2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) stimulates gonadotropin secretion in the immature female Sprague-Dawley rat through a pentobarbital-and estradiol-sensitive mechanism but does not alter gonadotropin-releasing hormone (GnRH) secretion by immortalized GnRH neurons in vitro

Biology of Reproduction

Volumn 68, Issue 6, 2003, Pages 2100-2106

  Petroff, Brian K ^a,b   Croutch, Claire R ^a   Hunter, Dora M ^a   Wierman, Margaret E ^c   Gao, Xin ^a,b  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Follicle stimulating hormone; Gonadotropin releasing hormone; Hypothalamus; Luteinizing hormone; Toxicology

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CHORIONIC GONADOTROPIN; ESTRADIOL; ESTRADIOL CIPIONATE; FOLLITROPIN; GONADORELIN; GONADOTROPIN; LUTEINIZING HORMONE; MESSENGER RNA; MIFEPRISTONE; PENTOBARBITAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL IMMORTALIZATION; FEMALE; FOLLITROPIN BLOOD LEVEL; FOLLITROPIN RELEASE; GENETIC TRANSFECTION; GONADOTROPIN RELEASE; IMMATURITY; IN VITRO STUDY; LUTEINIZING HORMONE BLOOD LEVEL; LUTEINIZING HORMONE RELEASE; NERVE CELL; NONHUMAN; OVULATION INHIBITION; PRIORITY JOURNAL; RAT; RAT STRAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELL LINE; ENVIRONMENTAL POLLUTANTS; ESTRADIOL; FEMALE; FOLLICLE STIMULATING HORMONE; GONADOTROPIN-RELEASING HORMONE; GONADOTROPINS; HORMONE ANTAGONISTS; HYPNOTICS AND SEDATIVES; LUTEINIZING HORMONE; MIFEPRISTONE; NEURONS; PENTOBARBITAL; PROMOTER REGIONS (GENETICS); RADIOIMMUNOASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, PROGESTERONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TETRACHLORODIBENZODIOXIN;

ANIMALIA; EQUIDAE;

EID: 0037837046     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.102.010439     Document Type: Article

References (32)

1. Pohl HR. ATSDR toxicological profile for chlorinated dibenzo-p-dioxins. Toxicol Ind Health 2000; 16:86-201.
2. Petroff BK, Gao X, Ohshima K, Shi F, Son D, Roby KF, Rozman KK, Watanabe G, Taya K, Terranova PF. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on serum inhibin concentrations and inhibin immunostaining during follicular development in female Sprague-Dawley rats. Reprod Toxicol 2002; 16:97-105.
3. Li X, Johnson DC, Rozman KK. Reproductive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in female rats: ovulation, hormonal regulation and possible mechanism(s). Toxicol Appl Pharmacol 1995; 133:321-327.
4. Li X, Johnson DC, Rozman KK. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases release of luteinizing hormone and follicle stimulating hormone from the pituitary of immature female rats in vivo and in vitro. Toxicol Appl Pharmacol 1997; 142:264-269.
5. Ho HM, Oshima K, Tompa D, Watanabe G, Taya K, Strawn EY, Rawlins RG, Hutz RJ. TCDD increases inhibin A production by luteinized granulosa cells in vitro. Biol Reprod 2002; 66(suppl 1):308.
6. Astroff B, Rowlands C, Dickereson R, Safe S. 2,3,7,8-tetrachlorodibenzo-p-dioxin inhibition of 17β-estradiol-induced increases in rat uterine epidermal growth factor receptor binding activity and gene expression. Mol Cell Endocrinol 1990; 72:247-252.
7. Holcomb M, Safe S. Inhibition of 7,12-dimethylbenzanthracene-induced rat mammary tumor growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cancer Lett 1994; 83:43-47.
8. Safe S, Wang F, Porter W, Duan R, McDougal A. Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms. Toxicol Lett 1998; 102-103:343-347.
9. Gao X, Mizuyachi K, Terranova PF, Rozman KK. 2,3,7,8-tetrachlorodibenzo-p-dioxin decreases responsiveness of the hypothalamus to estradiol as a feedback inducer of preovulatory gonadotropin secretion in the immature gonadotropin primed rat. Toxicol Appl Pharmacol 2001; 170:181-190.
10. Legan SJ, Karsch FJ. A daily signal for the LH surge in the rat. Endocrinology 1975; 96:57-62.
11. Levine JE. New concepts in the neuroendocrine regulation of gonadotropin surges in rats. Biol Reprod 1997; 56:293-302.
12. Everett J, Sawyer CH. A 24 hour periodicity in the "LH release apparatus" of female rats, disclosed by barbiturate sedation. Endocrinology 1950; 46:198-216.
13. Bauer-Dantoin AC, Tabesh B, Norgle JR, Levine JE. RU486 administration blocks neuropeptide Y potentiation of luteinizing hormone-releasing hormone-induced LH surge in proestrous rats. Endocrinology 1993; 133:2418-2423.
14. Xu M, Urban JH, Hill JW, Levine JE. Regulation of hypothalamic neuropeptide Y Y1 receptor gene expression during the estrous cycle: role of progesterone receptors. Endocrinology 2000; 141:3319-3327.
15. Terranova PF, Garza F: Relationship between the preovulatory luteinizing hormone (LH) surge and androstenedione synthesis of preantral follicles in the cyclic hamster: detection by in vitro responses to LH. Biol Reprod 1983; 29:630-636.
16. Mellon PL, Windle JJ, Goldsmith PC, Padula CA, Roberts JL, Weiner RI. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Cell 1990; 5:1-10.
17. Son DS, Ushinohama K, Gao X, Taylor CC, Roby KF, Rozman KK, Terranova PF. 2,3,7,8-tetrachlorodibenzo-p-dioxin blocks ovulation by a direct action on the ovary without alteration of ovarian steroidogenesis: lack of a direct effect on ovarian granulosa and thecal-interstitial cell steroidogenesis in vitro. Reprod Toxicol 1999; 13:521-530.
18. Goldman JM, Cooper RL, Rehnberg GL, Gabel S, McElroy WK, Hein J, Conn M. Age-related alterations in the stimulated release in vitro of catecholamines and luteinizing hormone-releasing hormone from the male rat hypothalamus. Neurochem Res 1987; 12:651-657.
19. Kepa JK, Spaulding AJ, Jacobsen BM, Fang Z, Xiong X, Radovick S, Wierman ME. Structure of the distal human gonadotropin releasing hormone (hGnRH) gene promoter and functional analysis in GT1-7 neuronal cells. Nucleic Acids Res 1996; 24:3614-3620.
20. Burbach KM, Poland A, Bradfield CA. Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc Natl Acad Sci U S A 1992; 89:8185-8189.
21. Sorrentino S. Ovulation in PMS-treated rats with gonadotropin releasing hormone after pentobarbital and melatonin block. Neuroendocrinol 1975; 19:170-176.
22. Johnston GAR, Willow M. GABA and barbiturate receptors. Trends Pharmacol Sci 1982; 6:328-330.
23. Olsen RW, Fischer JB, Dunwiddie TV. Barbiturate enhancement of γ-aminobutyric acid receptor binding and function as a mechanism of anesthesia. In: Roth RH, Miller KW (eds.), Molecular and Cellular Mechanisms of Anesthetics. New York: Plenum; 1986:165-177.
24. - ion channels modulated by multiple drug-binding sites. Trends Pharmacol Sci 1992; 13: 446-450.
25. Sadar MD, Westlind A, Blomstrand F, Andersson TB. Induction of CYP1A1 by GABA receptor ligands. Biochem Biophys Res Commun 1996; 229:231-237.
26. Hays LE, Carpenter CD, Peterson SL. Evidence that GABAergic neurons in the preoptic area of the rat brain are targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin during development. Env Health Persp 2002; 110:369-376.
27. Trewin AL, Conley LK, Woller M, Hutz RJ. The gonadotropin releasing hormone-induced release of follicle stimulating hormone and luteinizing hormone from female rat pituitary explants is not altered 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biol Reprod 2002; 66(suppl 1): 298.
28. Chappell PE, Levine JE. Stimulation of gonadotropin-releasing hormone surges by estrogen. I. Role of progesterone receptors. Endocrinology 2000; 141:1477-1485.
29. Kallo I, Butler JA, Barkovics-Kallo M, Goubillon ML, Coen CW. Oestrogen receptor beta-immunoreactivity in gonadotropin releasing hormone-expressing neurons: regulation by oestrogen. J Neuroendocrinol 2001; 13:741-748.
30. Buchanan CD, Mahesh VB, Brann DW. Estrogen-astrocyte-luteinizing hormone-releasing hormone signaling: a role for transforming growth factor-beta 1. Biol Reprod 2000; 62:1710-1721.
31. Peterson SL, Curran MA, Marconi SA, Carpenter DD, Lubbers LS, McAbee MD. Distribution of mRNAs encoding the aryl hydrocarbon receptor, ARNT and ARNT-2, in the rat brain and brainstem. J Comp Neurol 2000; 427:428-239.
32. Dalkin AC, Haisenleder DJ, Ortolano GA, Ellis TR, Marshall JC. The frequency of gonadotropin-releasing hormone stimulation differentially regulates gonadotropin subunit messenger ribonucleic acid expression. Endocrinology 1989; 125:917-924.