Comparative Oncogenomic Analysis of Copy Number Alterations in Human and Zebrafish Tumors Enables Cancer Driver Discovery

PLoS Genetics

Volumn 9, Issue 8, 2013, Pages

  Zhang, GuangJun ^a   Hoersch, Sebastian ^a,b   Amsterdam, Adam ^a   Whittaker, Charles A ^a   Beert, Eline ^c   Catchen, Julian M ^d   Farrington, Sarah ^a   Postlethwait, John H ^d   Legius, Eric ^c   Hopkins, Nancy ^a   Lees, Jacqueline A ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MERLIN; MICRORNA; NEUROFIBROMIN; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN MDM2; STEM CELL FACTOR; VASCULOTROPIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; COMPARATIVE GENOMIC HYBRIDIZATION; COMPARATIVE ONCOGENOMIC ANALYSIS; CONTROLLED STUDY; COPY NUMBER VARIATION; DIPLOIDY; FRA4B GENE; GAIN OF FUNCTION MUTATION; GENE AMPLIFICATION; GENE IDENTIFICATION; GENETIC CONSERVATION; GENETIC MODEL; GENOMICS; HETEROZYGOTE; HIFIA GENE; HOMOZYGOTE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; KDR GENE; KIT GENE; LOSS OF FUNCTION MUTATION; MALIGNANT PERIPHERAL NERVE SHEATH TUMOR; MDM2 GENE; MUTATIONAL ANALYSIS; NF2 GENE; NONHUMAN; PDFGR GENE; SPECIES COMPARISON; SYNTENY; TRIPLOIDY; TUMOR GENE; TUMOR SUPPRESSOR GENE; ZEBRA FISH;

ANEUPLOIDY; ANIMALS; CHROMOSOME ABERRATIONS; DNA COPY NUMBER VARIATIONS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, NEOPLASM; GENOME, HUMAN; GENOMICS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; NEURILEMMOMA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ZEBRAFISH;

EID: 84884641261     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003734     Document Type: Article

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