Environmental endocrine disruption of brain and behavior

Hormones, Brain and Behavior Online

Volumn , Issue , 2009, Pages 1789-1818

  Gore, A C ^a   Crews, D ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Androgen receptor; AVPV; Endocrine disruption; Epigenetics; Estrogen receptor; GnRH; Hypothalamus; Preoptic area; Progesterone receptor; Reproduction; SDN POA; Sexual differentiation; Transgenerational

Indexed keywords

EID: 84884792375     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-008088783-8.00056-5     Document Type: Chapter

References (267)

1. Adkins E.K. Embryonic exposure to an antiestrogen masculinizes behavior of female quail. Physiology and Behavior 1976, 17:357-359.
2. Adkins E.K., Nock B.L. The effects of the antiestrogen CI-628 on sexual behavior activated by androgen or estrogen in quail. Hormones and Behavior 1976, 7:417-429.
3. Adkins-Regan E. Sex hormones and sexual orientation in animals. Psychobiology 1988, 16:335-347.
4. Adkins-Regan E. Testosterone increases singing and aggression but not male-typical sexual partner preference in early estrogen treated female zebra finches. Hormones and Behavior 1999, 35:63-70.
5. Adkins-Regan E., Ascenzi M. Social and sexual behavior of male and female zebra finches treated with estradiol during the nestling period. Animal Behaviour 1987, 35:1100-1112.
6. Adkins-Regan E., Garcia M. Effect of flutamide (an antiandrogen) and diethylstilbestrol on the reproductive behavior of Japanese quail. Physiology and Behavior 1986, 36:419-425.
7. Andersen M.E., Dennison J.E. Mode of action and tissue dosimetry in current and future risk assessments. Science of the Total Environment 2001, 274:3-14.
8. Anway M.D., Cupp A.S., Uzumcu M., Skinner M.K. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science 2005, 308:1466-1469.
9. Anway M.D., Leathers C., Skinner M.K. Endocrine disruptor vinclozolin induced epigenetic transgenerational adult onset disease. Endocrinology 2006, 147:5515-5523.
10. Anway M.D., Skinner M.K. Epigenetic transgenerational actions of endocrine disruptors. Endocrinology 2006, 147:S43-S49.
11. Aragona B.J., Wang Z. The prairie vole (Microtus ochrogaster): An animal model for behavioral neuroendocrine research on pair bonding. Institute of Laboratory Animal Resources Journal 2004, 45:35-45.
12. Arukwe A. Cellular and molecular responses to endocrine-modulators and the impact on fish reproduction. Marine Pollution Bulletin 2001, 42:643-655.
13. Aste N., Balthazart J., Absil P., Grossman R., Mulhbauer R., Viglietti-Panzica C., Panzica G.C. Anatomical and neurochemical definition of the nucleus of the stria terminalis in Japanese quail (Coturnix japonica). Journal of Comparative Neurology 1998, 396:141-157.
14. Baatrup E., Junge M. Antiandrogenic pesticides disrupt sexual characteristics in the adult male guppy (Poecilia reticulata). Environmental Health Perspectives 2001, 109:1063-1070.
15. Balch G.C., Mackenzie C.A., Metcalfe C.D. Alterations to gonadal development and reproductive success in Japanese medaka (Oryzias latipes) exposed to 17alpha-ethinylestradiol. Environmental Toxicology and Chemistry 2004, 23:782-791.
16. Balthazart J., De Clerck A., Foidart A. Behavioral demasculinization of female quail is induced by estrogens: Studies with the new aromatase inhibitor R76713. Hormones and Behavior 1992, 26:179-203.
17. Barker D.J.P. The developmental origins of adult disease. European Journal of Epidemiology 2003, 18:733-736.
18. Bateson P. The return of the whole organism. Journal of Biosciences 2005, 30:31-39.
19. Bayley M., Larsen P.F., Baekgaard H., Baatrup E. The effects of vinclozolin, an anti-androgenic fungicide, on male guppy secondary sex characters and reproductive success. Biology of Reproduction 2003, 69:1951-1956.
20. Bayley M., Nielsen J.R., Baatrup E. Guppy sexual behavior as an effect biomarker of estrogen mimics. Ecotoxicology and Environment Safety 1999, 43:68-73.
21. Bergeron J.M., Crews D., McLachlan J.A. PCBs as environmental estrogens: Turtle sex determination as a biomarker of environmental contamination. Environmental Health Perspectives 1994, 102:780-781.
22. Bergeron J.M., Willingham E., Osborn C.T., Rhen T., Crews D. Developmental synergism of steroidal estrogens in sex determination. Environmental Health Perspectives 1999, 107:93-97.
23. Bern H.A. The new endocrinology: Its scope and its impact. American Zoologist 1990, 30:877-885.
24. Bishop C.A., Ng P., Pettit K.E., Kennedy S.W., Stegeman J.J., Norstrom R.J., Brooks R.J. Environmental contamination and developmental abnormalities in eggs and hatchlings of the common snapping turtle (Chelydra serpentina) from the Great Lakes-St Lawrence River basin (1989-91). Environmental Pollution 1998, 101:143-156.
25. Bokkers B.G.H., Slob W. Deriving a data-based interspecies assessment factor using the NOEL and benchmark dose approach. Critical Review in Toxicology 2007, 37:355-373.
26. Bosveld A.T., van den Berg M. Reproductive failure and endocrine disruption by organohalogens in fish-eating birds. Toxicology 2002, 181-182:155-159.
27. Bowden R.M., Ewert M.A., Nelson C.E. Environmental sex determination in a reptile varies seasonally and with yolk hormones. Proceedings of the Royal Society of London 2000, 267:1745-1749.
28. Bowe J., Li X.F., Sugden D., Katzenellenbogen J.A., Katzenellenbogen B.S., O'Byrne K.T. The effects of the phytoestrogen, coumestrol, on gonadotropin-releasing hormone (GnRH) mRNA expression in GT1-7 GnRH neurons. Journal of Neuroendocrinology 2003, 15:105-108.
29. Boyd S.K. Development of vasotocin pathways in the bullfrog brain. Cell and Tissue Research 1994, 276:593-602.
30. Boyd S.K., Tyler C.R., De Vries G.J. Sexual dimorphism in the vasotocin system of the bullfrog (Rana catesbeiana). Journal of Comparative Neurology 1992, 325:313-325.
31. Brezner E., Terkel J., Perry A.S. The effect of Aroclor 1254 (PCB) on the physiology of reproduction in the female rat - I. Comparative Biochemistry and Physiology 1984, 77C:65-70.
32. Brown H.E., Salamanca S., Stewart G., Uphouse L. Chlordecone (kepone) on the night of proestrus inhibits female sexual behavior in CDF-344 rats. Toxicology and Applied Pharmacology 1991, 110:97-106.
33. Bryan T.E., Gildersleeve R.P., Wiard R.P. Exposure of Japanese quail embryos to o, p-DDT has long-term effects on reproductive behaviors, hematology and feather morphology. Teratology 1989, 39:525-536.
34. Burger J., Fossi C., McClellan-Green P., Orlando O.F. Methodologies, bioindicators, and biomarkers of gender-related differences in wildlife exposed to environmental chemicals. Environmental Research 2007, 104:135-152.
35. Cariello M.O., Macedo R.H., Schwabl H. Androgens in eggs of communally bredding guira cuckoos (Guira guira). Hormones and Behavior 2006, 49:654-662.
36. Ceccarelli I., Della Seta D., Fiorenzani P., Farabollini F., Aloisi A.M. Estrogenic chemicals at puberty change ERα in the hypothalamus of male and female rats. Neurotoxicology and Teratology 2007, 29:108-115.
37. Chakraborty T.R., Hof P.R., Ng L., Gore A.C. Stereologic analysis of estrogen receptor alpha (ERα) expression in rat hypothalamus and its regulation by aging and estrogen. Journal of Comparative Neurology 2003, 466:409-421.
38. Chakraborty T.R., Ng L., Gore A.C. Age-related changes in estrogen receptor beta in rat hypothalamus: A quantitative analysis. Endocrinology 2003, 144:4164-4171.
39. Chakraborty T.R., Ng L., Gore A.C. Colocalization and hormone regulation of estrogen receptor alpha and NMDA receptor in the hypothalamus of female rats. Endocrinology 2003, 144:299-305.
40. Chang H.-S., Anway M.D., Rekow S.S., Skinner M.K. Transgenerational epigenetic imprinting of the male germline by endocrine disruptor exposure during gonadal sex determination. Endocrinology 2006, 147:5524-5541.
41. Christiansen S., Scholze M., Axelstad M., Boberg J., Kortenkamp A., Hass U. Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat. International Journal of Andrology 2008, 31:1-7.
42. Chung Y.-W., Clemens L.G. Effects of perinatal exposure to polychlorinated biphenyls on development of female sexual behavior. Bulletin of Environmental Contamination and Toxicology 1999, 62:664-670.
43. Chung Y.-W., Nunez A.A., Clemens L.G. Effects of neonatal polychlorinated biphenyl exposure on female sexual behavior. Physiology and Behavior 2001, 74:363-370.
44. Clark E.J., Norris D.O., Jones R.E. Interactions of gonadal steroids and pesticides (DDT, DDE) on gonaduct growth in larval tiger salamanders. Ambystoma tigrinum. General and Comparative Endocrinology 1998, 109:94-105.
45. Connor K., Ramamoorthy K., Moore M., et al. Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: Structure-activity relationships. Toxicology and Applied Pharmacology 1997, 145:111-123.
46. Coopersmith C., Erskine M.S. Influence of paced mating and number of intromissions on fertility in the laboratory rat. Journal of Reproduction and Fertility 1994, 102:451-458.
47. Crews D. Temperature-dependent sex determination: The interplay of steroid hormones and temperature. Zoological Science 1996, 13:1-13.
48. Crews D. Diversity and evolution of neuroendocrine mechanisms underlying reproductive behavior. Behavioral Endocrinology 2002, vol. 2:223-288. MIT Press, Cambridge, MA. J. Becker, S.M. Breedlove, D. Crews, M.M. McCarthy (Eds.).
49. Crews D., Bull J.J., Wibbels T. Estrogen and sex reversal in turtles: A dose-dependent phenomenon. General and Comparative Endocrinology 1991, 81:357-364.
50. Crews D., Gore A.C., Hsu T.S., et al. Transgenerational epigenetic imprints on mate preference. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:5942-5946.
51. Crews D., Putz O., Thomas P., Hayes T., Howdeshell K. Animal models for the study of the effects of mixtures, low doses, and the embryonic environment on the action of endocrine disrupting chemicals. Pure and Applied Chemistry 2003, 75:2305-2320.
52. Crews D., Willingham E., Skipper J.K. Endocrine disruptors: Present issues, future directions. Quarterly Review of Biology 2000, 75:243-260.
53. Cummings A.M., Stoker T., Kavlock R.K. Gender-based differences in endocrine and reproductive toxicity. Environmental Research 2007, 104:96-107.
54. Daston G.P. Do thresholds exist for developmental toxicants: A review of the theoretical and experimental evidence. Issues and Reviews in Teratology 1993, vol. 6:169-197. Plenum Press, New York. H. Kalter (Ed.).
55. Dickerson S.M., Gore A.C. Estrogenic environmental endocrine-disrupting chemical effects on reproductive neuroendocrine function and dysfunction across the life cycle. Reviews in Endocrine and Metabolic Disorders 2007, 8:143-159.
56. Dohler K.D. The pre- and postnatal influence of hormones and neurotransmitters on sexual differentiation of the mammalian hypothalamus. International Review of Cytology 1991, 131:1-57.
57. Dolinoy D.C., Huang D., Jirtle R.L. Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:13056-13061.
58. Eising C.M., Eikenaar C., Schwabl H., Groothuis T.G. Maternal androgens in black headed gull (Larus ridibundus) eggs: Consequences for chick development. Proceedings of the Royal Society B: Biological Sciences 2001, 268:839-846.
59. Elf P.K. Yolk steroid hormones and their possible roles in TSD species. Temperature-Dependent Sex Determination in Vertebrates 2004, 111-118. Smithsonian Books, Washington, DC. N. Valenzuela, V. Lance (Eds.).
60. Elf P.K., Lang J.W., Fivizzani A.J. Dynamics of yolk steroid hormones during development in a reptile with temperature-dependent sex determination. General and Comparative Endocrinology 2002, 127:34-39.
61. Faber K.A., Hughes C.L.J. The effects of neonatal exposure to diethylstilbestrol, genistein, and zearalenone on pituitary responsiveness and sexually dimorphic nucleus volume in the castrated adult rat. Biology of Reproduction 1991, 45:649-653.
62. Fan W., Yanase T., Morinaga H., et al. Herbicide atrazine activates SF-1 by direct affinity and concomitant co-activators recruitments to induce aromatase expression via promoter II. Biochemical and Biophysical Research Communications 2007, 355:1012-1018.
63. Fan W., Yanase T., Morinaga H., et al. Atrazine-induced aromatase expression is SF-1 dependent: Implications for endocrine disruption in wildlife and reproductive cancers in humans. Environmental Health Perspectives 2007, 115:720-727.
64. Faqi A.S., Dalsenter P.R., Merker H.J., Chahoud I. Effects on developmental landmarks and reproductive capability of 3,3′,4,4′-tetrachlorobiphenyl and 3,3′,4,4′,5-pentachlorobiphenyl in offspring of rats exposed during pregnancy. Human and Experimental Toxicology 1998, 17:365-372.
65. Fernie K.J., Smits J.E., Bortolotti G.R., Bird D.M. In ovo exposure to polychlorinated biphenyls: Reproductive effects on second-generation American kestrels. Archives of Environmental Contamination and Toxicology 2001, 40:544-550.
66. Guideline for the study and evaluation of gender differences in the clinical evaluation of drugs; notice. Federal Register 1993, 58:39406-39416. Food and Drug Administration.
67. Fox G.A., Gilman A.P., Peakall D.B., Anderka F.W. Behavioral abnormalities of nesting Lake Ontario herring gulls. Journal of Wildlife Management 1978, 42:477-483.
68. Fry D.M., Toone C.K. DDT-induced feminization of gull embryos. Science 1981, 213:922-924.
69. Fry D.M., Toone C.K., Speich S.M., Peard R.J. Sex ratio skew and breeding patterns of gulls: Demographic and toxicological considerations. Studies in Avian Biology 1987, 10:26-43.
70. Funabashi T., Kawaguchi M., Fukuko K. The endocrine disrupters butyl benzyl phthalate and bisphenol A increase the expression of progesterone receptor messenger ribonucleic acid in the preoptic area of adult ovariectomized rats. Neuroendocrinology 2001, 74:77-81.
71. Funabashi T., Sano A., Mitsushima D., Kimura F. Bisphenol A increases progesterone receptor immunoreactivity in the hypothalamus in a dose-dependent manner and affects sexual behaviour in adult ovariectomized rats. Journal of Neuroendocrinology 2005, 15:134-140.
72. Gale R.W., Bergeron J.M., Crews D. Turtle sex determination assay: Mass balance and responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3,3′,4,4′,5-pentachlorobiphenyl. Environmental Toxicology and Chemistry 2002, 21:2477-2482.
73. Gaylord D.W., Sheenan D.M., Young J.F., Mattison D.R. The threshold dose question in teratogenesis. Teratology 1988, 38:389-391.
74. Gee J.M., Craig-Veit C.B., Millam J.R. Posthatch methoxychlor exposure adversely affects reproduction in adult zebra finches, Taeniopygia guttata. Bulletin of Environmental Contamination and Toxicology 2004, 73:607-612.
75. Gellert R.J. Uterotrophic activity of polychlorinated biphenyls (PCB) and induction of precocious reproductive aging in neonatally treated female rats. Environmental Research 1978, 16:123-130.
76. Gil D., Graves J., Hazon N., Wells A. Male attractiveness and differential hormone investment in zebra finch eggs. Science 1999, 286:126-128.
77. Gochfeld M. Framework for gender differences in human and animal toxicology. Environmental Research 2007, 104:4-21.
78. Goodson J.L., Bass A.H. Social behavior functions and related anatomical characteristics of vasotocin/vasopressin systems in vertebrates. Brain Research - Brain Research Reviews 2001, 35:246-265.
79. Gore A.C. Environmental toxicant effects on neuroendocrine function. Endocrine 2001, 14:235-246.
80. Gore A.C. GnRH: The Master Molecule of Reproduction 2002, Kluwer Academic Publishers, Norwell, MA.
81. Gore A.C. Organochlorine pesticides directly regulate gonadotropin-releasing hormone gene expression and biosynthesis in the GT1-7 hypothalamic cell line. Molecular and Cellular Endocrinology 2002, 192:157-170.
82. Gore A.C. Endocrine-Disrupting Chemicals: From Basic Research to Clinical Practice 2007, Humana Press, Totowa, NJ.
83. Gore A.C. Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems. Frontiers in Neuroendocrinology 2008, 29:358-374.
84. Gore A.C., Heindel J.J., Zoeller R.T. Endocrine disruption for endocrinologists (and others). Endocrinology 2006, 147:S1-S3.
85. Gore A.C., Wu T.J., Oung T., Lee J.B., Woller M.J. A novel mechanism for endocrine-disrupting effects of polychlorinated biphenyls: Direct effects on gonadotropin-releasing hormone (GnRH) neurons. Journal of Neuroendocrinology 2002, 14:814-823.
86. Gorski R.A. Hypothalamic imprinting by gonadal steroid hormones. Advances in Experimental Medicine and Biology 2002, 511:57-70.
87. Gray L.E., Ferrell J.M., Ostby J.S. Alteration of behavioral sex differentiation by exposure to estrogenic compounds during a critical neonatal period: Effects of zearalenon, methoxychlor, and estradiol in hamsters. Toxicology and Applied Pharmacology 1985, 80:127-136.
88. Gray L.E. Neonatal chlordecone exposure alters behavioral sex differentiation in female hamsters. Neurotoxicology 1982, 3(2):67-79.
89. Gray L.E., Ostby J., Ferrell J., et al. A dose-response analysis of methoxychlor-induced alterations of reproductive development and function in the rat. Fundamental and Applied Toxicology 1989, 12:92-108.
90. Gray M.A., Teather K.L., Metcalfe C.D. Reproductive success and behavior of Japanese medaka (Oryzias latipes) exposed to 4-tert-octylphenol. Environmental Toxicology and Chemistry 1999, 18:2587-2594.
91. Greytak S.R., Callard G.V. Cloning of three estrogen receptors (ER) from killifish (Fundulus heteroclitus): Differences in populations from polluted and reference environments. General and Comparative Endocrinology 2007, 150:174-188.
92. Groothuis T.G., Schwabl H. Hormone-mediated maternal effects in birds: Mechanisms matter but what do we know of them?. Philosophical Transactions of the Royal Society of London, B: Biological Sciences 2008, 363(1497):1647-1661.
93. Grossman R., Jurkevich A., Kohler A. Sex dimorphism in the avian arginine vasotocin system with special emphasis to the bed nucleus of the stria terminalis. Comparative Biochemistry and Physiology, A: Molecular and Integrative Physiology 2002, 131:833-837.
94. Guerrero-Bosagna C., Sabat P., Valladares L. Environmental signaling and evolutionary change: Can exposure of pregnant mammals to environmental estrogens lead to epigenetically induced evolutionary changes in embryos?. Evolution and Development 2005, 7:341-350.
95. Guerrero-Bosagna C., Valladares L. Endocrine disruptors, epigenetically induced changes, and transgenerational transmission of characters and epigenetic states. Endocrine-Disrupting Chemicals: From Basic Research to Clinical Practice 2007, 175-192. Humana Press, Totowa, NJ. A.C. Gore (Ed.).
96. Gurney M.E., Konishi M. Hormone induced sexual differentiation of brain and behavior in zebra finches. Science 1980, 208:1380-1383.
97. Haegele M.A., Hudson R.H. Reduction of courtship behavior induced by DDE in male ringed turtle doves. Wilson Bulletin 1977, 89:593-601.
98. Halldin K. Impact of endocrine disrupting chemicals on reproduction in Japanese quail. Domestic Animal Endocrinology 2005, 29:420-429.
99. Halldin K., Berg C., Bergman A., Brandt I., Brunstrom B. Distribution of bisphenol A and tetrabromobisphenol A in quail eggs, embryos and laying birds and studies on reproduction variables in adults following in ovo exposure. Archives of Toxicology 2001, 75:597-603.
100. Halldin K., Berg C., Brandt I., Brunstrom B. Sexual behavior in Japanese quail as a test end point for endocrine disruption: Effects of in ovo exposure to ethinylestradiol and diethylstilbestrol. Environmental Health Perspectives 1999, 107:861-866.
101. Halldin K., Holm L., Ridderstrale Y., Brunstrom B. Reproductive impairment in Japanese quail (Coturnix japonica) after in ovo exposure to o p-DDT. Archives of Toxicology 2003, 77:116-122.
102. Hayes T.B., Case P., Chui S., et al. Pesticide mixtures, endocrine disruption, and amphibian declines: Are we underestimating the impact?. Environmental Health Perspectives 2006, 114(supplement 1):40-50.
103. Hayes T.B., Collins A., Lee M., Mendoza M., Noriega N., Stuart A.A., Vonk A. Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:5476-5480.
104. Hayes T.B., Stuart A.A., Mendoza M., et al. Characterization of atrazine-induced gonadal malformations in African clawed frogs (Xenopus laevis) and comparisons with effects of an androgen antagonist (cyproterone acetate) and exogenous estrogen (17beta-estradiol): Support for the demasculinization/feminization hypothesis. Environmental Health Perspectives 2006, 114:134-141.
105. Hays L.E., Carpenter C.D., Petersen S.L. Evidence that GABAergic neurons in the preoptic area of the rat brain are targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin during development. Environmental Health Perspectives 2002, 110(supplement 3):369-376.
106. Heinz G.H., Percival H.F., Jennings M.L. Contaminants in American alligator eggs from Lake Apopka, Lake Griffin, and Lake Okeechobee, Florida. Environmental Monitoring and Assessment 1991, 16:277-285.
107. Helbing C.C., Bailey C.M., Ji L., et al. Identification of gene expression indicators for thyroid axis disruption in a Xenopus laevis metamorphosis screening assay. Part 1: Effects on the brain. Aquatic Toxicology 2007, 82:227-241.
108. Henry L.A., Witt D.M. Resveratrol: Phytoestrogen effects on reproductive physiology and behavior in female rats. Hormones and Behavior 2002, 41:220-228.
109. Henry L.A., Witt D.M. Effects of neonatal resveratrol exposure on adult male and female reproductive physiology and behavior. Developmental Neuroscience 2006, 28:186-195.
110. Herbison A.E., Theodosis D.T. Localization of oestrogen receptors in preoptic neurons containing neurotensin but not tyrosine hydroxylase, cholecystokinin or luteinizing hormone-releasing hormone in the male and female rat. Neuroscience 1992, 50:283-298.
111. Hillsman K.D., Sanderson N.S., Crews D. Testosterone stimulates mounting behavior and arginine vasotocin expression in the brain of both sexual and unisexual whiptail lizards. Sexual Development 2006, 1:77-84.
112. Hoel D.G. Incorporation of background in dose-response models. Federation Proceedings 1980, 39:73-75.
113. Hoogesteijn A.L., DeVoogd T.J., Quimby F.W., De Caprio T., Kollias G.V. Reproductive impairment in zebra finches (Taeniopygia guttata). Environmental Toxicology and Chemistry 2005, 24:219-223.
114. Howell M.W., Black A.D., Bortone S.A. Abnormal expression of secondary sex characters in a population of mosquitofish, Gambusia affinis holbrooki: Evidence for environmentally-induced masculinization. Copeia 1980, 4:676-681.
115. Huang X., Harlan R.E. Absence of androgen receptors in LHRH immunoreactive neurons. Brain Research 1993, 624:309-311.
116. Hunt G.L., Hunt M.W. Female-female pairing in western gulls (Larus occidentalis) in Southern California. Science 1977, 196:1466-1467.
117. Iwaniuk A.N., Koperski D.T., Cheng K.M., Elliott J.E., Smith L.K., Wilson L.K., Wylie D.R. The effects of environmental exposure to DDT on the brain of a songbird: Changes in structures associated with mating and song. Behavioural Brain Research 2006, 173:1-10.
118. Jaenisch R., Bird B. Epigenetic regulation of gene expression, how the genome integrates intrinsic and environmental signals. Nature Genetics Supplement 2003, 33:245-254.
119. Jansen H.T., Cooke P.S., Porcelli J., Liu T.-C., Hansen L.G. Estrogenic and antiestrogenic actions of PCBs in the female rat: In vitro and in vivo studies. Reproductive Toxicology 1993, 7:237-248.
120. Jefferies D.J. The delay in ovulation produced by p, p′-DDT and its possible significance in the field. Ibis 1967, 109:266-272.
121. Jirtle R.L., Skinner M.K. Environmental epigenomic and disease susceptibility. Nature Reviews Genetics 2007, 8:253-262.
122. Jobling S., Coey S., Whitmore J.G., et al. Wild intersex roach (Rutilus rutilus) have reduced fertility. Biology of Reproduction 2002, 67:515-524.
123. Jurkevich A., Barth S.W., Grossman R. Sexual dimorphism of arg-vasotocin gene expressing neurons in the telencephalon and dorsal diencephalon of the domestic fowl: An immunocytochemical and in situ hybridization study. Cell and Tissue Research 1997, 287:69-77.
124. Jurkevich A., Barth S.W., Kuenzel W.J., Kohler A., Grossman R. Development of sexually dimorphic vasotocinergic system in the bed nucleus of stria terminalis in chickens. Journal of Comparative Neurology 1999, 408:46-60.
125. Jurkevich A., Grossman R., Balthazart J., Viglietti-Panzica C. Gender-related changes in the avian vasotocin system during ontogeny. Microscopy Research and Technique 2001, 55:27-36.
126. Kato H., Furuhashi T., Tanaka M., Katsu Y., Watanabe H., Ohta Y., Iguchi T. Effects of bisphenol A given neonatally on reproductive functions of male rats. Reproductive Toxicology 2006, 22:20-29.
127. Kelley D.B., Brenowitz E. Hormonal influences on courtship behavior. Behavioral Endocrinology 2002, vol. 2:289-330. MIT Press, Cambridge, MA. J. Becker, S.M. Breedlove, D. Crews, M.M. McCarthy (Eds.).
128. Keneko T., Yoshimoto H., Horiuchi S., Ikeda Y. Proceedings: Effects of PCB administration on two generations and its chronic toxicity on the third generation in mice. 2. Japanese Journal of Pharmacology 1974, 24:S44.
129. Kester M.H.A., Bulduk S., Tibboel D., et al. Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: A novel pathway explaining the estrogenic activity of PCBs. Endocrinology 2000, 141:1897-1900.
130. Khan I.A., Thomas P. Aroclor 1254-induced alterations in hypothalamic monoamine metabolism in the Atlantic croaker (Micropogonias undulatas): Correlation with pituitary gonadotropin release. Neurotoxicology 1997, 18:553-560.
131. Khan I.A., Thomas P. Disruption of neuroendocrine control of luteinizing hormone secretion by Aroclor 1254 involves inhibition of hypothalamic tryptophan hydroxylase activity. Biology of Reproduction 2001, 64:955-964.
132. Kholkute S.D., Rodriguez J., Dukelow W.R. Effects of polychlorinated biphenyls (PCBs) on in vitro fertilization in the mouse. Reproductive Toxicology 1994, 8:69-73.
133. Kidd K.A., Blanchfield P.J., Mills K.H., Palace V.P., Evans R.E., Lazorchak J.M., Flick R.W. Collapse of a fish population after exposure to a synthetic estrogen. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:8897-8901.
134. Kilic N., Sandal S., Colakoglu N., Kutlu S., Sevran A., Yilmaz B. Endocrine disruptive effects of polychlorinated biphenyls on the thyroid gland in female rats. Tohoku Journal of Experimental Medicine 2005, 206:327-332.
135. Kimura T., Okanoya K., Wada M. Effect of testosterone on the distribution of vasotocin immunoreactivity in the brain of the zebra finch, Taeniopygia guttata castanotis. Life Sciences 1999, 65:1663-1670.
136. Kirschner M., Gerhart J. Evolvability. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:8420-8427.
137. Kloas W., Lutz I. Amphibians as model to study endocrine disrupters. Journal of Chromatography 2006, 1130:16-27.
138. Koger C.S., Teh S.J., Hinton D.E. Determining the sensitive developmental stages of intersex induction in medaka (Oryzias latipes) exposed to 17 beta-estradiol or testosterone. Marine Environmental Research 2000, 50:201-206.
139. Kouki T., Kishitake M., Okamoto M., Oosuka I., Takebe M., Yamanouchi K. Effects of neonatal treatment with phytoestrogens, genistein and daidzein, on sex difference in female rat brain function: Estrous cycle and lordosis. Hormones and Behavior 2003, 44:140-145.
140. Kouki T., Okamoto M., Wada S., Kishitake M., Yamanouchi K. Suppressive effect of neonatal treatment with a phytoestrogen, coumestrol, on lordosis and estrous cycle in female rats. Brain Research Bulletin 2005, 64:449-454.
141. Kubo K., Arai O., Omura M., Watanabe R., Ogata R., Aou S. Low dose effect of bisphenol A on sexual differentiation of the brain and behavior in rats. Neuroscience Research 2003, 45:345-356.
142. Kuiper G.G.J.M., Lemmen J.G., Carlsson B., et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998, 139:4252-4263.
143. Lewontin R.C. The Triple Helix: Gene, Organism and Environment 2000, Harvard University Press, Cambridge, MA.
144. Lipar J.L., Ketterson E.D. Maternally derived yolk testosterone enhances the development of the hatching muscle in the red-winged blackbird Agelaius phoeniceus. Proceedings of the Royal Society B: Biological Sciences 2000, 267:2005-2010.
145. Lyche J.L., Oskam I.C., Skaare J.U., et al. Effects of gestational and lactational exposure to low doses of PCBs 126 and 153 on anterior pituitary and gonadal hormones and on puberty in female goats. Reproductive Toxicology 2004, 19:87-95.
146. Lyssimachou A., Jenssen B.M., Arukwe A. Brain cytochrome p450 aromatase gene isoforms and activity levels in Atlantic salmon after waterborne exposure to nominal environmental concentrations of the pharmaceutical ethynyl estradiol and antifoulant tributyltin. Toxicological Sciences 2006, 91:82-92.
147. Maerkel K., Durrer S., Henseler M., Schlumpf M., Lichtensteiger W. Sexually dimorphic gene regulation in brain as a target for endocrine disrupters: Developmental exposure of rats to 4-methylbenzylidene camphor. Toxicology and Applied Pharmacology 2007, 218:152-165.
148. Mansukhani V., Adkins-Regan E., Yang S. Sexual partner preference in female zebra finches: The role of early hormones and social enviroment. Hormones and Behavior 1996, 30:506-513.
149. Markman S., Leitner S., Catchpole C., Barnsley S., Muller C.T., Pascoe D., Buchanan K.L. Pollutants increase song complexity and the volume of the brain area HVC in a songbird. PLoS ONE 2008, 3:1-6.
150. Marler C.A., Boyd S.K., Wilczynski W. Forebrain arginine vasotocin correlates of alternative mating strategies in cricket frogs. Hormones and Behavior 1999, 36:53-61.
151. Martin T.E., Schwabl H. Variation in maternal effects and embryonic development rates among passerine species. Philosophical Transactions of the Royal Society of London B: Biological Sciences 2007, 363(1497):1663-1674.
152. Masutomi N., Shibutani M., Takagi H., Uneyama C., Takahashi N., Hirose M. Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life. Toxicology 2003, 192:149-170.
153. McAbee M.D., DonCarlos L.L. Regulation of androgen receptor messenger ribonucleic acid expression in the developing rat forebrain. Endocrinology 1999, 140:1807-1814.
154. McArthur M.L.B., Fox G.A., Peakall D.B., Philogene B.J.R. Ecological significance of behavioral and hormonal abnormalities in breeding ring doves fed an organochlorine chemical mixture. Archives of Environmental Contamination and Toxicology 1983, 12:343-353.
155. McCarty J.P., Secord A.L. Nest-building behaviour in PCB-contaminated tree swallows. Auk 1999, 116:55-63.
156. McCarty J.P., Secord A.L. Reproductive ecology of tree swallows (Tachycineta bicolor) with high levels of polychlorinated biphenyl contamination. Environmental Toxicology and Chemistry 1999, 18:1433-1439.
157. McClellan-Green P., Romano J., Oberdorster E. Does gender really matter in contaminant exposure? A case study using invertebrate models. Environmental Research 2007, 104:183-191.
158. McCoy G., Finlay M.F., Rhone A., James K., Cobb G.P. Chronic polychlorinated biphenyl exposure on three generations of oldfield mice (Peromyscus polionotus): Effects on reproduction, growth, and body residues. Archives of Environmental Contamination and Toxicology 1999, 28:431-435.
159. McGarvey C., Cates P.S., Brooks N.A., Swanson I.A., Milligan S.R., Coen C.W., O'Byrne K.T. Phytoestrogens and gonadotropin-releasing hormone pulse generator activity and pituitary luteinizing hormone release in the rat. Endocrinology 2001, 142:1202-1208.
160. McLachlan J.A. Environmental signaling: What embryos and evolution teach us about endocrine disrupting chemicals. Endocrine Reviews 2001, 22:319-341.
161. Mellon P.L., Windle J.J., Goldsmith P.C., Padula C.A., Roberts J.L., Weiner R.I. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron 1990, 5:1-10.
162. Millam J.R., Craig-Veit C.B., Quaglino A.E., Erichsen A.L., Famula T.R., Fry D.M. Posthatch oral estrogen exposure impairs adult reproductive performance of zebra finch in a sex-specific manner. Hormones and Behavior 2001, 40:542-549.
163. Millam J.R., Delwiche M.J., Craig-Veit C.B., Henderson J.D., Wilson B.W. Noninvasive characterization of the effects of diazinon on pigeons. Bulletin of Environmental Contamination and Toxicology 2000, 64:534-541.
164. Milnes M.R., Bermudez D.S., Bryan T.A., et al. Contaminant-induced feminization and demasculinization of nonmammalian vertebrate males in aquatic environments. Environmental Research 2006, 100:3-17.
165. Moniz A.C., Cruz-Casallas P.E., Oliveira C.A., et al. Perinatal fenvalerate exposure: Behavioral and endocrinology changes in male rats. Neurotoxicology and Teratology 1999, 21:611-618.
166. Moniz A.C., Cruz-Casallas P.E., Salzgeber S.A., Varoli F.M.F., Spinosa H.S., Bernardi M.M. Behavioral and endocrine changes induced by perinatal fenvalerate exposure in female rats. Neurotoxicology and Teratology 2005, 27:609-614.
167. Monje L., Varayoud J., Luque E.H., Ramos J.G. Neonatal exposure to bisphenol A modifies the abundance of estrogen receptor a transcripts with alternative 50-untranslated regions in the female rat preoptic area. Journal of Endocrinology 2007, 194:201-212.
168. Moore F.L., Richardson C., Lowry C.A. Sexual dimorphism in numbers of vasotocin-immunoreactive neurons in brain areas associated with reproductive behaviors in the roughskin newt. General and Comparative Endocrinology 2000, 117:281-298.
169. Mosconi G., Carnevali O., Franzoni M.F., et al. Environmental estrogens and reproductive biology in amphibians. General and Comparative Endocrinology 2002, 126:125-129.
170. Nash J.P., Kime D.E., Van der Ven L.T., et al. Long-term exposure to environmental concentrations of the pharmaceutical ethynylestradiol causes reproductive failure in fish. Environmental Health Perspectives 2004, 112:1725-1733.
171. Newbold R.R. Lessons learned from perinatal exposure to diethylstilbestrol. Toxicology and Applied Pharmacology 2004, 199:142-150.
172. Newbold R.R., Padilla-Banks E., Jefferson W.N. Adverse effects of the model environmental estrogen diethylstilbestrol (DES) are transmitted to subsequent generations. Endocrinology 2006, 147:S11-S17.
173. Nijhout H.F. The importance of context in genetics. American Scientist 2003, 91:416-418.
174. Noorden K.W., Noordenn E.J., Arnold A.P. Estrogen accumulation in the zebra finch song control nuclei: Implications for sexual differentiation and adult activation of song behavior. Journal of Neurobiology 1987, 18:569-582.
175. Ohtake F., Takeyama K., Matsumoto T., et al. Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature 2003, 423:545-550.
176. Orlando E.F., Guillette L.J. A re-examination of variation associated with environmentally stressed organisms. Human Reproduction Update 2001, 7:265-272.
177. Orlando E.F., Guillette L.J. Sexual dimorphic responses in wildlife exposed to endocrine disrupting chemicals. Environmental Research 2007, 104:163-173.
178. Ottinger M.A., Abdelnabi M.A., Henry P., McGary S., Thompson N., Wu J.M. Neuroendocrine and behavioral implications of endocrine disrupting chemicals in quail. Hormones and Behavior 2001, 40:234-247.
179. Ottinger M.A., Quinn M.J.J., Lavoie E., et al. Consequences of endocrine disrupting chemicals on reproductive endocrine function in birds: Establishing reliable end points of exposure. Domestic Animal Endocrinology 2005, 29:411-419.
180. Ottinger M.A., Vom Saal F.S. Impact of environmental endocrine disruptors on sexual differentiation in birds and mammals. Hormones, Brain and Behavior 2002, vol. 4:325-383. Elsevier, Oxford. D.W. Pfaff, A.P. Arnold, A.M. Etgen, S.E. Fahrbach (Eds.).
181. Ottinger M.A., Wu J.M., Hazelton J.L., et al. Assessing the consequences of the pesticide methoxychlor: Neuroendocrine and behavioral measures as indicators of biological impact of an estrogenic environmental chemical. Brain Research Bulletin 2005, 65:199-209.
182. Ozburn G.W., Morrison G.O. Development of a DDT-tolerant strain of laboratory mice. Nature 1962, 196:1009-1010.
183. Panzica G.C., Aste N., Castagna C., Viglietti-Panzica C., Balthazart J. Steroid-induced plasticity in the sexually dimorphic vasotocinergic innervation of the avian brain. Brain Research Review 2001, 37:178-200.
184. Panzica G.C., Mura E., Pessatti C., Viglietti-Panzica Early embryonic administration of xenoestrogens alters vasotocin system and male sexual behavior of the Japanese quail. Domestic Animal Endocrinology 2005, 29:436-445.
185. Panzica G.C., Viglietti-Panzica C. Gonadal steroid-dependent neuronal circuitries in avian limbic and preoptic regions. European Journal of Morphology 1999, 37:112-116.
186. Panzica G.C., Viglietti-Panzica C., Mura E., Quinn M.J.J., Lavoie E., Palanza P., Ottinger M.A. Effects of xenoestrogens on the differentiation of behaviorally-relevant neural circuits. Frontiers in Neuroendocrinology 2007, 28:179-200.
187. Panzica G.C., Viglietti-Panzica C., Ottinger M.A. Introduction: Neurobiological impact of environmental estrogens. Brain Research Bulletin 2005, 65:187-191.
188. Park D., Hempleman S.C., Propper C.R. Endosulfan exposure disrupts pheromonal systems in the red-spotted newt: A mechanism for subtle effects of environmental chemicals. Environmental Health Perspectives 2001, 109:669-673.
189. Park D., Propper C.R. Endosulfan affects pheromonal detection and glands in the male red-spotted newt (Notophthalmus viridescens). Bulletin of Environmental Contamination and Toxicology 2002, 69:609-616.
190. Patisaul H.B., Fortino A.E., Polston E.K. Neonatal genistein or bisphenol-A exposure alters sexual differentiation of the AVPV. Neurotoxicology and Teratology 2006, 28:111-118.
191. Peterman P.H., Gale R.W., Tillitt D.E., Feltz K.P. Analysis of non-ortho-PCBs in fish, bird eggs, sediments, soils, and SPMD samples by gas chromatography/high resolution mass spectrometry. Techniques in Aquatic Toxicology 1996, 517-553. Lewis, Boca Raton, FL. G.K. Ostrander (Ed.).
192. PetroffB.K., Croutch C.R., Hunter D.M., Wierman M.E., Gao X. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) stimulates gonadotropin secretion in the immature female Sprague-Dawley rat through a pentobarbital- and estradiol-sensitive mechanism but does not alter gonadotropin-releasing hormone (GnRH) secretion by immortalized GnRH neurons in vitro. Biology of Reproduction 2003, 68:2100-2106.
193. Phoenix C.H., Goy R.W., Gerall A.A., Young W.C. Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology 1959, 65:369-392.
194. Pilz K.M., Adkins-Regan E., Schwabl H. No sex difference in yolk steroid concentrations of avian eggs at laying. Biology Letters 2005, 1:318-321.
195. Podreka S., Georges A., Maher B., Limpus C. The environmental contaminant DDE fails to influence the outcome of sexual differentiation in the marine turtle Chelonia mydas. Environmental Health Perspectives 1998, 106:185-188.
196. Poonacha K.B., Wentworth B.C., Chapman A.B. Genetic resistance to DDT in the Japanese quail (Coturnix japonica). Poultry Science 1973, 52:841-846.
197. Propper C.R., Jones R.E., Lopez K.H. Distribution of arginine vasotocin in the brain of the lizard Anolis carolinensis. Cell and Tissue Research 1992, 267:391-398.
198. Qin A.-F., Qin X.-F., Yang L., Han-Ting L., Zhao X.-R., Xu X.-B. Feminizing/demasculinizing effects of polychlorinated biphenyls on the secondary sexual development of Xenopus laevis. Aquatic Toxicology 2007, 84:321-327.
199. Quadros P.S., Pfau J.L., Goldstein A.Y., DeVries G.J., Wagner C.K. Sex differences in progesterone receptor expression: A potential mechanism for estradiol-mediated sexual differentiation. Endocrinology 2002, 143:3727-3739.
200. Quaglino A.E., Craig-Veit C.B., Viant M.R., Erischen A.L., Fry D.M., Millam J.R. Oral estrogen masculinizes female zebra finch song system. Hormones and Behavior 2002, 41(2):236-241.
201. Radder R., Ali S., Shine R. Offspring sex is not related to maternal allocation of yolk steroids in the lizard Bassiana duperreyi (Scincidae). Physiological and Biochemical Zoology 2007, 80:220-227.
202. Rainwater T.R., Wood M.B., Millam J.R., Hooper M.J. Effects of perchlorate on growth and behavior of a granivorous passerine, the zebra finch (Taeniopygia guttata). Archives of Environmental Contamination and Toxicology 2007, 73:607-612.
203. Ramos J.G., Varayoud J., Kass L., Rodriguez H., Costabel L., Munoz-de-Toro M., Luque E.H. Bisphenol A induces both transient and permanent histofunctional alterations of the hypothalamic-pituitary-gonadal axis in prenatally exposed male rats. Endocrinology 2003, 144:3206-3215.
204. Reeder A.L., Ruiz M.O., Pessier A., et al. Intersexuality and the cricket frog decline: Historic and geographic trends. Environmental Health Perspectives 2004, 113:251-265.
205. Reiner A., Perkel J.D., Bruce L.L., et al. Revised nomenclature for avian telencephalon and some related brainstem nuclei. Journal of Comparative Neurology 2004, 473:377-414.
206. Rhees R.W., Shryne J.E., Gorski R.A. Onset of the hormone-sensitive perinatal period for sexual differentiation of the sexually dimorphic nucleus of the preoptic area in female rats. Journal of Neurobiology 1990, 21:781-786.
207. Rhen T., Crews D., Fivizzani A., Elf P.K. Reproductive tradeoffs and yolk steroids in female leopard geckos, Eublepharis macularius. Journal of Evolutionary Biology 2006, 19:1819-1829.
208. Roy D., Angelini N.L., Belsham D.D. Estrogen directly represses gonadotropin-releasing hormone (GnRH) gene expression in estrogen receptor-alpha (ERalpha) and ERbeta-expressing GT1-7 GnRH neurons. Endocrinology 1999, 140:5045-5053.
209. Rubin B.S., Lenkowski J.R., Schaeberle C.M., Vandenberg L.N., Ronsheim P.M., Soto A.M. Evidence of altered brain sexual differentiation in mice exposed perinatally to low, environmentally relevant levels of bisphenol A. Endocrinology 2006, 147:3681-3691.
210. Sager D.B. Effect of postnatal exposure to polychlorinated biphenyls on adult male reproductive function. Environmental Research 1983, 31:76-94.
211. Salama J., Chakraborty T.R., Ng L., Gore A.C. Effects of polychlorinated biphenyls (PCBs) on female reproductive development and estrogen receptor β expression. Environmental Health Perspectives 2003, 111:1278-1282.
212. Sar M. Estradiol is concentrated in tyrosine hydroxylase-containing neurons of the hypothalamus. Science 1984, 223:938-940.
213. Sar M., Sahu A., Crowley W.R., Kalra S.P. Localization of neuropeptide-Y immunoreactivity in estradiol-concentrating cells in the hypothalamus. Endocrinology 1990, 127:2752-2756.
214. Sar M., Stumpf W.E. Central noradrenergic neurons concentrate 3H-oestradiol. Nature 1981, 289:500-502.
215. Schwabl H. Yolk is a source of maternal testosterone for developing birds. Proceedings of the National Academy of Sciences of the United States of America 1993, 90:11446-11450.
216. Schwabl H. Maternal testosterone in the avian egg enhances postnatal growth. Comparative Biochemistry and Physiology, A: Physiology 1996, 114:271-276.
217. Segner H., Caroll K., Fenske M., et al. Identification of endocrine-disrupting effects in aquatic vertebrates and invertebrates: Report from the European IDEA project. Ecotoxicology and Environment Safety 2003, 54:302-314.
218. Sheehan D.M. No threshold dose-response curves for nongenotoxic chemicals: Findings and applications for risk assessment. Environmental Research 2006, 100:93-99.
219. Sheehan D.M., Willingham E.J., Bergeron J.M., Osborn C.T., Crews D. No threshold dose for estradiol-induced sex reversal of turtle embryos: How little is too much?. Environmental Health Perspectives 1999, 107:155-159.
220. Shekhar P.V., Werdell J., Basrur V.S. Environmental estrogen stimulation of growth and estrogen receptor function in preneoplastic and cancerous human breast cell lines. Journal of the National Cancer Institute 1997, 89:1774-1782.
221. Shibutani M., Masutomi N., Uneyama C., Abe N., Takagi H., Lee K.Y., Hirose M. Down-regulation of GAT-1 mRNA expression in the microdissected hypothalamic medial preoptic area of rat offspring exposed maternally to ethinylestradiol. Toxicology 2005, 208:35-48.
222. Shire J.G. The forms, uses and significance of genetic variation in endocrine systems. Biological Reviews 1976, 51:105-151.
223. Shivers B.D., Harlan R.E., Morrell J.I., PfaffD.W. Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurons. Nature 1983, 304:345-347.
224. Simerly R.B. Wired for reproduction: Organization and development of sexually dimorphic circuits in the mammalian forebrain. Annual Review in Neuroscience 2002, 25:507-536.
225. Skinner D.C., Caraty A., Allingham R. Unmasking the progesterone receptor in the preoptic area and hypothalamus of the ewe: No colocalization with gonadotropin-releasing neurons. Endocrinology 2001, 142:573-579.
226. Skinner M.K. What is an epigenetic transgenerational phenotype?. Reproductive Toxicology 2008, 25:2-6.
227. Smeets W.J.A.J., Sevensma J.J., Jonker A.J. Comparative analysis of vasotocin-like immunoreactivity in the brain of the turtle Pseudemys scripta elegans and the snake Python regius. Brain Behavior and Evolution 1990, 35:65-84.
228. Smith C.C., Taylor H.S. Xenoestrogen exposure imprints expression of genes (Hoxa10) required for normal uterine development. FASEB Journal 2007, 21:239-246.
229. Sockman K.W., Sharp P.J., Schwabl H. Orchestration of avian reproductive effort: An integration of the ultimate and proximate bases for flexibility in clutch size, incubation behaviour, and yolk androgen deposition. Biological Reviews of the Cambridge Philosophical Society 2006, 81:629-666.
230. Sower S.A., Reed K.L., Babbitt K.J. Limb malformations and abnormal sex hormone concentrations in frogs. Environmental Health Perspectives 2000, 108:1085-1090.
231. Spearow J.L., Domeny P., Sera R., Leffler R., Barkley M. Genetic variation in susceptibility to endocrine disruption by estrogen in mice. Science 1999, 285:1259-1261.
232. Steinberg R.M., Juenger T.E., Gore A.C. The effects of prenatal PCBs on adult female paced mating reproductive behaviors in rats. Hormones and Behavior 2007, 51:364-372.
233. Steinberg R.M., Walker D.M., Juenger T.E., Woller M.J., Gore A.C. The effects of prenatal PCBs on adult female rat reproduction. Development, reproductive physiology, and second generational effects. Biology of Reproduction 2008, 78:1091-1101.
234. Stoll C.J., Voorn P. The distribution of hypothalamic and extrahypothalamic vasotocinergic cells and fibers in the brain of a lizard, Gekko gecko: Presence of a sexual difference. Journal of Comparative Neurology 1985, 239:193-204.
235. Takagi H., Shibutani M., Masutomi N., Uneyama C., Takahashi N., Mitsumori K., Hirose M. Lack of maternal ditary exposure effects of bisphenol A and nonylphenol during the critical period for brain sexual differentiation on the reproductive/endocrine systems in later life. Archives of Toxicology 2004, 78:97-105.
236. Thepen T., Ooorn P., Stool D.J., Sluiter A.A., Pool C.W., Lohman A.M. Mesotocin and vasotocin in the brain of the lizard Gekko gecko: An immunocytochemical study. Cell and Tissue Research 1987, 250:649-656.
237. Thigpen J.E., Setchell K.D.R., Padilla-Banks E., et al. Variations in phytoestrogen content between different mill dates of the same diet produces significant differences in the time of vaginal opening in CD-1 mice and F344 rats but not in CD Sprague-Dawley rats. Environmental Health Perspectives 2007, 115:1717-1726.
238. Thornton J. Pandora's Poison: Chlorine, Health and a New Environmental Strategy 2000, MIT Press, Cambridge, MA.
239. Thornton J.W. The solution to the problem of endocrine disruption. Endocrine-Disrupting Chemicals: From Basic Research to Clinical Practice 2007, 329-347. Humana Press, Totowa, NJ. A.C. Gore (Ed.).
240. Titus-ErnstoffL., Troisi R., Hatch E.E., et al. Menstrual and reproductive characteristics of women whose mothers were exposed in utero to diethylstilbestrol (DES). International Journal of Epidemiology 2006, 35:862-868.
241. Toft G., Edwards T.M., Baatrup E., Guillette L.J. Disturbed sexual characteristics in male mosquitofish (Gambusia holbrooki) from a Lake contaminated with endocrine disruptors. Environmental Health Perspectives 2003, 111:695-701.
242. Turcotte J.C., Hunt P.J.B., Blaustein J.D. Estrogenic effects of zearalenone on the expression of progestin receptors and sexual behavior in female rats. Hormones and Behavior 2005, 47:178-184.
243. Uphouse L., Eckols K., Sierra V., Kolodziej M., Brown H. Failure of chlordecone (Kepone) to induce behavioral estrus in adult ovariectomized rats. Neurotoxicology 1986, 7:127-141.
244. Verboven N., Monaghan P., Evans D.M., Schwabl H., Evans N., Whitelaw C., Nager R.G. Maternal condition, yolk androgens and offspring performance: A supplemental feeding experiment in the lesser black-backed gull (Larus fuscus). Proceedings of Biological Sciences 2003, 270:2223-2232.
245. Viglietti-Panzica C., Aste N., Balthazart J., Panzica G.C. Vasotocinergic innervation of sexually dimorphic medial preoptic nucleus of the male Japanese quail: Influence of testosterone. Brain Research 1994, 657:171-184.
246. Von Englehardt N., Dijkstra C., Daan S., Groothuis T.G. Effects of 17-beta-estradiol treatment of female zebra finches on offspring sex ratio and survival. Hormones and Behavior 2004, 45:306-313.
247. Voorhuis T.A., Kiss J.Z., de Dloet E.R., de Wied D. Testosterone-sensitive vasotocin-immunoreactive cells and fibers in the canary brain. Brain Research 1988, 442:139-146.
248. Vos J.G., Dybing E., Greim H.A., et al. Health effects of endocrine-disrupting chemicals on wildlife, with special reference to the European situation. Critical Reviews in Toxicology 2000, 30:71-133.
249. Walker B.E., Haven M.I. Intensity of multigenerational carcinogenesis for diethylstilbestrol in mice. Carcinogenesis 1997, 18:791-793.
250. Walker D.M., Gore A.C. Endocrine-disrupting chemicals and the brain. Endocrine-Disrupting Chemicals: From Basic Research to Clinical Practice 2007, 63-109. Humana Press, Totowa, NJ. A.C. Gore (Ed.).
251. Wang X.Q., Fang J., Nunez A.A., Clemens L.G. Developmental exposure to polychlorinated biphenyls affects sexual behavior of rats. Physiology and Behavior 2002, 75:689-696.
252. Welshons W.V., Nagel S.C., vom Saal F.S. Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology 2006, 147:S56-S69.
253. Welshons W.V., Thayer K.A., Judy B.M., Taylor J.A., Curran E.M., Vom Saal F.S. Large effects from small exposures. I. Mechanisms for endocrine disrupting chemicals with estrogen activity. Envronmental Health Perspectives 2003, 111:994-1006.
254. West-Eberhard M.J. Evolution in the light of developmental and cell biology, and vice versa. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:8417-8419.
255. West-Eberhard M.J. Developmental Plasticity and Evolution 2003, Oxford University Press, Oxford.
256. Whitten P.L., Lewis C., Russell E., Naftolin F. Phytoestrogen influences on the development of behavior and gonadotropin function. Proceedings of the Society for Experimental Biology and Medicine 1995, 208:82-86.
257. Wiegand S.J., Terasawa E., Bridson W.E. Persistent estrus and blockade of progesterone-induced LH release follows lesions which do not damage the suprachiasmatic nucleus. Endocrinology 1978, 102:1645-1648.
258. Williams T.D. Parental and first generation effects of exogenous 17beta-estradiol on reproductive performance of female zebra finches (Taeniopygia guttata). Hormones and Behavior 1999, 35:135-143.
259. Willingham E. Endocrine-disrupting compounds and mixtures: Unexpected dose-response. Archives of Environmental Contamination and Toxicology 2004, 46:265-269.
260. Willingham E., Crews D. Sex reversal effects of environmentally relevant xenobiotic concentrations in the red-eared slider turtle, a species with temperature-dependent sex determination. General and Comparative Endocrinology 1999, 113:429-435.
261. Willingham E., Crews D. The slider turtle: An animal model for the study of low doses and mixtures. American Zoologist 2000, 40:421-429.
262. Wintermantel T.M., Campbell R.E., Porteous R., et al. Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility. Neuron 2006, 52:271-280.
263. Witorsch R.J. Can biological effects and environmental risks be predicted?. Regulatory Toxicology and Pharmacology 2002, 36:118-130.
264. Woodhouse A.J., Cooke G.M. Suppression of aromatase activity in vitro by PCBs 28 and 105 and Aroclor 1221. Toxicology Letters 2004, 152:91-100.
265. Yin W., Gore A.C. Neuroendocrine control of reproductive aging: Roles of GnRH neurons. Reproduction 2006, 131:403-414.
266. Young L.J., Crews D. Comparative neuroendocrinology of steroid receptor gene expression and regulation: Relationship to physiology and behavior. Trends in Endocrinology and Metabolism 1995, 6:317-323.
267. Zala S.M., Penn D.J. Abnormal behaviours induced by chemical pollution: A review of the evidence and new challenges. Animal Behaviour 2004, 68:649-664.