메뉴 건너뛰기




Volumn 35, Issue 3, 2013, Pages 305-317

Pharmacogenetics in schizophrenia: A review of clozapine studies

Author keywords

Adverse effects; Clozapine; Pharmacogenetics; Polymorphisms; Schizophrenia

Indexed keywords

ALPHA 2A ADRENERGIC RECEPTOR; APOLIPOPROTEIN A; ATP BINDING CASSETTE SUB FAMILY B MEMBER 1; BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; CATECHOLAMINE RECEPTOR; CLOZAPINE; CYTOCHROME P450; DEBRISOQUINE; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE TRANSPORTER; DYSBINDIN; GDNF FAMILY RECEPTOR ALPHA 2; MELANOCORTIN 4 RECEPTOR; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); NEUREXIN 1; OLANZAPINE; OXYTOCIN PREPROPEPTIDE; PEPTIDES AND PROTEINS; PROTEIN KINASE ALPHA 2 CATALYTIC SUBUNIT; PROTEIN KINASE BETA 2 NON-CATALYTIC SUBUNIT; PROTEIN KINASE GAMMA 2 NON CATALYTIC SUBUNIT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); RISPERIDONE; ROUNDABOUT AXON GUIDANCE RECEPTOR HOMOLOG 1; SEROTONIN RECEPTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84885112561     PISSN: 15164446     EISSN: None     Source Type: Journal    
DOI: 10.1590/1516-4446-2012-0970     Document Type: Review
Times cited : (23)

References (171)
  • 1
    • 22144432283 scopus 로고    scopus 로고
    • A systematic review of the prevalence of schizophrenia
    • Saha S, Chant D, Welham J, McGrath J. A systematic review of the prevalence of schizophrenia. PLoS Med. 2005;2:e141.
    • (2005) PLoS Med. , vol.2
    • Saha, S.1    Chant, D.2    Welham, J.3    McGrath, J.4
  • 2
    • 84885164182 scopus 로고    scopus 로고
    • Esquizofrenia: Diretrizes e algoritmo para o tratamento farmacológico
    • In: Cordioli AV, editor. 3rd ed. Porto Alegre: Artmed
    • Pádua AC, Gama CS, Lobato MI, Belmonte-de-Abreu OS. Esquizofrenia: diretrizes e algoritmo para o tratamento farmacológico. In: Cordioli AV, editor. Psicofármacos: consulta rápida. 3rd ed. Porto Alegre: Artmed; 2005. p. 343.
    • (2005) Psicofármacos: Consulta rápida. , pp. 343
    • Pádua, A.C.1    Gama, C.S.2    Lobato, M.I.3    Belmonte-de-Abreu, O.S.4
  • 3
    • 0035749665 scopus 로고    scopus 로고
    • Pharmacogenomics and schizophrenia: Clinical implications
    • Malhotra AK. Pharmacogenomics and schizophrenia: clinical implications. Pharmacogenomics J. 2001;1:109-14.
    • (2001) Pharmacogenomics J. , vol.1 , pp. 109-114
    • Malhotra, A.K.1
  • 4
    • 12344326514 scopus 로고    scopus 로고
    • Treatments for schizophrenia: A critical review of pharmacology and mechanisms of action of antipsychotic drugs
    • Miyamoto S, Duncan GE, Marx CE, Lieberman JA. Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol Psychiatry. 2005;10:79-104.
    • (2005) Mol Psychiatry. , vol.10 , pp. 79-104
    • Miyamoto, S.1    Duncan, G.E.2    Marx, C.E.3    Lieberman, J.A.4
  • 5
    • 0032909923 scopus 로고    scopus 로고
    • Pharmacologic and pharmacokinetic considerations in choosing an antipsychotic
    • Ereshefsky L. Pharmacologic and pharmacokinetic considerations in choosing an antipsychotic. J Clin Psychiatry. 1999;60:20-30.
    • (1999) J Clin Psychiatry. , vol.60 , pp. 20-30
    • Ereshefsky, L.1
  • 6
    • 84857948217 scopus 로고    scopus 로고
    • The pharmacogenetics of symptom response to antipsychotic drugs
    • Reynolds GP. The pharmacogenetics of symptom response to antipsychotic drugs. Psychiatry Investig. 2012;9:1-7.
    • (2012) Psychiatry Investig. , vol.9 , pp. 1-7
    • Reynolds, G.P.1
  • 7
    • 35048827065 scopus 로고    scopus 로고
    • Adverse effects of atypical antipsychotics: Differential risk and clinical implications
    • Haddad PM, Sharma SG. Adverse effects of atypical antipsychotics: differential risk and clinical implications. CNS Drugs. 2007;21:911-36.
    • (2007) CNS Drugs. , vol.21 , pp. 911-936
    • Haddad, P.M.1    Sharma, S.G.2
  • 8
    • 33947646865 scopus 로고    scopus 로고
    • Potential genetic causes of heterogeneity of treatment effects
    • Goldstein DB, Need AC, Singh R, Sisodiya SM. Potential genetic causes of heterogeneity of treatment effects. Am J Med. 2007;120:S21-5.
    • (2007) Am J Med. , vol.120
    • Goldstein, D.B.1    Need, A.C.2    Singh, R.3    Sisodiya, S.M.4
  • 9
    • 13344278706 scopus 로고    scopus 로고
    • Monozygotic twins concordant for response to clozapine
    • Vojvoda D, Grimmell K, Sernyak M, Mazure CM. Monozygotic twins concordant for response to clozapine. Lancet. 1996;347:61.
    • (1996) Lancet. , vol.347 , pp. 61
    • Vojvoda, D.1    Grimmell, K.2    Sernyak, M.3    Mazure, C.M.4
  • 14
    • 79952419578 scopus 로고    scopus 로고
    • Agranulocytosis related to clozapine in monozygotic twins and association with allelic variants of multidrug resistance gene MDR1
    • Anil Yagcioglu AE, Ilhan BC, Goktas MT, Babaoglu MO, Uz E, Yazici MK. Agranulocytosis related to clozapine in monozygotic twins and association with allelic variants of multidrug resistance gene MDR1. J Clin Psychopharmacology. 2011;31:247-9.
    • (2011) J Clin Psychopharmacology. , vol.31 , pp. 247-249
    • Anil Yagcioglu, A.E.1    Ilhan, B.C.2    Goktas, M.T.3    Babaoglu, M.O.4    Uz, E.5    Yazici, M.K.6
  • 16
    • 80555145254 scopus 로고    scopus 로고
    • Pharmacogenetics of response to antipsychotics in patients with schizophrenia
    • Arranz MJ, Rivera M, Munro JC. Pharmacogenetics of response to antipsychotics in patients with schizophrenia. CNS Drugs. 2011;25:933-69.
    • (2011) CNS Drugs. , vol.25 , pp. 933-969
    • Arranz, M.J.1    Rivera, M.2    Munro, J.C.3
  • 19
    • 84863724265 scopus 로고    scopus 로고
    • Association study of 27 annotated genes for clozapine pharmacogenetics: Validation of preexisting studies and identification of a new candidate gene, ABCB1, for treatment response
    • Lee ST, Ryu S, Kim SR, Kim MJ, Kim S, Kim JW, et al. Association study of 27 annotated genes for clozapine pharmacogenetics: validation of preexisting studies and identification of a new candidate gene, ABCB1, for treatment response. J Clin Psychopharmacol. 2012;32:441-8.
    • (2012) J Clin Psychopharmacol. , vol.32 , pp. 441-448
    • Lee, S.T.1    Ryu, S.2    Kim, S.R.3    Kim, M.J.4    Kim, S.5    Kim, J.W.6
  • 20
    • 33846624143 scopus 로고    scopus 로고
    • COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia
    • Woodward ND, Jayathilake K, Meltzer HY. COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia. Schizophr Res. 2007;90:86-96.
    • (2007) Schizophr Res. , vol.90 , pp. 86-96
    • Woodward, N.D.1    Jayathilake, K.2    Meltzer, H.Y.3
  • 22
    • 34548854787 scopus 로고    scopus 로고
    • Association study of four dopamine D1 receptor gene polymorphisms and clozapine treatment response
    • Hwang R, Shinkai T, De Luca V, Ni X, Potkin SG, Lieberman JA, et al. Association study of four dopamine D1 receptor gene polymorphisms and clozapine treatment response. J Psychopharmacol. 2007;21:718-27.
    • (2007) J Psychopharmacol. , vol.21 , pp. 718-727
    • Hwang, R.1    Shinkai, T.2    De Luca, V.3    Ni, X.4    Potkin, S.G.5    Lieberman, J.A.6
  • 23
    • 0344951296 scopus 로고    scopus 로고
    • D1 receptor alleles predict PET metabolic correlates of clinical response to clozapine
    • Potkin SG, Basile VS, Jin Y, Masellis M, Badri F, Keator D, et al. D1 receptor alleles predict PET metabolic correlates of clinical response to clozapine. Mol Psychiatry. 2003;8:109-13.
    • (2003) Mol Psychiatry. , vol.8 , pp. 109-113
    • Potkin, S.G.1    Basile, V.S.2    Jin, Y.3    Masellis, M.4    Badri, F.5    Keator, D.6
  • 24
    • 0002333514 scopus 로고    scopus 로고
    • Allelic variation in the promoter region of the dopamine D2 receptor gene and clozapine response
    • Malhotra AK, Buchanan RW, Kim S, Kestler L, Breier A, Pickar D, et al. Allelic variation in the promoter region of the dopamine D2 receptor gene and clozapine response. Schizophr Res. 1999;36:92-3.
    • (1999) Schizophr Res. , vol.36 , pp. 92-93
    • Malhotra, A.K.1    Buchanan, R.W.2    Kim, S.3    Kestler, L.4    Breier, A.5    Pickar, D.6
  • 25
    • 26644464161 scopus 로고    scopus 로고
    • Association study of 12 polymorphisms spanning the dopamine D(2) receptor gene and clozapine treatment response in two treatment refractory/intolerant populations
    • Hwang R, Shinkai T, De Luca V, Muller DJ, Ni X, Macciardi F, et al. Association study of 12 polymorphisms spanning the dopamine D(2) receptor gene and clozapine treatment response in two treatment refractory/intolerant populations. Psychopharmacology (Berl). 2005;181:179-87.
    • (2005) Psychopharmacology (Berl). , vol.181 , pp. 179-187
    • Hwang, R.1    Shinkai, T.2    De Luca, V.3    Muller, D.J.4    Ni, X.5    McCiardi, F.6
  • 26
    • 33645993851 scopus 로고    scopus 로고
    • Dopamine D2 receptor gene variants and quantitative measures of positive and negative symptom response following clozapine treatment
    • Hwang R, Shinkai T, Deluca V, Macciardi F, Potkin S, Meltzer HY, et al. Dopamine D2 receptor gene variants and quantitative measures of positive and negative symptom response following clozapine treatment. Eur Neuropsychopharmacol. 2006;16:248-59.
    • (2006) Eur Neuropsychopharmacol. , vol.16 , pp. 248-259
    • Hwang, R.1    Shinkai, T.2    Deluca, V.3    McCiardi, F.4    Potkin, S.5    Meltzer, H.Y.6
  • 27
    • 0030005962 scopus 로고    scopus 로고
    • Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia
    • Shaikh S, Collier DA, Sham PC, Ball D, Aitchison K, Vallada H, et al. Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia. Hum Genet. 1996;97:714-9.
    • (1996) Hum Genet. , vol.97 , pp. 714-719
    • Shaikh, S.1    Collier, D.A.2    Sham, P.C.3    Ball, D.4    Aitchison, K.5    Vallada, H.6
  • 29
    • 27744556147 scopus 로고    scopus 로고
    • Dopamine D4 receptor gene exon III polymorphism and interindividual variation in response to clozapine
    • Zhao AL, Zhao JP, Zhang YH, Xue ZM, Chen JD, Chen XG. Dopamine D4 receptor gene exon III polymorphism and interindividual variation in response to clozapine. The Int J Neurosci. 2005;115:1539-47.
    • (2005) The Int J Neurosci. , vol.115 , pp. 1539-1547
    • Zhao, A.L.1    Zhao, J.P.2    Zhang, Y.H.3    Xue, Z.M.4    Chen, J.D.5    Chen, X.G.6
  • 31
    • 70149084020 scopus 로고    scopus 로고
    • The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation
    • Zuo L, Luo X, Krystal JH, Cramer J, Charney DS, Gelernter J. The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation. Pharmacogenet Genomics. 2009;19:437-46.
    • (2009) Pharmacogenet Genomics. , vol.19 , pp. 437-446
    • Zuo, L.1    Luo, X.2    Krystal, J.H.3    Cramer, J.4    Charney, D.S.5    Gelernter, J.6
  • 33
    • 24044544831 scopus 로고    scopus 로고
    • Suggestive association between the C825T polymorphism of the Gprotein beta3 subunit gene (GNB3) and clinical improvement with antipsychotics in schizophrenia
    • Muller DJ, De Luca V, Sicard T, King N, Hwang R, Volavka J, et al. Suggestive association between the C825T polymorphism of the Gprotein beta3 subunit gene (GNB3) and clinical improvement with antipsychotics in schizophrenia. Eur Neuropsychopharmacol. 2005;15:525-31.
    • (2005) Eur Neuropsychopharmacol. , vol.15 , pp. 525-531
    • Muller, D.J.1    De Luca, V.2    Sicard, T.3    King, N.4    Hwang, R.5    Volavka, J.6
  • 35
    • 0029100429 scopus 로고
    • Association between clozapine response and allelic variation in 5-HT2A receptor gene
    • Arranz M, Collier D, Sodhi M, Ball D, Roberts G, Price J, et al. Association between clozapine response and allelic variation in 5-HT2A receptor gene. Lancet. 1995;346:281-2.
    • (1995) Lancet. , vol.346 , pp. 281-282
    • Arranz, M.1    Collier, D.2    Sodhi, M.3    Ball, D.4    Roberts, G.5    Price, J.6
  • 36
    • 0035124830 scopus 로고    scopus 로고
    • Evidence for an association between polymorphism in the serotonin-2A receptor variant (102T/C) and increment of N100 amplitude in schizophrenics treated with clozapine
    • Yu YW, Tsai SJ, Yang KH, Lin CH, Chen MC, Hong CJ. Evidence for an association between polymorphism in the serotonin-2A receptor variant (102T/C) and increment of N100 amplitude in schizophrenics treated with clozapine. Neuropsychobiology. 2001;43:79-82.
    • (2001) Neuropsychobiology. , vol.43 , pp. 79-82
    • Yu, Y.W.1    Tsai, S.J.2    Yang, K.H.3    Lin, C.H.4    Chen, M.C.5    Hong, C.J.6
  • 38
    • 0030592571 scopus 로고    scopus 로고
    • Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine
    • Arranz MJ, Collier DA, Munro J, Sham P, Kirov G, Sodhi M, et al. Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine. Neurosci Lett. 1996;217:177-8.
    • (1996) Neurosci Lett. , vol.217 , pp. 177-178
    • Arranz, M.J.1    Collier, D.A.2    Munro, J.3    Sham, P.4    Kirov, G.5    Sodhi, M.6
  • 39
    • 0031963472 scopus 로고    scopus 로고
    • Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine
    • Arranz MJ, Munro J, Owen MJ, Spurlock G, Sham PC, Zhao J, et al. Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine. Mol Psychiatry. 1998;3:61-6.
    • (1998) Mol Psychiatry. , vol.3 , pp. 61-66
    • Arranz, M.J.1    Munro, J.2    Owen, M.J.3    Spurlock, G.4    Sham, P.C.5    Zhao, J.6
  • 40
    • 0029551796 scopus 로고
    • Association between clozapine response and allelic variation in the 5-HT2C receptor gene
    • Sodhi MS, Arranz MJ, Curtis D, Ball DM, Sham P, Roberts GW, et al. Association between clozapine response and allelic variation in the 5-HT2C receptor gene. Neuroreport. 1995;7:169-72.
    • (1995) Neuroreport. , vol.7 , pp. 169-172
    • Sodhi, M.S.1    Arranz, M.J.2    Curtis, D.3    Ball, D.M.4    Sham, P.5    Roberts, G.W.6
  • 41
    • 84871647741 scopus 로고    scopus 로고
    • Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia
    • Rajkumar AP, Poonkuzhali B, Kuruvilla A, Srivastava A, Jacob M, Jacob KS. Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia. Psychopharmacology (Berl). 2012;224:441-9.
    • (2012) Psychopharmacology (Berl). , vol.224 , pp. 441-449
    • Rajkumar, A.P.1    Poonkuzhali, B.2    Kuruvilla, A.3    Srivastava, A.4    Jacob, M.5    Jacob, K.S.6
  • 43
    • 0033606080 scopus 로고    scopus 로고
    • Serotonin-6 receptor variant (C267T) and clinical response to clozapine
    • Yu YW, Tsai SJ, Lin CH, Hsu CP, Yang KH, Hong CJ. Serotonin-6 receptor variant (C267T) and clinical response to clozapine. Neuroreport. 1999;10:1231-3.
    • (1999) Neuroreport. , vol.10 , pp. 1231-1233
    • Yu, Y.W.1    Tsai, S.J.2    Lin, C.H.3    Hsu, C.P.4    Yang, K.H.5    Hong, C.J.6
  • 46
    • 77955057308 scopus 로고    scopus 로고
    • Pharacogenetic effects of dopamine transporter gene polymorphisms on response to chlorpromazine and clozapine and on extrapyramidal syndrome in schizophrenia
    • Xu M, Xing Q, Li S, Zheng Y, Wu S, Gao R, et al. Pharacogenetic effects of dopamine transporter gene polymorphisms on response to chlorpromazine and clozapine and on extrapyramidal syndrome in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:1026-32.
    • (2010) Prog Neuropsychopharmacol Biol Psychiatry. , vol.34 , pp. 1026-1032
    • Xu, M.1    Xing, Q.2    Li, S.3    Zheng, Y.4    Wu, S.5    Gao, R.6
  • 49
    • 33748557803 scopus 로고    scopus 로고
    • Family and case-control association study of the tumor necrosis factor-alpha (TNF-alpha) gene with schizophrenia and response to antipsychotic medication
    • Zai G, Muller DJ, Volavka J, Czobor P, Lieberman JA, Meltzer HY, et al. Family and case-control association study of the tumor necrosis factor-alpha (TNF-alpha) gene with schizophrenia and response to antipsychotic medication. Psychopharmacology (Berl). 2006;188:171-82.
    • (2006) Psychopharmacology (Berl). , vol.188 , pp. 171-182
    • Zai, G.1    Muller, D.J.2    Volavka, J.3    Czobor, P.4    Lieberman, J.A.5    Meltzer, H.Y.6
  • 50
    • 78951469329 scopus 로고    scopus 로고
    • Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia
    • Jassim G, Ferno J, Theisen FM, Haberhausen M, Christoforou A, Havik B, et al. Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia. Pharmacopsychiatry. 2011;44:15-20.
    • (2011) Pharmacopsychiatry. , vol.44 , pp. 15-20
    • Jassim, G.1    Ferno, J.2    Theisen, F.M.3    Haberhausen, M.4    Christoforou, A.5    Havik, B.6
  • 51
    • 25144477595 scopus 로고    scopus 로고
    • Polymorphism of the adrenergic receptor alpha 2a-1291C. G genetic variation and clozapine-induced weight gain
    • Wang YC, Bai YM, Chen JY, Lin CC, Lai IC, Liou YJ. Polymorphism of the adrenergic receptor alpha 2a-1291C. G genetic variation and clozapine-induced weight gain. J Neural Transm. 2005;112: 1463-8.
    • (2005) J Neural Transm. , vol.112 , pp. 1463-1468
    • Wang, Y.C.1    Bai, Y.M.2    Chen, J.Y.3    Lin, C.C.4    Lai, I.C.5    Liou, Y.J.6
  • 52
    • 70449510603 scopus 로고    scopus 로고
    • Association of the alpha 2A adrenergic receptor-1291C/G polymorphism and antipsychotic-induced weight gain in European-Americans
    • Sickert L, Muller DJ, Tiwari AK, Shaikh S, Zai C, De Souza R, et al. Association of the alpha 2A adrenergic receptor-1291C/G polymorphism and antipsychotic-induced weight gain in European-Americans. Pharmacogenomics. 2009;10:1169-76.
    • (2009) Pharmacogenomics. , vol.10 , pp. 1169-1176
    • Sickert, L.1    Muller, D.J.2    Tiwari, A.K.3    Shaikh, S.4    Zai, C.5    De Souza, R.6
  • 53
    • 84855875337 scopus 로고    scopus 로고
    • Association study of brain-derived neurotrophic factor gene polymorphisms and body weight change in schizophrenic patients under long-term atypical antipsychotic treatment
    • Tsai A, Liou YJ, Hong CJ, Wu CL, Tsai SJ, Bai YM. Association study of brain-derived neurotrophic factor gene polymorphisms and body weight change in schizophrenic patients under long-term atypical antipsychotic treatment. Neuromolecular Med. 2011;13: 328-33.
    • (2011) Neuromolecular Med. , vol.13 , pp. 328-333
    • Tsai, A.1    Liou, Y.J.2    Hong, C.J.3    Wu, C.L.4    Tsai, S.J.5    Bai, Y.M.6
  • 54
    • 77952424738 scopus 로고    scopus 로고
    • Dopamine receptor D2 gene is associated with weight gain in schizophrenic patients under long-term atypical antipsychotic treatment
    • Hong CJ, Liou YJ, Bai YM, Chen TT, Wang YC, Tsai SJ. Dopamine receptor D2 gene is associated with weight gain in schizophrenic patients under long-term atypical antipsychotic treatment. Pharmacogenet Genomics. 2010;20:359-66.
    • (2010) Pharmacogenet Genomics. , vol.20 , pp. 359-366
    • Hong, C.J.1    Liou, Y.J.2    Bai, Y.M.3    Chen, T.T.4    Wang, Y.C.5    Tsai, S.J.6
  • 55
    • 84858996108 scopus 로고    scopus 로고
    • Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain
    • Muller DJ, Zai CC, Sicard M, Remington E, Souza RP, Tiwari AK, et al. Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain. Pharmacogenomics J. 2012;12:156-64.
    • (2012) Pharmacogenomics J. , vol.12 , pp. 156-164
    • Muller, D.J.1    Zai, C.C.2    Sicard, M.3    Remington, E.4    Souza, R.P.5    Tiwari, A.K.6
  • 56
    • 25144497419 scopus 로고    scopus 로고
    • C825T polymorphism in the human G protein beta3 subunit gene is associated with long-term clozapine treatment-induced body weight change in the Chinese population
    • Wang YC, Bai YM, Chen JY, Lin CC, Lai IC, Liou YJ. C825T polymorphism in the human G protein beta3 subunit gene is associated with long-term clozapine treatment-induced body weight change in the Chinese population. Pharmacogene Genomics. 2005;15:743-8.
    • (2005) Pharmacogene Genomics. , vol.15 , pp. 743-748
    • Wang, Y.C.1    Bai, Y.M.2    Chen, J.Y.3    Lin, C.C.4    Lai, I.C.5    Liou, Y.J.6
  • 57
    • 62649152001 scopus 로고    scopus 로고
    • Association between HTR2C and HTR2A polymorphisms and metabolic abnormalities in patients treated with olanzapine or clozapine
    • Gunes A, Melkersson KI, Scordo MG, Dahl ML. Association between HTR2C and HTR2A polymorphisms and metabolic abnormalities in patients treated with olanzapine or clozapine. J Clin Psychopharmacol. 2009;29:65-8.
    • (2009) J Clin Psychopharmacol. , vol.29 , pp. 65-68
    • Gunes, A.1    Melkersson, K.I.2    Scordo, M.G.3    Dahl, M.L.4
  • 58
    • 0038474172 scopus 로고    scopus 로고
    • Polymorphism of the promoter region of the serotonin 5-HT(2C) receptor gene and clozapineinduced weight gain
    • Reynolds GP, Zhang Z, Zhang X. Polymorphism of the promoter region of the serotonin 5-HT(2C) receptor gene and clozapineinduced weight gain. Am J Psychiatry. 2003;160:677-9.
    • (2003) Am J Psychiatry. , vol.160 , pp. 677-679
    • Reynolds, G.P.1    Zhang, Z.2    Zhang, X.3
  • 60
    • 77952924290 scopus 로고    scopus 로고
    • Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample
    • Opgen-Rhein C, Brandl EJ, Muller DJ, Neuhaus AH, Tiwari AK, Sander T, et al. Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample. Pharmacogenomics. 2010;11:773-80.
    • (2010) Pharmacogenomics. , vol.11 , pp. 773-780
    • Opgen-Rhein, C.1    Brandl, E.J.2    Muller, D.J.3    Neuhaus, A.H.4    Tiwari, A.K.5    Sander, T.6
  • 61
    • 60549089825 scopus 로고    scopus 로고
    • Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotictreated schizophrenic patients: Perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?
    • Le Hellard S, Theisen FM, Haberhausen M, Raeder MB, Ferno J, Gebhardt S, et al. Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotictreated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects? Mol Psychiatry. 2009;14:308-17.
    • (2009) Mol Psychiatry. , vol.14 , pp. 308-317
    • Le Hellard, S.1    Theisen, F.M.2    Haberhausen, M.3    Raeder, M.B.4    Ferno, J.5    Gebhardt, S.6
  • 62
    • 34248592726 scopus 로고    scopus 로고
    • Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population
    • Zhang XY, Tan YL, Zhou DF, Haile CN, Cao LY, Xu Q, et al. Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population. J Clin Psychopharmacol. 2007;27:246-51.
    • (2007) J Clin Psychopharmacol. , vol.27 , pp. 246-251
    • Zhang, X.Y.1    Tan, Y.L.2    Zhou, D.F.3    Haile, C.N.4    Cao, L.Y.5    Xu, Q.6
  • 63
    • 84878228310 scopus 로고    scopus 로고
    • Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene
    • Chowdhury NI, Tiwari AK, Souza RP, Zai CC, Shaikh SA, Chen S, et al. Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene. Pharmacogenomics. 2013;13:272-9.
    • (2013) Pharmacogenomics. , vol.13 , pp. 272-279
    • Chowdhury, N.I.1    Tiwari, A.K.2    Souza, R.P.3    Zai, C.C.4    Shaikh, S.A.5    Chen, S.6
  • 64
    • 84865975078 scopus 로고    scopus 로고
    • Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic druginduced weight gain
    • Malhotra AK, Correll CU, Chowdhury NI, Muller DJ, Gregersen PK, Lee AT, et al. Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic druginduced weight gain. Arch Gen Psychiatry. 2012;69:904-12.
    • (2012) Arch Gen Psychiatry. , vol.69 , pp. 904-912
    • Malhotra, A.K.1    Correll, C.U.2    Chowdhury, N.I.3    Muller, D.J.4    Gregersen, P.K.5    Lee, A.T.6
  • 65
    • 84858291188 scopus 로고    scopus 로고
    • Association study between variants of AMPactivated protein kinase catalytic and regulatory subunit genes with antipsychotic-induced weight gain
    • Souza RP, Tiwari AK, Chowdhury NI, Ceddia RB, Lieberman JA, Meltzer HY, et al. Association study between variants of AMPactivated protein kinase catalytic and regulatory subunit genes with antipsychotic-induced weight gain. J Psychiatr Res. 2012;46:462-8.
    • (2012) J Psychiatr Res. , vol.46 , pp. 462-468
    • Souza, R.P.1    Tiwari, A.K.2    Chowdhury, N.I.3    Ceddia, R.B.4    Lieberman, J.A.5    Meltzer, H.Y.6
  • 67
    • 77953937453 scopus 로고    scopus 로고
    • Genetic association between TNF-alpha-308 G. A polymorphism and longitudinal weight change during clozapine treatment
    • Wang YC, Bai YM, Chen JY, Lin CC, Lai IC, Liou YJ. Genetic association between TNF-alpha-308 G. A polymorphism and longitudinal weight change during clozapine treatment. Hum Psychopharmacol. 2010;25:303-9.
    • (2010) Hum Psychopharmacol. , vol.25 , pp. 303-309
    • Wang, Y.C.1    Bai, Y.M.2    Chen, J.Y.3    Lin, C.C.4    Lai, I.C.5    Liou, Y.J.6
  • 70
    • 84856209453 scopus 로고    scopus 로고
    • Association between HTR2C gene polymorphisms and the metabolic syndrome in patients using antipsychotics: A replication study
    • Risselada AJ, Vehof J, Bruggeman R, Wilffert B, Cohen D, Al Hadithy AF, et al. Association between HTR2C gene polymorphisms and the metabolic syndrome in patients using antipsychotics: a replication study. The Pharmacogenomics J. 2012;12:62-7.
    • (2012) The Pharmacogenomics J. , vol.12 , pp. 62-67
    • Risselada, A.J.1    Vehof, J.2    Bruggeman, R.3    Wilffert, B.4    Cohen, D.5    Al Hadithy, A.F.6
  • 71
    • 78951473163 scopus 로고    scopus 로고
    • Association between HTR2C polymorphisms and metabolic syndrome in patients with schizophrenia treated with atypical antipsychotics
    • Bai YM, Chen TT, Liou YJ, Hong CJ, Tsai SJ. Association between HTR2C polymorphisms and metabolic syndrome in patients with schizophrenia treated with atypical antipsychotics. Schizophr Res. 2011;125:179-86.
    • (2011) Schizophr Res. , vol.125 , pp. 179-186
    • Bai, Y.M.1    Chen, T.T.2    Liou, Y.J.3    Hong, C.J.4    Tsai, S.J.5
  • 73
    • 77955471578 scopus 로고    scopus 로고
    • MTHFR genotype and differential evolution of metabolic parameters after initiation of a second generation antipsychotic: An observational study
    • van Winkel R, Moons T, Peerbooms O, Rutten B, Peuskens J, Claes S, et al. MTHFR genotype and differential evolution of metabolic parameters after initiation of a second generation antipsychotic: an observational study. Int Clin Psychopharmacol. 2010;25:270-6.
    • (2010) Int Clin Psychopharmacol. , vol.25 , pp. 270-276
    • van Winkel, R.1    Moons, T.2    Peerbooms, O.3    Rutten, B.4    Peuskens, J.5    Claes, S.6
  • 74
    • 44049109281 scopus 로고    scopus 로고
    • Allelic variation in ApoC3, ApoA5 and LPL genes and first and second generation antipsychotic effects on serum lipids in patients with schizophrenia
    • Smith RC, Segman RH, Golcer-Dubner T, Pavlov V, Lerer B. Allelic variation in ApoC3, ApoA5 and LPL genes and first and second generation antipsychotic effects on serum lipids in patients with schizophrenia. Pharmacogenomics J. 2008;8:228-36.
    • (2008) Pharmacogenomics J. , vol.8 , pp. 228-236
    • Smith, R.C.1    Segman, R.H.2    Golcer-Dubner, T.3    Pavlov, V.4    Lerer, B.5
  • 75
    • 79951813616 scopus 로고    scopus 로고
    • Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs
    • Adkins DE, Aberg K, McClay JL, Bukszar J, Zhao Z, Jia P, et al. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. Mol Psychiatry. 2011;16:321-32.
    • (2011) Mol Psychiatry. , vol.16 , pp. 321-332
    • Adkins, D.E.1    Aberg, K.2    McClay, J.L.3    Bukszar, J.4    Zhao, Z.5    Jia, P.6
  • 76
    • 0027967729 scopus 로고
    • HSP70-2 9.0 kb variant is in linkage disequilibrium with the HLA-B and DRB1* alleles associated with clozapine-induced agranulocytosis
    • Corzo D, Yunis JJ, Yunis EJ, Howard A, Lieberman JA. HSP70-2 9.0 kb variant is in linkage disequilibrium with the HLA-B and DRB1* alleles associated with clozapine-induced agranulocytosis. J Clin Psychiatry. 1994;55:149-52.
    • (1994) J Clin Psychiatry. , vol.55 , pp. 149-152
    • Corzo, D.1    Yunis, J.J.2    Yunis, E.J.3    Howard, A.4    Lieberman, J.A.5
  • 77
    • 0028820611 scopus 로고
    • The major histocompatibility complex region marked by HSP70-1 and HSP70-2 variants is associated with clozapineinduced agranulocytosis in two different ethnic groups
    • Corzo D, Yunis JJ, Salazar M, Lieberman JA, Howard A, Awdeh Z, et al. The major histocompatibility complex region marked by HSP70-1 and HSP70-2 variants is associated with clozapineinduced agranulocytosis in two different ethnic groups. Blood. 1995;86:3835-40.
    • (1995) Blood. , vol.86 , pp. 3835-3840
    • Corzo, D.1    Yunis, J.J.2    Salazar, M.3    Lieberman, J.A.4    Howard, A.5    Awdeh, Z.6
  • 79
    • 0031965777 scopus 로고    scopus 로고
    • HLAB38 and clozapine-induced agranulocytosis in Israeli Jewish schizophrenic patients
    • Valevski A, Klein T, Gazit E, Meged S, Stein D, Elizur A, et al. HLAB38 and clozapine-induced agranulocytosis in Israeli Jewish schizophrenic patients. Eur J Immunogenet. 1998;25:11-3.
    • (1998) Eur J Immunogenet. , vol.25 , pp. 11-13
    • Valevski, A.1    Klein, T.2    Gazit, E.3    Meged, S.4    Stein, D.5    Elizur, A.6
  • 80
    • 0035100014 scopus 로고    scopus 로고
    • Further evidence of human leukocyte antigen-encoded susceptibility to clozapine-induced agranulocytosis independent of ancestry
    • Dettling M, Schaub RT, Mueller-Oerlinghausen B, Roots I, Cascorbi I. Further evidence of human leukocyte antigen-encoded susceptibility to clozapine-induced agranulocytosis independent of ancestry. Pharmacogenetics. 2001;11:135-41.
    • (2001) Pharmacogenetics. , vol.11 , pp. 135-141
    • Dettling, M.1    Schaub, R.T.2    Mueller-Oerlinghausen, B.3    Roots, I.4    Cascorbi, I.5
  • 81
    • 79955508661 scopus 로고    scopus 로고
    • Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis
    • Athanasiou MC, Dettling M, Cascorbi I, Mosyagin I, Salisbury BA, Pierz KA, et al. Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis. J Clin Psychiatry. 2011;72:458-63.
    • (2011) J Clin Psychiatry. , vol.72 , pp. 458-463
    • Athanasiou, M.C.1    Dettling, M.2    Cascorbi, I.3    Mosyagin, I.4    Salisbury, B.A.5    Pierz, K.A.6
  • 83
    • 0030992688 scopus 로고    scopus 로고
    • Tumor necrosis factor constellation polymorphism and clozapine-induced agranulocytosis in two different ethnic groups
    • Turbay D, Lieberman J, Alper CA, Delgado JC, Corzo D, Yunis JJ, et al. Tumor necrosis factor constellation polymorphism and clozapine-induced agranulocytosis in two different ethnic groups. Blood. 1997;89:4167-74.
    • (1997) Blood. , vol.89 , pp. 4167-4174
    • Turbay, D.1    Lieberman, J.2    Alper, C.A.3    Delgado, J.C.4    Corzo, D.5    Yunis, J.J.6
  • 84
    • 84872387438 scopus 로고    scopus 로고
    • Association between CYP1A2 polymorphisms and clozapineinduced adverse reactions in patients with schizophrenia
    • Ferrari M, Bolla E, Bortolaso P, Callegari C, Poloni N, Lecchini S, et al. Association between CYP1A2 polymorphisms and clozapineinduced adverse reactions in patients with schizophrenia. Psychiatry Res. 2012;200:1014-7.
    • (2012) Psychiatry Res. , vol.200 , pp. 1014-1017
    • Ferrari, M.1    Bolla, E.2    Bortolaso, P.3    Callegari, C.4    Poloni, N.5    Lecchini, S.6
  • 86
    • 4344702329 scopus 로고    scopus 로고
    • Pharmacogenetics of antipsychoatics
    • Ozaki N. Pharmacogenetics of antipsychoatics. Nagoya J Med Sci. 2004;67:1-7.
    • (2004) Nagoya J Med Sci. , vol.67 , pp. 1-7
    • Ozaki, N.1
  • 87
    • 84872466656 scopus 로고    scopus 로고
    • Human Cytochrome P450 (CYP) Allele Nomenclature Committee [Internet]. [cited 2013 July 1]
    • Human Cytochrome P450 (CYP) Allele Nomenclature Committee [Internet]. The Human Cytochrome P450 (CYP) Allele Nomenclature Database. [cited 2013 July 1]. http://www.cypalleles. ki.se/
    • The Human Cytochrome P450 (CYP) Allele Nomenclature Database.
  • 88
    • 0037339287 scopus 로고    scopus 로고
    • The effect of smoking and cytochrome P450 CYP1A2 genetic polymorphism on clozapine clearance and dose requirement
    • van der Weide J, Steijns LS, van Weelden MJ. The effect of smoking and cytochrome P450 CYP1A2 genetic polymorphism on clozapine clearance and dose requirement. Pharmacogenetics. 2003;13:169-72.
    • (2003) Pharmacogenetics. , vol.13 , pp. 169-172
    • van der Weide, J.1    Steijns, L.S.2    van Weelden, M.J.3
  • 91
    • 0028307888 scopus 로고
    • Disposition of clozapine in man: Lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms
    • Dahl ML, Llerena A, Bondesson U, Lindstrom L, Bertilsson L. Disposition of clozapine in man: lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms. Br J Clin Pharmacol. 1994;37:71-4.
    • (1994) Br J Clin Pharmacol. , vol.37 , pp. 71-74
    • Dahl, M.L.1    Llerena, A.2    Bondesson, U.3    Lindstrom, L.4    Bertilsson, L.5
  • 92
    • 0035749505 scopus 로고    scopus 로고
    • Pharmacogenetics for the individualization of psychiatric treatment
    • Arranz MJ, Collier D, Kerwin RW. Pharmacogenetics for the individualization of psychiatric treatment. Am J Pharmacogenomics. 2001;1:3-10.
    • (2001) Am J Pharmacogenomics. , vol.1 , pp. 3-10
    • Arranz, M.J.1    Collier, D.2    Kerwin, R.W.3
  • 93
    • 0027971612 scopus 로고
    • Functional neuroimaging and pharmacogenetic studies of clozapine's action at dopamine receptors
    • Kerwin RW, Pilowsky L, Munro J, Shaikh S, Gill M, Collier D. Functional neuroimaging and pharmacogenetic studies of clozapine's action at dopamine receptors. J Clin Psychiatry. 1994;55:57-62.
    • (1994) J Clin Psychiatry. , vol.55 , pp. 57-62
    • Kerwin, R.W.1    Pilowsky, L.2    Munro, J.3    Shaikh, S.4    Gill, M.5    Collier, D.6
  • 94
    • 0028172045 scopus 로고
    • Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine
    • Rao PA, Pickar D, Gejman PV, Ram A, Gershon ES, Gelernter J. Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine. Arch Gen Psychiatry. 1994;51:912-7.
    • (1994) Arch Gen Psychiatry. , vol.51 , pp. 912-917
    • Rao, P.A.1    Pickar, D.2    Gejman, P.V.3    Ram, A.4    Gershon, E.S.5    Gelernter, J.6
  • 95
    • 0029560535 scopus 로고
    • Analysis of clozapine response and polymorphisms of the dopamine D4 receptor gene (DRD4) in schizophrenic patients
    • Shaikh S, Collier DA, Sham P, Pilowsky L, Sharma T, Lin LK, et al. Analysis of clozapine response and polymorphisms of the dopamine D4 receptor gene (DRD4) in schizophrenic patients. Am J Med Genet. 1995;60:541-5.
    • (1995) Am J Med Genet. , vol.60 , pp. 541-545
    • Shaikh, S.1    Collier, D.A.2    Sham, P.3    Pilowsky, L.4    Sharma, T.5    Lin, L.K.6
  • 96
    • 0030296697 scopus 로고    scopus 로고
    • Efficacy and side-effects of clozapine: Testing for association with allelic variation in the dopamine D4 receptor gene
    • Rietschel M, Naber D, Oberlander H, Holzbach R, Fimmers R, Eggermann K, et al. Efficacy and side-effects of clozapine: testing for association with allelic variation in the dopamine D4 receptor gene. Neuropsychopharmacology. 1996;15:491-6.
    • (1996) Neuropsychopharmacology. , vol.15 , pp. 491-496
    • Rietschel, M.1    Naber, D.2    Oberlander, H.3    Holzbach, R.4    Fimmers, R.5    Eggermann, K.6
  • 97
    • 0030940989 scopus 로고    scopus 로고
    • Dopamine D4 receptor gene polymorphisms: Relation to ethnicity, no association with schizophrenia and response to clozapine in Israeli subjects
    • Kohn Y, Ebstein RP, Heresco-Levy U, Shapira B, Nemanov L, Gritsenko I, et al. Dopamine D4 receptor gene polymorphisms: relation to ethnicity, no association with schizophrenia and response to clozapine in Israeli subjects. Eur Neuropsychopharmacol. 1997;7:39-43.
    • (1997) Eur Neuropsychopharmacol. , vol.7 , pp. 39-43
    • Kohn, Y.1    Ebstein, R.P.2    Heresco-Levy, U.3    Shapira, B.4    Nemanov, L.5    Gritsenko, I.6
  • 98
    • 0033945594 scopus 로고    scopus 로고
    • Dopamine D4 receptor 48-bp repeat polymorphism: No association with response to antipsychotic treatment, but association with catatonic schizophrenia
    • Kaiser R, Konneker M, Henneken M, Dettling M, Muller-Oerlinghausen B, Roots I, et al. Dopamine D4 receptor 48-bp repeat polymorphism: no association with response to antipsychotic treatment, but association with catatonic schizophrenia. Mol Psychiatry. 2000;5:418-24.
    • (2000) Mol Psychiatry. , vol.5 , pp. 418-424
    • Kaiser, R.1    Konneker, M.2    Henneken, M.3    Dettling, M.4    Muller-Oerlinghausen, B.5    Roots, I.6
  • 99
    • 0032922634 scopus 로고    scopus 로고
    • Genetics of novel therapeutic targets in schizophrenia
    • Kerwin R, Owen M. Genetics of novel therapeutic targets in schizophrenia. Br J Psychiatry Suppl. 1999:1-4.
    • (1999) Br J Psychiatry Suppl. , pp. 1-4
    • Kerwin, R.1    Owen, M.2
  • 100
    • 0029762472 scopus 로고    scopus 로고
    • Assessment of association of D3 dopamine receptor MscI polymorphism with schizophrenia: Analysis of symptom ratings, family history, age at onset, and movement disorders
    • Gaitonde EJ, Morris A, Sivagnanasundaram S, McKenna PJ, Hunt DM, Mollon JD. Assessment of association of D3 dopamine receptor MscI polymorphism with schizophrenia: analysis of symptom ratings, family history, age at onset, and movement disorders. Am J Med Genet. 1996;67:455-8.
    • (1996) Am J Med Genet. , vol.67 , pp. 455-458
    • Gaitonde, E.J.1    Morris, A.2    Sivagnanasundaram, S.3    McKenna, P.J.4    Hunt, D.M.5    Mollon, J.D.6
  • 101
    • 0031594223 scopus 로고    scopus 로고
    • The dopamine D3 receptor (DRD3) Ser9Gly polymorphism and schizophrenia: A haplotype relative risk study and association with clozapine response
    • Malhotra AK, Goldman D, Buchanan RW, Rooney W, Clifton A, Kosmidis MH, et al. The dopamine D3 receptor (DRD3) Ser9Gly polymorphism and schizophrenia: a haplotype relative risk study and association with clozapine response. Mol Psychiatry. 1998;3:72-5.
    • (1998) Mol Psychiatry. , vol.3 , pp. 72-75
    • Malhotra, A.K.1    Goldman, D.2    Buchanan, R.W.3    Rooney, W.4    Clifton, A.5    Kosmidis, M.H.6
  • 105
    • 77952887880 scopus 로고    scopus 로고
    • Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: Exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant
    • Hwang R, Zai C, Tiwari A, Muller DJ, Arranz MJ, Morris AG, et al. Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant. Pharmacogenomics J. 2010;10:200-18.
    • (2010) Pharmacogenomics J. , vol.10 , pp. 200-218
    • Hwang, R.1    Zai, C.2    Tiwari, A.3    Muller, D.J.4    Arranz, M.J.5    Morris, A.G.6
  • 106
    • 79951920911 scopus 로고    scopus 로고
    • Gene-gene interaction analyses between NMDA receptor subunit and dopamine receptor gene variants and clozapine response
    • Hwang R, Souza RP, Tiwari AK, Zai CC, Muller DJ, Potkin SG, et al. Gene-gene interaction analyses between NMDA receptor subunit and dopamine receptor gene variants and clozapine response. Pharmacogenomics. 2011;12:277-91.
    • (2011) Pharmacogenomics. , vol.12 , pp. 277-291
    • Hwang, R.1    Souza, R.P.2    Tiwari, A.K.3    Zai, C.C.4    Muller, D.J.5    Potkin, S.G.6
  • 108
    • 77952887880 scopus 로고    scopus 로고
    • Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: Exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant
    • Hwang R, Zai C, Tiwari A, Muller DJ, Arranz MJ, Morris AG, et al. Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant. Pharmacogenomics J. 2010;10:200-18.
    • (2010) Pharmacogenomics J. , vol.10 , pp. 200-218
    • Hwang, R.1    Zai, C.2    Tiwari, A.3    Muller, D.J.4    Arranz, M.J.5    Morris, A.G.6
  • 109
    • 0026481115 scopus 로고
    • Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4
    • Seeman P. Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4. Neuropsychopharmacology. 1992;7:261-84.
    • (1992) Neuropsychopharmacology. , vol.7 , pp. 261-284
    • Seeman, P.1
  • 110
    • 0032217288 scopus 로고    scopus 로고
    • Lack of association between a polymorphism in the promoter region of the dopamine-2 receptor gene and clozapine response
    • Arranz MJ, Li T, Munro J, Liu X, Murray R, Collier DA, et al. Lack of association between a polymorphism in the promoter region of the dopamine-2 receptor gene and clozapine response. Pharmacogenetics. 1998;8:481-4.
    • (1998) Pharmacogenetics. , vol.8 , pp. 481-484
    • Arranz, M.J.1    Li, T.2    Munro, J.3    Liu, X.4    Murray, R.5    Collier, D.A.6
  • 112
    • 77954224633 scopus 로고    scopus 로고
    • D2 receptor genetic variation and clinical response to antipsychotic drug treatment: A meta-analysis
    • Zhang JP, Lencz T, Malhotra AK. D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysis. Am J Psychiatry. 2010;167:763-72.
    • (2010) Am J Psychiatry. , vol.167 , pp. 763-772
    • Zhang, J.P.1    Lencz, T.2    Malhotra, A.K.3
  • 113
    • 0347363538 scopus 로고    scopus 로고
    • Role of dopamine D3 receptor (DRD3) and dopamine transporter (DAT) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia
    • Szekeres G, Keri S, Juhasz A, Rimanoczy A, Szendi I, Czimmer C, et al. Role of dopamine D3 receptor (DRD3) and dopamine transporter (DAT) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2004;124B:1-5.
    • (2004) Am J Med Genet B Neuropsychiatr Genet. , vol.124 B , pp. 1-5
    • Szekeres, G.1    Keri, S.2    Juhasz, A.3    Rimanoczy, A.4    Szendi, I.5    Czimmer, C.6
  • 114
    • 0034104356 scopus 로고    scopus 로고
    • Neurotransmitter-related genes and antipsychotic response: Pharmacogenetics meets psychiatric treatment
    • Arranz MJ, Kerwin RW. Neurotransmitter-related genes and antipsychotic response: pharmacogenetics meets psychiatric treatment. Ann Med. 2000;32:128-33.
    • (2000) Ann Med. , vol.32 , pp. 128-133
    • Arranz, M.J.1    Kerwin, R.W.2
  • 115
    • 0029670417 scopus 로고    scopus 로고
    • 5-HT2 receptor gene locus: Association with schizophrenia or treatment response not detected
    • Nimgaonkar VL, Zhang XR, Brar JS, DeLeo M, Ganguli R. 5-HT2 receptor gene locus: association with schizophrenia or treatment response not detected. Psychiatr Genet. 1996;6:23-7.
    • (1996) Psychiatr Genet. , vol.6 , pp. 23-27
    • Nimgaonkar, V.L.1    Zhang, X.R.2    Brar, J.S.3    DeLeo, M.4    Ganguli, R.5
  • 118
    • 0029790119 scopus 로고    scopus 로고
    • Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine
    • Malhotra AK, Goldman D, Ozaki N, Breier A, Buchanan R, Pickar D. Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine. Am J Psychiatry. 1996;153:1092-4.
    • (1996) Am J Psychiatry. , vol.153 , pp. 1092-1094
    • Malhotra, A.K.1    Goldman, D.2    Ozaki, N.3    Breier, A.4    Buchanan, R.5    Pickar, D.6
  • 119
    • 0002964661 scopus 로고    scopus 로고
    • No evidence for association of serotonin-2A receptor variant (102T/C) with schizophrenia or clozapine response in a Chinese population
    • Lin CH, Tsai SJ, Yu YW, Song HL, Tu PC, Sim CB, et al. No evidence for association of serotonin-2A receptor variant (102T/C) with schizophrenia or clozapine response in a Chinese population. Neuroreport. 1999;10:57-60.
    • (1999) Neuroreport. , vol.10 , pp. 57-60
    • Lin, C.H.1    Tsai, S.J.2    Yu, Y.W.3    Song, H.L.4    Tu, P.C.5    Sim, C.B.6
  • 120
    • 13844254110 scopus 로고    scopus 로고
    • Negative symptoms of schizophrenia could explain discrepant data on the association between the 5-HT2A receptor gene and response to antipsychotics
    • Hamdani N, Bonniere M, Ades J, Hamon M, Boni C, Gorwood P. Negative symptoms of schizophrenia could explain discrepant data on the association between the 5-HT2A receptor gene and response to antipsychotics. Neurosci Lett. 2005;377:69-74.
    • (2005) Neurosci Lett. , vol.377 , pp. 69-74
    • Hamdani, N.1    Bonniere, M.2    Ades, J.3    Hamon, M.4    Boni, C.5    Gorwood, P.6
  • 121
    • 0032572611 scopus 로고    scopus 로고
    • Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response
    • Arranz MJ, Munro J, Sham P, Kirov G, Murray RM, Collier DA, et al. Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response. Schizophr Res. 1998;32:93-9.
    • (1998) Schizophr Res. , vol.32 , pp. 93-99
    • Arranz, M.J.1    Munro, J.2    Sham, P.3    Kirov, G.4    Murray, R.M.5    Collier, D.A.6
  • 123
    • 0030738648 scopus 로고    scopus 로고
    • Efficacy and side-effects of clozapine not associated with variation in the 5-HT2C receptor
    • Rietschel M, Naber D, Fimmers R, Moller HJ, Propping P, Nothen MM. Efficacy and side-effects of clozapine not associated with variation in the 5-HT2C receptor. Neuroreport. 1997;8:1999-2003.
    • (1997) Neuroreport. , vol.8 , pp. 1999-2003
    • Rietschel, M.1    Naber, D.2    Fimmers, R.3    Moller, H.J.4    Propping, P.5    Nothen, M.M.6
  • 124
    • 0035863032 scopus 로고    scopus 로고
    • Lack of association between the T--. C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia
    • Masellis M, Basile VS, Meltzer HY, Lieberman JA, Sevy S, Goldman DA, et al. Lack of association between the T--. C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. Schizophr Res. 2001;47:49-58.
    • (2001) Schizophr Res. , vol.47 , pp. 49-58
    • Masellis, M.1    Basile, V.S.2    Meltzer, H.Y.3    Lieberman, J.A.4    Sevy, S.5    Goldman, D.A.6
  • 125
    • 0012820694 scopus 로고    scopus 로고
    • Association analysis of the 5-HT5A gene in depression, psychosis and antipsychotic response
    • Birkett JT, Arranz MJ, Munro J, Osbourn S, Kerwin RW, Collier DA. Association analysis of the 5-HT5A gene in depression, psychosis and antipsychotic response. Neuroreport. 2000;11:2017-20.
    • (2000) Neuroreport. , vol.11 , pp. 2017-2020
    • Birkett, J.T.1    Arranz, M.J.2    Munro, J.3    Osbourn, S.4    Kerwin, R.W.5    Collier, D.A.6
  • 127
    • 0034283750 scopus 로고    scopus 로고
    • Association study of a functional serotonin transporter gene polymorphism with schizophrenia, psychopathology and clozapine response
    • Tsai SJ, Hong CJ, Yu YW, Lin CH, Song HL, Lai HC, et al. Association study of a functional serotonin transporter gene polymorphism with schizophrenia, psychopathology and clozapine response. Schizophr Res. 2000;44:177-81.
    • (2000) Schizophr Res. , vol.44 , pp. 177-181
    • Tsai, S.J.1    Hong, C.J.2    Yu, Y.W.3    Lin, C.H.4    Song, H.L.5    Lai, H.C.6
  • 128
    • 0035118875 scopus 로고    scopus 로고
    • Serotonin transporter polymorphisms: No association with response to antipsychotic treatment, but associations with the schizoparanoid and residual subtypes of schizophrenia
    • Kaiser R, Tremblay PB, Schmider J, Henneken M, Dettling M, Muller-Oerlinghausen B, et al. Serotonin transporter polymorphisms: no association with response to antipsychotic treatment, but associations with the schizoparanoid and residual subtypes of schizophrenia. Mol Psychiatry. 2001;6:179-85.
    • (2001) Mol Psychiatry. , vol.6 , pp. 179-185
    • Kaiser, R.1    Tremblay, P.B.2    Schmider, J.3    Henneken, M.4    Dettling, M.5    Muller-Oerlinghausen, B.6
  • 129
    • 0033956560 scopus 로고    scopus 로고
    • No influence of adrenergic receptor polymorphisms on schizophrenia and antipsychotic response
    • Bolonna AA, Arranz MJ, Munro J, Osborne S, Petouni M, Martinez M, et al. No influence of adrenergic receptor polymorphisms on schizophrenia and antipsychotic response. Neurosci Lett. 2000; 280:65-8.
    • (2000) Neurosci Lett. , vol.280 , pp. 65-68
    • Bolonna, A.A.1    Arranz, M.J.2    Munro, J.3    Osborne, S.4    Petouni, M.5    Martinez, M.6
  • 130
    • 0035871218 scopus 로고    scopus 로고
    • Association analysis of polymorphism in the promoter region of the alpha2a-adrenoceptor gene with schizophrenia and clozapine response
    • Tsai SJ, Wang YC, Yu Younger WY, Lin CH, Yang KH, Hong CJ. Association analysis of polymorphism in the promoter region of the alpha2a-adrenoceptor gene with schizophrenia and clozapine response. Schizophr Res. 2001;49:53-8.
    • (2001) Schizophr Res. , vol.49 , pp. 53-58
    • Tsai, S.J.1    Wang, Y.C.2    Yu Younger, W.Y.3    Lin, C.H.4    Yang, K.H.5    Hong, C.J.6
  • 131
    • 0142091432 scopus 로고    scopus 로고
    • An association study of a brain-derived neurotrophic factor Val66Met polymorphism and clozapine response of schizophrenic patients
    • Hong CJ, Yu YW, Lin CH, Tsai SJ. An association study of a brain-derived neurotrophic factor Val66Met polymorphism and clozapine response of schizophrenic patients. Neurosci Lett. 2003;349:206-8.
    • (2003) Neurosci Lett. , vol.349 , pp. 206-208
    • Hong, C.J.1    Yu, Y.W.2    Lin, C.H.3    Tsai, S.J.4
  • 132
    • 73449117175 scopus 로고    scopus 로고
    • Lack of association of GPX1 and MnSOD genes with symptom severity and response to clozapine treatment in schizophrenia subjects
    • Souza RP, Tampakeras M, Basile V, Shinkai T, Rosa DV, Potkin S, et al. Lack of association of GPX1 and MnSOD genes with symptom severity and response to clozapine treatment in schizophrenia subjects. Human Psychopharmacol. 2009;24:676-9.
    • (2009) Human Psychopharmacol. , vol.24 , pp. 676-679
    • Souza, R.P.1    Tampakeras, M.2    Basile, V.3    Shinkai, T.4    Rosa, D.V.5    Potkin, S.6
  • 133
    • 0035703938 scopus 로고    scopus 로고
    • Association analysis for NMDA receptor subunit 2B (GRIN2B) genetic variants and psychopathology and clozapine response in schizophrenia
    • Hong CJ, Yu YW, Lin CH, Cheng CY, Tsai SJ. Association analysis for NMDA receptor subunit 2B (GRIN2B) genetic variants and psychopathology and clozapine response in schizophrenia. Psychiatr Genet. 2001;11:219-22.
    • (2001) Psychiatr Genet. , vol.11 , pp. 219-222
    • Hong, C.J.1    Yu, Y.W.2    Lin, C.H.3    Cheng, C.Y.4    Tsai, S.J.5
  • 134
    • 0037195542 scopus 로고    scopus 로고
    • Investigation of promoter variants of the histamine 1 and 2 receptors in schizophrenia and clozapine response
    • Mancama D, Arranz MJ, Munro J, Osborne S, Makoff A, Collier D, et al. Investigation of promoter variants of the histamine 1 and 2 receptors in schizophrenia and clozapine response. Neurosci Lett. 2002;333:207-11.
    • (2002) Neurosci Lett. , vol.333 , pp. 207-211
    • Mancama, D.1    Arranz, M.J.2    Munro, J.3    Osborne, S.4    Makoff, A.5    Collier, D.6
  • 135
    • 0242583205 scopus 로고    scopus 로고
    • No association of tumor necrosis factor alpha gene polymorphisms with schizophrenia or response to clozapine
    • Tsai SJ, Hong CJ, Yu YW, Lin CH, Liu LL. No association of tumor necrosis factor alpha gene polymorphisms with schizophrenia or response to clozapine. Schizophr Res. 2003;65:27-32.
    • (2003) Schizophr Res. , vol.65 , pp. 27-32
    • Tsai, S.J.1    Hong, C.J.2    Yu, Y.W.3    Lin, C.H.4    Liu, L.L.5
  • 136
    • 0035052252 scopus 로고    scopus 로고
    • Genetic variants of the serotonin system and weight change during clozapine treatment
    • Hong CJ, Lin CH, Yu YW, Yang KH, Tsai SJ. Genetic variants of the serotonin system and weight change during clozapine treatment. Pharmacogenetics. 2001;11:265-8.
    • (2001) Pharmacogenetics. , vol.11 , pp. 265-268
    • Hong, C.J.1    Lin, C.H.2    Yu, Y.W.3    Yang, K.H.4    Tsai, S.J.5
  • 137
    • 0034785813 scopus 로고    scopus 로고
    • Genetic dissection of atypical antipsychotic-induced weight gain: Novel preliminary data on the pharmacogenetic puzzle
    • Basile VS, Masellis M, McIntyre RS, Meltzer HY, Lieberman JA, Kennedy JL. Genetic dissection of atypical antipsychotic-induced weight gain: novel preliminary data on the pharmacogenetic puzzle. J Clin Psychiatry. 2001;62:45-66.
    • (2001) J Clin Psychiatry. , vol.62 , pp. 45-66
    • Basile, V.S.1    Masellis, M.2    McIntyre, R.S.3    Meltzer, H.Y.4    Lieberman, J.A.5    Kennedy, J.L.6
  • 138
    • 0037202751 scopus 로고    scopus 로고
    • 759C/T genetic variation of 5HT(2C) receptor and clozapine-induced weight gain
    • Tsai SJ, Hong CJ, Yu YW, Lin CH.-759C/T genetic variation of 5HT(2C) receptor and clozapine-induced weight gain. Lancet. 2002;360:1790.
    • (2002) Lancet. , vol.360 , pp. 1790
    • Tsai, S.J.1    Hong, C.J.2    Yu, Y.W.3    Lin, C.H.4
  • 139
    • 4644225416 scopus 로고    scopus 로고
    • Lack of association between the-759C/T polymorphism of the 5-HT2C receptor gene and clozapine-induced weight gain among German schizophrenic individuals
    • Theisen FM, Hinney A, Bromel T, Heinzel-Gutenbrunner M, Martin M, Krieg JC, et al. Lack of association between the-759C/T polymorphism of the 5-HT2C receptor gene and clozapine-induced weight gain among German schizophrenic individuals. Psychiatr Genet. 2004;14:139-42.
    • (2004) Psychiatr Genet. , vol.14 , pp. 139-142
    • Theisen, F.M.1    Hinney, A.2    Bromel, T.3    Heinzel-Gutenbrunner, M.4    Martin, M.5    Krieg, J.C.6
  • 141
  • 143
    • 79957661982 scopus 로고    scopus 로고
    • Functional consequences of two HTR2C polymorphisms associated with antipsychotic-induced weight gain
    • Hill MJ, Reynolds GP. Functional consequences of two HTR2C polymorphisms associated with antipsychotic-induced weight gain. Pharmacogenomics. 2011;12:727-34.
    • (2011) Pharmacogenomics. , vol.12 , pp. 727-734
    • Hill, M.J.1    Reynolds, G.P.2
  • 144
    • 2642586378 scopus 로고    scopus 로고
    • Association study of adrenergic beta3 receptor (Trp64Arg) and G-protein beta3 subunit gene (C825T) polymorphisms and weight change during clozapine treatment
    • Tsai SJ, Yu YW, Lin CH, Wang YC, Chen JY, Hong CJ. Association study of adrenergic beta3 receptor (Trp64Arg) and G-protein beta3 subunit gene (C825T) polymorphisms and weight change during clozapine treatment. Neuropsychobiology. 2004;50:37-40.
    • (2004) Neuropsychobiology. , vol.50 , pp. 37-40
    • Tsai, S.J.1    Yu, Y.W.2    Lin, C.H.3    Wang, Y.C.4    Chen, J.Y.5    Hong, C.J.6
  • 145
    • 77950902489 scopus 로고    scopus 로고
    • Association study of polymorphisms in insulin induced gene 2 (INSIG2) with antipsychotic-induced weight gain in European and African-American schizophrenia patients
    • Tiwari AK, Zai CC, Meltzer HY, Lieberman JA, Muller DJ, Kennedy JL. Association study of polymorphisms in insulin induced gene 2 (INSIG2) with antipsychotic-induced weight gain in European and African-American schizophrenia patients. Hum Psychopharmacol. 2010;25:253-9.
    • (2010) Hum Psychopharmacol. , vol.25 , pp. 253-259
    • Tiwari, A.K.1    Zai, C.C.2    Meltzer, H.Y.3    Lieberman, J.A.4    Muller, D.J.5    Kennedy, J.L.6
  • 146
    • 82455162579 scopus 로고    scopus 로고
    • TNF-alpha-308 G. A polymorphism and weight gain in patients with schizophrenia under long-term clozapine, risperidone or olanzapine treatment
    • Huang HH, Wang YC, Wu CL, Hong CJ, Bai YM, Tsai SJ, et al. TNF-alpha-308 G. A polymorphism and weight gain in patients with schizophrenia under long-term clozapine, risperidone or olanzapine treatment. Neurosci Lett. 2011;504:277-80.
    • (2011) Neurosci Lett. , vol.504 , pp. 277-280
    • Huang, H.H.1    Wang, Y.C.2    Wu, C.L.3    Hong, C.J.4    Bai, Y.M.5    Tsai, S.J.6
  • 147
    • 78649505049 scopus 로고    scopus 로고
    • Association study of polymorphisms in cholecystokinin gene and its receptors with antipsychotic induced weight gain in schizophrenia patients
    • Tiwari AK, Rodgers JB, Sicard M, Zai CC, Likhodi O, Freeman N, et al. Association study of polymorphisms in cholecystokinin gene and its receptors with antipsychotic induced weight gain in schizophrenia patients. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:1484-90.
    • (2010) Prog Neuropsychopharmacol Biol Psychiatry. , vol.34 , pp. 1484-1490
    • Tiwari, A.K.1    Rodgers, J.B.2    Sicard, M.3    Zai, C.C.4    Likhodi, O.5    Freeman, N.6
  • 148
    • 77951098236 scopus 로고    scopus 로고
    • A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia
    • Tiwari AK, Zai CC, Likhodi O, Lisker A, Singh D, Souza RP, et al. A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia. Neuropsychopharmacology. 2010;35:1315-24.
    • (2010) Neuropsychopharmacology. , vol.35 , pp. 1315-1324
    • Tiwari, A.K.1    Zai, C.C.2    Likhodi, O.3    Lisker, A.4    Singh, D.5    Souza, R.P.6
  • 149
    • 84859791325 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala: Lack of association with weight gain in psychiatric inpatients treated with olanzapine or clozapine
    • Staeker J, Leucht S, Steimer W. Peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala: lack of association with weight gain in psychiatric inpatients treated with olanzapine or clozapine. Mol Diagn Ther. 2012;16:93-8.
    • (2012) Mol Diagn Ther. , vol.16 , pp. 93-98
    • Staeker, J.1    Leucht, S.2    Steimer, W.3
  • 150
    • 0030296697 scopus 로고    scopus 로고
    • Efficacy and side-effects of clozapine: Testing for association with allelic variation in the dopamine D4 receptor gene
    • Rietschel M, Naber D, Oberlander H, Holzbach R, Fimmers R, Eggermann K, et al. Efficacy and side-effects of clozapine: testing for association with allelic variation in the dopamine D4 receptor gene. Neuropsychopharmacology. 1996;15:491-6.
    • (1996) Neuropsychopharmacology. , vol.15 , pp. 491-496
    • Rietschel, M.1    Naber, D.2    Oberlander, H.3    Holzbach, R.4    Fimmers, R.5    Eggermann, K.6
  • 151
    • 0036755421 scopus 로고    scopus 로고
    • Genetic variant of the histamine-1 receptor (glu349asp) and body weight change during clozapine treatment
    • Hong CJ, Lin CH, Yu YW, Chang SC, Wang SY, Tsai SJ. Genetic variant of the histamine-1 receptor (glu349asp) and body weight change during clozapine treatment. Psychiatr Genet. 2002;12:169-71.
    • (2002) Psychiatr Genet. , vol.12 , pp. 169-171
    • Hong, C.J.1    Lin, C.H.2    Yu, Y.W.3    Chang, S.C.4    Wang, S.Y.5    Tsai, S.J.6
  • 152
  • 154
    • 0033674522 scopus 로고    scopus 로고
    • Clozapine-induced agranulocytosis and hereditary polymorphisms of clozapine metabolizing enzymes: No association with myeloperoxidase and cytochrome P4502D6
    • Dettling M, Sachse C, Muller-Oerlinghausen B, Roots I, Brockmoller J, Rolfs A, et al. Clozapine-induced agranulocytosis and hereditary polymorphisms of clozapine metabolizing enzymes: no association with myeloperoxidase and cytochrome P4502D6. Pharmacopsychiatry. 2000;33:218-20.
    • (2000) Pharmacopsychiatry. , vol.33 , pp. 218-220
    • Dettling, M.1    Sachse, C.2    Muller-Oerlinghausen, B.3    Roots, I.4    Brockmoller, J.5    Rolfs, A.6
  • 155
    • 79951521421 scopus 로고    scopus 로고
    • Progress and promise of genomewide association studies for human complex trait genetics
    • Stranger BE, Stahl EA, Raj T. Progress and promise of genomewide association studies for human complex trait genetics. Genetics. 2011;187:367-83.
    • (2011) Genetics. , vol.187 , pp. 367-383
    • Stranger, B.E.1    Stahl, E.A.2    Raj, T.3
  • 156
    • 84864342355 scopus 로고    scopus 로고
    • Pharmacogenetics in psychiatry: Translating research into clinical practice
    • Malhotra AK, Zhang JP, Lencz T. Pharmacogenetics in psychiatry: translating research into clinical practice. Mol Psychiatry. 2012;17:760-9.
    • (2012) Mol Psychiatry. , vol.17 , pp. 760-769
    • Malhotra, A.K.1    Zhang, J.P.2    Lencz, T.3
  • 158
    • 0034660559 scopus 로고    scopus 로고
    • Searching for genetic determinants in the new millennium
    • Risch NJ. Searching for genetic determinants in the new millennium. Nature. 2000;405:847-56.
    • (2000) Nature. , vol.405 , pp. 847-856
    • Risch, N.J.1
  • 160
    • 2342460272 scopus 로고    scopus 로고
    • Evidence that RNA editing modulates splice site selection in the 5-HT2C receptor gene
    • Flomen R, Knight J, Sham P, Kerwin R, Makoff A. Evidence that RNA editing modulates splice site selection in the 5-HT2C receptor gene. Nucleic Acids Res. 2004;32:2113-22.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 2113-2122
    • Flomen, R.1    Knight, J.2    Sham, P.3    Kerwin, R.4    Makoff, A.5
  • 161
    • 22244471085 scopus 로고    scopus 로고
    • Genetics and epigenetics in major psychiatric disorders: Dilemmas, achievements, applications, and future scope
    • Abdolmaleky HM, Thiagalingam S, Wilcox M. Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope. Am J Pharmacogenomics. 2005;5:149-60.
    • (2005) Am J Pharmacogenomics. , vol.5 , pp. 149-160
    • Abdolmaleky, H.M.1    Thiagalingam, S.2    Wilcox, M.3
  • 162
    • 0033358548 scopus 로고    scopus 로고
    • Use of unlinked genetic markers to detect population stratification in association studies
    • Pritchard JK, Rosenberg NA. Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet. 1999;65:220-8.
    • (1999) Am J Hum Genet. , vol.65 , pp. 220-228
    • Pritchard, J.K.1    Rosenberg, N.A.2
  • 163
    • 33646152737 scopus 로고    scopus 로고
    • Pharmacogenetics of antipsychotic therapy: Pivotal research issues and the prospects for clinical implementation
    • Lerer B, Segman RH. Pharmacogenetics of antipsychotic therapy: pivotal research issues and the prospects for clinical implementation. Dialogues Clin Neurosci. 2006;8:85-94.
    • (2006) Dialogues Clin Neurosci. , vol.8 , pp. 85-94
    • Lerer, B.1    Segman, R.H.2
  • 164
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet. 2010;42:1118-25.
    • (2010) Nat Genet. , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.2    Barrett, J.C.3    Wang, K.4    Radford-Smith, G.L.5    Ahmad, T.6
  • 165
    • 84864590971 scopus 로고    scopus 로고
    • Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia
    • Jia P, Wang L, Fanous AH, Pato CN, Edwards TL, Zhao Z. Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia. PLoS Comput Biol. 2012;8:e1002587.
    • (2012) PLoS Comput Biol. , vol.8
    • Jia, P.1    Wang, L.2    Fanous, A.H.3    Pato, C.N.4    Edwards, T.L.5    Zhao, Z.6
  • 166
    • 77954891473 scopus 로고    scopus 로고
    • GWAS: Heritability missing in action?
    • Clarke AJ, Cooper DN. GWAS: heritability missing in action? Eur J Hum Genet. 2010;18:859-61.
    • (2010) Eur J Hum Genet. , vol.18 , pp. 859-861
    • Clarke, A.J.1    Cooper, D.N.2
  • 167
    • 67349166946 scopus 로고    scopus 로고
    • Detecting gene-gene interactions that underlie human diseases
    • Cordell HJ. Detecting gene-gene interactions that underlie human diseases. Nat Ver Genet. 2009;10:392-404.
    • (2009) Nat Ver Genet. , vol.10 , pp. 392-404
    • Cordell, H.J.1
  • 168
    • 0034660559 scopus 로고    scopus 로고
    • Searching for genetic determinants in the new millennium
    • Risch NJ. Searching for genetic determinants in the new millennium. Nature. 2000;405:847-56.
    • (2000) Nature. , vol.405 , pp. 847-856
    • Risch, N.J.1
  • 169
    • 77949497074 scopus 로고    scopus 로고
    • Bioinformatics challenges for genome-wide association studies
    • Moore JH, Asselbergs FW, Williams SM. Bioinformatics challenges for genome-wide association studies. Bioinformatics. 2010;26:445-55.
    • (2010) Bioinformatics. , vol.26 , pp. 445-455
    • Moore, J.H.1    Asselbergs, F.W.2    Williams, S.M.3
  • 170
    • 0038448311 scopus 로고    scopus 로고
    • The National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project: Schizophrenia trial design and protocol development
    • Stroup TS, McEvoy JP, Swartz MS, Byerly MJ, Glick ID, Canive JM, et al. The National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project: schizophrenia trial design and protocol development. Schizophr Bull. 2003;29:15-31.
    • (2003) Schizophr Bull. , vol.29 , pp. 15-31
    • Stroup, T.S.1    McEvoy, J.P.2    Swartz, M.S.3    Byerly, M.J.4    Glick, I.D.5    Canive, J.M.6
  • 171
    • 33847769752 scopus 로고    scopus 로고
    • Fitting the drug to the patient
    • Mayor S. Fitting the drug to the patient. BMJ. 2007;334:452-3.
    • (2007) BMJ. , vol.334 , pp. 452-453
    • Mayor, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.