisbw%3D
    • Moskaluk CA, Hruban RH, Kern SE. p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res. 1997;57(11):2140-3.
    • (1997) Cancer Res , vol.57 , Issue.11 , pp. 2140-2143
    • Moskaluk, C.A.1    Hruban, R.H.2    Kern, S.E.3
  • 18
    • 61349100218 scopus 로고    scopus 로고
    • KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: Implications for the human pancreatic cancer cell of origin
    • 10.1158/1541-7786.mcr-08-0206 19208745 10.1158/1541-7786.MCR-08-0206 1:CAS:528:DC%2BD1MXitlWgtro%3D
    • Shi C, Hong SM, Lim P, Kamiyama H, Khan M, Anders RA, et al. KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin. Mol Cancer Res. 2009;7(2):230-6. doi: 10.1158/1541-7786.mcr-08-0206.
    • (2009) Mol Cancer Res , vol.7 , Issue.2 , pp. 230-236
    • Shi, C.1    Hong, S.M.2    Lim, P.3    Kamiyama, H.4    Khan, M.5    Anders, R.A.6
  • 19
    • 0141742113 scopus 로고    scopus 로고
    • Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray
    • 10.1097/01.mp.0000086072.56290.fb 13679454 10.1097/01.MP.0000086072. 56290.FB
    • Maitra A, Adsay NV, Argani P, Iacobuzio-Donahue C, De Marzo A, Cameron JL, et al. Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. Mod Pathol. 2003;16(9):902-12. doi: 10.1097/01.mp.0000086072.56290.fb.
    • (2003) Mod Pathol , vol.16 , Issue.9 , pp. 902-912
    • Maitra, A.1    Adsay, N.V.2    Argani, P.3    Iacobuzio-Donahue, C.4    De Marzo, A.5    Cameron, J.L.6
  • 20
    • 0032532379 scopus 로고    scopus 로고
    • Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: Loss of intranuclear expression
    • 9788631 1:CAS:528:DyaK1cXmslWrtrw%3D
    • Wilentz RE, Geradts J, Maynard R, Offerhaus GJ, Kang M, Goggins M, et al. Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression. Cancer Res. 1998;58(20):4740-4.
    • (1998) Cancer Res , vol.58 , Issue.20 , pp. 4740-4744
    • Wilentz, R.E.1    Geradts, J.2    Maynard, R.3    Offerhaus, G.J.4    Kang, M.5    Goggins, M.6
  • 21
    • 84862777152 scopus 로고    scopus 로고
    • Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia
    • e9. doi: 10.1053/j.gastro.2011.12.042
    • Kanda M, Matthaei H, Wu J, Hong SM, Yu J, Borges M, et al. Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia. Gastroenterology. 2012;142(4):730-3 e9. doi: 10.1053/j.gastro.2011.12.042.
    • (2012) Gastroenterology , vol.142 , Issue.4 , pp. 730-733
    • Kanda, M.1    Matthaei, H.2    Wu, J.3    Hong, S.M.4    Yu, J.5    Borges, M.6
  • 22
    • 0034032009 scopus 로고    scopus 로고
    • Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression
    • 10766191 1:CAS:528:DC%2BD3cXisVymsr0%3D
    • Wilentz RE, Iacobuzio-Donahue CA, Argani P, McCarthy DM, Parsons JL, Yeo CJ, et al. Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res. 2000;60(7):2002-6.
    • (2000) Cancer Res , vol.60 , Issue.7 , pp. 2002-2006
    • Wilentz, R.E.1    Iacobuzio-Donahue, C.A.2    Argani, P.3    McCarthy, D.M.4    Parsons, J.L.5    Yeo, C.J.6
  • 23
    • 0036841802 scopus 로고    scopus 로고
    • Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia
    • 10.1016/s0002-9440(10)64432-x 12414502 10.1016/S0002-9440(10)64432-X
    • van Heek NT, Meeker AK, Kern SE, Yeo CJ, Lillemoe KD, Cameron JL, et al. Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia. Am J Pathol. 2002;161(5):1541-7. doi: 10.1016/s0002-9440(10)64432-x.
    • (2002) Am J Pathol , vol.161 , Issue.5 , pp. 1541-1547
    • Van Heek, N.T.1    Meeker, A.K.2    Kern, S.E.3    Yeo, C.J.4    Lillemoe, K.D.5    Cameron, J.L.6
  • 24
    • 84867347114 scopus 로고    scopus 로고
    • Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing
    • 10.1371/journal.pone.0043192 23071490 10.1371/journal.pone.0043192 1:CAS:528:DC%2BC38XhsFOrsrzF
    • Liang WS, Craig DW, Carpten J, Borad MJ, Demeure MJ, Weiss GJ, et al. Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing. PloS ONE. 2012;7(10):e43192. doi: 10.1371/journal.pone. 0043192.
    • (2012) PloS ONE , vol.7 , Issue.10 , pp. 43192
    • Liang, W.S.1    Craig, D.W.2    Carpten, J.3    Borad, M.J.4    Demeure, M.J.5    Weiss, G.J.6
  • 25
    • 84869091997 scopus 로고    scopus 로고
    • Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
    • 10.1038/nature11547 23103869 10.1038/nature11547 1:CAS:528: DC%2BC38XhsFOmt7jN
    • Biankin AV, Waddell N, Kassahn KS, Gingras MC, Muthuswamy LB, Johns AL, et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature. 2012;491(7424):399-405. doi: 10.1038/nature11547.
    • (2012) Nature , vol.491 , Issue.7424 , pp. 399-405
    • Biankin, A.V.1    Waddell, N.2    Kassahn, K.S.3    Gingras, M.C.4    Muthuswamy, L.B.5    Johns, A.L.6
  • 26
    • 45349107664 scopus 로고    scopus 로고
    • Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection
    • 10.4161/cbt.7.3.5362 1:CAS:528:DC%2BD1cXpvFGmtro%3D
    • Shi C, Fukushima N, Abe T, Bian Y, Hua L, Wendelburg BJ, et al. Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection. Cancer Biol Therapy. 2008;7(3):353-60.
    • (2008) Cancer Biol Therapy , vol.7 , Issue.3 , pp. 353-360
    • Shi, C.1    Fukushima, N.2    Abe, T.3    Bian, Y.4    Hua, L.5    Wendelburg, B.J.6
  • 27
    • 0036239123 scopus 로고    scopus 로고
    • K-ras, p53, and DPC4 (MAD4) alterations in fine-needle aspirates of the pancreas: A molecular panel correlates with and supplements cytologic diagnosis
    • 10.1309/5rq0-jcqu-5xf2-51lq 12090425 10.1309/5RQ0-JCQU-5XF2-51LQ
    • van Heek T, Rader AE, Offerhaus GJ, McCarthy DM, Goggins M, Hruban RH, et al. K-ras, p53, and DPC4 (MAD4) alterations in fine-needle aspirates of the pancreas: a molecular panel correlates with and supplements cytologic diagnosis. Am J Clin Pathol. 2002;117(5):755-65. doi: 10.1309/5rq0-jcqu-5xf2-51lq.
    • (2002) Am J Clin Pathol , vol.117 , Issue.5 , pp. 755-765
    • Van Heek, T.1    Rader, A.E.2    Offerhaus, G.J.3    McCarthy, D.M.4    Goggins, M.5    Hruban, R.H.6
  • 28
    • 17944382039 scopus 로고    scopus 로고
    • Immunohistochemical labeling for the Dpc4 gene product is a specific marker for adenocarcinoma in biopsy specimens of the pancreas and bile duct
    • 10.1309/wf03-nfce-7brh-7c26 11764071 10.1309/WF03-NFCE-7BRH-7C26 1:STN:280:DC%2BD38%2FjvVSjtg%3D%3D
    • Tascilar M, Offerhaus GJ, Altink R, Argani P, Sohn TA, Yeo CJ, et al. Immunohistochemical labeling for the Dpc4 gene product is a specific marker for adenocarcinoma in biopsy specimens of the pancreas and bile duct. Am J Clin Pathol. 2001;116(6):831-7. doi: 10.1309/wf03-nfce-7brh-7c26.
    • (2001) Am J Clin Pathol , vol.116 , Issue.6 , pp. 831-837
    • Tascilar, M.1    Offerhaus, G.J.2    Altink, R.3    Argani, P.4    Sohn, T.A.5    Yeo, C.J.6
  • 29
    • 0033891752 scopus 로고    scopus 로고
    • Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas: A new marker of DPC4 inactivation
    • 10.1016/s0002-9440(10)64703-7 10623651 10.1016/S0002-9440(10)64703-7 1:CAS:528:DC%2BD3cXns1ymtA%3D%3D
    • Wilentz RE, Su GH, Dai JL, Sparks AB, Argani P, Sohn TA, et al. Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas: a new marker of DPC4 inactivation. Am J Pathol. 2000;156(1):37-43. doi: 10.1016/s0002-9440(10)64703-7.
    • (2000) Am J Pathol , vol.156 , Issue.1 , pp. 37-43
    • Wilentz, R.E.1    Su, G.H.2    Dai, J.L.3    Sparks, A.B.4    Argani, P.5    Sohn, T.A.6
  • 30
    • 68049115773 scopus 로고    scopus 로고
    • SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer
    • 10.1158/1078-0432.ccr-09-0227 19584151 10.1158/1078-0432.CCR-09-0227 1:CAS:528:DC%2BD1MXosV2ltLg%3D
    • Blackford A, Serrano OK, Wolfgang CL, Parmigiani G, Jones S, Zhang X, et al. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res. 2009;15(14):4674-9. doi: 10.1158/1078-0432.ccr-09-0227.
    • (2009) Clin Cancer Res , vol.15 , Issue.14 , pp. 4674-4679
    • Blackford, A.1    Serrano, O.K.2    Wolfgang, C.L.3    Parmigiani, G.4    Jones, S.5    Zhang, X.6
  • 31
    • 78049398107 scopus 로고    scopus 로고
    • Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    • 10.1038/nature09515 20981102 10.1038/nature09515 1:CAS:528: DC%2BC3cXhtlCjtrvI
    • Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature. 2010;467(7319):1114-7. doi: 10.1038/nature09515.
    • (2010) Nature , vol.467 , Issue.7319 , pp. 1114-1117
    • Yachida, S.1    Jones, S.2    Bozic, I.3    Antal, T.4    Leary, R.5    Fu, B.6
  • 33
    • 11144353646 scopus 로고    scopus 로고
    • Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds
    • 15059921 10.1158/0008-5472.CAN-03-3823 1:CAS:528:DC%2BD2cXis1yju7s%3D
    • Klein AP, Brune KA, Petersen GM, Goggins M, Tersmette AC, Offerhaus GJ, et al. Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds. Cancer Res. 2004;64(7):2634-8.
    • (2004) Cancer Res , vol.64 , Issue.7 , pp. 2634-2638
    • Klein, A.P.1    Brune, K.A.2    Petersen, G.M.3    Goggins, M.4    Tersmette, A.C.5    Offerhaus, G.J.6
  • 34
    • 0037420026 scopus 로고    scopus 로고
    • BRCA2 germline mutations in familial pancreatic carcinoma
    • 12569143 10.1093/jnci/95.3.214 1:CAS:528:DC%2BD3sXit1emsL0%3D
    • Hahn SA, Greenhalf B, Ellis I, Sina-Frey M, Rieder H, Korte B, et al. BRCA2 germline mutations in familial pancreatic carcinoma. J Natl Cancer Inst. 2003;95(3):214-21.
    • (2003) J Natl Cancer Inst , vol.95 , Issue.3 , pp. 214-221
    • Hahn, S.A.1    Greenhalf, B.2    Ellis, I.3    Sina-Frey, M.4    Rieder, H.5    Korte, B.6
  • 35
    • 33847762750 scopus 로고    scopus 로고
    • The prevalence of BRCA2 mutations in familial pancreatic cancer
    • 10.1158/1055-9965.epi-06-0783 17301269 10.1158/1055-9965.EPI-06-0783 1:CAS:528:DC%2BD2sXhs1ylsLY%3D
    • Couch FJ, Johnson MR, Rabe KG, Brune K, de Andrade M, Goggins M, et al. The prevalence of BRCA2 mutations in familial pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2007;16(2):342-6. doi: 10.1158/1055-9965.epi-06-0783.
    • (2007) Cancer Epidemiol Biomarkers Prev , vol.16 , Issue.2 , pp. 342-346
    • Couch, F.J.1    Johnson, M.R.2    Rabe, K.G.3    Brune, K.4    De Andrade, M.5    Goggins, M.6
  • 36
    • 64849092309 scopus 로고    scopus 로고
    • Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene
    • 10.1126/science.1171202 19264984 10.1126/science.1171202 1:CAS:528:DC%2BD1MXktFalsr0%3D
    • Jones S, Hruban RH, Kamiyama M, Borges M, Zhang X, Parsons DW, et al. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science. 2009;324(5924):217. doi: 10.1126/science.1171202.
    • (2009) Science , vol.324 , Issue.5924 , pp. 217
    • Jones, S.1    Hruban, R.H.2    Kamiyama, M.3    Borges, M.4    Zhang, X.5    Parsons, D.W.6
  • 37
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • 10.1056/NEJMoa0900212 19553641 10.1056/NEJMoa0900212 1:CAS:528: DC%2BD1MXosVKrtrw%3D
    • Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med. 2009;361(2):123-34. doi: 10.1056/NEJMoa0900212.
    • (2009) N Engl J Med , vol.361 , Issue.2 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3    Tutt, A.4    Wu, P.5    Mergui-Roelvink, M.6
  • 38
    • 0029102927 scopus 로고
    • Brief report: A familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene
    • 10.1056/nejm199510123331505 7666917 10.1056/NEJM199510123331505 1:CAS:528:DyaK2MXpsVSltrY%3D
    • Whelan AJ, Bartsch D, Goodfellow PJ. Brief report: a familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene. N Engl J Med. 1995;333(15):975-7. doi: 10.1056/nejm199510123331505.
    • (1995) N Engl J Med , vol.333 , Issue.15 , pp. 975-977
    • Whelan, A.J.1    Bartsch, D.2    Goodfellow, P.J.3
  • 39
    • 0029129816 scopus 로고
    • Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations
    • 10.1056/nejm199510123331504 7666916 10.1056/NEJM199510123331504 1:STN:280:DyaK2Mzps1ekug%3D%3D
    • Goldstein AM, Fraser MC, Struewing JP, Hussussian CJ, Ranade K, Zametkin DP, et al. Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations. N Engl J Med. 1995;333(15):970-4. doi: 10.1056/ nejm199510123331504.
    • (1995) N Engl J Med , vol.333 , Issue.15 , pp. 970-974
    • Goldstein, A.M.1    Fraser, M.C.2    Struewing, J.P.3    Hussussian, C.J.4    Ranade, K.5    Zametkin, D.P.6
  • 40
    • 58149229703 scopus 로고    scopus 로고
    • Increased risk of cancer other than melanoma in CDKN2A founder mutation (p16-Leiden)-positive melanoma families
    • 10.1158/1078-0432.ccr-08-0403 18981015 10.1158/1078-0432.CCR-08-0403
    • de Snoo FA, Bishop DT, Bergman W, van Leeuwen I, van der Drift C, van Nieuwpoort FA, et al. Increased risk of cancer other than melanoma in CDKN2A founder mutation (p16-Leiden)-positive melanoma families. Clin Cancer Res. 2008;14(21):7151-7. doi: 10.1158/1078-0432.ccr-08-0403.
    • (2008) Clin Cancer Res , vol.14 , Issue.21 , pp. 7151-7157
    • De Snoo, F.A.1    Bishop, D.T.2    Bergman, W.3    Van Leeuwen, I.4    Van Der Drift, C.5    Van Nieuwpoort, F.A.6
  • 41
    • 79952742260 scopus 로고    scopus 로고
    • Prevalence of CDKN2A mutations in pancreatic cancer patients: Implications for genetic counseling
    • 10.1038/ejhg.2010.198 21150883 10.1038/ejhg.2010.198 1:CAS:528: DC%2BC3MXjsVCku7Y%3D
    • McWilliams RR, Wieben ED, Rabe KG, Pedersen KS, Wu Y, Sicotte H, et al. Prevalence of CDKN2A mutations in pancreatic cancer patients: implications for genetic counseling. Eur J Hum Genet. 2011;19(4):472-8. doi: 10.1038/ejhg.2010. 198.
    • (2011) Eur J Hum Genet , vol.19 , Issue.4 , pp. 472-478
    • McWilliams, R.R.1    Wieben, E.D.2    Rabe, K.G.3    Pedersen, K.S.4    Wu, Y.5    Sicotte, H.6
  • 42
    • 0036895738 scopus 로고    scopus 로고
    • CDKN2A germline mutations in familial pancreatic cancer
    • 10.1097/01.sla.0000036393.89509.4e 12454511 10.1097/00000658-200212000- 00005
    • Bartsch DK, Sina-Frey M, Lang S, Wild A, Gerdes B, Barth P, et al. CDKN2A germline mutations in familial pancreatic cancer. Ann Surg. 2002;236(6):730-7. doi: 10.1097/01.sla.0000036393.89509.4e.
    • (2002) Ann Surg , vol.236 , Issue.6 , pp. 730-737
    • Bartsch, D.K.1    Sina-Frey, M.2    Lang, S.3    Wild, A.4    Gerdes, B.5    Barth, P.6
  • 43
    • 0023192463 scopus 로고
    • Increased risk of cancer in the Peutz-Jeghers syndrome
    • 10.1056/nejm198706113162404 3587280 10.1056/NEJM198706113162404 1:STN:280:DyaL2s3ivVylsw%3D%3D
    • Giardiello FM, Welsh SB, Hamilton SR, Offerhaus GJ, Gittelsohn AM, Booker SV, et al. Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med. 1987;316(24):1511-4. doi: 10.1056/nejm198706113162404.
    • (1987) N Engl J Med , vol.316 , Issue.24 , pp. 1511-1514
    • Giardiello, F.M.1    Welsh, S.B.2    Hamilton, S.R.3    Offerhaus, G.J.4    Gittelsohn, A.M.5    Booker, S.V.6
  • 44
    • 0032984141 scopus 로고    scopus 로고
    • Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers
    • 10.1016/s0002-9440(10)65440-5 10362809 10.1016/S0002-9440(10)65440-5 1:CAS:528:DyaK1MXjvFGrtL0%3D
    • Su GH, Hruban RH, Bansal RK, Bova GS, Tang DJ, Shekher MC, et al. Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. Am J Pathol. 1999;154(6):1835-40. doi: 10.1016/s0002-9440(10)65440-5.
    • (1999) Am J Pathol , vol.154 , Issue.6 , pp. 1835-1840
    • Su, G.H.1    Hruban, R.H.2    Bansal, R.K.3    Bova, G.S.4    Tang, D.J.5    Shekher, M.C.6
  • 45
    • 10144246566 scopus 로고    scopus 로고
    • Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene
    • 10.1038/ng1096-141 8841182 10.1038/ng1096-141 1:CAS:528: DyaK28XmtVKnt7g%3D
    • Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MJ, Ulrich CD, et al. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet. 1996;14(2):141-5. doi: 10.1038/ng1096-141.
    • (1996) Nat Genet , vol.14 , Issue.2 , pp. 141-145
    • Whitcomb, D.C.1    Gorry, M.C.2    Preston, R.A.3    Furey, W.4    Sossenheimer, M.J.5    Ulrich, C.D.6
  • 46
    • 0034039578 scopus 로고    scopus 로고
    • Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis
    • 10.1038/76088 10835640 10.1038/76088 1:CAS:528:DC%2BD3cXjvFOgtLk%3D
    • Witt H, Luck W, Hennies HC, Classen M, Kage A, Lass U, et al. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet. 2000;25(2):213-6. doi: 10.1038/76088.
    • (2000) Nat Genet , vol.25 , Issue.2 , pp. 213-216
    • Witt, H.1    Luck, W.2    Hennies, H.C.3    Classen, M.4    Kage, A.5    Lass, U.6
  • 47
    • 68149173367 scopus 로고    scopus 로고
    • Hereditary pancreatitis: Clinical features and inheritance characteristics of the R122C mutation in the cationic trypsinogen gene (PRSS1) in six Spanish families
    • 19454815
    • de las Heras-Castano G, Castro-Senosiain B, Fontalba A, Lopez-Hoyos M, Sanchez-Juan P. Hereditary pancreatitis: clinical features and inheritance characteristics of the R122C mutation in the cationic trypsinogen gene (PRSS1) in six Spanish families. JOP. 2009;10(3):249-55.
    • (2009) JOP , vol.10 , Issue.3 , pp. 249-255
    • De Las Heras-Castano, G.1    Castro-Senosiain, B.2    Fontalba, A.3    Lopez-Hoyos, M.4    Sanchez-Juan, P.5
  • 48
    • 0027294719 scopus 로고
    • Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group
    • 10.1056/nejm199305203282001 8479461 10.1056/NEJM199305203282001 1:STN:280:DyaK3s3ktFahug%3D%3D
    • Lowenfels AB, Maisonneuve P, Cavallini G, Ammann RW, Lankisch PG, Andersen JR, et al. Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N Engl J Med. 1993;328(20):1433-7. doi: 10.1056/nejm199305203282001.
    • (1993) N Engl J Med , vol.328 , Issue.20 , pp. 1433-1437
    • Lowenfels, A.B.1    Maisonneuve, P.2    Cavallini, G.3    Ammann, R.W.4    Lankisch, P.G.5    Andersen, J.R.6
  • 49
    • 0030975440 scopus 로고    scopus 로고
    • Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group
    • 9091646 10.1093/jnci/89.6.442 1:STN:280:DyaK2s3ivVWhug%3D%3D
    • Lowenfels AB, Maisonneuve P, DiMagno EP, Elitsur Y, Gates LK Jr, Perrault J, et al. Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group. J Natl Cancer Inst. 1997;89(6):442-6.
    • (1997) J Natl Cancer Inst , vol.89 , Issue.6 , pp. 442-446
    • Lowenfels, A.B.1    Maisonneuve, P.2    Dimagno, E.P.3    Elitsur, Y.4    Gates, Jr.L.K.5    Perrault, J.6
  • 50
    • 84863830403 scopus 로고    scopus 로고
    • ATM mutations in patients with hereditary pancreatic cancer
    • 10.1158/2159-8290.cd-11-0194 22585167 10.1158/2159-8290.CD-11-0194 1:CAS:528:DC%2BC38XmtlKgsQ%3D%3D
    • Roberts NJ, Jiao Y, Yu J, Kopelovich L, Petersen GM, Bondy ML, et al. ATM mutations in patients with hereditary pancreatic cancer. Cancer Discov. 2012;2(1):41-6. doi: 10.1158/2159-8290.cd-11-0194.
    • (2012) Cancer Discov , vol.2 , Issue.1 , pp. 41-46
    • Roberts, N.J.1    Jiao, Y.2    Yu, J.3    Kopelovich, L.4    Petersen, G.M.5    Bondy, M.L.6
  • 51
    • 79960660466 scopus 로고    scopus 로고
    • Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development
    • 92ra66 doi: 10.1126/scitranslmed.3002543
    • Wu J, Matthaei H, Maitra A, Dal Molin M, Wood LD, Eshleman JR, et al. Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development. Sci Transl Med. 2011;3(92):92ra66. doi: 10.1126/scitranslmed. 3002543.
    • (2011) Sci Transl Med. , vol.3 , pp. 92
    • Wu, J.1    Matthaei, H.2    Maitra, A.3    Dal Molin, M.4    Wood, L.D.5    Eshleman, J.R.6
  • 52
    • 0036110390 scopus 로고    scopus 로고
    • Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma
    • 12010891 10.1136/gut.50.6.861 1:CAS:528:DC%2BD38XkvVGktLw%3D
    • Biankin AV, Biankin SA, Kench JG, Morey AL, Lee CS, Head DR, et al. Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma. Gut. 2002;50(6):861-8.
    • (2002) Gut , vol.50 , Issue.6 , pp. 861-868
    • Biankin, A.V.1    Biankin, S.A.2    Kench, J.G.3    Morey, A.L.4    Lee, C.S.5    Head, D.R.6
  • 53
    • 0033807873 scopus 로고    scopus 로고
    • P53 protein expression in intraductal papillary mucinous tumors (IPMT) of the pancreas as an indicator of tumor malignancy
    • 11020860 1:STN:280:DC%2BD3cvmslCktA%3D%3D
    • Kawahira H, Kobayashi S, Kaneko K, Asano T, Ochiai T. p53 protein expression in intraductal papillary mucinous tumors (IPMT) of the pancreas as an indicator of tumor malignancy. Hepatogastroenterology. 2000;47(34):973-7.
    • (2000) Hepatogastroenterology , vol.47 , Issue.34 , pp. 973-977
    • Kawahira, H.1    Kobayashi, S.2    Kaneko, K.3    Asano, T.4    Ochiai, T.5
  • 54
    • 0029921032 scopus 로고    scopus 로고
    • K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas
    • 8740403 10.1097/00006676-199605000-00007 1:STN:280:DyaK28zhtVClsw%3D%3D
    • Satoh K, Shimosegawa T, Moriizumi S, Koizumi M, Toyota T. K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas. Pancreas. 1996;12(4):362-8.
    • (1996) Pancreas , vol.12 , Issue.4 , pp. 362-368
    • Satoh, K.1    Shimosegawa, T.2    Moriizumi, S.3    Koizumi, M.4    Toyota, T.5
  • 55
    • 58749096579 scopus 로고    scopus 로고
    • Histologic, immunohistochemical, and molecular classification of 52 IPMNs of the pancreas
    • 10.1097/PAI.0b013e31817c02c6 18813127 10.1097/PAI.0b013e31817c02c6 1:CAS:528:DC%2BD1cXhsFajtL7J
    • Chadwick B, Willmore-Payne C, Tripp S, Layfield LJ, Hirschowitz S, Holden J. Histologic, immunohistochemical, and molecular classification of 52 IPMNs of the pancreas. Appl Immunohistochem Mol Morphol. 2009;17(1):31-9. doi: 10.1097/PAI.0b013e31817c02c6.
    • (2009) Appl Immunohistochem Mol Morphol , vol.17 , Issue.1 , pp. 31-39
    • Chadwick, B.1    Willmore-Payne, C.2    Tripp, S.3    Layfield, L.J.4    Hirschowitz, S.5    Holden, J.6
  • 56
    • 79952069133 scopus 로고    scopus 로고
    • High-throughput mutation profiling in intraductal papillary mucinous neoplasm (IPMN)
    • 10.1007/s11605-010-1411-8 21225475 10.1007/s11605-010-1411-8
    • Lubezky N, Ben-Haim M, Marmor S, Brazowsky E, Rechavi G, Klausner JM, et al. High-throughput mutation profiling in intraductal papillary mucinous neoplasm (IPMN). J Gastrointest Surg. 2011;15(3):503-11. doi: 10.1007/s11605-010-1411-8.
    • (2011) J Gastrointest Surg , vol.15 , Issue.3 , pp. 503-511
    • Lubezky, N.1    Ben-Haim, M.2    Marmor, S.3    Brazowsky, E.4    Rechavi, G.5    Klausner, J.M.6
  • 57
    • 0034495006 scopus 로고    scopus 로고
    • Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: Comparison with conventional ductal adenocarcinomas
    • 10.1016/s0002-9440(10)64589-0 10980115 10.1016/S0002-9440(10)64589-0 1:CAS:528:DC%2BD3cXmvFWqt74%3D
    • Iacobuzio-Donahue CA, Klimstra DS, Adsay NV, Wilentz RE, Argani P, Sohn TA, et al. Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas. Am J Pathol. 2000;157(3):755-61. doi: 10.1016/s0002-9440(10)64589-0.
    • (2000) Am J Pathol , vol.157 , Issue.3 , pp. 755-761
    • Iacobuzio-Donahue, C.A.1    Klimstra, D.S.2    Adsay, N.V.3    Wilentz, R.E.4    Argani, P.5    Sohn, T.A.6
  • 58
    • 84859757956 scopus 로고    scopus 로고
    • Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas
    • 10.1038/srep00161 22355676 10.1038/srep00161
    • Furukawa T, Kuboki Y, Tanji E, Yoshida S, Hatori T, Yamamoto M, et al. Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas. Sci Rep. 2011;1:161. doi: 10.1038/srep00161.
    • (2011) Sci Rep , vol.1 , pp. 161
    • Furukawa, T.1    Kuboki, Y.2    Tanji, E.3    Yoshida, S.4    Hatori, T.5    Yamamoto, M.6
  • 59
    • 84862907854 scopus 로고    scopus 로고
    • Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
    • 10.1073/pnas.1118046108 22158988 10.1073/pnas.1118046108 1:CAS:528:DC%2BC38XnvVGhuw%3D%3D
    • Wu J, Jiao Y, Dal Molin M, Maitra A, de Wilde RF, Wood LD, et al. Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci USA. 2011;108(52):21188-93. doi: 10.1073/pnas.1118046108.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.52 , pp. 21188-21193
    • Wu, J.1    Jiao, Y.2    Dal Molin, M.3    Maitra, A.4    De Wilde, R.F.5    Wood, L.D.6
  • 60
    • 45549106185 scopus 로고    scopus 로고
    • Mutational analyses of multiple oncogenic pathways in intraductal papillary mucinous neoplasms of the pancreas
    • 10.1097/MPA.0b013e318158a4d2 18376308 10.1097/MPA.0b013e318158a4d2 1:CAS:528:DC%2BD1cXjt1eqsLc%3D
    • Schonleben F, Allendorf JD, Qiu W, Li X, Ho DJ, Ciau NT, et al. Mutational analyses of multiple oncogenic pathways in intraductal papillary mucinous neoplasms of the pancreas. Pancreas. 2008;36(2):168-72. doi: 10.1097/MPA.0b013e318158a4d2.
    • (2008) Pancreas , vol.36 , Issue.2 , pp. 168-172
    • Schonleben, F.1    Allendorf, J.D.2    Qiu, W.3    Li, X.4    Ho, D.J.5    Ciau, N.T.6
  • 61
    • 43349105069 scopus 로고    scopus 로고
    • PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas
    • 10.1007/s00423-008-0285-7 18343945 10.1007/s00423-008-0285-7
    • Schonleben F, Qiu W, Remotti HE, Hohenberger W, Su GH. PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas. Langenbecks Arch Surg. 2008;393(3):289-96. doi: 10.1007/s00423-008-0285-7.
    • (2008) Langenbecks Arch Surg , vol.393 , Issue.3 , pp. 289-296
    • Schonleben, F.1    Qiu, W.2    Remotti, H.E.3    Hohenberger, W.4    Su, G.H.5
  • 62
    • 0035184065 scopus 로고    scopus 로고
    • STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas
    • 10.1016/s0002-9440(10)63053-2 11733352 10.1016/S0002-9440(10)63053-2 1:CAS:528:DC%2BD38XhslarsA%3D%3D
    • Sato N, Rosty C, Jansen M, Fukushima N, Ueki T, Yeo CJ, et al. STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas. Am J Pathol. 2001;159(6):2017-22. doi: 10.1016/s0002-9440(10) 63053-2.
    • (2001) Am J Pathol , vol.159 , Issue.6 , pp. 2017-2022
    • Sato, N.1    Rosty, C.2    Jansen, M.3    Fukushima, N.4    Ueki, T.5    Yeo, C.J.6
  • 63
    • 0025942634 scopus 로고
    • C-Ki-ras point mutations in ductectatic-type mucinous cystic neoplasms of the pancreas
    • 1955373 10.1111/j.1349-7006.1991.tb01756.x 1:STN:280: DyaK38%2FmsVGgsA%3D%3D
    • Yanagisawa A, Kato Y, Ohtake K, Kitagawa T, Ohashi K, Hori M, et al. c-Ki-ras point mutations in ductectatic-type mucinous cystic neoplasms of the pancreas. Jpn J Cancer Res. 1991;82(10):1057-60.
    • (1991) Jpn J Cancer Res , vol.82 , Issue.10 , pp. 1057-1060
    • Yanagisawa, A.1    Kato, Y.2    Ohtake, K.3    Kitagawa, T.4    Ohashi, K.5    Hori, M.6
  • 64
    • 0033497531 scopus 로고    scopus 로고
    • Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy
    • (discussion 9-11)
    • Jimenez RE, Warshaw AL, Z'Graggen K, Hartwig W, Taylor DZ, Compton CC, et al. Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy. Ann Surg. 1999;230(4):501-9 (discussion 9-11).
    • (1999) Ann Surg. , vol.230 , Issue.4 , pp. 501-509
    • Jimenez, R.E.1    Warshaw, A.L.2    Z'Graggen, K.3    Hartwig, W.4    Taylor, D.Z.5    Compton, C.C.6
  • 65
    • 0242522859 scopus 로고    scopus 로고
    • Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas
    • 10.1097/01.mp.0000094088.37888.a6 14614047 10.1097/01.MP.0000094088. 37888.A6
    • Kim SG, Wu TT, Lee JH, Yun YK, Issa JP, Hamilton SR, et al. Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas. Mod Pathol. 2003;16(11):1086-94. doi: 10.1097/01.mp.0000094088.37888.a6.
    • (2003) Mod Pathol , vol.16 , Issue.11 , pp. 1086-1094
    • Kim, S.G.1    Wu, T.T.2    Lee, J.H.3    Yun, Y.K.4    Issa, J.P.5    Hamilton, S.R.6
  • 66
    • 0036447148 scopus 로고    scopus 로고
    • Clonality and K-ras mutation analyses of epithelia in intraductal papillary mucinous tumor and mucinous cystic tumor of the pancreas
    • 10.1007/s00428-002-0645-6 12447672 10.1007/s00428-002-0645-6 1:CAS:528:DC%2BD3sXos1emuw%3D%3D
    • Yoshizawa K, Nagai H, Sakurai S, Hironaka M, Morinaga S, Saitoh K, et al. Clonality and K-ras mutation analyses of epithelia in intraductal papillary mucinous tumor and mucinous cystic tumor of the pancreas. Virchows Arch. 2002;441(5):437-43. doi: 10.1007/s00428-002-0645-6.
    • (2002) Virchows Arch , vol.441 , Issue.5 , pp. 437-443
    • Yoshizawa, K.1    Nagai, H.2    Sakurai, S.3    Hironaka, M.4    Morinaga, S.5    Saitoh, K.6
  • 67
    • 17644412007 scopus 로고    scopus 로고
    • Mucinous cystic carcinoma of the pancreas: A unique cell line and xenograft model of a preinvasive lesion
    • 10.1007/s00428-004-1167-1 15688169 10.1007/s00428-004-1167-1
    • Sorio C, Capelli P, Lissandrini D, Moore PS, Balzarini P, Falconi M, et al. Mucinous cystic carcinoma of the pancreas: a unique cell line and xenograft model of a preinvasive lesion. Virchows Arch. 2005;446(3):239-45. doi: 10.1007/s00428-004-1167-1.
    • (2005) Virchows Arch , vol.446 , Issue.3 , pp. 239-245
    • Sorio, C.1    Capelli, P.2    Lissandrini, D.3    Moore, P.S.4    Balzarini, P.5    Falconi, M.6
  • 68
    • 0036209038 scopus 로고    scopus 로고
    • The mucin profile of noninvasive and invasive mucinous cystic neoplasms of the pancreas
    • 11914624 10.1097/00000478-200204000-00008 1:STN:280: DC%2BD387otFGksQ%3D%3D
    • Luttges J, Feyerabend B, Buchelt T, Pacena M, Kloppel G. The mucin profile of noninvasive and invasive mucinous cystic neoplasms of the pancreas. Am J Surg Pathol. 2002;26(4):466-71.
    • (2002) Am J Surg Pathol , vol.26 , Issue.4 , pp. 466-471
    • Luttges, J.1    Feyerabend, B.2    Buchelt, T.3    Pacena, M.4    Kloppel, G.5
  • 69
    • 0033759142 scopus 로고    scopus 로고
    • Dpc4 protein in mucinous cystic neoplasms of the pancreas: Frequent loss of expression in invasive carcinomas suggests a role in genetic progression
    • 11075857 10.1097/00000478-200011000-00011 1:STN:280: DC%2BD3M%2FjtlGrsg%3D%3D
    • Iacobuzio-Donahue CA, Wilentz RE, Argani P, Yeo CJ, Cameron JL, Kern SE, et al. Dpc4 protein in mucinous cystic neoplasms of the pancreas: frequent loss of expression in invasive carcinomas suggests a role in genetic progression. Am J Surg Pathol. 2000;24(11):1544-8.
    • (2000) Am J Surg Pathol , vol.24 , Issue.11 , pp. 1544-1548
    • Iacobuzio-Donahue, C.A.1    Wilentz, R.E.2    Argani, P.3    Yeo, C.J.4    Cameron, J.L.5    Kern, S.E.6
  • 70
    • 0035139644 scopus 로고    scopus 로고
    • Molecular characterization of pancreatic serous microcystic adenomas: Evidence for a tumor suppressor gene on chromosome 10q
    • 10.1016/s0002-9440(10)63971-5 11141506 10.1016/S0002-9440(10)63971-5 1:CAS:528:DC%2BD3MXmsFOjtA%3D%3D
    • Moore PS, Zamboni G, Brighenti A, Lissandrini D, Antonello D, Capelli P, et al. Molecular characterization of pancreatic serous microcystic adenomas: evidence for a tumor suppressor gene on chromosome 10q. Am J Pathol. 2001;158(1):317-21. doi: 10.1016/s0002-9440(10)63971-5.
    • (2001) Am J Pathol , vol.158 , Issue.1 , pp. 317-321
    • Moore, P.S.1    Zamboni, G.2    Brighenti, A.3    Lissandrini, D.4    Antonello, D.5    Capelli, P.6
  • 71
    • 0031962921 scopus 로고    scopus 로고
    • Immunohistochemical and molecular biological studies of serous cystadenoma of the pancreas
    • 9436861 10.1097/00006676-199801000-00007 1:STN:280:DyaK1c%2Fpslelsw%3D%3D
    • Ishikawa T, Nakao A, Nomoto S, Hosono J, Harada A, Nonami T, et al. Immunohistochemical and molecular biological studies of serous cystadenoma of the pancreas. Pancreas. 1998;16(1):40-4.
    • (1998) Pancreas , vol.16 , Issue.1 , pp. 40-44
    • Ishikawa, T.1    Nakao, A.2    Nomoto, S.3    Hosono, J.4    Harada, A.5    Nonami, T.6
  • 72
    • 0030880947 scopus 로고    scopus 로고
    • Allelic deletion and mutation of the von Hippel-Lindau (VHL) tumor suppressor gene in pancreatic microcystic adenomas
    • 9327728 1:CAS:528:DyaK2sXmvFGmtbc%3D
    • Vortmeyer AO, Lubensky IA, Fogt F, Linehan WM, Khettry U, Zhuang Z. Allelic deletion and mutation of the von Hippel-Lindau (VHL) tumor suppressor gene in pancreatic microcystic adenomas. Am J Pathol. 1997;151(4):951-6.
    • (1997) Am J Pathol , vol.151 , Issue.4 , pp. 951-956
    • Vortmeyer, A.O.1    Lubensky, I.A.2    Fogt, F.3    Linehan, W.M.4    Khettry, U.5    Zhuang, Z.6
  • 73
    • 0036105502 scopus 로고    scopus 로고
    • Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations
    • 11943721 10.1016/S0002-9440(10)62563-1 1:CAS:528:DC%2BD38XjsFGjtrc%3D
    • Abraham SC, Klimstra DS, Wilentz RE, Yeo CJ, Conlon K, Brennan M, et al. Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations. Am J Pathol. 2002;160(4):1361-9.
    • (2002) Am J Pathol , vol.160 , Issue.4 , pp. 1361-1369
    • Abraham, S.C.1    Klimstra, D.S.2    Wilentz, R.E.3    Yeo, C.J.4    Conlon, K.5    Brennan, M.6
  • 74
    • 0035156850 scopus 로고    scopus 로고
    • Pancreatic tumours: Molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis
    • 10.1054/bjoc.2000.1567 11161385 10.1054/bjoc.2000.1567 1:CAS:528:DC%2BD3MXht1Wgsr0%3D
    • Moore PS, Orlandini S, Zamboni G, Capelli P, Rigaud G, Falconi M, et al. Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis. Br J Cancer. 2001;84(2):253-62. doi: 10.1054/bjoc.2000.1567.
    • (2001) Br J Cancer , vol.84 , Issue.2 , pp. 253-262
    • Moore, P.S.1    Orlandini, S.2    Zamboni, G.3    Capelli, P.4    Rigaud, G.5    Falconi, M.6
  • 75
    • 33749073592 scopus 로고    scopus 로고
    • Accumulation of beta-catenin protein, mutations in exon-3 of the beta-catenin gene and a loss of heterozygosity of 5q22 in solid pseudopapillary tumor of the pancreas
    • doi: 10.1002/jso.20509
    • Min Kim S, Sun CD, Park KC, Kim HG, Lee WJ, Choi SH. Accumulation of beta-catenin protein, mutations in exon-3 of the beta-catenin gene and a loss of heterozygosity of 5q22 in solid pseudopapillary tumor of the pancreas. J Surg Oncol. 2006;94(5):418-25. doi: 10.1002/jso.20509.
    • (2006) J Surg Oncol. , vol.94 , Issue.5 , pp. 418-425
    • Min Kim, S.1    Sun, C.D.2    Park, K.C.3    Kim, H.G.4    Lee, W.J.5    Choi, S.H.6
  • 76
    • 0035577867 scopus 로고    scopus 로고
    • Frequent beta-catenin mutation and cytoplasmic/nuclear accumulation in pancreatic solid-pseudopapillary neoplasm
    • 11731417 1:CAS:528:DC%2BD3MXptFCktLs%3D
    • Tanaka Y, Kato K, Notohara K, Hojo H, Ijiri R, Miyake T, et al. Frequent beta-catenin mutation and cytoplasmic/nuclear accumulation in pancreatic solid-pseudopapillary neoplasm. Cancer Res. 2001;61(23):8401-4.
    • (2001) Cancer Res , vol.61 , Issue.23 , pp. 8401-8404
    • Tanaka, Y.1    Kato, K.2    Notohara, K.3    Hojo, H.4    Ijiri, R.5    Miyake, T.6
  • 77
    • 38149027162 scopus 로고    scopus 로고
    • Impaired E-cadherin expression and glutamine synthetase overexpression in solid pseudopapillary neoplasm of the pancreas
    • 10.1097/mpa.0b013e318137a9da 18192886 10.1097/mpa.0b013e318137a9da 1:CAS:528:DC%2BD1cXhtVCgsLw%3D
    • Audard V, Cavard C, Richa H, Infante M, Couvelard A, Sauvanet A, et al. Impaired E-cadherin expression and glutamine synthetase overexpression in solid pseudopapillary neoplasm of the pancreas. Pancreas. 2008;36(1):80-3. doi: 10.1097/mpa.0b013e318137a9da.
    • (2008) Pancreas , vol.36 , Issue.1 , pp. 80-83
    • Audard, V.1    Cavard, C.2    Richa, H.3    Infante, M.4    Couvelard, A.5    Sauvanet, A.6
  • 79
    • 2142768216 scopus 로고    scopus 로고
    • Diagnosis of pancreatic cystic neoplasms: A report of the cooperative pancreatic cyst study
    • 15131794 10.1053/j.gastro.2004.02.013
    • Brugge WR, Lewandrowski K, Lee-Lewandrowski E, Centeno BA, Szydlo T, Regan S, et al. Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study. Gastroenterology. 2004;126(5):1330-6.
    • (2004) Gastroenterology , vol.126 , Issue.5 , pp. 1330-1336
    • Brugge, W.R.1    Lewandrowski, K.2    Lee-Lewandrowski, E.3    Centeno, B.A.4    Szydlo, T.5    Regan, S.6
  • 80
    • 33748073452 scopus 로고    scopus 로고
    • K-Ras and microsatellite marker analysis of fine-needle aspirates from intraductal papillary mucinous neoplasms of the pancreas
    • 10.1002/dc.20511 16900481 10.1002/dc.20511
    • Schoedel KE, Finkelstein SD, Ohori NP. K-Ras and microsatellite marker analysis of fine-needle aspirates from intraductal papillary mucinous neoplasms of the pancreas. Diagn Cytopathol. 2006;34(9):605-8. doi: 10.1002/dc.20511.
    • (2006) Diagn Cytopathol , vol.34 , Issue.9 , pp. 605-608
    • Schoedel, K.E.1    Finkelstein, S.D.2    Ohori, N.P.3
  • 81
    • 26244468907 scopus 로고    scopus 로고
    • The role of pancreatic cyst fluid molecular analysis in predicting cyst pathology
    • 16234041 10.1016/S1542-3565(05)00409-X 1:CAS:528:DC%2BD2MXhtFyltLbK
    • Khalid A, McGrath KM, Zahid M, Wilson M, Brody D, Swalsky P, et al. The role of pancreatic cyst fluid molecular analysis in predicting cyst pathology. Clin Gastroenterol Hepatol. 2005;3(10):967-73.
    • (2005) Clin Gastroenterol Hepatol , vol.3 , Issue.10 , pp. 967-973
    • Khalid, A.1    McGrath, K.M.2    Zahid, M.3    Wilson, M.4    Brody, D.5    Swalsky, P.6
  • 82
    • 65349151178 scopus 로고    scopus 로고
    • Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: A report of the PANDA study
    • 10.1016/j.gie.2008.07.033 19152896 10.1016/j.gie.2008.07.033
    • Khalid A, Zahid M, Finkelstein SD, LeBlanc JK, Kaushik N, Ahmad N, et al. Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study. Gastrointest Endosc. 2009;69(6):1095-102. doi: 10.1016/j.gie.2008.07.033.
    • (2009) Gastrointest Endosc , vol.69 , Issue.6 , pp. 1095-1102
    • Khalid, A.1    Zahid, M.2    Finkelstein, S.D.3    Leblanc, J.K.4    Kaushik, N.5    Ahmad, N.6
  • 83
    • 79952279828 scopus 로고    scopus 로고
    • DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors
    • 10.1126/science.1200609 21252315 10.1126/science.1200609 1:CAS:528:DC%2BC3MXislOku70%3D
    • Jiao Y, Shi C, Edil BH, de Wilde RF, Klimstra DS, Maitra A, et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science. 2011;331(6021):1199-203. doi: 10.1126/science.1200609.
    • (2011) Science , vol.331 , Issue.6021 , pp. 1199-1203
    • Jiao, Y.1    Shi, C.2    Edil, B.H.3    De Wilde, R.F.4    Klimstra, D.S.5    Maitra, A.6
  • 84
    • 0032005227 scopus 로고    scopus 로고
    • Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, malignant tumors of the endocrine pancreas
    • 9458074 1:CAS:528:DyaK1cXnsFaqug%3D%3D
    • Hessman O, Lindberg D, Skogseid B, Carling T, Hellman P, Rastad J, et al. Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, malignant tumors of the endocrine pancreas. Cancer Res. 1998;58(3):377-9.
    • (1998) Cancer Res , vol.58 , Issue.3 , pp. 377-379
    • Hessman, O.1    Lindberg, D.2    Skogseid, B.3    Carling, T.4    Hellman, P.5    Rastad, J.6
  • 85
    • 0344699339 scopus 로고    scopus 로고
    • Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms
    • 10.1016/s0002-9440(10)65289-3 10027401 10.1016/S0002-9440(10)65289-3 1:CAS:528:DyaK1MXjtVCqtr4%3D
    • Gortz B, Roth J, Krahenmann A, de Krijger RR, Muletta-Feurer S, Rutimann K, et al. Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms. Am J Pathol. 1999;154(2):429-36. doi: 10.1016/s0002-9440(10)65289-3.
    • (1999) Am J Pathol , vol.154 , Issue.2 , pp. 429-436
    • Gortz, B.1    Roth, J.2    Krahenmann, A.3    De Krijger, R.R.4    Muletta-Feurer, S.5    Rutimann, K.6
  • 86
    • 0030810185 scopus 로고    scopus 로고
    • Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas
    • 9354421 1:CAS:528:DyaK2sXnt12gtbo%3D
    • Zhuang Z, Vortmeyer AO, Pack S, Huang S, Pham TA, Wang C, et al. Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas. Cancer Res. 1997;57(21):4682-6.
    • (1997) Cancer Res , vol.57 , Issue.21 , pp. 4682-4686
    • Zhuang, Z.1    Vortmeyer, A.O.2    Pack, S.3    Huang, S.4    Pham, T.A.5    Wang, C.6
  • 87
    • 0031586496 scopus 로고    scopus 로고
    • Mutations in the MEN i gene in sporadic neuroendocrine tumours of gastroenteropancreatic system
    • 10.1016/s0140-6736(05)63453-8 9652567 10.1016/S0140-6736(05)63453-8 1:STN:280:DyaK1czhsVKktw%3D%3D
    • Toliat MR, Berger W, Ropers HH, Neuhaus P, Wiedenmann B. Mutations in the MEN I gene in sporadic neuroendocrine tumours of gastroenteropancreatic system. Lancet. 1997;350(9086):1223. doi: 10.1016/s0140-6736(05)63453-8.
    • (1997) Lancet , vol.350 , Issue.9086 , pp. 1223
    • Toliat, M.R.1    Berger, W.2    Ropers, H.H.3    Neuhaus, P.4    Wiedenmann, B.5
  • 88
    • 0032190114 scopus 로고    scopus 로고
    • Mutation of the MENIN gene in sporadic pancreatic endocrine tumors
    • 9766672 1:CAS:528:DyaK1cXmsVyqtr0%3D
    • Wang EH, Ebrahimi SA, Wu AY, Kashefi C, Passaro E Jr, Sawicki MP. Mutation of the MENIN gene in sporadic pancreatic endocrine tumors. Cancer Res. 1998;58(19):4417-20.
    • (1998) Cancer Res , vol.58 , Issue.19 , pp. 4417-4420
    • Wang, E.H.1    Ebrahimi, S.A.2    Wu, A.Y.3    Kashefi, C.4    Passaro, Jr.E.5    Sawicki, M.P.6
  • 89
    • 17344363260 scopus 로고    scopus 로고
    • Characterization of mutations in patients with multiple endocrine neoplasia type 1
    • 10.1086/301729 9463336 10.1086/301729 1:CAS:528:DyaK1cXhslGjs70%3D
    • Bassett JH, Forbes SA, Pannett AA, Lloyd SE, Christie PT, Wooding C, et al. Characterization of mutations in patients with multiple endocrine neoplasia type 1. Am J Hum Genet. 1998;62(2):232-44. doi: 10.1086/301729.
    • (1998) Am J Hum Genet , vol.62 , Issue.2 , pp. 232-244
    • Bassett, J.H.1    Forbes, S.A.2    Pannett, A.A.3    Lloyd, S.E.4    Christie, P.T.5    Wooding, C.6
  • 90
    • 79960700556 scopus 로고    scopus 로고
    • Altered telomeres in tumors with ATRX and DAXX mutations
    • 10.1126/science.1207313 21719641 10.1126/science.1207313 1:CAS:528:DC%2BC3MXovF2mtb8%3D
    • Heaphy CM, de Wilde RF, Jiao Y, Klein AP, Edil BH, Shi C, et al. Altered telomeres in tumors with ATRX and DAXX mutations. Science. 2011;333(6041):425. doi: 10.1126/science.1207313.
    • (2011) Science , vol.333 , Issue.6041 , pp. 425
    • Heaphy, C.M.1    De Wilde, R.F.2    Jiao, Y.3    Klein, A.P.4    Edil, B.H.5    Shi, C.6
  • 91
    • 0031015729 scopus 로고    scopus 로고
    • Telomerase activity is detected in pancreatic cancer but not in benign tumors
    • 9000577 1:CAS:528:DyaK2sXntFKgsg%3D%3D
    • Hiyama E, Kodama T, Shinbara K, Iwao T, Itoh M, Hiyama K, et al. Telomerase activity is detected in pancreatic cancer but not in benign tumors. Cancer Res. 1997;57(2):326-31.
    • (1997) Cancer Res , vol.57 , Issue.2 , pp. 326-331
    • Hiyama, E.1    Kodama, T.2    Shinbara, K.3    Iwao, T.4    Itoh, M.5    Hiyama, K.6
  • 92
    • 84863474126 scopus 로고    scopus 로고
    • Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors
    • 10.1038/modpathol.2012.53 22575867
    • de Wilde RF, Heaphy CM, Maitra A, Meeker AK, Edil BH, Wolfgang CL, et al. Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors. Mod Pathol. 2012;. doi: 10.1038/modpathol.2012.53.
    • (2012) Mod Pathol
    • De Wilde, R.F.1    Heaphy, C.M.2    Maitra, A.3    Meeker, A.K.4    Edil, B.H.5    Wolfgang, C.L.6
  • 93
    • 0032529238 scopus 로고    scopus 로고
    • Localization of putative tumor suppressor loci by genome-wide allelotyping in human pancreatic endocrine tumors
    • 9721882 1:CAS:528:DyaK1cXlsFajtLg%3D
    • Chung DC, Brown SB, Graeme-Cook F, Tillotson LG, Warshaw AL, Jensen RT, et al. Localization of putative tumor suppressor loci by genome-wide allelotyping in human pancreatic endocrine tumors. Cancer Res. 1998;58(16):3706-11.
    • (1998) Cancer Res , vol.58 , Issue.16 , pp. 3706-3711
    • Chung, D.C.1    Brown, S.B.2    Graeme-Cook, F.3    Tillotson, L.G.4    Warshaw, A.L.5    Jensen, R.T.6
  • 94
    • 13244284719 scopus 로고    scopus 로고
    • BRAF gene mutations are rare events in gastroenteropancreatic neuroendocrine tumors
    • 15842051 10.1309/YQBR9C05RU4DD3RN 1:CAS:528:DC%2BD2MXhvFGntr4%3D
    • Tannapfel A, Vomschloss S, Karhoff D, Markwarth A, Hengge UR, Wittekind C, et al. BRAF gene mutations are rare events in gastroenteropancreatic neuroendocrine tumors. Am J Clin Pathol. 2005;123(2):256-60.
    • (2005) Am J Clin Pathol , vol.123 , Issue.2 , pp. 256-260
    • Tannapfel, A.1    Vomschloss, S.2    Karhoff, D.3    Markwarth, A.4    Hengge, U.R.5    Wittekind, C.6
  • 95
    • 72549083643 scopus 로고    scopus 로고
    • VHL inactivation is an important pathway for the development of malignant sporadic pancreatic endocrine tumors
    • 10.1677/erc-08-0297 19690016 10.1677/ERC-08-0297 1:CAS:528: DC%2BC3cXhtFOgu7c%3D
    • Schmitt AM, Schmid S, Rudolph T, Anlauf M, Prinz C, Kloppel G, et al. VHL inactivation is an important pathway for the development of malignant sporadic pancreatic endocrine tumors. Endocr Relat Cancer. 2009;16(4):1219-27. doi: 10.1677/erc-08-0297.
    • (2009) Endocr Relat Cancer , vol.16 , Issue.4 , pp. 1219-1227
    • Schmitt, A.M.1    Schmid, S.2    Rudolph, T.3    Anlauf, M.4    Prinz, C.5    Kloppel, G.6
  • 96
    • 79851500081 scopus 로고    scopus 로고
    • Everolimus for advanced pancreatic neuroendocrine tumors
    • 10.1056/NEJMoa1009290 21306238 10.1056/NEJMoa1009290 1:CAS:528: DC%2BC3MXhvVyiu7s%3D
    • Yao JC, Shah MH, Ito T, Bohas CL, Wolin EM, Van Cutsem E, et al. Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med. 2011;364(6):514-23. doi: 10.1056/NEJMoa1009290.
    • (2011) N Engl J Med , vol.364 , Issue.6 , pp. 514-523
    • Yao, J.C.1    Shah, M.H.2    Ito, T.3    Bohas, C.L.4    Wolin, E.M.5    Van Cutsem, E.6
  • 97
    • 0028829658 scopus 로고
    • Pancreatoblastoma. A clinicopathologic study and review of the literature
    • 7503360 10.1097/00000478-199512000-00005 1:STN:280:DyaK28%2FotlKktA%3D%3D
    • Klimstra DS, Wenig BM, Adair CF, Heffess CS. Pancreatoblastoma. A clinicopathologic study and review of the literature. Am J Surg Pathol. 1995;19(12):1371-89.
    • (1995) Am J Surg Pathol , vol.19 , Issue.12 , pp. 1371-1389
    • Klimstra, D.S.1    Wenig, B.M.2    Adair, C.F.3    Heffess, C.S.4
  • 98
    • 0036120621 scopus 로고    scopus 로고
    • Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: Frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway
    • 11891193 10.1016/S0002-9440(10)64917-6 1:CAS:528:DC%2BD38XisVemt78%3D
    • Abraham SC, Wu TT, Hruban RH, Lee JH, Yeo CJ, Conlon K, et al. Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway. Am J Pathol. 2002;160(3):953-62.
    • (2002) Am J Pathol , vol.160 , Issue.3 , pp. 953-962
    • Abraham, S.C.1    Wu, T.T.2    Hruban, R.H.3    Lee, J.H.4    Yeo, C.J.5    Conlon, K.6
  • 99
    • 0034131138 scopus 로고    scopus 로고
    • Pancreatic acinar carcinoma shows a distinct pattern of chromosomal imbalances by comparative genomic hybridization
    • 10862035 10.1002/1098-2264(200007)28:3<294: AID-GCC7>3.0.CO;2-N 1:CAS:528:DC%2BD3cXks1Skt7c%3D
    • Taruscio D, Paradisi S, Zamboni G, Rigaud G, Falconi M, Scarpa A. Pancreatic acinar carcinoma shows a distinct pattern of chromosomal imbalances by comparative genomic hybridization. Genes Chromosomes Cancer. 2000;28(3):294-9.
    • (2000) Genes Chromosomes Cancer , vol.28 , Issue.3 , pp. 294-299
    • Taruscio, D.1    Paradisi, S.2    Zamboni, G.3    Rigaud, G.4    Falconi, M.5    Scarpa, A.6
  • 100
    • 0034569983 scopus 로고    scopus 로고
    • Allelotype of pancreatic acinar cell carcinoma
    • 11072247 10.1002/1097-0215(20001201)88:5<772: AID-IJC14>3.0.CO;2-W 1:CAS:528:DC%2BD3cXot1SqtLo%3D
    • Rigaud G, Moore PS, Zamboni G, Orlandini S, Taruscio D, Paradisi S, et al. Allelotype of pancreatic acinar cell carcinoma. Int J Cancer. 2000;88(5):772-7.
    • (2000) Int J Cancer , vol.88 , Issue.5 , pp. 772-777
    • Rigaud, G.1    Moore, P.S.2    Zamboni, G.3    Orlandini, S.4    Taruscio, D.5    Paradisi, S.6
  • 101
    • 69749092294 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization to visualize genetic abnormalities in interphase cells of acinar cell carcinoma, ductal adenocarcinoma, and islet cell carcinoma of the pancreas
    • 10.4065/84.9.801 19720778 10.4065/84.9.801 1:CAS:528:DC%2BD1MXhtFKntbbK
    • Dewald GW, Smyrk TC, Thorland EC, McWilliams RR, Van Dyke DL, Keefe JG, et al. Fluorescence in situ hybridization to visualize genetic abnormalities in interphase cells of acinar cell carcinoma, ductal adenocarcinoma, and islet cell carcinoma of the pancreas. Mayo Clin Proc. 2009;84(9):801-10. doi: 10.4065/84.9.801.
    • (2009) Mayo Clin Proc , vol.84 , Issue.9 , pp. 801-810
    • Dewald, G.W.1    Smyrk, T.C.2    Thorland, E.C.3    McWilliams, R.R.4    Van Dyke, D.L.5    Keefe, J.G.6
  • 102
    • 0027718103 scopus 로고
    • Pancreatic acinar cell carcinoma. An analysis of cell lineage markers, p53 expression, and Ki-ras mutation
    • 8362971 1:CAS:528:DyaK2cXhtlSqtLc%3D
    • Hoorens A, Lemoine NR, McLellan E, Morohoshi T, Kamisawa T, Heitz PU, et al. Pancreatic acinar cell carcinoma. An analysis of cell lineage markers, p53 expression, and Ki-ras mutation. Am J Pathol. 1993;143(3):685-98.
    • (1993) Am J Pathol , vol.143 , Issue.3 , pp. 685-698
    • Hoorens, A.1    Lemoine, N.R.2    McLellan, E.3    Morohoshi, T.4    Kamisawa, T.5    Heitz, P.U.6
  • 103
    • 80052400707 scopus 로고    scopus 로고
    • Analysis of LKB1 mutations and other molecular alterations in pancreatic acinar cell carcinoma
    • 10.1038/modpathol.2011.83 21572398 10.1038/modpathol.2011.83
    • de Wilde RF, Ottenhof NA, Jansen M, Morsink FH, de Leng WW, Offerhaus GJ, et al. Analysis of LKB1 mutations and other molecular alterations in pancreatic acinar cell carcinoma. Mod Pathol. 2011;24(9):1229-36. doi: 10.1038/modpathol.2011.83.
    • (2011) Mod Pathol , vol.24 , Issue.9 , pp. 1229-1236
    • De Wilde, R.F.1    Ottenhof, N.A.2    Jansen, M.3    Morsink, F.H.4    De Leng, W.W.5    Offerhaus, G.J.6
  • 104
    • 0031974106 scopus 로고    scopus 로고
    • Evaluation of p53 mutation in pancreatic acinar cell carcinomas of humans and transgenic mice
    • 9436856 10.1097/00006676-199801000-00002 1:STN:280:DyaK1c%2FpslemtA%3D%3D
    • Terhune PG, Memoli VA, Longnecker DS. Evaluation of p53 mutation in pancreatic acinar cell carcinomas of humans and transgenic mice. Pancreas. 1998;16(1):6-12.
    • (1998) Pancreas , vol.16 , Issue.1 , pp. 6-12
    • Terhune, P.G.1    Memoli, V.A.2    Longnecker, D.S.3
  • 105
    • 0035152551 scopus 로고    scopus 로고
    • Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas: Frequent alterations in the APC/beta-catenin pathway and chromosome 11p
    • 11696422 10.1016/S0002-9440(10)63008-8 1:CAS:528:DC%2BD3MXoslartL0%3D
    • Abraham SC, Wu TT, Klimstra DS, Finn LS, Lee JH, Yeo CJ, et al. Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas: frequent alterations in the APC/beta-catenin pathway and chromosome 11p. Am J Pathol. 2001;159(5):1619-27.
    • (2001) Am J Pathol , vol.159 , Issue.5 , pp. 1619-1627
    • Abraham, S.C.1    Wu, T.T.2    Klimstra, D.S.3    Finn, L.S.4    Lee, J.H.5    Yeo, C.J.6
  • 106
    • 0036105787 scopus 로고    scopus 로고
    • Beckwith-Wiedemann syndrome, pancreatoblastoma, and the wnt signaling pathway
    • (author reply 2)
    • Kerr NJ, Fukuzawa R, Reeve AE, Sullivan MJ. Beckwith-Wiedemann syndrome, pancreatoblastoma, and the wnt signaling pathway. Am J Pathol. 2002;160(4):1541-2 (author reply 2).
    • (2002) Am J Pathol. , vol.160 , Issue.4 , pp. 1541-1542
    • Kerr, N.J.1    Fukuzawa, R.2    Reeve, A.E.3    Sullivan, M.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.