Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesis

American Journal of Pathology

Volumn 182, Issue 3, 2013, Pages 646-667

  Kazmi, Syed J ^a   Byer, Stephanie J ^a   Eckert, Jenell M ^a   Turk, Amy N ^a   Huijbregts, Richard P H ^a   Brossier, Nicole M ^a,b,d   Grizzle, William E ^a   Mikhail, Fady M ^c   Roth, Kevin A ^a   Carroll, Steven L ^a,b  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; NEU DIFFERENTIATION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; CANCER GROWTH; CARCINOGENESIS; CHROMOSOME 11; CHROMOSOME LOSS; COMPARATIVE GENOMIC HYBRIDIZATION; COPY NUMBER VARIATION; GENE OVEREXPRESSION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALIGNANT PERIPHERAL NERVE SHEATH TUMOR; MOUSE; NEUROFIBROMA; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SARCOMA; SCHWANN CELL; SOMATIC MUTATION; TRANSGENIC MOUSE; TUMOR CELL CULTURE;

ANIMALS; BASE PAIRING; CELL CYCLE; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMES, MAMMALIAN; COMPARATIVE GENOMIC HYBRIDIZATION; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DNA COPY NUMBER VARIATIONS; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE SHEATH NEOPLASMS; NEUREGULIN-1; NEUROFIBROMA; NEUROFIBROMIN 1; PERIPHERAL NERVOUS SYSTEM; RAS PROTEINS; SIGNAL TRANSDUCTION; TUMOR MARKERS, BIOLOGICAL;

EID: 84874536556     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.11.017     Document Type: Article

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