Polymorphism of the promoter region of the serotonin 5-HT2C receptor gene and clozapine-induced weight gain

American Journal of Psychiatry

Volumn 160, Issue 4, 2003, Pages 677-679

  Reynolds, Gavin P ^a   Zhang, Zhijun ^b   Zhang, XiaoBin ^b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; SEROTONIN 2C RECEPTOR; NEUROLEPTIC AGENT; SEROTONIN RECEPTOR;

ALLELE; ARTICLE; BODY WEIGHT DISORDER; CLINICAL ARTICLE; CLINICAL TRIAL; DISEASE ASSOCIATION; DNA POLYMORPHISM; DRUG EFFECT; DRUG SAFETY; FEMALE; GENE IDENTIFICATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MALE; PATIENT MONITORING; PRIORITY JOURNAL; PROMOTER REGION; SCHIZOPHRENIA; WEIGHT GAIN; BODY MASS; CHINA; COMPARATIVE STUDY; ETHNOLOGY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; PHENOTYPE; SEX DIFFERENCE;

ANTIPSYCHOTIC AGENTS; BODY MASS INDEX; CHINA; CLOZAPINE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; PHENOTYPE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); RECEPTORS, SEROTONIN; SCHIZOPHRENIA; SEX FACTORS; WEIGHT GAIN;

EID: 0038474172     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.160.4.677     Document Type: Article

References (9)

1. Allison DB, Mentore JL, Heo M, Chandler LP, Cappelleri JC, Infante MC, Weiden PJ: Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry 1999; 156:1686-1696
2. Casey DE, Zorn SH: The pharmacology of weight gain with antipsychotics. J Clin Psychiatry 2001; 62(suppl 7):4-10
3. Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, Julius D: Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors. Nature 1995; 374:542-546
4. Basile VS, Masellis M, McIntyre RS, Meltzer HY, Lieberman JA, Kennedy JL: Genetic dissection of atypical antipsychotic-induced weight gain; novel preliminary data on the pharmacogenetic puzzle. J Clin Psychiatry 2001; 62(suppl 23):46-66
5. Sodhi MS, Arranz MJ, Curtis D, Ball DM, Sham P, Roberts GW, Price J, Collier DA, Kerwin RW: Association between clozapine response and allelic variation in the 5-HT2C receptor gene. Neuroreport 1995; 7:169-172
6. Segman RH, Heresco-Levy U, Finkel B, Inbar R, Neeman T, Schlafman M, Dorevitch A, Yakir A, Lerner A, Goltser T, Shelevoy A, Lerer B: Association between the serotonin 2C receptor gene and tardive dyskinesia in chronic schizophrenia: additive contribution of 5HT2CSer and DRD3Gly alleles to susceptibility. Psychopharmacology (Berl) 2000; 152:408-413
7. Lentes KU, Hinney A, Ziegler A, Rosenkranz K, Wurmser H, Barth N, Jacob K, Coners H, Mayer H, Grzeschik KH, Schäfer H, Remschmidt H, Pirke KM, Hebebrand J: Evaluation of a Cys23Ser mutation within the human 5-HT2C receptor gene: no evidence for an association of the mutant allele with obesity or underweight in children, adolescents and young adults. Life Sci 1997; 61:PL9-PL16
8. Yuan X, Yamada K, Ishiyama-Shigemoto S, Koyama W, Nonaka K: Identification of polymorphic loci in the promoter region of the serotonin 5HT2C receptor gene and their association with obesity and type II diabetes. Diabetologia 2000; 43:373-376
9. Reynolds GP, Zhang ZJ, Zhang XB: Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism. Lancet 2002; 359:2086-2087