K-ras Mutation and p53 Protein Accumulation in Intraductal Mucin-Hypersecreting Neoplasms of the Pancreas

Pancreas

Volumn 12, Issue 4, 1996, Pages 362-368

  Satoh, Kennichi ^a,b   Shimosegawa, Tooru ^a   Moriizumi, Shigeki ^a   Koizumi, Masaru ^a   Toyota, Takayoshi ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Iwate Prefectural Central Hospital   (Japan)

Author keywords

Intraductal mucin hypersecreting neoplasm of the pancreas; K ras gene; p53

Indexed keywords

PROTEIN P53;

ARTICLE; CHROMOSOME 17P; DRUG ACCUMULATION; GENE FREQUENCY; GENE LOCATION; GENE MUTATION; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ONCOGENE K RAS; ONCOGENE RAS; PANCREAS CANCER; PANCREAS SECRETION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADENOMA; AGED; ANTIBODIES, MONOCLONAL; CARCINOMA IN SITU; CELL NUCLEUS; FEMALE; GENES, RAS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0029921032     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-199605000-00007     Document Type: Article

References (35)

1. Rickaert F, Cremer M, Deviére J, et al. Intraductal mucin-hypersecreting neoplasms of the pancreas: A clinicopathologic study of eight patients. Gastroenterology 1991;101: 512-9.
2. Satoh K, Sawai T, Shimosegawa T, Koizumi M, et al. The point mutation of c-Ki-ras at codon 12 in carcinoma of the pancreatic head region and in intraductal mucin-hypersecreting neoplasm of the pancreas. Int J Pancreatol 1993;14: 135-43.
3. Tada M, Omata M, Ohio M. Ras gene mutations in intraductal papillary neoplasms of the pancreas. Analysis in five cases. Cancer 1991;67:634-7.
4. Yanagisawa A, Kato Y, Ohtake K, et al. C-Ki-ras point mutation in ductectatic-type mucinous cystic neoplasms of the pancreas. Jpn J Cancer Res 1991;82:1057-60.
5. Reich NC, Levine AJ. Growth regulation of a cellular tumour antigen, p53, in nontransformed cells. Nature 1984; 308:199-201.
6. Levine AJ, Momand JM, Finlay CA. The p53 tumor suppressor gene. Nature 1991;351:453-6.
7. Nigro JM, Baker SJ, Preisinger AC, et al. Mutations in the p53 gene occur in diverse human tumor types. Nature 1989; 342:705-8.
8. Campo E, de la Calle-Martin O, Miguel R, et al. Loss of heterozygosity of p53 gene and p53 protein expression in human colorectal carcinomas. Cancer Res 1991;51:4436-42.
9. Davidoff AM, Humphrey PA, Iglehart JD, Marks JR. Genetic basis for p53 overexpression in human breast cancer. Proc Natl Acad Sci USA 1991;88:5006-10.
10. Bodner SM, Minna JD, Jensen SM, et al. Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation. Oncogene 1992;7:743-9.
11. Moll UM, Riou G, Levine AJ. Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc Natl Acad Sci USA 1992;89:7262-6.
12. Shin DM, Kim J, Ro JY, et al. Activation of p53 gene expression in premalignant lesions during head and neck tumorigenesis. Cancer Res 1994;54:321-6.
13. Lambkin HA, Mothersill CM, Kelehan P. Variations in immunohistochemical detection of p53 protein overexpression in cervical carcinomas with different antibodies and methods of detection. J Pathol 1994;172:13-8.
14. Jacquemier J, Molès JP, Penault-Llorca F, et al. p53 immunohistochemical analysis in breast cancer with four monoclonal antibodies: comparison of staining and PCR-SSCP results. Br J Cancer 1994;69:846-52.
15. Barton CM, Staddon SL, Hughes CM, et al. Abnormalities of p53 tumor suppressor gene in human pancreatic cancer. Br J Cancer 1991;64:1076-82.
16. Casey G, Yamanaka Y, Friess H, et al. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis. Cancer Lett 1993;69:151-60.
17. Scarpa A, Paola C, Mukai K, et al. Pancreatic adenocarcinomas frequently show p53 gene mutations. Am J Pathol 1993;142:1534-43.
18. Kalthoff H, Schmiegel W, Roeder C, et al. p53 and K-RAS alterations in pancreatic epithelial cell lesions. Oncogene 1993;8:289-98.
19. Pellegata NS, Sessa F, Renault B, et al. K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions. Cancer Res 1994; 54:1556-60.
20. Redston MS, Caldas C, Seymour AB, et al. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions. Cancer Res 1994;54:3025-33.
21. Digiuseppe JA, Hruban RH, Goodman SN, et al. Overexpression of p53 protein in adenocarcinoma of the pancreas. Am J Clin Pathol 1994;101:684-8.
22. Reich NC, Oren M, Levine AJ. Two distinct mechanisms regulate the levels of cellular tumor antigen, p53. Mol Cell Biol 1983;3:2143-50.
23. Finlay CA, Hinds PW, Tan T-H, Eliyahu D, Oren M, Levine AJ. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol Cell Biol 1988;8:531-9.
24. Sessa F, Pellegata NS, Bonato M, et al. Mutations of p53 and K-ras in intraductal papillary tumors are related to grade of epithelial dysplasia. Digestion 1993;54:308-9 (abstract).
25. Parada LF, Land H, Weinberg RA, Wolf D, Rotter V. Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation. Nature 1984;312:649-51.
26. Eliyahu D, Raz A, Gruss P, Givol D, Oren M. Participation of p53 cellular tumor antigen in transformation of normal embryonic cells. Nature 1984;312:646-9.
27. Wright DK, Manos MM. Sample preparation from paraffin-embedded tissues. In: Michael IA, ed. PCR protocols: a guide to methods and applications. New York: Academic Press, 1990:153-8.
28. Kahn SM, Jiang W, Culbertson TA, et al. Rapid and sensitive nonradioactive detection of mutant K-ras genes via "enriched" PCR amplification. Oncogene 1991;6:1079-83.
29. Lemoine NR, Jain S, Hughes CM, et al. Ki-ras oncogene activation in preinvasive pancreatic cancer. Gastroenterology 1992;102:230-6.
30. Wynford-Thomas D. P53 in tumour pathology: Can we trust immunocytochemistry? J Pathol 1992;166:329-30.
31. Hall PA, Lane DP. p53 in tumor pathology: can we trust immunohistochemistry? - revisited! J Pathol 1994;172:1-4.
32. Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988;53:549-54.
33. Hruban RH, van Mansfeld ADM, Offerhaus GJA, et al. K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol 1993;143:545-54.
34. Satoh K, Ohtani H, Shimosegawa T, Koizumi M, Sawai T, Toyota T. Infrequent stromal expression of gelatinase A and intact basement membrane in intraductal neoplasms of the pancreas. Gastroenterology 1994;107:1488-95.
35. Kozuka S, Sasa R, Taki T, et al. Relation of pancreatic duct hyperplasia to carcinoma. Cancer 1979;43:1418-28.