-
1
-
-
0033043389
-
Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase
-
Andjelkovic M, Maira SM, Cron P, Parker PJ, Hemmings BA (1999) Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase. Mol Cell Biol 19:5061-5072 (Pubitemid 29289544)
-
(1999)
Molecular and Cellular Biology
, vol.19
, Issue.7
, pp. 5061-5072
-
-
Andjelkovic, M.1
Maira, S.-M.2
Cron, P.3
Parker, P.J.4
Hemmings, B.A.5
-
2
-
-
79960311304
-
Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure
-
10.2174/138161211796390976 21631421 10.2174/138161211796390976 1:CAS:528:DC%2BC3MXhtVKqtrbI
-
Aoyagi T, Matsui T (2011) Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure. Curr Pharm Des 17:1818-1824. doi: 10.2174/138161211796390976
-
(2011)
Curr Pharm des
, vol.17
, pp. 1818-1824
-
-
Aoyagi, T.1
Matsui, T.2
-
3
-
-
78650472007
-
C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling
-
10.1016/j.cell.2010.11.036 10.1016/j.cell.2010.11.036
-
Boström P, Mann N, Wu J, Quintero PA, Plovie ER, Panáková D, Gupta RK, Xiao C, MacRae CA, Rosenzweig A, Spiegelman BM (2010) C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell 23(143):1072-1083. doi: 10.1016/j.cell.2010.11.036
-
(2010)
Cell
, vol.23
, Issue.143
, pp. 1072-1083
-
-
Boström, P.1
Mann, N.2
Wu, J.3
Quintero, P.A.4
Plovie, E.R.5
Panáková, D.6
Gupta, R.K.7
Xiao, C.8
Macrae, C.A.9
Rosenzweig, A.10
Spiegelman, B.M.11
-
4
-
-
0033515625
-
A human protein kinase Bγ with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain
-
DOI 10.1074/jbc.274.14.9133
-
Brodbeck D, Cron P, Hemmings BA (1999) A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem 274:9133-9136. doi: 10.1074/jbc.274.14.9133 (Pubitemid 29180216)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.14
, pp. 9133-9136
-
-
Brodbeck, D.1
Cron, P.2
Hemmings, B.A.3
-
5
-
-
0036843158
-
Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death
-
DOI 10.1161/01.RES.0000038488.38975.1A
-
Bueno OF, Molkentin JD (2002) Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death. Circ Res 91:776-781. doi: 10.1161/01.RES.0000038488.38975.1A (Pubitemid 35285074)
-
(2002)
Circulation Research
, vol.91
, Issue.9
, pp. 776-781
-
-
Bueno, O.F.1
Molkentin, J.D.2
-
6
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
DOI 10.1126/science.296.5573.1655
-
Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296:1655-1657. doi: 10.1126/science.296.5573.1655 (Pubitemid 34579158)
-
(2002)
Science
, vol.296
, Issue.5573
, pp. 1655-1657
-
-
Cantley, L.C.1
-
7
-
-
84876021970
-
Comprehensive expression profiling of microRNAs in laryngeal squamous cell carcinoma
-
10.1002/hed.23011 22605671 10.1002/hed.23011
-
Cao P, Zhou L, Zhang J, Zheng F, Wang H, Ma D, Tian J (2013) Comprehensive expression profiling of microRNAs in laryngeal squamous cell carcinoma. Head Neck 35:720-728. doi: 10.1002/hed.23011
-
(2013)
Head Neck
, vol.35
, Issue.5
, pp. 720-728
-
-
Cao, P.1
Zhou, L.2
Zhang, J.3
Zheng, F.4
Wang, H.5
Ma, D.6
Tian, J.7
-
8
-
-
79953249325
-
MicroRNA in prostate, bladder, and kidney cancer: A systematic review
-
10.1016/j.eururo.2011.01.044 21296484 10.1016/j.eururo.2011.01.044 1:CAS:528:DC%2BC3MXkt1aktbc%3D
-
Catto JW, Alcaraz A, Bjartell AS, De White Vere R, Evans CP, Fussel S, Hamdy FC, Kallioniemi O, Mengual L, Schlomm T, Visakorpi T (2011) MicroRNA in prostate, bladder, and kidney cancer: a systematic review. Eur Urol 59:671-681. doi: 10.1016/j.eururo.2011.01.044
-
(2011)
Eur Urol
, vol.59
, pp. 671-681
-
-
Catto, J.W.1
Alcaraz, A.2
Bjartell, A.S.3
De White Vere, R.4
Evans, C.P.5
Fussel, S.6
Hamdy, F.C.7
Kallioniemi, O.8
Mengual, L.9
Schlomm, T.10
Visakorpi, T.11
-
9
-
-
34447318648
-
MicroRNAs are aberrantly expressed in hypertrophic heart: Do they play a pole in cardiac hypertrophy?
-
DOI 10.2353/ajpath.2007.061170
-
Cheng Y, Ji R, Yue J, Yang J, Liu X, Chen H, Dean DB, Zhang C (2007) MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy? Am J Pathol 170:1831-1840. doi: 10.2353/ajpath.2007.061170 (Pubitemid 47339258)
-
(2007)
American Journal of Pathology
, vol.170
, Issue.6
, pp. 1831-1840
-
-
Cheng, Y.1
Ji, R.2
Yue, J.3
Yang, J.4
Liu, X.5
Chen, H.6
Dean, D.B.7
Zhang, C.8
-
10
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)
-
DOI 10.1126/science.292.5522.1728
-
Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB 3rd, Kaestner KH, Bartolomei MS, Shulman GI, Birnbaum MJ (2001a) Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292:1728-1731. doi: 10.1126/science.292.5522.1728 (Pubitemid 32506248)
-
(2001)
Science
, vol.292
, Issue.5522
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
Thorvaldsen, J.L.4
Chu, Q.5
Crenshaw III, E.B.6
Kaestner, K.H.7
Bartolomei, M.S.8
Shulman, G.I.9
Birnbaum, M.J.10
-
11
-
-
0035914388
-
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
-
10.1074/jbc.C100462200 11533044 10.1074/jbc.C100462200 1:CAS:528:DC%2BD3MXnvVens70%3D
-
Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ (2001b) Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 276:38349-38352. doi: 10.1074/jbc.C100462200
-
(2001)
J Biol Chem
, vol.276
, pp. 38349-38352
-
-
Cho, H.1
Thorvaldsen, J.L.2
Chu, Q.3
Feng, F.4
Birnbaum, M.J.5
-
12
-
-
0037125980
-
Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice
-
10.1073/pnas.172376399 12237475 10.1073/pnas.172376399 1:CAS:528:DC%2BD38XntlCksLY%3D
-
Condorelli G, Drusco A, Stassi G, Bellacosa A, Roncarati R, Iaccarino G, Russo MA, Gu Y, Dalton N, Chung C, Latronico MV, Napoli C, Sadoshima J, Croce CM, Ross J Jr (2002) Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci USA 99:12333-12338. doi: 10.1073/pnas.172376399
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12333-12338
-
-
Condorelli, G.1
Drusco, A.2
Stassi, G.3
Bellacosa, A.4
Roncarati, R.5
Iaccarino, G.6
Russo, M.A.7
Gu, Y.8
Dalton, N.9
Chung, C.10
Latronico, M.V.11
Napoli, C.12
Sadoshima, J.13
Croce, C.M.14
Ross, Jr.J.15
-
13
-
-
18644372367
-
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways
-
DOI 10.1016/S0092-8674(02)00969-8
-
Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki T, Hirsch E, Suzuki A, Shioi T, Irie-Sasaki J, Sah R, Cheng HY, Rybin VO, Lembo G, Fratta L, Oliveira-dos-Santos AJ, Benovic JL, Kahn CR, Izumo S, Steinberg SF, Wymann MP, Backx PH, Penninger JM (2002) Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 110:737-749. doi: 10.1016/S0092-8674(02)00969-8 (Pubitemid 35283963)
-
(2002)
Cell
, vol.110
, Issue.6
, pp. 737-749
-
-
Crackower, M.A.1
Oudit, G.Y.2
Kozieradzki, I.3
Sarao, R.4
Sun, H.5
Sasaki, T.6
Hirsch, E.7
Suzuki, A.8
Shioi, T.9
Irie-Sasaki, J.10
Sah, R.11
Cheng, H.-Y.M.12
Rybin, V.O.13
Lembo, G.14
Fratta, L.15
Oliveira-dos-Santos, A.J.16
Benovic, J.L.17
Kahn C.Ronald18
Izumo, S.19
Steinberg, S.F.20
Wymann, M.P.21
Backx, P.H.22
Penninger, J.M.23
more..
-
14
-
-
84863981799
-
Swimming training in rats increases cardiac MicroRNA-126 expression and angiogenesis
-
doi: 10.1249/MSS.0b013e31824e8a36
-
da Silva Jr ND, Fernandes T, Soci UP, Monteiro AW, Phillips MI, de Oliveira EM (2012) Swimming training in rats increases cardiac MicroRNA-126 expression and angiogenesis. Med Sci Sports Exerc 44: 1453-1462. doi: 10.1249/MSS.0b013e31824e8a36
-
(2012)
Med Sci Sports Exerc
, vol.44
, pp. 1453-1462
-
-
Da Silva Jr., N.D.1
Fernandes, T.2
Soci, U.P.3
Monteiro, A.W.4
Phillips, M.I.5
De Oliveira, E.M.6
-
15
-
-
33646449520
-
Akt1 is required for physiological cardiac growth
-
10.1161/CIRCULATIONAHA.105.595231 16636172 10.1161/CIRCULATIONAHA.105. 595231 1:CAS:528:DC%2BD28XjslKiur0%3D
-
DeBosch B, Treskov I, Lupu TS, Weinheimer C, Kovacs A, Courtois M, Muslin AJ (2006) Akt1 is required for physiological cardiac growth. Circulation 113:2097-2104. doi: 10.1161/CIRCULATIONAHA.105.595231
-
(2006)
Circulation
, vol.113
, pp. 2097-2104
-
-
Debosch, B.1
Treskov, I.2
Lupu, T.S.3
Weinheimer, C.4
Kovacs, A.5
Courtois, M.6
Muslin, A.J.7
-
16
-
-
34247877577
-
The fuzzy logic of physiological cardiac hypertrophy
-
DOI 10.1161/HYPERTENSIONAHA.106.079426
-
Dorn GW 2nd (2007) The fuzzy logic of physiological cardiac hypertrophy. Hypertension 49:962-970. doi: 10.1161/HYPERTENSIONAHA.106.079426 (Pubitemid 351664301)
-
(2007)
Hypertension
, vol.49
, Issue.5
, pp. 962-970
-
-
Dorn II, G.W.1
-
17
-
-
78149406551
-
Akt2 deficiency promotes cardiac induction of Rab4a and myocardial beta-adrenergic hypersensitivity
-
10.1016/j.yjmcc.2010.08.011 20728450 10.1016/j.yjmcc.2010.08.011 1:CAS:528:DC%2BC3cXhtlyktbjM
-
Etzion S, Etzion Y, DeBosch B, Crawford PA, Muslin AJ (2010) Akt2 deficiency promotes cardiac induction of Rab4a and myocardial beta-adrenergic hypersensitivity. J Mol Cell Cardiol 49:931-940. doi: 10.1016/j.yjmcc.2010.08. 011
-
(2010)
J Mol Cell Cardiol
, vol.49
, pp. 931-940
-
-
Etzion, S.1
Etzion, Y.2
Debosch, B.3
Crawford, P.A.4
Muslin, A.J.5
-
18
-
-
0035976615
-
Phosphatidic acid-mediated mitogenic activation of mTOR signaling
-
DOI 10.1126/science.1066015
-
Fang Y, Vilella-Bach M, Bachmann R, Flanigan A, Chen J (2001) Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 294:1942-1945. doi: 10.1126/science.1066015 (Pubitemid 33101594)
-
(2001)
Science
, vol.294
, Issue.5548
, pp. 1942-1945
-
-
Fang, Y.1
Vilella-Bach, M.2
Bachmann, R.3
Flanigan, A.4
Chen, J.5
-
19
-
-
80051473367
-
Aerobic exercise training-induced left ventricular hypertrophy involves regulatory microRNAs, decreased angiotensin-converting enzyme-angiotensin II, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin (1-7)
-
10.1161/HYPERTENSIONAHA.110.168252 21709209 10.1161/HYPERTENSIONAHA.110. 168252 1:CAS:528:DC%2BC3MXptFCks7w%3D
-
Fernandes T, Hashimoto NY, Magalhães FC, Fernandes FB, Casarini DE, Carmona AK, Krieger JE, Phillips MI, Oliveira EM (2011) Aerobic exercise training-induced left ventricular hypertrophy involves regulatory microRNAs, decreased angiotensin-converting enzyme-angiotensin II, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin (1-7). Hypertension 58:182-189. doi: 10.1161/HYPERTENSIONAHA.110.168252
-
(2011)
Hypertension
, vol.58
, pp. 182-189
-
-
Fernandes, T.1
Hashimoto, N.Y.2
Magalhães, F.C.3
Fernandes, F.B.4
Casarini, D.E.5
Carmona, A.K.6
Krieger, J.E.7
Phillips, M.I.8
Oliveira, E.M.9
-
20
-
-
84856005897
-
Focal adhesion kinase - The basis of local hypertrophic signaling domains
-
10.1016/j.yjmcc.2011.06.021 21749874 10.1016/j.yjmcc.2011.06.021 1:CAS:528:DC%2BC38XhtFGhtL8%3D
-
Franchini KG (2012) Focal adhesion kinase - the basis of local hypertrophic signaling domains. J Mol Cell Cardiol 52:485-492. doi: 10.1016/j.yjmcc.2011.06.021
-
(2012)
J Mol Cell Cardiol
, vol.52
, pp. 485-492
-
-
Franchini, K.G.1
-
21
-
-
85047693348
-
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ
-
DOI 10.1172/JCI200316885
-
Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, Hildebrandt AL, Coskran T, Black SC, Brees DJ, Wicks JR, McNeish JD, Coleman KG (2003) Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J Clin Invest 112:197-208. doi: 10.1172/JCI16885 (Pubitemid 38056356)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.2
, pp. 197-208
-
-
Garofalo, R.S.1
Orena, S.J.2
Rafidi, K.3
Torchia, A.J.4
Stock, J.L.5
Hildebrandt, A.L.6
Coskran, T.7
Black, S.C.8
Brees, D.J.9
Wicks, J.R.10
McNeish, J.D.11
Coleman, K.G.12
-
22
-
-
0032910168
-
Organization and regulation of mitogen-activated protein kinase signaling pathways
-
DOI 10.1016/S0955-0674(99)80028-3
-
Garrington TP, Johnson GL (1999) Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr Opin Cell Biol 11:211-218. doi: 10.1016/S0955-0674(99)80028-3 (Pubitemid 29164036)
-
(1999)
Current Opinion in Cell Biology
, vol.11
, Issue.2
, pp. 211-218
-
-
Garrington, T.P.1
Johnson, G.L.2
-
23
-
-
34347220473
-
Defining the Role of mTOR in Cancer
-
DOI 10.1016/j.ccr.2007.05.008, PII S1535610807001511
-
Guertin DA, Sabatini DM (2007) Defining the role of mTOR in cancer. Cancer Cell 12:9-22. doi: 10.1016/j.ccr.2007.05.008 (Pubitemid 47001784)
-
(2007)
Cancer Cell
, vol.12
, Issue.1
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
24
-
-
22144477115
-
MicroRNAs in vertebrate development
-
DOI 10.1016/j.gde.2005.06.012, PII S0959437X05000985, Pattern Formation and Defvelopment Mechanisms
-
Harfe BD (2005) MicroRNAs in vertebrate development. Curr Opin Genet Dev 15:410-415. doi: 10.1016/j.gde.2005.06.012 (Pubitemid 40982092)
-
(2005)
Current Opinion in Genetics and Development
, vol.15
, Issue.4
, pp. 410-415
-
-
Harfe, B.D.1
-
25
-
-
33748323383
-
Regulation of cardiac hypertrophy by intracellular signalling pathways
-
DOI 10.1038/nrm1983, PII NRM1983
-
Heineke J, Molkentin JD (2006) Regulation of cardiac hypertrophy by intracellular signaling pathways. Nat Rev Mol Cell Biol 7:589-600. doi: 10.1038/nrm1983 (Pubitemid 44325350)
-
(2006)
Nature Reviews Molecular Cell Biology
, vol.7
, Issue.8
, pp. 589-600
-
-
Heineke, J.1
Molkentin, J.D.2
-
26
-
-
44449161481
-
The TSC1-TSC2 complex: A molecular switchboard controlling cell growth
-
DOI 10.1042/BJ20080281
-
Huang J, Manning BD (2008) The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J 412:179-190. doi: 10.1042/BJ20080281 (Pubitemid 351758225)
-
(2008)
Biochemical Journal
, vol.412
, Issue.2
, pp. 179-190
-
-
Huang, J.1
Manning, B.D.2
-
27
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
DOI 10.1038/ncb839
-
Inoki K, Li Y, Zhu T, Wu J, Guan KL (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4:648-657. doi: 10.1038/ncb839 (Pubitemid 34993700)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.9
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.-L.5
-
28
-
-
70149083112
-
Two new miR-16 targets: Caprin-1 and HMGA1, proteins implicated in cell proliferation
-
10.1042/BC20080213 19250063 10.1042/BC20080213 1:CAS:528: DC%2BD1MXotVensb8%3D
-
Kaddar T, Rouault JP, Chien WW, Chebel A, Gadoux M, Salles G, Ffrench M, Magaud JP (2009) Two new miR-16 targets: caprin-1 and HMGA1, proteins implicated in cell proliferation. Biol Cell 101:511-524. doi: 10.1042/BC20080213
-
(2009)
Biol Cell
, vol.101
, pp. 511-524
-
-
Kaddar, T.1
Rouault, J.P.2
Chien, W.W.3
Chebel, A.4
Gadoux, M.5
Salles, G.6
Ffrench, M.7
Magaud, J.P.8
-
29
-
-
55049090844
-
Insulin-like growth factor i receptor signaling is required for exercise-induced cardiac hypertrophy
-
10.1210/me.2008-0265 18801929 10.1210/me.2008-0265 1:CAS:528: DC%2BD1cXhtleitbbM
-
Kim J, Wende AR, Sena S, Theobald HA, Soto J, Sloan C, Wayment BE, Litwin SE, Holzenberger M, LeRoith D, Abel ED (2008) Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. Mol Endocrinol 22:2531-2543. doi: 10.1210/me.2008-0265
-
(2008)
Mol Endocrinol
, vol.22
, pp. 2531-2543
-
-
Kim, J.1
Wende, A.R.2
Sena, S.3
Theobald, H.A.4
Soto, J.5
Sloan, C.6
Wayment, B.E.7
Litwin, S.E.8
Holzenberger, M.9
Leroith, D.10
Abel, E.D.11
-
30
-
-
0037310664
-
Physiological functions of Pten in mouse tissues
-
Kishimoto H, Hamada K, Saunders M, Backman S, Sasaki T, Nakano T, Mak TW, Suzuki A (2003) Physiological functions of Pten in mouse tissues. Cell Struct Funct 28:11-21. doi: 10.1247/csf.28.11 (Pubitemid 36443125)
-
(2003)
Cell Structure and Function
, vol.28
, Issue.1
, pp. 11-21
-
-
Kishimoto, H.1
Hamada, K.2
Saunders, M.3
Backman, S.4
Sasaki, T.5
Nakano, T.6
Mak, T.W.7
Suzuki, A.8
-
31
-
-
35848955229
-
Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling
-
DOI 10.1038/sj.onc.1210520, PII 1210520
-
Lackey J, Barnett J, Davidson L, Batty IH, Leslie NR, Downes CP (2007) Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling. Oncogene 26:7132-7142. doi: 10.1038/sj.onc.1210520 (Pubitemid 350059678)
-
(2007)
Oncogene
, vol.26
, Issue.50
, pp. 7132-7142
-
-
Lackey, J.1
Barnett, J.2
Davidson, L.3
Batty, I.H.4
Leslie, N.R.5
Downes, C.P.6
-
32
-
-
84866393036
-
MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA
-
10.1016/j.bbrc.2012.08.075 10.1016/j.bbrc.2012.08.075
-
Lang Q, Ling C (2012) MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA. Biochem Biophys Res Commun 21(426):247-252. doi: 10.1016/j.bbrc.2012.08.075
-
(2012)
Biochem Biophys Res Commun
, vol.21
, Issue.426
, pp. 247-252
-
-
Lang, Q.1
Ling, C.2
-
33
-
-
84874807522
-
Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging
-
1:CAS:528:DC%2BC3sXjsVSitL8%3D
-
Leontieva OV, Paszkiewicz GM, Blagosklonny MV (2012) Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging. Aging-US 4:899-916
-
(2012)
Aging-US
, vol.4
, pp. 899-916
-
-
Leontieva, O.V.1
Paszkiewicz, G.M.2
Blagosklonny, M.V.3
-
34
-
-
4344684649
-
PTEN function: How normal cells control it and tumour cells lose it
-
DOI 10.1042/BJ20040825
-
Leslie NR, Downes CP (2004) PTEN function: how normal cells control it and tumour cells lose it. Biochem J 382:1-11. doi: 10.1042/BJ20040825 (Pubitemid 39141560)
-
(2004)
Biochemical Journal
, vol.382
, Issue.1
, pp. 1-11
-
-
Leslie, N.R.1
Downes, C.P.2
-
35
-
-
0034654298
-
Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: Differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase
-
DOI 10.1042/0264-6021:3460827
-
Leslie NR, Gray A, Pass I, Orchiston EA, Downes CP (2000) Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase. Biochem J 346(Pt 3):827-833. doi: 10.1042/0264-6021:3460827 (Pubitemid 30171047)
-
(2000)
Biochemical Journal
, vol.346
, Issue.3
, pp. 827-833
-
-
Leslie, N.R.1
Gray, A.2
Pass, I.3
Orchiston, E.A.4
Downes, C.P.5
-
36
-
-
33846184559
-
3-Dependent and -Independent Roles for PTEN in the Control of Cell Migration
-
DOI 10.1016/j.cub.2006.12.026, PII S0960982206026601
-
Leslie NR, Yang X, Downes CP, Weijer CJ (2007) PtdIns(3,4,5)P(3)- dependent and -independent roles for PTEN in the control of cell migration. Curr Biol 17:115-125. doi: 10.1016/j.cub.2006.12.026 (Pubitemid 46107842)
-
(2007)
Current Biology
, vol.17
, Issue.2
, pp. 115-125
-
-
Leslie, N.R.1
Yang, X.2
Downes, C.P.3
Weijer, C.J.4
-
37
-
-
84867664852
-
MiRNA-21 reverses high glucose and high insulin induced insulin resistance in 3T3-L1 adipocytes through targeting phosphatase and tensin homologue
-
10.1055/s-0032-1311644 22956257 10.1055/s-0032-1311644 1:CAS:528:DC%2BC38XhvVKlt77J
-
Ling HY, Hu B, Hu XB, Zhong J, Feng SD, Qin L, Liu G, Wen GB, Liao DF (2012) MiRNA-21 reverses high glucose and high insulin induced insulin resistance in 3T3-L1 adipocytes through targeting phosphatase and tensin homologue. Exp Clin Endocrinol Diabetes 120:553-559. doi: 10.1055/s-0032-1311644
-
(2012)
Exp Clin Endocrinol Diabetes
, vol.120
, pp. 553-559
-
-
Ling, H.Y.1
Hu, B.2
Hu, X.B.3
Zhong, J.4
Feng, S.D.5
Qin, L.6
Liu, G.7
Wen, G.B.8
Liao, D.F.9
-
38
-
-
58849139162
-
The roles of microRNA in cancer and apoptosis
-
10.1111/j.1469-185X.2008.00061.x 19046400 10.1111/j.1469-185X.2008.00061. x
-
Lynam-Lennon N, Maher SG, Reynolds JV (2009) The roles of microRNA in cancer and apoptosis. Biol Rev Camb Philos Soc 84:55-71. doi: 10.1111/j.1469-185X.2008.00061.x
-
(2009)
Biol Rev Camb Philos Soc
, vol.84
, pp. 55-71
-
-
Lynam-Lennon, N.1
Maher, S.G.2
Reynolds, J.V.3
-
39
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
DOI 10.1074/jbc.273.22.13375
-
Maehama T, Dixon JE (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273:13375-13378. doi: 10.1074/jbc.273.22.13375 (Pubitemid 28268370)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.22
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
40
-
-
0032904432
-
PTEN: A tumour suppressor that functions as a phospholipid phosphatase
-
DOI 10.1016/S0962-8924(99)01519-6, PII S0962892499015196
-
Maehama T, Dixon JE (1999) PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol 9:125-128. doi: 10.1016/S0962- 8924(99)01519-6 (Pubitemid 29161437)
-
(1999)
Trends in Cell Biology
, vol.9
, Issue.4
, pp. 125-128
-
-
Maehama, T.1
Dixon, J.E.2
-
41
-
-
54449101472
-
Shp2 negatively regulates growth in cardiomyocytes by controlling focal adhesion kinase/Src and mTOR pathways
-
10.1161/CIRCRESAHA.108.179754 18757826 10.1161/CIRCRESAHA.108.179754 1:CAS:528:DC%2BD1cXhtFOis77P
-
Marin TM, Clemente CF, Santos AM, Picardi PK, Pascoal VD, Lopes-Cendes I, Saad MJ, Franchini KG (2008) Shp2 negatively regulates growth in cardiomyocytes by controlling focal adhesion kinase/Src and mTOR pathways. Circ Res 103:813-824. doi: 10.1161/CIRCRESAHA.108.179754
-
(2008)
Circ Res
, vol.103
, pp. 813-824
-
-
Marin, T.M.1
Clemente, C.F.2
Santos, A.M.3
Picardi, P.K.4
Pascoal, V.D.5
Lopes-Cendes, I.6
Saad, M.J.7
Franchini, K.G.8
-
42
-
-
11144253483
-
Convergent signal transduction pathways controlling cardiomyocyte survival and function: The role of PI 3-kinase and Akt
-
DOI 10.1016/j.yjmcc.2004.11.005, PII S0022282804003268
-
Matsui T, Rosenzweig A (2005) Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt. J Mol Cell Cardiol 38:63-71. doi: 10.1016/j.yjmcc.2004.11.005 (Pubitemid 40038652)
-
(2005)
Journal of Molecular and Cellular Cardiology
, vol.38
, Issue.1
, pp. 63-71
-
-
Matsui, T.1
Rosenzweig, A.2
-
43
-
-
0037151104
-
Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart
-
DOI 10.1074/jbc.M200347200
-
Matsui T, Li L, Wu JC, Cook SA, Nagoshi T, Picard MH, Liao R, Rosenzweig A (2002) Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem 277:22896-22901. doi: 10.1074/jbc.M200347200 (Pubitemid 34967272)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.25
, pp. 22896-22901
-
-
Matsui, T.1
Li, N.2
Wu, J.C.3
Cook, S.A.4
Nagoshi, T.5
Picard, M.H.6
Liao, R.7
Rosenzweig, A.8
-
44
-
-
33846966331
-
Differences between pathological and physiological cardiac hypertrophy: Novel therapeutic strategies to treat heart failure
-
10.1111/j.1440-1681.2007.04585.x 17324134 10.1111/j.1440-1681.2007.04585. x 1:CAS:528:DC%2BD2sXjvVOiur8%3D
-
McMullen JR, Jennings GL (2007) Differences between pathological and physiological cardiac hypertrophy: novel therapeutic strategies to treat heart failure. Clin Exp Pharmacol Physiol 34:255-262. doi: 10.1111/j.1440-1681.2007. 04585.x
-
(2007)
Clin Exp Pharmacol Physiol
, vol.34
, pp. 255-262
-
-
McMullen, J.R.1
Jennings, G.L.2
-
45
-
-
0142027759
-
Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy
-
DOI 10.1073/pnas.1934654100
-
McMullen JR, Shioi T, Zhang L, Tarnavski O, Sherwood MC, Kang PM, Izumo S (2003) Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy. Proc Natl Acad Sci USA 100:12355-12360. doi: 10.1073/pnas.1934654100 (Pubitemid 37271564)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.21
, pp. 12355-12360
-
-
McMullen, J.R.1
Shioi, T.2
Zhang, L.3
Tarnavski, O.4
Sherwood, M.C.5
Kang, P.M.6
Izumo, S.7
-
46
-
-
3042608187
-
Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload
-
DOI 10.1161/01.CIR.0000130641.08705.45
-
McMullen JR, Sherwood MC, Tarnavski O, Zhang L, Dorfman AL, Shioi T, Izumo S (2004) Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. Circulation 109:3050-3055. doi: 10.1161/01.CIR.0000130641.08705.45 (Pubitemid 38808328)
-
(2004)
Circulation
, vol.109
, Issue.24
, pp. 3050-3055
-
-
McMullen, J.R.1
Sherwood, M.C.2
Tarnavski, O.3
Zhang, L.4
Dorfman, A.L.5
Shioi, T.6
Izumo, S.7
-
47
-
-
33846318098
-
Protective effects of exercise and phosphoinositide 3-kinase(p110α) signaling in dilated and hypertrophic cardiomyopathy
-
DOI 10.1073/pnas.0606663104
-
McMullen JR, Amirahmadi F, Woodcock EA, Schinke-Braun M, Bouwman RD, Hewitt KA, Mollica JP, Zhang L, Zhang Y, Shioi T, Buerger A, Izumo S, Jay PY, Jennings GL (2007) Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy. Proc Natl Acad Sci USA 104:612-617. doi: 10.1073/pnas.0606663104 (Pubitemid 46123073)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.2
, pp. 612-617
-
-
McMullen, J.R.1
Amirahmadi, F.2
Woodcock, E.A.3
Schinke-Braun, M.4
Bouwman, R.D.5
Hewitt, K.A.6
Mollica, J.P.7
Zhang, L.8
Zhang, Y.9
Shioi, T.10
Buerger, A.11
Izumo, S.12
Jay, P.Y.13
Jennings, G.L.14
-
48
-
-
11844272602
-
Swimming training increases cardiac vagal activity and induces cardiac hypertrophy in rats
-
Medeiros A, Oliveira EM, Gianolla R, Casarini DE, NegraËœo CE, Brum PC (2004) Swimming training increases cardiac vagal activity and induces cardiac hypertrophy in rats. Braz J Med Biol Res 37:1909-1917. doi: 10.1590/S0100-879X2004001200018 (Pubitemid 40089945)
-
(2004)
Brazilian Journal of Medical and Biological Research
, vol.37
, Issue.12
, pp. 1909-1917
-
-
Medeiros, A.1
Oliveira, E.M.2
Gianolla, R.3
Casarini, D.E.4
Negrao, C.E.5
Brum, P.C.6
-
49
-
-
39049192580
-
Role of Akt in cardiac growth and metabolism
-
(discussion 126-131, 152-155, 272-276)
-
Muslin AJ, DeBosch B (2006) Role of Akt in cardiac growth and metabolism. Novartis Found Symp 274:118-126 (discussion 126-131, 152-155, 272-276)
-
(2006)
Novartis Found Symp
, vol.274
, pp. 118-126
-
-
Muslin, A.J.1
Debosch, B.2
-
50
-
-
33751427153
-
Effects of fasting and refeeding on expression of atrogin-1 and Akt/FOXO signaling pathway in skeletal muscle of chicks
-
DOI 10.1271/bbb.60274
-
Nakashima K, Yakabe Y, Yamazaki M, Abe H (2006) Effects of fasting and refeeding on expression of atrogin-1 and Akt/FOXO signaling pathway in skeletal muscle of chicks. Biosci Biotechnol Biochem 70:2775-2778. doi: 10.1271/bbb.60274 (Pubitemid 44819854)
-
(2006)
Bioscience, Biotechnology and Biochemistry
, vol.70
, Issue.11
, pp. 2775-2778
-
-
Nakashima, K.1
Yakabe, Y.2
Yamazaki, M.3
Abe, H.4
-
51
-
-
0033429554
-
Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
-
DOI 10.1042/0264-6021:3440427
-
Navé BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR (1999) Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J 344(Pt 2):427-431. doi: 10.1042/0264-6021:3440427 (Pubitemid 30011599)
-
(1999)
Biochemical Journal
, vol.344
, Issue.2
, pp. 427-431
-
-
Nave, B.T.1
Ouwens, D.M.2
Withers, D.J.3
Alessi, D.R.4
Shepherd, P.R.5
-
52
-
-
84870359532
-
Replacement treatment with microRNA-143 and -145 induces synergistic inhibition of the growth of human bladder cancer cells by regulating PI3K/Akt and MAPK signaling pathways
-
10.1016/j.canlet.2012.10.017 23104321 10.1016/j.canlet.2012.10.017 1:CAS:528:DC%2BC38Xhs12ksb3L
-
Noguchi S, Yasui Y, Iwasaki J, Kumazaki M, Yamada N, Naito S, Akao Y (2013) Replacement treatment with microRNA-143 and -145 induces synergistic inhibition of the growth of human bladder cancer cells by regulating PI3K/Akt and MAPK signaling pathways. Cancer Lett 328:353-361. doi: 10.1016/j.canlet. 2012.10.017
-
(2013)
Cancer Lett
, vol.328
, pp. 353-361
-
-
Noguchi, S.1
Yasui, Y.2
Iwasaki, J.3
Kumazaki, M.4
Yamada, N.5
Naito, S.6
Akao, Y.7
-
53
-
-
67650507500
-
Local reninangiotensin system regulates left ventricular hypertrophy induced by swimming training independent of circulating renin: A pharmacological study
-
10.1177/1470320309102304 19286754 10.1177/1470320309102304 1:CAS:528:DC%2BD1MXlvVWgsrg%3D
-
Oliveira EM, Sasaki MS, Cerêncio M, Baraúna VG, Krieger JE (2009) Local reninangiotensin system regulates left ventricular hypertrophy induced by swimming training independent of circulating renin: a pharmacological study. J Renin Angiotensin Aldosterone Syst 10:15-23. doi: 10.1177/ 1470320309102304
-
(2009)
J Renin Angiotensin Aldosterone Syst
, vol.10
, pp. 15-23
-
-
Oliveira, E.M.1
Sasaki, M.S.2
Cerêncio, M.3
Baraúna, V.G.4
Krieger, J.E.5
-
54
-
-
3242698804
-
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease
-
DOI 10.1016/j.yjmcc.2004.05.015, PII S0022282804001567
-
Oudit GY, Sun H, Kerfant BG, Crackower MA, Penninger JM, Backx PH (2004) The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol 37:449-471. doi: 10.1016/j.yjmcc.2004.05.015 (Pubitemid 38953373)
-
(2004)
Journal of Molecular and Cellular Cardiology
, vol.37
, Issue.2
, pp. 449-471
-
-
Oudit, G.Y.1
Sun, H.2
Kerfant, B.-G.3
Crackower, M.A.4
Penninger, J.M.5
Backx, P.H.6
-
55
-
-
35348921181
-
Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo
-
DOI 10.1073/pnas.0610906104
-
Purcell NH, Wilkins BJ, York A, Saba-El-Leil MK, Meloche S, Robbins J, Molkentin JD (2007) Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proc Natl Acad Sci USA 104:14074-14079. doi: 10.1073/pnas.0610906104 (Pubitemid 350003337)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.35
, pp. 14074-14079
-
-
Purcell, N.H.1
Wilkins, B.J.2
York, A.3
Saba-El-Leil, M.K.4
Meloche, S.5
Robbins, J.6
Molkentin, J.D.7
-
56
-
-
79952102213
-
Plexin-B1 is a target of miR-214 in cervical cancer and promotes the growth and invasion of HeLa cells
-
10.1016/j.biocel.2011.01.002 21216304 10.1016/j.biocel.2011.01.002 1:CAS:528:DC%2BC3MXisFGmtbY%3D
-
Qiang R, Wang F, Shi LY, Liu M, Chen S, Wan HY, Li YX, Li X, Gao SY, Sun BC, Tang H (2011) Plexin-B1 is a target of miR-214 in cervical cancer and promotes the growth and invasion of HeLa cells. Int J Biochem Cell Biol 43:632-641. doi: 10.1016/j.biocel.2011.01.002
-
(2011)
Int J Biochem Cell Biol
, vol.43
, pp. 632-641
-
-
Qiang, R.1
Wang, F.2
Shi, L.Y.3
Liu, M.4
Chen, S.5
Wan, H.Y.6
Li, Y.X.7
Li, X.8
Gao, S.Y.9
Sun, B.C.10
Tang, H.11
-
57
-
-
84864307724
-
Negative regulation of miR-145 by C/EBP-β through the Akt pathway in cancer cells
-
10.1093/nar/gks324 22495929 10.1093/nar/gks324 1:CAS:528: DC%2BC38XhtF2rsLrP
-
Sachdeva M, Liu Q, Cao J, Lu Z, Mo YY (2012) Negative regulation of miR-145 by C/EBP-β through the Akt pathway in cancer cells. Nucleic Acids Res 40:6683-6692. doi: 10.1093/nar/gks324
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 6683-6692
-
-
Sachdeva, M.1
Liu, Q.2
Cao, J.3
Lu, Z.4
Mo, Y.Y.5
-
58
-
-
0034644525
-
TOR, a central controller of cell growth
-
10.1016/S0092-8674(00)00117-3 11057898 10.1016/S0092-8674(00)00117-3 1:CAS:528:DC%2BD3cXns1CltrY%3D
-
Schmelzle T, Hall MN (2000) TOR, a central controller of cell growth. Cell 103:253-262. doi: 10.1016/S0092-8674(00)00117-3
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
59
-
-
0033786596
-
Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice
-
10.1677/joe.0.1670107 11018758 10.1677/joe.0.1670107 1:CAS:528: DC%2BD3MXptVeitA%3D%3D
-
Shao J, Yamashita H, Qiao L, Friedman JE (2000) Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice. J Endocrinol 167:107-115. doi: 10.1677/joe.0.1670107
-
(2000)
J Endocrinol
, vol.167
, pp. 107-115
-
-
Shao, J.1
Yamashita, H.2
Qiao, L.3
Friedman, J.E.4
-
60
-
-
46649112177
-
Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function
-
10.1074/jbc.M801510200 18326485 10.1074/jbc.M801510200 1:CAS:528:DC%2BD1cXls12ls78%3D
-
Shen WH, Chen Z, Shi S, Chen H, Zhu W, Penner A, Bu G, Li W, Boyle DW, Rubart M, Field LJ, Abraham R, Liechty EA, Shou W (2008) Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function. J Biol Chem 283:13842-13849. doi: 10.1074/jbc.M801510200
-
(2008)
J Biol Chem
, vol.283
, pp. 13842-13849
-
-
Shen, W.H.1
Chen, Z.2
Shi, S.3
Chen, H.4
Zhu, W.5
Penner, A.6
Bu, G.7
Li, W.8
Boyle, D.W.9
Rubart, M.10
Field, L.J.11
Abraham, R.12
Liechty, E.A.13
Shou, W.14
-
61
-
-
0036200937
-
Akt/protein kinase B promotes organ growth in transgenic mice
-
DOI 10.1128/MCB.22.8.2799-2809.2002
-
Shioi T, McMullen JR, Kang PM, Douglas PS, Obata T, Franke TF, Cantley LC, Izumo S (2002) Akt/protein kinase B promotes organ growth in transgenic mice. Mol Cell Biol 22:2799-2809. doi: 10.1128/MCB.22.8.2799-2809 (Pubitemid 34263000)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.8
, pp. 2799-2809
-
-
Shioi, T.1
McMullen, J.R.2
Kang, P.M.3
Douglas, P.S.4
Obata, T.5
Franke, T.F.6
Cantley, L.C.7
Izumo, S.8
-
62
-
-
0037382861
-
Rapamycin attenuates load-induced cardiac hypertrophy in mice
-
DOI 10.1161/01.CIR.0000057979.36322.88
-
Shioi T, McMullen JR, Tarnavski O, Converso K, Sherwood MC, Manning WJ, Izumo S (2003) Rapamycin attenuates load-induced cardiac hypertrophy in mice. Circulation 107:1664-1670. doi: 10.1161/01.CIR.0000057979.36322.88 (Pubitemid 36397337)
-
(2003)
Circulation
, vol.107
, Issue.12
, pp. 1664-1670
-
-
Shioi, T.1
McMullen, J.R.2
Tarnavski, O.3
Converso, K.4
Sherwood, M.C.5
Manning, W.J.6
Izumo, S.7
-
63
-
-
79959312396
-
MicroRNAs 29 are involved in the improvement of ventricular compliance promoted by aerobic exercise training in rats
-
10.1152/physiolgenomics.00145.2010 21447748 10.1152/physiolgenomics. 00145.2010 1:CAS:528:DC%2BC3MXhtV2nsLrE
-
Soci UP, Fernandes T, Hashimoto NY, Mota GF, Amadeu MA, Rosa KT, Irigoyen MC, Phillips MI, Oliveira EM (2011) MicroRNAs 29 are involved in the improvement of ventricular compliance promoted by aerobic exercise training in rats. Physiol Genomics 43:665-673. doi: 10.1152/physiolgenomics.00145.2010
-
(2011)
Physiol Genomics
, vol.43
, pp. 665-673
-
-
Soci, U.P.1
Fernandes, T.2
Hashimoto, N.Y.3
Mota, G.F.4
Amadeu, M.A.5
Rosa, K.T.6
Irigoyen, M.C.7
Phillips, M.I.8
Oliveira, E.M.9
-
64
-
-
73349120282
-
Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats
-
10.1161/HYPERTENSIONAHA.109.138818 19884565 10.1161/HYPERTENSIONAHA.109. 138818 1:CAS:528:DC%2BD1MXhtl2qurnK
-
Soesanto W, Lin HY, Hu E, Lefler S, Litwin SE, Sena S, Abel ED, Symons JD, Jalili T (2009) Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats. Hypertension 54:1321-1327. doi: 10.1161/HYPERTENSIONAHA.109.138818
-
(2009)
Hypertension
, vol.54
, pp. 1321-1327
-
-
Soesanto, W.1
Lin, H.Y.2
Hu, E.3
Lefler, S.4
Litwin, S.E.5
Sena, S.6
Abel, E.D.7
Symons, J.D.8
Jalili, T.9
-
65
-
-
78649668307
-
MTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy
-
10.1152/ajpcell.00338.2010 20861467 10.1152/ajpcell.00338.2010 1:CAS:528:DC%2BC3cXhs1aisbvM
-
Song X, Kusakari Y, Xiao CY, Kinsella SD, Rosenberg MA, Scherrer-Crosbie M, Hara K, Rosenzweig A, Matsui T (2010) mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy. Am J Physiol Cell Physiol 299:C1256-C1266. doi: 10.1152/ajpcell.00338.2010
-
(2010)
Am J Physiol Cell Physiol
, vol.299
-
-
Song, X.1
Kusakari, Y.2
Xiao, C.Y.3
Kinsella, S.D.4
Rosenberg, M.A.5
Scherrer-Crosbie, M.6
Hara, K.7
Rosenzweig, A.8
Matsui, T.9
-
66
-
-
0032563677
-
'Stress-responsive' mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium
-
Sugden PH, Clerk A (1998) "Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium. Circ Res 24:345-352. doi: 10.1161/01.RES.83.4.345 (Pubitemid 28389964)
-
(1998)
Circulation Research
, vol.83
, Issue.4
, pp. 345-352
-
-
Sugden, P.H.1
Clerk, A.2
-
67
-
-
34249729491
-
Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy
-
DOI 10.1016/j.yjmcc.2007.04.004, PII S0022282807009789
-
Tatsuguchi M, Seok HY, Callis TE, Thomson JM, Chen JF, Newman M, Rojas M, Hammond SM, Wang DZ (2007) Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J Mol Cell Cardiol 42:1137-1141. doi: 10.1016/j.yjmcc.2007.04.004 (Pubitemid 46829201)
-
(2007)
Journal of Molecular and Cellular Cardiology
, vol.42
, Issue.6
, pp. 1137-1141
-
-
Tatsuguchi, M.1
Seok, H.Y.2
Callis, T.E.3
Thomson, J.M.4
Chen, J.-F.5
Newman, M.6
Rojas, M.7
Hammond, S.M.8
Wang, D.-Z.9
-
68
-
-
62449294691
-
The miR-17-92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma
-
10.1073/pnas.0809579106 19196975 10.1073/pnas.0809579106 1:CAS:528:DC%2BD1MXislaht7o%3D
-
Uziel T, Karginov FV, Xie S, Parker JS, Wang YD, Gajjar A, He L, Ellison D, Gilbertson RJ, Hannon G, Roussel MF (2009) The miR-17-92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma. Proc Natl Acad Sci USA 106:2812-2817. doi: 10.1073/pnas.0809579106
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 2812-2817
-
-
Uziel, T.1
Karginov, F.V.2
Xie, S.3
Parker, J.S.4
Wang, Y.D.5
Gajjar, A.6
He, L.7
Ellison, D.8
Gilbertson, R.J.9
Hannon, G.10
Roussel, M.F.11
-
69
-
-
34848838292
-
MicroRNAs: Powerful new regulators of heart disease and provocative therapeutic targets
-
DOI 10.1172/JCI33099
-
Van Rooij E, Olson EN (2007) Micro RNAs: powerful new regulators of heart disease and provocative therapeutic agents. J Clin Invest 117:2369-2376. doi: 10.1172/JCI33099 (Pubitemid 47494334)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.9
, pp. 2369-2376
-
-
Van Rooij, E.1
Olson, E.N.2
-
70
-
-
55449100829
-
Toward microRNA-based therapeutics for heart disease: The sense in antisense
-
10.1161/CIRCRESAHA.108.183426 18948630 10.1161/CIRCRESAHA.108.183426
-
Van Rooij E, Marshall WS, Olson EN (2008) Toward microRNA-based therapeutics for heart disease: the sense in antisense. Circ Res 103:919-928. doi: 10.1161/CIRCRESAHA.108.183426
-
(2008)
Circ Res
, vol.103
, pp. 919-928
-
-
Van Rooij, E.1
Marshall, W.S.2
Olson, E.N.3
-
71
-
-
0030805703
-
Phosphoinositide 3-kinases: A conserved family of signal transducers
-
DOI 10.1016/S0968-0004(97)01061-X, PII S096800049701061X
-
Vanhaesebroeck B, Leevers SJ, Panayotou G, Waterfield MD (1997) Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem Sci 22:267-272. doi: 10.1016/S0968-0004(97)01061-X (Pubitemid 27310948)
-
(1997)
Trends in Biochemical Sciences
, vol.22
, Issue.7
, pp. 267-272
-
-
Vanhaesebroeck, B.1
Leevers, S.J.2
Panayotou, G.3
Waterfield, M.D.4
Waterfield, M.D.5
-
72
-
-
84855338187
-
Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle
-
10.1152/ajpendo.00207.2011 22028408 10.1152/ajpendo.00207.2011 1:CAS:528:DC%2BC38XhvVKqtLw%3D
-
Vendelbo MH, Clasen BF, Treebak JT, Møller L, Krusenstjerna- Hafstrøm T, Madsen M, Nielsen TS, Stødkilde-Jørgensen H, Pedersen SB, Jørgensen JO, Goodyear LJ, Wojtaszewski JF, Møller N, Jessen N (2012) Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle. Am J Physiol Endocrinol Metab 302:E190-E200. doi: 10.1152/ajpendo.00207.2011
-
(2012)
Am J Physiol Endocrinol Metab
, vol.302
-
-
Vendelbo, M.H.1
Clasen, B.F.2
Treebak, J.T.3
Møller, L.4
Krusenstjerna-Hafstrøm, T.5
Madsen, M.6
Nielsen, T.S.7
Stødkilde- Jørgensen, H.8
Pedersen, S.B.9
Jørgensen, J.O.10
Goodyear, L.J.11
Wojtaszewski, J.F.12
Møller, N.13
Jessen, N.14
-
73
-
-
84871988002
-
The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signaling
-
10.1002/emmm.201201369 23197407 10.1002/emmm.201201369 1:CAS:528:DC%2BC3sXntFSm
-
Wang RH, He JP, Su ML, Luo J, Xu M, Du XD, Chen HZ, Wang WJ, Wang Y, Zhang N, Zhao BX, Zhao WX, Shan ZG, Han JH, Chang CS, Wu Q (2013) The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signaling. EMBO Mol Med 5:137-148. doi: 10.1002/emmm.201201369
-
(2013)
EMBO Mol Med
, vol.5
, pp. 137-148
-
-
Wang, R.H.1
He, J.P.2
Su, M.L.3
Luo, J.4
Xu, M.5
Du, X.D.6
Chen, H.Z.7
Wang, W.J.8
Wang, Y.9
Zhang, N.10
Zhao, B.X.11
Zhao, W.X.12
Shan, Z.G.13
Han, J.H.14
Chang, C.S.15
Wu, Q.16
-
74
-
-
19944430614
-
Muscle-specific Pten deletion protects against insulin resistance and diabetes
-
DOI 10.1128/MCB.25.3.1135-1145.2005
-
Wijesekara N, Konrad D, Eweida M, Jefferies C, Liadis N, Giacca A, Crackower M, Suzuki A, Mak TW, Kahn CR, Klip A, Woo M (2005) Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol 25:1135-1145. doi: 10.1128/MCB.25.3.1135-1145.2005 (Pubitemid 40165819)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.3
, pp. 1135-1145
-
-
Wijesekara, N.1
Konrad, D.2
Eweida, M.3
Jefferies, C.4
Liadis, N.5
Giacca, A.6
Crackower, M.7
Suzuki, A.8
Mak, T.W.9
Kahn, C.R.10
Klip, A.11
Woo, M.12
-
75
-
-
32044465506
-
TOR signaling in growth and metabolism
-
DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
-
Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124:471-484. doi: 10.1016/j.cell.2006.01.016 (Pubitemid 43199434)
-
(2006)
Cell
, vol.124
, Issue.3
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
76
-
-
84862959239
-
Attenuation of microRNA-22 derepressed PTEN to effectively protect rat cardiomyocytes from hypertrophy
-
10.1002/jcp.22852 21618527 10.1002/jcp.22852 1:CAS:528: DC%2BC38XlvVCruw%3D%3D
-
Xu XD, Song XW, Li Q, Wang GK, Jing Q, Qin YW (2012) Attenuation of microRNA-22 derepressed PTEN to effectively protect rat cardiomyocytes from hypertrophy. J Cell Physiol 227:1391-1398. doi: 10.1002/jcp.22852
-
(2012)
J Cell Physiol
, vol.227
, pp. 1391-1398
-
-
Xu, X.D.1
Song, X.W.2
Li, Q.3
Wang, G.K.4
Jing, Q.5
Qin, Y.W.6
-
77
-
-
34547907805
-
Expanding mTOR signaling
-
DOI 10.1038/cr.2007.64, PII CR200764
-
Yang Q, Guan KL (2007) Expanding mTOR signaling. Cell Res 17:666-681. doi: 10.1038/cr.2007.64 (Pubitemid 47255937)
-
(2007)
Cell Research
, vol.17
, Issue.8
, pp. 666-681
-
-
Yang, Q.1
Guan, K.-L.2
-
78
-
-
66549101276
-
Patterns of microRNA expression characterize stages of human B-cell differentiation
-
10.1182/blood-2008-09-178186 19202128 10.1182/blood-2008-09-178186 1:CAS:528:DC%2BD1MXnvVyqtbc%3D
-
Zhang J, Jima DD, Jacobs C, Fischer R, Gottwein E, Huang G, Lugar PL, Lagoo AS, Rizzieri DA, Friedman DR, Weinberg JB, Lipsky PE, Dave SS (2009) Patterns of microRNA expression characterize stages of human B-cell differentiation. Blood 113:4586-4594. doi: 10.1182/blood-2008-09-178186
-
(2009)
Blood
, vol.113
, pp. 4586-4594
-
-
Zhang, J.1
Jima, D.D.2
Jacobs, C.3
Fischer, R.4
Gottwein, E.5
Huang, G.6
Lugar, P.L.7
Lagoo, A.S.8
Rizzieri, D.A.9
Friedman, D.R.10
Weinberg, J.B.11
Lipsky, P.E.12
Dave, S.S.13
-
79
-
-
77955290360
-
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice
-
10.1172/JCI43008 20644257 10.1172/JCI43008 1:CAS:528:DC%2BC3cXhtVaiur7L
-
Zhang D, Contu R, Latronico MV, Zhang J, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown JH, Chen J, Sonenberg N, Condorelli G (2010) MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest 120:2805-2816. doi: 10.1172/JCI43008
-
(2010)
J Clin Invest
, vol.120
, pp. 2805-2816
-
-
Zhang, D.1
Contu, R.2
Latronico, M.V.3
Zhang, J.4
Rizzi, R.5
Catalucci, D.6
Miyamoto, S.7
Huang, K.8
Ceci, M.9
Gu, Y.10
Dalton, N.D.11
Peterson, K.L.12
Guan, K.L.13
Brown, J.H.14
Chen, J.15
Sonenberg, N.16
Condorelli, G.17
-
80
-
-
84873542829
-
MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN
-
10.1093/carcin/bgs346 23125220 10.1093/carcin/bgs346 1:CAS:528: DC%2BC3sXitlCltL0%3D
-
Zhang LY, Ho-Fun Lee V, Wong AM, Kwong DL, Zhu YH, Dong SS, Kong KL, Chen J, Tsao SW, Guan XY, Fu L (2013) microRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. Carcinogenesis 34:454-463. doi: 10.1093/carcin/bgs346
-
(2013)
Carcinogenesis
, vol.34
, pp. 454-463
-
-
Zhang, L.Y.1
Ho-Fun Lee, V.2
Wong, A.M.3
Kwong, D.L.4
Zhu, Y.H.5
Dong, S.S.6
Kong, K.L.7
Chen, J.8
Tsao, S.W.9
Guan, X.Y.10
Fu, L.11
-
81
-
-
78650510609
-
MTOR: From growth signal integration to cancer, diabetes and ageing
-
10.1038/nrm3025 21157483 10.1038/nrm3025 1:CAS:528:DC%2BC3cXhsFGqsbnK
-
Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12:21-35. doi: 10.1038/nrm3025
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
|