Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection

Journal of Immunology

Volumn 188, Issue 5, 2012, Pages 2173-2178

  Mackay, Laura K ^a   Wakim, Linda ^b   Van Vliet, Catherine J ^a   Jones, Claerwen M ^a   Mueller, Scott N ^a   Bannard, Oliver ^c   Fearon, Douglas T ^c   Heath, William R ^a   Carbone, Francis R ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; EFFECTOR CELL; HERPES SIMPLEX VIRUS; IMMUNOSTIMULATION; LATENT VIRUS INFECTION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS REACTIVATION;

ADOPTIVE TRANSFER; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; EPITOPES, T-LYMPHOCYTE; GANGLIA, SENSORY; GRANZYMES; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; VIRAL ENVELOPE PROTEINS; VIRUS ACTIVATION; VIRUS LATENCY;

EID: 84857473338     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1102719     Document Type: Article

References (40)

1. Zajac, A. J., J. N. Blattman, K. Murali-Krishna, D. J. Sourdive, M. Suresh, J. D. Altman, and R. Ahmed. 1998. Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med. 188: 2205-2213. (Pubitemid 29028493)
2. Gallimore, A., A. Glithero, A. Godkin, A. C. Tissot, A. Plückthun, T. Elliott, H. Hengartner, and R. Zinkernagel. 1998. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J. Exp. Med. 187: 1383-1393. (Pubitemid 28215398)
3. + T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained. Eur. J. Immunol. 30: 2479-2487.
4. + T lymphocytes after infection with hepatitis C virus. J. Virol. 75: 5550-5558.
5. + T cells and nonspecific bone marrow-derived cells. J. Virol. 61: 3930-3937.
6. Lechner, F., D. K. Wong, P. R. Dunbar, R. Chapman, R. T. Chung, P. Dohrenwend, G. Robbins, R. Phillips, P. Klenerman, and B. D. Walker. 2000. Analysis of successful immune responses in persons infected with hepatitis C virus. J. Exp. Med. 191: 1499-1512. (Pubitemid 30257347)
7. Klenerman, P., and A. Hill. 2005. T cells and viral persistence: lessons from diverse infections. Nat. Immunol. 6: 873-879. (Pubitemid 43090441)
8. Shin, H., and E. J. Wherry. 2007. CD8 T cell dysfunction during chronic viral infection. Curr. Opin. Immunol. 19: 408-415. (Pubitemid 47284857)
9. Wherry, E. J., J. N. Blattman, K. Murali-Krishna, R. van der Most, and R. Ahmed. 2003. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J. Virol. 77: 4911-4927. (Pubitemid 36402840)
10. Gewurz, B. E., J. M. Vyas, and H. L. Ploegh. 2007. Herpesvirus evasion of T-cell immunity. In Human Herpesviruses: Biology, Therapy and Immunoprophylaxis. A. Arvin, G. Campadelli-Fiume, E. Mocarski, P. S. Moore, B. Roizman, R. Whitley, and K. Yamanishi, eds. Cambridge University Press, Cambridge, U.K, p. 1117-1136.
11. Virgin, H. W., E. J. Wherry, and R. Ahmed. 2009. Redefining chronic viral infection. Cell 138: 30-50.
12. Meyers, J. D. 1986. Infection in bone marrow transplant recipients. Am. J. Med. 81(1A): 27-38. (Pubitemid 16054012)
13. Patel, R., and C. V. Paya. 1997. Infections in solid-organ transplant recipients. Clin. Microbiol. Rev. 10: 86-124. (Pubitemid 27042833)
14. + T cells are selectively activated and retained in latently infected sensory ganglia. Immunity 18: 593-603.
15. + T cell clones and the maintenance of replicative function during a persistent viral infection. J. Immunol. 185: 7141-7145.
16. +) T cell exhaustion and promotes maintenance of herpes simplex virus 1 latency. J. Immunol. 184: 277-286.
17. Wakim, L. M., J. Waithman, N. van Rooijen, W. R. Heath, and F. R. Carbone. 2008. Dendritic cell-induced memory T cell activation in nonlymphoid tissues. Science 319: 198-202.
18. + T cells that had developed an effector phenotype. Science 323: 505-509.
19. Mueller, S. N., W. Heath, J. D. McLain, F. R. Carbone, and C. M. Jones. 2002. Characterization of two TCR transgenic mouse lines specific for herpes simplex virus. Immunol. Cell Biol. 80: 156-163. (Pubitemid 34298088)
20. Stock, A. T., C. M. Jones, W. R. Heath, and F. R. Carbone. 2006. CTL response compensation for the loss of an immunodominant class I-restricted HSV-1 determinant. Immunol. Cell Biol. 84: 543-550. (Pubitemid 44657027)
21. + T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation. J. Immunol. 172: 392-397.
22. + T cells after herpes simplex virus type 1 skin infection. Immunol. Cell Biol. 89: 143-148.
23. Roizman, B., D. M. Knipe, and R. Whitley. 2007. Herpes simplex viruses. In Fields Virology, 5th Ed. D. M. Knipe and P. M. Howley, eds. Lippincott, Williams & Wilkins, Philadelphia, PA, p. 2501-2601.
24. Cantin, E. M., D. R. Hinton, J. Chen, and H. Openshaw. 1995. Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1. J. Virol. 69: 4898-4905.
25. + T cell inhibition of HSV-1 reactivation from neuronal latency. Science 322: 268-271.
26. +) T cells in the lung airways during respiratory virus challenge. Immunity 33: 96-105.
27. Rocha, B., A. Grandien, and A. A. Freitas. 1995. Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance. J. Exp. Med. 181: 993-1003.
28. Seder, R. A., P. A. Darrah, and M. Roederer. 2008. T-cell quality in memory and protection: implications for vaccine design. Nat. Rev. Immunol. 8: 247-258. (Pubitemid 351432801)
29. Barber, D. L., E. J. Wherry, D. Masopust, B. Zhu, J. P. Allison, A. H. Sharpe, G. J. Freeman, and R. Ahmed. 2006. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439: 682-687. (Pubitemid 43237609)
30. + T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat. Immunol. 10: 29-37.
31. Jin, H. T., A. C. Anderson, W. G. Tan, E. E. West, S. J. Ha, K. Araki, G. J. Freeman, V. K. Kuchroo, and R. Ahmed. 2010. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc. Natl. Acad. Sci. USA 107: 14733-14738.
32. Wald, A., L. Corey, R. Cone, A. Hobson, G. Davis, and J. Zeh. 1997. Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment. J. Clin. Invest. 99: 1092-1097. (Pubitemid 27123647)
33. Stevens, J. G., and M. L. Cook. 1971. Latent herpes simplex virus in spinal ganglia of mice. Science 173: 843-845.
34. Sheridan, B. S., K. M. Khanna, G. M. Frank, and R. L. Hendricks. 2006. Latent virus influences the generation and maintenance of CD8+ T cell memory. J. Immunol. 177: 8356-8364. (Pubitemid 44893797)
35. + T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. J. Virol. 85: 4184-4197.
36. + T cells in latently infected trigeminal ganglia: a novel immune evasion mechanism. J. Virol. 85: 9127-9138.
37. Held, K., A. Junker, K. Dornmair, E. Meinl, I. Sinicina, T. Brandt, D. Theil, and T. Derfuss. 2011. Expression of herpes simplex virus 1-encoded microRNAs in human trigeminal ganglia and their relation to local T-cell infiltrates. J. Virol. 85: 9680-9685.
38. Sawtell, N. M. 1997. Comprehensive quantification of herpes simplex virus latency at the single-cell level. J. Virol. 71: 5423-5431. (Pubitemid 27258219)
39. +) T-cell attenuation of cutaneous herpes simplex virus infection reduces the average viral copy number of the ensuing latent infection. Immunol. Cell Biol. 86: 666-675.
40. Feldman, L. T., A. R. Ellison, C. C. Voytek, L. Yang, P. Krause, and T. P. Margolis. 2002. Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice. Proc. Natl. Acad. Sci. USA 99: 978-983. (Pubitemid 34106621)