Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation

Journal of Experimental Medicine

Volumn 204, Issue 3, 2007, Pages 595-603

  Zhu, Jia ^a,c   Koelle, David M ^a,c,d   Cao, Jianhong ^c   Vazquez, Julio ^c   Meei, Li Huang ^a,c   Hladik, Florian ^a,b,c   Wald, Anna ^a,c   Corey, Lawrence ^a,c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

^d BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN; QUANTUM DOT; VIRUS DNA;

ADULT; ARTICLE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DERMOEPIDERMAL JUNCTION; FEMALE; GENITAL HERPES; GENITAL TRACT INFECTION; HERPES SIMPLEX; HERPES SIMPLEX VIRUS; HERPES SIMPLEX VIRUS 2; HUMAN; IMMUNOSURVEILLANCE; MALE; NERVE ENDING; PRIORITY JOURNAL; SENSORY NERVE; SKIN; VIRUS DETECTION;

ADULT; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; FEMALE; GENITALIA, FEMALE; GENITALIA, MALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; HUMANS; MALE; MIDDLE AGED; NERVE ENDINGS; SKIN DISEASES, VIRAL; VIRUS ACTIVATION;

EID: 33947424353     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20061792     Document Type: Article

References (34)

1. Posavad, C.M., D.M. Koelle, M.F. Shaughnessy, and L. Corey. 1997. Severe genital herpes infections in HIV-infected individuals with impaired HSV-specific CD8+ cytotoxic T lymphocyte responses. Proc. Natl. Acad. Sci. USA. 94:10289-10294.
2. Koelle, D.M., and L. Corey. 2003. Recent progress in herpes simplex virus immunobiology and vaccine research. Clin. Microbiol. Rev. 16:96-113.
3. Augenbraun, M., J. Feldman, K. Chirgwin, J. Zenilman, L. Clarke, J. DeHovitz, S. Landesman, and H. Minkoff. 1995. Increased genital shedding of herpes simplex virus type 2 in HIV-seropositive women. Ann. Intern. Med. 123:845-847.
4. Khanna, K.M., R.H. Bonneau, P.R. Kinchington, and R.L. Hendricks. 2003. Herpes simplex virus-specific memory CD8(+) T cells are selectively activated and retained in latently infected sensory ganglia. Immunity. 18:593-603.
5. Liu, T., K.M. Khanna, X. Chen, D.J. Fink, and R.L. Hendricks. 2000. CD8+ T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons. J. Exp. Med. 191:1459-1466.
6. Cunningham, A.L., R.R. Turner, A.C. Miller, M.F. Para, and T.C. Merigan. 1985. Evolution of recurrent herpes simplex lesions: an immunohistologic study. J. Clin. Invest. 75:226-233.
7. Koelle, D.M., H. Abbo, A. Peck, K. Ziegweid, and L. Corey. 1994. Direct recovery of herpes simplex virus (HSV)-specific T lymphocyte clones from recurrent genital HSV-2 lesions. J. Infect. Dis. 169:956-961.
8. Koelle, D.M., H. Chen, M.A. Gavin, A. Wald, W.W. Kwok, and L. Corey. 2001. CD8 CTL from genital herpes simplex lesions: recognition of viral tegument and immediate early proteins and lysis of infected cutaneous cells. J. Immunol. 166:4049-4058.
9. Koelle, D.M., C.M. Posavad, G.R. Barnum, M.L. Johnson, J.M. Frank, and L. Corey. 1998. Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes. J. Clin. Invest. 101:1500-1508.
10. Haanen, J.B., M.G. van Oijen, F. Tirion, L.C. Oomen, A.M. Kruisbeek, F.A. Vyth-Dreese, and T.N. Schumacher. 2000. In situ detection of virus- and tumor-specific T-cell immunity. Nat. Med. 6:1056-1060.
11. Skinner, P.J., M.A. Daniels, C.S. Schmidt, S.C. Jameson, and A.T. Haase. 2000. Cutting edge: In situ tetramer staining of antigen-specific T cells in tissues. J. Immunol. 165:613-617.
12. Schmitz, J.E., R.S. Veazey, M.J. Kuroda, D.B. Levy, A. Seth, K.G. Mansfield, C.E. Nickerson, M.A. Lifton, X. Alvarez, A.A. Lackner, and N.L. Letvin. 2001. Simian immunodeficiency virus (SIV)-specific cytotoxic T lymphocytes in gastrointestinal tissues of chronically SIV-infected rhesus monkeys. Blood. 98:3757-3761.
13. McGavern, D.B., U. Christen, and M.B. Oldstone. 2002. Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo. Nat. Immunol. 3:918-925.
14. Hosken, N., P. McGowan, A. Meier, D.M. Koelle, P. Sleath, F. Wegener, M. Elliott, L. Grabstein, C. Posavad, and L. Corey. 2006. Diversity of the CD8+ T cell response to herpes simpolex virus type 2 proteins among persons with genital herpes. J. Virol. 80:5509-5515.
15. McMichael, A.J., and S.L. Rowland-Jones. 2001. Cellular immune responses to HIV. Nature. 410:980-987.
16. Hislop, A.D., N.H. Gudgeon, M.F. Callan, C. Fazou, H. Hasegawa, M. Salmon, and A.B. Rickinson. 2001. EBV-specific CD8+ T cell memory: relationships between epitope specificity, cell phenotype, and immediate effector function. J. Immunol. 167:2019-2029.
17. Fellner, M. 1976. Green autoflurescence in human epidermal cells. Arch. Dermatol. 112:667-670.
18. Zeng, H., C. MacAulay, D.I. McLean, and B. Palcic. 1995. Spectroscopic and microscopic characteristics of human skin autofluorescence emission. Photochem. Photobiol. 61:639-645.
19. Na, R., I.M. Stender, M. Henriksen, and H.C. Wulf. 2001. Autofluorescence of human skin is age-related after correction for skin pigmentation and redness. J. Invest. Dermatol. 116:536-540.
20. Bruchez, M., Jr., M. Moronne, P. Gin, S. Weiss, and A.P. Alivisatos. 1998. Semiconductor nanocrystals as fluorescent biological labels. Science. 281:2013-2016.
21. Pinaud, F., X. Michalet, L.A. Bentolila, J.M. Tsay, S. Doose, J.J. Li, G. Iyer, and S. Weiss. 2006. Advances in fluorescence imaging with quantum dot bio-probes. Biomaterials. 27:1679-1687.
22. Wu, X., H. Liu, J. Liu, K.N. Haley, J.A. Treadway, J.P. Larson, N. Ge, F. Peale, and M.P. Bruchez. 2003. Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nat. Biotechnol. 21:41-46.
23. Chattopadhyay, P.K., D.A. Price, T.F. Harper, M.R. Betts, J. Yu, E. Gostick, S.P. Perfetto, P. Goepfert, R.A. Koup, S.C. De Rosa, et al. 2006. Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry. Nat. Med. 12:972-977.
24. Koelle, D.M., Z. Liu, C.L. McClurkan, R.C. Cevallos, J. Vieira, N.A. Hosken, C.A. Meseda, D.C. Snow, A. Wald, and L. Corey. 2003. Immunodominance among herpes simplex virus-specific CD8 T-cells expressing a tissue-specific homing receptor. Proc. Natl. Acad. Sci. USA. 100:12899-12904.
25. Khanna, K.M., A.J. Lepisto, V. Decman, and R.L. Hendricks. 2004. Immune control of herpes simplex virus during latency. Curr. Opin. Immunol. 16:463-469.
26. Prabhakaran, K., B.S. Sheridan, P.R. Kinchington, K.M. Khanna, V. Decman, K. Lathrop, and R.L. Hendricks. 2005. Sensory neurons regulate the effector functions of CD8(+) T cells in controlling HSV-1 latency ex vivo. Immunity. 23:515-525.
27. Wald, A., L. Corey, R. Cone, A. Hobson, G. Davis, and J. Zeh. 1997. Frequent genital herpes simplex virus 2 shedding in immunocompetent women: effect of acyclovir treatment. J. Clin. Invest. 99:1092-1097.
28. Wald, A., J. Zeh, S. Selke, T. Warren, A.J. Ryncarz, R. Ashley, J.N. Krieger, and L. Corey. 2000. Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons. N. Engl. J. Med. 342:844-850.
29. Gupta, R., A. Wald, E. Krantz, S. Selke, T. Warren, M. Vargas-Cortes, G. Miller, and L. Corey. 2004. Valacyclovir and acyclovir for suppression of shedding of herpes simplex virus in the genital tract. J. Infect. Dis. 190:1374-1381.
30. Tschachler, E., C.M. Reinisch, C. Mayer, K. Paiha, H. Lassmann, and W. Weninger. 2004. Sheet preparations expose the dermal nerve plexus of human skin and render the dermal nerve end organ accessible to extensive analysis. J. Invest. Dermatol. 122:177-182.
31. Altman, J.D., P.A. Moss, P.J. Goulder, D.H. Barouch, M.G. McHeyzer-Williams, J.I. Bell, A.J. McMichael, and M.M. Davis. 1996. Phenotypic analysis of antigen-specific T lymphocytes. Science. 274:94-96.
32. Magaret, A.S., A. Wald, M.L. Huang, S. Selke, and L. Corey. 2007. Optimizing PCR positivity criterion for detection of HSV DNA on skin and mucosa. J. Clin. Microbiol. In press.
33. Wald, A., M.L. Huang, D. Carrell, S. Selke, and L. Corey. 2003. Polymerase chain reaction for detection of herpes simplex virus (HSV) DNA on mucosal surfaces: comparison with HSV isolation in cell culture. J. Infect. Dis. 188:1345-1351.
34. Corey, L., M.L. Huang, S. Selke, and A. Wald. 2005. Differentiation of herpes simplex virus types 1 and 2 in clinical samples by a real-time taqman PCR assay. J. Med. Virol. 76:350-355.