Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 30, 2008, Pages 10408-10413

  MacInnes, Alyson W ^a   Amsterdam, Adam ^a   Whittaker, Charles A ^a   Hopkins, Nancy ^a   Lees, Jacqueline A ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

MPNST; Protein synthesis

Indexed keywords

MONOCLONAL ANTIBODY; PROTEASOME INHIBITOR; PROTEIN P53; RIBOSOME PROTEIN;

ARTICLE; CARCINOGENESIS; GAMMA IRRADIATION; GENE CONTROL; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; IN VIVO STUDY; NERVE SHEATH TUMOR; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SYNTHESIS; ZEBRA FISH;

ANIMALS; CELL LINE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MODELS, GENETIC; NERVE SHEATH NEOPLASMS; NERVOUS SYSTEM NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POINT MUTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; RIBOSOMAL PROTEINS; SEQUENCE ANALYSIS, DNA; TUMOR SUPPRESSOR PROTEIN P53; ZEBRAFISH;

DANIO RERIO;

EID: 48749119887     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0805036105     Document Type: Article

References (39)

1. Amsterdam A, et al. (2004) Many ribosomal protein genes are cancer genes in zebrafish. PLoS Biol 2:E139.
2. Golling G, et al. (2002) Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Nat Genet 31:135-140.
3. Amsterdam A, et al. (2004) Identification of 315 genes essential for early zebrafish development. Proc Natl Acad Sci USA 101:12792-12797.
4. Amsterdam A, et al. (1999) A large-scale insertional mutagenesis screen in zebrafish. Genes Dev 13:2713-2724.
5. Lai K (2006) A cancer screen in zebrafish identifies many ribosomal proteins as haplo-insufficient tumor suppressor. PhD dissertation (Massachusetts Institute of Technology, Cambridge, MA).
6. Oliver ER, Saunders TL, Tarle SA, Glaser T (2004) Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute. Development (Cambridge, UK) 131:3907-3920.
7. Marygold SJ, et al. (2007) The ribosomal protein genes and Minute loci of Drosophila melanogaster. Genome Biol 8:R216.
8. Berghmans S, et al. (2005) tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci USA 102:407-412.
9. Lane DP (2005) Exploiting the p53 pathway for the diagnosis and therapy of human cancer. Cold Spring Harb Symp Quant Biol 70:489-497.
10. Momand J, Zambetti GP, Olson DC, George D, Levine AJ (1992) The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69:1237-1245.
11. Honda R, Tanaka H, Yasuda H (1997) Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 420:25-27.
12. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW (1991) Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51:6304-6311.
13. Lu X, Lane DP (1993) Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes? Cell 75:765-778.
14. Maki CG, Huibregtse JM, Howley PM (1996) In vivo ubiquitination and proteasome-mediated degradation of p53(1). Cancer Res 56:2649-2654.
15. Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B (1992) Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358:80-83.
16. Zhang Y, Xiong Y, Yarbrough WG (1998) ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92:725-734.
17. Langheinrich U, Hennen E, Stott G, Vacun G (2002) Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling. Curr Biol 12:2023-2028.
18. Draptchinskaia N, et al. (1999) The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia. Nat Genet 21:169-175.
19. Gazda HT, et al. (2006) Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia. Am J Hum Genet 79:1110-1118.
20. Cmejla R, Cmejlova J, Handrkova H, Petrak J, Pospisilova D (2007) Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia. Hum Mutat 28:1178-1182.
21. Willig TN, Gazda H, Sieff CA (2000) Diamond-Blackfan anemia. Curr Opin Hematol 7:85-94.
22. Lipton JM, et al. (2001) Osteogenic sarcoma associated with Diamond-Blackfan anemia: A report from the Diamond-Blackfan Anemia Registry. J Pediatr Hematol Oncol 23:39-44.
23. Boultwood J, Lewis S, Wainscoat JS (1994) The 5q-syndrome. Blood 84:3253-3260.
24. Ebert BL, et al. (2008) Identification of RPS14 as a 5q-syndrome gene by RNA interference screen. Nature 451:335-339.
25. Lohrum MA, Ludwig RL, Kubbutat MH, Hanlon M, Vousden KH (2003) Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell 3:577-587.
26. Marechal V, Elenbaas B, Piette J, Nicolas JC, Levine AJ (1994) The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes. Mol Cell Biol 14:7414-7420.
27. Dai MS, Lu H (2004) Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5. J Biol Chem 279:44475-44482.
28. Chen D, et al. (2007) Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: Binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene 26:5029-5037.
29. Jin A, Itahana K, O'Keefe K, Zhang Y (2004) Inhibition of HDM2 and activation of p53 by ribosomal protein L23. Mol Cell Biol 24:7669-7680.
30. Takagi M, Absalon MJ, McLure KG, Kastan MB (2005) Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 123:49-63.
31. Anderson SJ, et al. (2007) Ablation of ribosomal protein L22 selectively impairs alpha-beta T cell development by activation of a p53-dependent checkpoint. Immunity 26:759-772.
32. Chen J, et al. (2005) Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes Dev 19:2900-2911.
33. Bortoluzzi S, d'Alessi F, Romualdi C, Danieli GA (2001) Differential expression of genes coding for ribosomal proteins in different human tissues. Bioinformatics 17:1152-1157.
34. O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT (2005) c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435:839-843.
35. Poy MN, et al. (2004) A pancreatic islet-specific microRNA regulates insulin secretion. Nature 432:226-230.
36. Jackson RJ, Standart N (2007) How do microRNAs regulate gene expression? Sci STKE 2007:re1.
37. Suzuki R, Shimodaira H (2006) Pvclust: An R package for assessing the uncertainty in hierarchical clustering. Bioinformatics 22:1540-1542.
38. Trimarchi JM, Fairchild B, Wen J, Lees JA (2001) The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proc Natl Acad Sci USA 98:1519-1524.
39. Gaiano N, et al. (1996) Insertional mutagenesis and rapid cloning of essential genes in zebrafish. Nature 383:829-832.