The chemical chaperon 4-phenylbutyric acid ameliorates hepatic steatosis through inhibition of de novo lipogenesis in high-fructose-fed rats

International Journal of Molecular Medicine

Volumn 32, Issue 5, 2013, Pages 1029-1036

  Ren, Lu Ping ^a   Song, Guang Yao ^a   Hu, Zhi Juan ^a   Zhang, Mingming ^a   Peng, Lanbo ^a   Chen, Shu Chun ^a   Wei, Limin ^a   Li, Fan ^a   Sun, Wen ^a  

^a Hebei People's General Hospital   (China)

Author keywords

Endoplasmic reticulum stress; Fatty liver; Fructose; Lipogenesis

Indexed keywords

4 PHENYLBUTYRIC ACID; FRUCTOSE; INSULIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; FATTY LIVER; HISTOLOGY; INSULIN RESISTANCE; LIPID DIET; LIPOGENESIS; MALE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; FATTY LIVER; FRUCTOSE; IN SITU NICK-END LABELING; LIPOGENESIS; MALE; PHENYLBUTYRATES; RATS; RATS, WISTAR;

EID: 84885080233     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1493     Document Type: Article

References (35)

1. Malavolti M, Battistini NC, Miglioli L, et al.: Influence of lifestyle habits, nutritional status and insulin resistance in NAFLD. Front Biosci (Elite Ed) 4: 1015-1023, 2012.
2. Cankurtaran M, Tayfur O, Yavuz B.B., Geyik S., Akhan O and Arslan S: Insulin resistance and metabolic syndrome in patients with NAFLD but without diabetes: effect of a 6 month regime intervention. Acta Gastroenterol Belg 70: 253-259, 2007.
3. Moore JB: Non-alcoholic fatty liver disease: the hepatic consequence of obesity and the metabolic syndrome. Proc Nutr Soc 69: 211-220, 2010.
4. Moore JB: Symposium 1: Overnutrition: consequences and solutions Non-alcoholic fatty liver disease: the hepatic consequence of obesity and the metabolic syndrome. Proc Nutr Soc 1-10, 2010.
5. Ouyang X, Cirillo P, Sautin Y., et al.: Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol 48: 993-999, 2008.
6. Nomura K and Yamanouchi T: The role of fructose-enriched diets in mechanisms of nonalcoholic fatty liver disease. J Nutr Biochem 23: 203-208, 2012.
7. Yilmaz Y: Review article: fructose in non-alcoholic fatty liver disease. Aliment Pharmacol Ther 35: 1135-1144, 2012.
8. Kanuri G, Spruss A, Wagnerberger S., Bischoff SC and Bergheim I: Role of tumor necrosis factor α (TNFα) in the onset of fructose-induced nonalcoholic fatty liver disease in mice. J Nutr Biochem 22: 527-534, 2011.
9. Hsieh PS: Inflammatory change of fatty liver induced by intraportal low-dose lipopolysaccharide infusion deteriorates pancreatic insulin secretion in fructose-induced insulin-resistant rats. Liver Int 28: 1167-1175, 2008.
10. Aragno M, Tomasinelli CE, Vercellinatto I, et al.: SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats. Free Radic Biol Med 47: 1067-1074, 2009.
11. Oyadomari S, Harding H P, Zhang Y, Oyadomari M and Ron D: Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab 7: 520-532, 2008.
12. Kammoun HL, Chabanon H, Hainault I., et al.: GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest 119: 1201-1215, 2009.
13. Lee AH, Scapa EF, Cohen DE and Glimcher LH: Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 32 0: 149 2-149 6, 2 0 08.
14. Ozcan U, Cao Q, Yilmaz E., et al.: Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306: 457-4 61, 2 0 0 4.
15. Ozcan U, Yilmaz E, Ozcan L., et al.: Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313: 1137-1140, 2006.
16. Yang JS, Kim JT, Jeon J, et al.: Changes in hepatic gene expression upon oral administration of taurine-conjugated ursodeoxycholic acid in ob/ob mice. PLoS One 5: e13858, 2010.
17. Ren L.P., Chan SM, Zeng X.Y., et al.: Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance. PLoS One 7: e30816, 2012.
18. Sewter C, Berger D, Considine R.V., et al.: Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha. Diabetes 51: 1035-1041, 2002.
19. Ye JM, Doyle PJ, Iglesias M.A., Watson DG, Cooney GJ and Kraegen EW: Peroxisome proliferator-activated receptor (PPAR)-alpha activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: comparison with PPAR-gamma activation. Diabetes 50: 411-417, 2001.
20. Boncompagni E, Gini E, Ferrigno A., et al.: Decreased apoptosis in fatty livers submitted to subnormothermic machine-perfusion respect to cold storage. Eur J Histochem 55: e40, 2011.
21. Yu C, Chen Y, Cline G.W., et al.: Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 277: 50230-50236, 2002.
22. Samuel VT: Fructose induced lipogenesis: from sugar to fat to insulin resistance. Trends Endocrinol Metab 22: 60-65, 2011.
23. Iizuka K, Bruick RK, Liang G, Horton JD and Uyeda K: Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci USA 101: 7281-7286, 2004.
24. Mosbah IB, Zaouali MA, Martel C, et al.: IGL-1 solution reduces endoplasmic reticulum stress and apoptosis in rat liver transplantation. Cell Death Dis 3: e279, 2012.
25. Malhotra JD and Kaufman RJ: Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal 9: 2277-2293, 2007.
26. Shimizu Y and Hendershot LM: Oxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen species. Antioxid Redox Signal 11: 2317-2331, 20 09.
27. Cullinan SB and Diehl JA: Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway. Int J Biochem Cell Biol 38: 317-332, 2006.
28. Song B, Scheuner D, Ron D., Pennathur S and Kaufman RJ: Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest 118: 3378-3389, 2008.
29. Gentile CL, Frye MA and Pagliassotti MJ: Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease. Biofactors 37: 8-16, 2011.
30. Back SH, Scheuner D, Han J., et al.: Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab 10: 13-26, 20 09.
31. Liu Y, Adachi M, Zhao S., et al.: Preventing oxidative stress: a new role for XBP1. Cell Death Differ 16: 847-857, 2009.
32. Cao J, Dai DL, Yao L, et al.: Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway. Mol Cell Biochem 364: 115-129, 2012.
33. Alkhouri N, Carter-Kent C and Feldstein AE: Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications. Expert Rev Gastroenterol Hepatol 5: 201-212, 2 011.
34. Jin W.P., Quan XQ, Meng F.P., Cui XD and Piao HJ: Relationship among hepatocyte apoptosis, P450 2E1 and oxidative stress in alcoholic liver disease of rats. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 19: 419-421, 2007 (In Chinese).
35. Haynes CM, Titus EA and Cooper AA: Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death. Mol Cell 15: 767-776, 2004.