Pentamethylquercetin reduces fat deposition via Sirt1-mediated pathways in male obese mice induced by a high fat diet

Food and Chemical Toxicology

Volumn 62, Issue , 2013, Pages 463-469

  Ying, Hua Zong ^a   Zang, Jia Na ^b   Deng, Li Li ^b   Wang, Zhi Yuan ^a   Yu, Chen huan ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

Mammalian target of rapamycin (mTOR); Obesity; Pentamethylquercetin; Sirtuin1 (Sirt1)

Indexed keywords

ANTIOBESITY AGENT; FAS ANTIGEN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INITIATION FACTOR 4E BINDING PROTEIN 1; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PENTAMETHYLQUERCETIN; PERILIPIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SIRTUIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

4EBP1 GENE; ADIPOGENESIS; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATGL GENE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG MECHANISM; FAS GENE; GENE; GLUCOSE BLOOD LEVEL; HSL GENE; LIPID ANALYSIS; LIPID DIET; LIPID STORAGE; MALE; MOUSE; MTOR GENE; NONHUMAN; OBESITY; PERILIPIN GENE; PPAR GAMMA GENE; PROTEIN EXPRESSION; S6K1 GENE; SIGNAL TRANSDUCTION; SIRT1 GENE; SREBP1 GENE; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN;

ANIMALIA; MAMMALIA; MUS;

MAMMALIAN TARGET OF RAPAMYCIN (MTOR); OBESITY; PENTAMETHYLQUERCETIN; SIRTUIN1 (SIRT1);

ADIPOGENESIS; ADIPOSE TISSUE; ADIPOSE TISSUE, WHITE; ANIMALS; DIET, HIGH-FAT; GENE EXPRESSION REGULATION; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; NIACINAMIDE; OBESITY; QUERCETIN; SIGNAL TRANSDUCTION; SIRTUIN 1; TOR SERINE-THREONINE KINASES; TRIGLYCERIDES; WEIGHT GAIN;

EID: 84884714609     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.09.002     Document Type: Article

References (52)

1. Ahn J., Lee H., Jang J., Kim S., Taeyoul Ha T. Anti-obesity effects of glabridin-rich supercritical carbon dioxide extract of licorice in high-fat-fed obesemice. Food Chem. Toxicol. 2013, 51:439-445.
2. Boots A.W., Haenen G.R.M.M., Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur. J. Pharmacol. 2008, 585:325-337.
3. Brunette D.D. Resuscitation of the morbidly obese patient. Am. J. Emerg. Med. 2004, 22:40-47.
4. Chaves V.E., Frasson D., Kawashita N.H. Several agents and pathways regulate lipolysis in adipocytes. Biochimie 2011, 93:1631-1640.
5. Chen S., Xiao X., Feng X., Li W., Zhou N., Zheng L., Sun Y., Zhang Z., Zhu W. Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression. J. Nutr. Biochem. 2012, 23:1100-1112.
6. Christian P., Sacco J., Adeli K. Autophagy: Emerging roles in lipid homeostasis and metabolic control. BBA-Mol. Cell Biol. L 2013, 1831:819-824.
7. Chung S., Yao H., Caito S., Hwang J., Arunachalam G., Rahman I. Regulation of SIRT1 in cellular functions: role of polyphenols. Arch. Biochem. Biophys. 2010, 501:79-90.
8. Clapham J.C., Arch J.R.S. Targeting thermogenesis and related pathways in anti-obesity drug discovery. Pharmacol. Therapeut. 2011, 131:295-308.
9. Hagen R.M., Rodriguez-Cuenca S., Vidal-Puig A. An allostatic control of membrane lipid composition by SREBP1. FEBS Lett. 2010, 584:2689-2698.
10. He T., Chen L., Chen Y., Han Y., Yang W.Q. In vivo and in vitro protective effects of pentamethylquercetin on cardiac hypertrophy. Cardiovas. Drug. Ther. 2012, 26:109-120.
11. Hollman P.C.H., Gaag M.V.D., Mengelers M.J.B., Van Trijp J.M.P., De Vries J.H.M., Katan M.B. Absorption and disposition kinetics of the dietary antioxidant quercetin in man. Free Radical Bio. Med. 1996, 21:703-707.
12. Kim Y.J., Park T. Genes are differentially expressed in the epididymal fat of rats rendered obese by a high-fat diet. Nutr. Res. 2008, 28:414-422.
13. Lampidonis A.D., Rogdakis E., Voutsinas G.E., Stravopodis D.J. The resurgence of Hormone-Sensitive Lipase (HSL) in mammalian lipolysis. Gene 2011, 477:1-11.
14. Lee H., Park D., Yoon M. Korean red ginseng (Panax ginseng) prevents obesity by inhibiting angiogenesis in high fat diet-inducedobeseC57BL/6J mice. Food Chem. Toxicol. 2013, 53:402-408.
15. Li X.H., Xin X., Wang Y., Wu J.Z., Jin Z.D., Ma L.N., Nie C.J., Xiao X., Hua Y., Jin M.W. Pentamethylquercetin protects against diabetes-related cognitive deficits in diabetic Goto-Kakizaki Rats. J. Alzheimers Dis. 2013, 34:755-767.
16. Mao Z., Liang Y., Du X., Sun Z. 3,3',4',5,7-Pentamethylquercetin reduces angiotensin II-induced cardiac hypertrophy and apoptosis in rats. Can. J. Physiol. Pharmacol. 2009, 87:720-728.
17. Martin G., Schoonjans K., Staels B., Auwerx J. PPARγ activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes. Atherosclerosis 1998, 137:S75-S80.
18. Matsuda H., Kogami Y., Nakamura S., Sugiyama T., Ueno T., Yoshikawa M. Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. Bioorg. Med. Chem. 2011, 19:2835-2841.
19. Murota K., Terao J. Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. Arch. Biochem. Biophys. 2003, 417:12-17.
20. Nedergaard J., Petrovic N., Lindgren E.M., Jacobsson A., Cannon B. PPARγ in the control of brown adipocyte differentiation. BBA-Mol. Basis Dis. 2005, 1740:293-304.
21. Nijjar P.S., Burke F.M., Bloesch A., Rader D.J. Role of dietary supplements in lowering low-density lipoprotein cholesterol: a review. J. Clin. Lipidol. 2010, 4:248-258.
22. Otake Y., Hsieh F., Walle T. Glucuronidation versus oxidation of the flavonoid galangin by human liver microsomes and hepatocytes. Drug Metab. Dispos. 2002, 30:576-581.
23. Pallauf K., Rimbach G. Autophagy, polyphenols and healthy ageing. Ageing Res. Rev. 2013, 12:237-252.
24. Pang W., Xiong Y., Wang Y., Tong Q., Yang G. Sirt1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine preadipocytes. Exp. Cell Res. 2013, 319:670-683.
25. Park S.H., Park H.S., Lee J.H., Chi G.Y., Kim G.Y., Moon S.K., Chang Y.C., Hyun J.W., Kim W.J., Choi Y.H. Induction of endoplasmic reticulum stress-mediated apoptosis and non-canonical autophagy by luteolin in NCI-H460 lung carcinoma cells. Food Chem. Toxicol. 2013, 56:100-109.
26. Picard F., Kurtev M., Chung N., Topark-Ngarm A., Senawong T., Machado De Oliveira R., Leid M., McBurney M.W., Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 2004, 429:771-776.
27. Powers T. Cell growth control: mTOR takes on fat. Mol. Cell 2008, 31:775-776.
28. Rotimi O.A., Olayiwola I.O., Ademuyiwa O., Balogun E.A. Effects of fibre-enriched diets on tissue lipid profiles of MSG obese rats. Food Chem. Toxicol. 2012, 50:4062-4067.
29. Russo M., Spagnuolo C., Tedesco I., Bilotto S., Russo G.L. The flavonoid quercetin in disease prevention and therapy: facts and fancies. Biochem. Pharmacol. 2012, 83:6-15.
30. Seiva F.R.F., Chuffa L.G.A., Braga C.P., Amorim J.P.A., Fernandes A.A.H. Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations. Food Chem. Toxicol. 2012, 50:3556-3561.
31. Sergent T., Vanderstraeten J., Winand J., Beguin P., Schneider Y.J. Phenolic compounds and plant extracts as potential natural anti-obesity substances. Food Chem. 2012, 135:68-73.
32. Serra A., Macià A., Romero M.P., Reguant J., Ortega N., Maria-José Motilva M.J. Metabolic pathways of the colonicmetabolismof flavonoids (flavonols, flavones and flavanones) and phenolic acids. Food Chem. 2012, 130:383-393.
33. Shen J.Z., Ma L.N., Han Y., Liu J.X., Yang W.Q., Chen L., Liu Y., Hu Y., Jin M.W. Pentamethylquercetin generates beneficial effects in monosodium glutamate-induced obese mice and C2C12 myotubes by activating AMP-activated protein kinase. Diabetologia 2012, 55:1836-1846.
34. Shin S.Y., Hyun J., Yu J.R., Lim Y., Lee Y.H. 5-Methoxyflavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells. Toxicol. Appl. Pharm. 2011, 254:288-298.
35. Shiota A., Shimabukuro M., Fukuda D., Soeki T., Sato H., Uematsu E., Hirata Y., Kurobe H., Sakaue H., Nakaya Y., Masuzaki H., Sata M. Activation of AMPK-Sirt1 pathway by telmisartan in white adipose tissue: a possible link to anti-metabolic effects. Eur. J. Pharmacol. 2012, 692:84-90.
36. Sun Y., Zou M., Hu C., Qin Y., Song X., Lu N., Guo Q. Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway. Food Chem. Toxicol. 2013, 51:53-60.
37. Tsuji P.A., Winn R.N., Walle T. Accumulation and metabolism of the anticancer flavonoid 5,7-dimethoxyflavone compared to its unmethylated analog chrysin in the Atlantic killifish. Chem. Biol. Interact. 2006, 164:85-92.
38. Walle T. Absorption and metabolism of flavonoids. Free Radical Bio. Med. 2004, 36:829-837.
39. Walle T. Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption. Mol. Pharm. 2007, 4:826-832.
40. Walle U.K., Walle T. Bioavailable flavonoids: cytochrome P450-mediate metabolism of methoxyflavones. Drug Metab. Dispos. 2007, 35:1985-1989.
41. Wang K., Liu R., Li J., Mao J., Lei Y., Wu J., Zeng J., Zhang T., Wu H., Chen L., Huang C., Wei Y. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling. Autophagy 2011, 7:966-978.
42. Wang Y., Xin X., Jin Z., Hu Y., Li X., Wu J., Jin M. Anti-diabetic effects of pentamethylquercetin in neonatally streptozotocin-induced diabetic rats. Eur. J Pharmacol. 2011, 668:347-353.
43. Wat E., Tandy S., Kapera E., Kamili A., Chung R.W.S., Brown A., Rowney M., Cohn J.S. Dietaryphospholipid-rich dairy milk extract reduces hepatomegaly, hepatic steatosis andhyperlipidemiain mice fed a high-fat diet. Atherosclerosis 2009, 205:144-150.
44. Wen X., Walle T. Methylated flavonoids have greatly improved intestinal absorption and metabolic stability. Drug Metab. Dispos. 2006, 34:1786-1792.
45. Xu X., Ye L., Araki K., Ahmed R. MTOR, linking metabolism and immunity. Semin. Immunol. 2012, 24:429-435.
46. Yang J., Wang N., Zhu Y., Feng P. Roles of sirt1 in high glucose-induced endothelial impairment: association with diabetic atherosclerosis. Arch. Med. Res. 2011, 42:354-360.
47. Yao H., Rahman I. Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. Biochem. Pharmacol. 2012, 84:1332-1339.
48. Ying H.Z., Liu Y.H., Yu B., Wang Z.Y., Zang J.N., Yu C.H. Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils. Food Chem. Toxicol. 2013, 52:53-60.
49. Yoshizaki T., Kusunoki C., Kondo M., Yasuda M., Kume S., Morino K., Sekine O., Ugi S., Uzu T., Nishio Y., Kashiwagi A., Maegawa H. Autophagy regulates inflammation in adipocytes. Biochem. Biophys. Res. Co. 2012, 417:352-357.
50. Yu C.H., Dai X.Y., Chen Q., Zang J.N., Deng L.L., Liu Y.H., Ying H.Z. Hypolipidemic and antioxidant activities of polysaccharides from Rosae Laevigatae Fructus in rats. Carbohyd. Polym. 2013, 94:56-62.
51. Zhang Y., Huang C. Targeting adipocyte apoptosis: a novel strategy for obesity therapy. Biochem. Bioph. Res. Co. 2012, 417:1-4.
52. Zhang Y., Zeng X., Jin S. Autophagy in adipose tissue biology. Pharmacol. Res. 2012, 66:505-512.