Sexual behavior in Japanese quail as a test end point for endocrine disruption: Effects of in ovo exposure to ethinylestradiol and diethylstilbestrol

Environmental Health Perspectives

Volumn 107, Issue 11, 1999, Pages 861-866

  Halldin, Krister ^a   Berg, Cecilia ^a   Brandt, Ingvar ^a   Brunström, Björn ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Diethylstilbestrol; Endocrine disruption; Environmental estrogens; Ethinylestradiol; Japanese quail; Sexual behavior; Test system; Testis; Testosterone

Indexed keywords

DIETHYLSTILBESTROL; ETHINYLESTRADIOL; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CLOACA; CONTROLLED STUDY; ENDOCRINE FUNCTION; MALE; NONHUMAN; PRIORITY JOURNAL; QUAIL; SEXUAL BEHAVIOR; SEXUAL MATURITY; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL; TOXICITY TESTING; ZYGOTE;

EID: 0032804631     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.99107861     Document Type: Article

References (61)

1. Bryan TE, Gildersleeve RP, Wiard RP. Exposure of Japanese quail embryos to o,p'-DDT has long-term effects on reproductive behaviors, hematology and feather morphology. Teratology 39:525-536 (1989).
2. Peterson RE, Theobald HM, Kimmel GL. Developmental and reproductive toxicity of dioxins and related compounds: cross-species comparisons. Crit Rev Toxicol 23:283-335 (1993).
3. Crews D, Bergeron JM, McLachlan JA. The role of estrogen in turtle sex determination and the effect of PCBs. Environ Health Perspect 103(suppl 7):73-77 (1995).
4. Fry DM. Reproductive effects in birds exposed to pesticides and industrial chemicals. Environ Health Perspect 103(suppl 7):165-171 (1995).
5. MacLellan KNM, Bird DM, Fry DM, Cowles JL. Reproductive and morphological effects of o,p'-dicofol on two generations of captive American kestrels. Arch Environ Contam Toxicol 30:364-372 (1996).
6. Crain DA, Guillette LJ Jr, Rooney AA, Pickford DB. Alterations in steroidogenesis in alligators (Alligator mississippiensis) exposed naturally and experimentally to environmental contaminants. Environ Health Perspect 105:528-533 (1997).
7. Gray LE Jr, Ostby J. Effects of pesticides and toxic substances on behavioral and morphological reproductive development: Endocrine versus nonendocrine mechanisms. Toxicol Ind Health 14:159-184 (1998).
8. Steinmetz R, Mitchner NA, Grant A, Allen DL, Bigsby RM, Ben Jonathan N. The xenoestrogen bisphenol A induces growth, differentiation, and c-fos gene expression in the female reproductive tract. Endocrinology 139:2741-2747 (1998).
9. Fox GA. Epidemiological and pathobiological evidence of contaminant-induced alterations in sexual development in free-living wildlife. In: Chemically-Induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection (Colborn T, Clement C, eds). Princeton, NJ:Princeton Scientific Publishing Co, 1992:147-158.
10. Guillette LJ Jr, Gross TS, Masson GR, Matter JM, Percival HF, Woodward AR. Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida. Environ Health Perspect 102:680-688 (1994).
11. Facemire CF, Gross TS, Guillette LJ Jr. Reproductive impairment in the Florida panther: nature or nurture? Environ Health Perspect 103(suppl 4):76-86 (1995).
12. Lye CM, Frid CLJ, Gill ME, McDormick D Abnormalities in the reproductive health of flounder Platichthys flesus exposed to effluent from a sewage treatment works. Mar Pollut Bull 34:34-41 (1997).
13. Fry DM, Toone CK. DDT-induced feminization of gull embryos. Science 213:922-924 (1981).
14. Fry DM, Toone CK, Speich SM, Peard RJ. Sex ratio skew and breeding patterns of gulls: demographic and toxicological considerations. Stud Avian Biol 10:26-43 (1987).
15. Soto AM, Justicia H, Wray JW, Sonnenschein C. p-Nonyl-phenol: an estrogenic xenobiotic released from "modified" polystyrene. Environ Health Perspect 92:167-173 (1991).
16. Thomas P, Smith J. Binding of xenobiotics to the estrogen receptor of spotted seatrout: a screening assay for potential estrogenic effects. Mar Environ Res 35:147-151 (1993).
17. White R, Jobling S, Hoare SA, Sumpter JP, Parker MG. Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 135:175-182 (1994).
18. Gaido KW, Leonard LS, Lovell S, Gould JC, Babai D, Portier CJ, McDonnell DP. Evaluation of chemicals with endocrine modulation activity in a yeast-based steroid hormone receptor gene transcription assay. Toxicol Appl Pharmacol 143:205-212 (1997).
19. Bolger R, Wiese TE, Ervin K, Nestich S, Checovich W. Rapid screening of environmental chemicals for estrogen receptor binding capacity. Environ Health Perspect 106:551-557 (1998).
20. Soto AM, Sonnenschein C, Chung KL, Fernandez MF, Olea N, Serrano FO. The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ Health Perspect 103(suppl 7):113-122 (1995).
21. Nagel SC, vom Saal FS, Thayer KA, Dhar MG, Boechler M, Welshons WV. Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol. Environ Health Perspect 105:70-76 (1997).
22. Rubin BL, Dorfman AS, Black L, Dorfman RI. Bioassay of estrogens using the mouse uterine response. Endocrinology 49:429-439 (1951).
23. Dorfman RI, Dorfman AS. Estrogen assays using the rat uterus. Endocrinology 55:65-69 (1954).
24. vom Saal FS, Timms BG, Montano MM, Palanza P, Thayer KA, Nagel SC, Dhar MD, Ganjam VK, Parmigiani S, Welshons WV. Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses. Proc Natl Acad Sci USA 94:2056-2061 (1997).
25. Adkins EK. Hormonal basis of sexual differentiation in the Japanese quail. J Comp Physiol Psychol 89:61-71 (1975).
26. Balthazart J, Tlemcani O, Ball GF. Do sex differences in the brain explain sex differences in the hormonal induction of reproductive behavior? What 25 years of research on the Japanese quail tells us. Horm Behav 30:627-661 (1996).
27. Whitsett JM, Irvin EW, Edens FW, Thaxton JP. Demasculinization of male Japanese quail by prenatal estrogen treatment. Horm Behav 8:254-263 (1977).
28. Adkins EK. Effect of embryonic treatment with estradiol or testosterone on sexual differentiation of the quail brain. Neuroendocrinology 29:178-185 (1979).
29. Schumacher M, Hendrick JC, Balthazart J. Sexual differentiation in quail: critical period and hormonal specificity. Horm Behav 23:130-149 (1989).
30. Panzica GC, Viglietti-Panzica C, Balthazart J. The sexually dimorphic medial preoptic nucleus of quail: a key brain area mediating steroid action on male sexual behavior. Front Neuroendocrinol 17:51-125 (1996).
31. Ottinger MA, Abdelnabi MA. Neuroendocrine systems and avian sexual differentiation. Am Zool 37:514-523 (1997).
32. Adkins EK. Embryonic exposure to an antiestrogen masculinizes behavior of female quail. Physiol Behav 17:357-359 (1976).
33. Balthazart J, De Clerck A, Foidart A. Behavioral demasculinization of female quail is induced by estrogens: studies with the new aromatase inhibitor, R76713. Horm Behav 26:179-203 (1992).
34. Adkins EK, Adler NT. Hormonal control of behavior in the Japanese quail. J Comp Physiol Psychol 81:27-36 (1972).
35. Hutchison RE. Hormonal differentiation of sexual behavior in Japanese quail. Horm Behav 11:363-387 (1978).
36. Ankley G, Mihaich E, Stahl R, Tillitt D, Colborn T, McMaster S, Miller R, Bantle J, Campbell P, Denslow N, et al. Overview of a workshop on screening methods for detecting potential (anti-) estrogenic/androgenic chemicals in wildlife. Environ Toxicol Chem 17:68-87 (1998).
37. Tabak HH, Bloomhuff RN, Bunch RL. Steroid hormones as water pollutants II. Studies on the persistency and stability of natural urinary and synthetic ovulation-inhibiting hormones in untreated and treated wastewaters. Dev Ind Microbiol 11:367-376 (1981).
38. Desbrow C, Routledge EJ, Brighty GC, Sumpter JP, Waldock M. Identification of estrogenic chemicals in STW effluent. 1. Chemical fractionation and in vitro biological screening. Environ Sci Technol 32:1549-1558 (1998).
39. Larsson DGJ, Adolfsson-Erici M, Parkkonen J, Petersson M, Berg AH, Olsson P-E, Förlin L. Ethinyloestradiol - an undesired fish contraceptive? Aquat Toxicol 45:91-97 (1999).
40. Brunström B, Örberg J. A method for studying embryotoxicity of lipophilic substances experimentally introduced into hens' eggs. Ambio 11:209-211 (1982).
41. Brunström B, Darnerud PO. Toxicity and distribution in chick embryos of 3,3′,4,4′-tetrachlorobiphenyl injected into the eggs. Toxicology 27:103-110 (1983).
42. Alexandre C, Balthazart J. Effects of metabolism inhibitors, antiestrogens and antiandrogens on the androgen and estrogen induced sexual behavior in Japanese quail. Physiol Behav 38:581-591 (1986).
43. Ottinger MA, Follett BK. Circulating levels of luteinizing hormone and androgen in mature male Japanese quail over 24 hours. Poult Sci 66:1411-1413 (1987).
44. Berg C, Halldin K, Fridolfsson A-K, Brandt I, Brunström B. The avian egg as a test system for endocrine disrupters: effects of diethylstilbestrol and ethynylestradiol on sex organ development. Sci Total Environ 233:57-66 (1999).
45. Gildersleeve RP, Tilson HA, Mitchell C. Injection of diethylstilbestrol on the 1st day of incubation affects morphology of sex glands and reproductive behavior of Japanese quail (Coturnix coturnix japonica). Teratology 31:101-110 (1985).
46. Wilson JA, Glick B. Ontogeny of mating behavior in the chicken. Am J Physiol 218:951-955 (1970).
47. Whitsett JM, Vandenbergh JG, eds. Hormonal Influences on Brain and Behavioral Development. New York:Academic Press, 1977.
48. Balthazart J, Surlemont C. Androgen and estrogen action in the preoptic area and activation of copulatory behavior in quail. Physiol Behav 48:599-609 (1990).
49. Viglietti-Panzica C, Garcia-Ojeda E, Aste N, Castagna C, Panzica GC. Sexual dimorphism of vasotocin system in the Japanese quail [abstract]. Soc Neurosci Abstr 23:799 (1997).
50. Panzica GC, Castagna C, Viglietti-Panzica C, Russo C, Tlemcani O, Balthazart J. Organisational effects of estrogens on brain vasotocin and sexual behavior in quail. J Neurobiol 37:684-699 (1998).
51. Balthazart J. Correlation between the sexually dimorphic aromatase of the preoptic area and sexual behavior in quail: effects of neonatal manipulations of the hormonal milieu. Arch Int Physiol Biochim 97:465-482 (1989).
52. Aste N, Panzica GC, Viglietti Panzica C, Balthazart J. Effects of in ovo estradiol benzoate treatments on sexual behavior and size of neurons in the sexually dimorphic medial preoptic nucleus of Japanese quail. Brain Res Bull 27:713-720 (1991).
53. Scheib D, Guichard A, Mignot T-M, Cedard L. Steroidogenesis by gonads of normal and of diethylstilbestrol-treated quail embryos: radioimmunoassay on organ cultures. Gen Comp Endocrinol 43:519-526 (1981).
54. Scheib D, Reyss-Brion M. Feminization of the quail by early diethylstilbestrol treatment: histoenzymological investigations on steroid dehydrogenases in the gonads. Arch Anat Microscop Morphol Exp 68:85-98 (1979).
55. Zenick H, Clegg ED. Assessment of male reproductive toxicity: a risk assessment approach. In: Principles and Methods of Toxicology (Hayes AW, ed). New York:Raven Press, 1989:275-310.
56. Sinha Hikim AP, Amador AG, Klemake HG, Bartke A, Russel LD. Correlative morphology and endocrinology of sertoli cells in hamster testis in active and inactive states of spermatogenesis. Endocrinology 125:1829-1843 (1989).
57. Schein MW, Diamond M, Carter CS. Sexual performance levels of male Japanese quail (Coturnix coturnix japonica). Anim Behav 20:61-67 (1972).
58. Balthazart J, Castagna C, Ball GF. Differential effects of D1 and D2 dopamine-receptor agonists and antagonists on appetitive and consummatory aspects of male sexual behaviar in Japanese quail. Physiol Behav 62:571-580 (1997).
59. Castagna C, Ball GF, Balthazart J. Effects of dopamine agonists on appetitive and consummatory male sexual behavior in Japanese quail. Pharmacol Biochem Behav 58:403-414 (1997).
60. Adkins EK, Koutnik DL, Morris JB, Pniewski EE, Boop JJ. Further evidence that androgen aromatization is essential for the activation of copulation in male quail (Coturnix coturnix japonica). Physiol Behav 24:441-446 (1980).
61. Foidart A, Harada N, Balthazart J. Effects of steroidal and non steroidal aromatase inhibitors on sexual behavior and aromatase-immunoreactive cells and fibers in the quail brain. Brain Res 657:105-123 (1994).