Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay

Cellular Signalling

Volumn 25, Issue 12, 2013, Pages 2848-2855

  Storaska, Andrew J ^a   Mei, Jian P ^a   Wu, Meng ^b,h   Li, Min ^b   Wade, Susan M ^a   Blazer, Levi L ^a,i   Sjögren, Benita ^a,c   Hopkins, Corey R ^d,e,g   Lindsley, Craig W ^d,e,g   Lin, Zhihong ^b,h   Babcock, Joseph J ^b   McManus, Owen B ^b,j   Neubig, Richard R ^a,c,f  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d VANDERBILT UNIVERSITY   (United States)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^g UNIVERSITY OF MICHIGAN   (United States)

^h UNIVERSITY OF IOWA   (United States)

ⁱ Cayman Chemical   (United States)

^j Essen Bioscience   (United States)

more..

Author keywords

G protein coupled receptors; High throughput screen; M3 muscarinic acetylcholine receptor; Regulator of G protein signaling; Small molecule inhibitor

Indexed keywords

DOXYCYCLINE; G PROTEIN COUPLED RECEPTOR; MUSCARINIC M3 RECEPTOR; PROTEIN INHIBITOR; RGS PROTEIN INHIBITOR; RGS4 PROTEIN; UNCLASSIFIED DRUG; CALCIUM; GUANINE NUCLEOTIDE BINDING PROTEIN; MOLECULAR LIBRARY; RGS PROTEIN;

ARTICLE; BINDING AFFINITY; CALCIUM TRANSPORT; CELL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PENETRATION; DRUG SELECTIVITY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN PROTEIN INTERACTION; THERMOSTABILITY; ANTAGONISTS AND INHIBITORS; CALCIUM SIGNALING; CELL LINE; CHEMISTRY; DRUG EFFECTS; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; PRECLINICAL STUDY; SIGNAL TRANSDUCTION;

CALCIUM; CALCIUM SIGNALING; CELL LINE; DRUG EVALUATION, PRECLINICAL; GTP-BINDING PROTEINS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; RECEPTOR, MUSCARINIC M3; RGS PROTEINS; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES;

EID: 84884741934     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2013.09.007     Document Type: Article

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