A novel mechanism for endocrine-disrupting effects of polychlorinated biphenyls: Direct effects on gonodotropin-releasing hormone neurones

Journal of Neuroendocrinology

Volumn 14, Issue 10, 2002, Pages 814-823

  Gore, A C ^a   Wu, T J ^a   Oung, T ^a   Lee, J B ^a   Woller, M J ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN WHITEWATER   (United States)

Author keywords

780; Aroclor 1221; Aroclor 1254; Endocrine disruptor; GnRH; GT1 cell; ICI 182; Oestrogen

Indexed keywords

ANTIESTROGEN; AROCLOR 1254; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; GONADORELIN; MESSENGER RNA; PEPTIDE HORMONE; POLYCHLORINATED BIPHENYL DERIVATIVE; ANTITHYROID AGENT; AROCLOR; AROCLOR 1221; DRUG DERIVATIVE; ESTRADIOL; POLYCHLORINATED BIPHENYL;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL LINE; CELL SECRETION; CENTRAL NERVOUS SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; GENE EXPRESSION; GONADORELIN RELEASE; HORMONE DETERMINATION; HORMONE SYNTHESIS; HYPOTHALAMUS; INHIBITION KINETICS; MOUSE; NERVE CELL; NERVE FIBER GROWTH; NEUROENDOCRINE SYSTEM; NEUROSECRETORY CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REPRODUCTIVE TOXICITY; ANIMAL; CELL NUCLEUS; CYTOLOGY; CYTOPLASM; DOSE RESPONSE; DRUG EFFECT; GENETICS; METABOLISM; NEUROSECRETION; PHYSIOLOGY; POLLUTANT;

ANIMALS; ANTITHYROID AGENTS; AROCLOR 1254; AROCLORS; CELL LINE, TRANSFORMED; CELL NUCLEUS; CYTOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; ESTRADIOL; ESTROGEN ANTAGONISTS; GENE EXPRESSION; GONADOTROPIN-RELEASING HORMONE; MICE; NEURONS; NEUROSECRETORY SYSTEMS; POLYCHLORINATED BIPHENYLS; RNA, MESSENGER;

EID: 0036798513     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2002.00845.x     Document Type: Article

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