Association study of brain-derived neurotrophic factor gene polymorphisms and body weight change in schizophrenic patients under long-term atypical antipsychotic treatment

NeuroMolecular Medicine

Volumn 13, Issue 4, 2011, Pages 328-333

  Tsai, Ashley ^a   Liou, Ying Jay ^b,c   Hong, Chen Jee ^b,c   Wu, Chia Liang ^d   Tsai, Shih Jen ^b,c   Bai, Ya Mei ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d YULI VETERANS HOSPITAL   (Taiwan)

Author keywords

Atypical antipsychotic; Brain derived neurotrophic factor; Schizophrenia; Single nucleotide polymorphisms; Weight change

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; CLOZAPINE; OLANZAPINE; RISPERIDONE;

ADULT; ADVERSE OUTCOME; AGED; ARTICLE; BRAIN DERIVED NEUROTROPHIC FACTOR GENE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; DRUG EXPOSURE; FEMALE; GENE; GENE DOSAGE; GENE FREQUENCY; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC RISK; GENETIC VARIABILITY; HAPLOTYPE MAP; HOMOZYGOSITY; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SCHIZOPHRENIA; SEX DIFFERENCE; SIDE EFFECT; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT DURATION; WEIGHT CHANGE; WEIGHT GAIN;

ADULT; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CLOZAPINE; FEMALE; GENETIC ASSOCIATION STUDIES; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RISPERIDONE; SCHIZOPHRENIA; WEIGHT GAIN; YOUNG ADULT;

EID: 84855875337     PISSN: 15351084     EISSN: 15591174     Source Type: Journal    
DOI: 10.1007/s12017-011-8159-5     Document Type: Article

References (34)

1. Angelucci, F., Aloe, L., Iannitelli, A., Gruber, S. H., & Mathé, A. A. (2005). Effect of chronic olanzapine treatment on nerve growth factor and brain-derived neurotrophic factor in the rat brain. European Neuropsychopharmacology, 15, 311-317. (Pubitemid 40487735)
2. Angelucci, F., Mathé, A. A., & Aloe, L. (2000). Brain-derived neurotrophic factor and tyrosine kinase receptor TrkB in rat brain are significantly altered after haloperidol and risperidone administration. Journal of Neuroscience Research, 60, 783-794. (Pubitemid 30399550)
3. Beckers, S., Peeters, A., Zegers, D., Mertens, I., Van Gaal, L., & Van Hul, W. (2008). Association of the BDNF Val66Met variation with obesity in women. Molecular Genetics and Metabolism, 95, 110-112.
4. Calarge, C. A., Ellingrod, V. L., Zimmerman, B., Acion, L., Sivitz, W. I., & Schlechte, J. A. (2009). Leptin gene-2548G/A variants predict risperidone-associated weight gain in children and adolescents. Psychiatric Genetics, 19, 320-327.
5. Cho, S. C., Kim, J. W., Kim, H. W., Kim, B. N., Shin, M. S., Cho, D. Y., et al. (2011). Effect of ADRA2A and BDNF gene-gene interaction on the continuous performance test phenotype. Psychiatric Genetics, 21, 132-135.
6. Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., et al. (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell, 112, 257-269. (Pubitemid 36144114)
7. Hong, C. J., Lin, C. H., Yu, Y. W., Yang, K. H., & Tsai, S. J. (2001). Genetic variants of the serotonin system and weight change during clozapine treatment. Pharmacogenetics and Genomics, 11, 265-268.
8. Hong, C. J., Liou, Y. J., Bai, Y. M., Chen, T. T., Wang, Y. C., & Tsai, S. J. (2010). Dopamine receptor D2 gene is associated with weight gain in schizophrenic patients under long-term atypical antipsychotic treatment. Pharmacogenetics and Genomics, 20, 359-366.
9. Kane, J. M., Barrett, E. J., Casey, D. E., Correll, C. U., Gelenberg, A. J., Klein, S., et al. (2004). Metabolic effects of treatment with atypical antipsychotics. Journal of Clinical Psychiatry, 65, 1447-1455.
10. Kawachi, I. (1999). Physical and psychological consequences of weight gain. Journal of Clinical Psychiatry, 60(Suppl 21), 5-9. (Pubitemid 29523626)
11. Lane, H. Y., Liu, Y. C., Huang, C. L., Chang, Y. C., Wu, P. L., Lu, C. T., et al. (2006). Risperidone-related weight gain: Genetic and nongenetic predictors. Journal of Clinical Psychopharmacology, 26, 128-134.
12. Le Hellard, S., Theisen, F. M., Haberhausen, M., Raeder, M. B., Fernø, J., Gebhardt, S., et al. (2009). Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: Perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects? Molecular Psychiatry, 14, 308-317.
13. Leadbetter, R., Shutty, M., Pavalonis, D., Vieweg, V., Higgins, P., & Downs, M. (1992). Clozapine-induced weight gain: Prevalence and clinical relevance. The American Journal of Psychiatry, 149, 68-72.
14. Lebrun, B., Bariohay, B., Moyse, E., & Jean, A. (2006). Brain-derived neurotrophic factor (BDNF) and food intake regulation: A minireview. Autonomic Neuroscience, 126, 30-38. (Pubitemid 43833352)
15. Licinio, J., Dong, C., & Wong, M. L. (2009). Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response. Archives of General Psychiatry, 66, 488-497.
16. Müller, D. J., & Kennedy, J. L. (2006). Genetics of antipsychotic treatment emergent weight gain in schizophrenia. Pharmacogenomics, 7, 863-887. (Pubitemid 44446736)
17. Müller, D. J., Klempan, T. A., De Luca, V., Sicard, T., Volavka, J., Czobor, P., et al. (2005). The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia. Neuroscience Letters, 379, 81-89.
18. Petryshen, T. L., Sabeti, P. C., Aldinger, K. A., Fry, B., Fan, J. B., Schaffner, S. F., et al. (2010). Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Molecular Psychiatry, 15, 810-815.
19. Popp, J., Leucht, S., Heres, S., & Steimer, W. (2009). DRD4 48 bp VNTR but not 5-HT 2C Cys23Ser receptor polymorphism is related to antipsychotic-induced weight gain. The Pharmacogenomics Journal, 9, 71-77.
20. Reynolds, G. P., Zhang, Z. J., & Zhang, X. B. (2002). Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism. Lancet, 359, 2086-2087. (Pubitemid 34680975)
21. Ribasés, M., Gratacòs, M., Fernández-Aranda, F., Bellodi, L., Boni, C., Anderluh, M., et al. (2005). Association of BDNF with restricting anorexia nervosa and minimum body mass index: A family-based association study of eight European populations. European Journal of Human Genetics, 13, 428-434. (Pubitemid 40520933)
22. Russell, J. M., & Mackell, J. A. (2001). Bodyweight gain associated with atypical antipsychotics: Epidemiology and therapeutic implications. CNS Drugs, 15, 537-551. (Pubitemid 32735379)
23. Sickert, L., Müller, D. J., Tiwari, A. K., Shaikh, S., Zai, C., De Souza, R., et al. (2009). Association of the alpha2A adrenergic receptor -1291C/G polymorphism and antipsychotic-induced weight gain in European-Americans. Pharmacogenomics, 10, 1169-1176.
24. Storey, J. D. (2002). A direct approach to false discovery rate. Journal of the Royal Statistical Society: Series B, 64, 479-498.
25. Theisen, F. M., Gebhardt, S., Haberhausen, M., Heinzel-Gutenbrunner, M., Wehmeier, P. M., Krieg, J. C., et al. (2005). Clozapineinduced weight gain: A study in monozygotic twins and same-sex sib pairs. Psychiatric Genetics, 15, 285-289. (Pubitemid 44491467)
26. Toriya, M., Maekawa, F., Maejima, Y., Onaka, T., Fujiwara, K., Nakagawa, T., et al. (2010). Long-term infusion of brain-derived neurotrophic factor reduces food intake and body weight via a corticotrophin-releasing hormone pathway in the paraventricular nucleus of the hypothalamus. Journal of Neuroendocrinology, 22, 987-995.
27. Ujike, H., Nomura, A., Morita, Y., Morio, A., Okahisa, Y., Kotaka, T., et al. (2008). Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: A cohort study. Journal of Clinical Psychiatry, 69, 1416-1422.
28. Unger, T. J., Calderon, G. A., Bradley, L. C., Sena-Esteves, M., & Rios, M. (2007). Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. The Journal of Neuroscience, 27, 14265-14274.
29. Wang, Y. C., Bai, Y. M., Chen, J. Y., Lin, C. C., Lai, I. C., & Liou, Y. J. (2005). C825T polymorphism in the human G protein beta3 subunit gene is associated with long-term clozapine treatmentinduced body weight change in the Chinese population. Pharmacogenetics and Genomics, 15, 743-748.
30. Wehmeier, P. M., Gebhardt, S., Schmidtke, J., Remschmidt, H., Hebebrand, J., & Theisen, F. M. (2005). Clozapine: Weight gain in a pair of monozygotic twins concordant for schizophrenia and mild mental retardation. Psychiatry Research, 133, 273-276. (Pubitemid 40312160)
31. Yia, Z., Yu, S., & Fang, Y. (2011). Association of the brain-derived neurotrophic factor (BDNF) gene polymorphisms with earlyonset and female schizophrenia in the Chinese population. European Psychiatry, 26(Suppl 1), 863.
32. Zeilinger, S., Pinto, L. A., Nockher, W. A., Depner, M., Klopp, N., Illig, T., et al. (2009). The effect of BDNF gene variants on asthma in German children. Allergy, 64, 1790-1794.
33. Zhang, X. Y., Tan, Y. L., Zhou, D. F., Cao, L. Y., Wu, G. Y., Xu, Q., et al. (2007). Serum BDNF levels and weight gain in schizophrenic patients on long-term treatment with antipsychotics. Journal of Psychiatric Research, 41, 997-1004. (Pubitemid 47304448)
34. Zhang, X. Y., Zhou, D. F., Wu, G. Y., Cao, L. Y., Tan, Y. L., Haile, C. N., et al. (2008). BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia. Neuropsychopharmacology, 33, 2200-2205. (Pubitemid 351992089)