Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: A FACS-based, high-throughput selection and analytical tool

Protein Engineering, Design and Selection

Volumn 26, Issue 10, 2013, Pages 663-670

  Xu, Yingda ^a   Roach, William ^a   Sun, Tingwan ^a   Jain, Tushar ^a   Prinz, Bianka ^a   Yu, Ta Yi ^a   Torrey, Joshua ^a   Thomas, Jerry ^a   Bobrowicz, Piotr ^a   Vásquez, Maximiliano ^a   Wittrup, K Dane ^a   Krauland, Eric ^a  

^a Adimab LLC   (Lebanon)

Author keywords

antibody; cross interaction chromatography; directed evolution; flow cytometry; polyspecificity

Indexed keywords

ANTIBODY LIBRARY; BIOPHYSICAL CHARACTERIZATION; CROSS INTERACTIONS; DIRECTED EVOLUTION; ENZYME LINKED IMMUNOSORBENT ASSAY; POLYSPECIFICITY; POOR SOLUBILITIES; PRESENTATION SYSTEM;

ANTIGENS; ASSAYS; CHROMATOGRAPHY; FLOW CYTOMETRY; LIBRARIES; SOLUBILITY; TOOLS;

ANTIBODIES;

ANTIBODY LIBRARY; ANTIBODY POLYSPECIFICITY; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BACULOVIRUS; CELL SELECTION; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR INTERACTION; PRIORITY JOURNAL; VIRAL CLEARANCE; YEAST;

ANTIBODY; CROSS INTERACTION CHROMATOGRAPHY; DIRECTED EVOLUTION; FLOW CYTOMETRY; POLYSPECIFICITY;

ANTIBODIES; CELL LINE; CELL MEMBRANE; CELL SURFACE DISPLAY TECHNIQUES; CROSS REACTIONS; DIRECTED MOLECULAR EVOLUTION; FLOW CYTOMETRY; HUMANS; PROTEIN STABILITY; SOLUBILITY; TEMPERATURE; YEASTS;

EID: 84885002758     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzt047     Document Type: Article

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