-
1
-
-
2342496712
-
FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
-
Accili D., Arden K.C. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 2004, 117:421-426.
-
(2004)
Cell
, vol.117
, pp. 421-426
-
-
Accili, D.1
Arden, K.C.2
-
2
-
-
0034708832
-
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
-
Aguirre V., Uchida T., Yenush L., Davis R., White M.F. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J.Biol. Chem. 2000, 275:9047-9054.
-
(2000)
J.Biol. Chem.
, vol.275
, pp. 9047-9054
-
-
Aguirre, V.1
Uchida, T.2
Yenush, L.3
Davis, R.4
White, M.F.5
-
3
-
-
79959559899
-
Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling
-
Alic N., Andrews T.D., Giannakou M.E., Papatheodorou I., Slack C., Hoddinott M.P., Cochemé H.M., Schuster E.F., Thornton J.M., Partridge L. Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. Mol. Syst. Biol. 2011, 7:502.
-
(2011)
Mol. Syst. Biol.
, vol.7
, pp. 502
-
-
Alic, N.1
Andrews, T.D.2
Giannakou, M.E.3
Papatheodorou, I.4
Slack, C.5
Hoddinott, M.P.6
Cochemé, H.M.7
Schuster, E.F.8
Thornton, J.M.9
Partridge, L.10
-
4
-
-
79959387473
-
Altered skeletal muscle lipase expression and activity contribute to insulin resistance in humans
-
Badin P.M., Louche K., Mairal A., Liebisch G., Schmitz G., Rustan A.C., Smith S.R., Langin D., Moro C. Altered skeletal muscle lipase expression and activity contribute to insulin resistance in humans. Diabetes 2011, 60:1734-1742.
-
(2011)
Diabetes
, vol.60
, pp. 1734-1742
-
-
Badin, P.M.1
Louche, K.2
Mairal, A.3
Liebisch, G.4
Schmitz, G.5
Rustan, A.C.6
Smith, S.R.7
Langin, D.8
Moro, C.9
-
5
-
-
84861885929
-
The critical role of metabolic pathways in aging
-
Barzilai N., Huffman D.M., Muzumdar R.H., Bartke A. The critical role of metabolic pathways in aging. Diabetes 2012, 61:1315-1322.
-
(2012)
Diabetes
, vol.61
, pp. 1315-1322
-
-
Barzilai, N.1
Huffman, D.M.2
Muzumdar, R.H.3
Bartke, A.4
-
6
-
-
33747880238
-
Endocrine signaling in Caenorhabditis elegans controls stress response and longevity
-
Baumeister R., Schaffitzel E., Hertweck M. Endocrine signaling in Caenorhabditis elegans controls stress response and longevity. J.Endocrinol. 2006, 190:191-202.
-
(2006)
J.Endocrinol.
, vol.190
, pp. 191-202
-
-
Baumeister, R.1
Schaffitzel, E.2
Hertweck, M.3
-
7
-
-
52949093944
-
JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut
-
Biteau B., Hochmuth C.E., Jasper H. JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. Cell Stem Cell 2008, 3:442-455.
-
(2008)
Cell Stem Cell
, vol.3
, pp. 442-455
-
-
Biteau, B.1
Hochmuth, C.E.2
Jasper, H.3
-
8
-
-
78449240115
-
Lifespan extension by preserving proliferative homeostasis in Drosophila
-
Biteau B., Karpac J., Supoyo S., Degennaro M., Lehmann R., Jasper H. Lifespan extension by preserving proliferative homeostasis in Drosophila. PLoS Genet. 2010, 6:e1001159.
-
(2010)
PLoS Genet.
, vol.6
-
-
Biteau, B.1
Karpac, J.2
Supoyo, S.3
Degennaro, M.4
Lehmann, R.5
Jasper, H.6
-
9
-
-
80755174406
-
Maintaining tissue homeostasis: dynamic control of somatic stem cell activity
-
Biteau B., Hochmuth C.E., Jasper H. Maintaining tissue homeostasis: dynamic control of somatic stem cell activity. Cell Stem Cell 2011, 9:402-411.
-
(2011)
Cell Stem Cell
, vol.9
, pp. 402-411
-
-
Biteau, B.1
Hochmuth, C.E.2
Jasper, H.3
-
10
-
-
79954630776
-
Regulation of Drosophila lifespan by JNK signaling
-
Biteau B., Karpac J., Hwangbo D., Jasper H. Regulation of Drosophila lifespan by JNK signaling. Exp. Gerontol. 2011, 46:349-354.
-
(2011)
Exp. Gerontol.
, vol.46
, pp. 349-354
-
-
Biteau, B.1
Karpac, J.2
Hwangbo, D.3
Jasper, H.4
-
11
-
-
0037942739
-
Extended longevity in mice lacking the insulin receptor in adipose tissue
-
Blüher M., Kahn B.B., Kahn C.R. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003, 299:572-574.
-
(2003)
Science
, vol.299
, pp. 572-574
-
-
Blüher, M.1
Kahn, B.B.2
Kahn, C.R.3
-
12
-
-
70349617469
-
Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila
-
Buchon N., Broderick N.A., Chakrabarti S., Lemaitre B. Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev. 2009, 23:2333-2344.
-
(2009)
Genes Dev.
, vol.23
, pp. 2333-2344
-
-
Buchon, N.1
Broderick, N.A.2
Chakrabarti, S.3
Lemaitre, B.4
-
14
-
-
67649403606
-
FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes
-
Chakrabarti P., Kandror K.V. FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes. J.Biol. Chem. 2009, 284:13296-13300.
-
(2009)
J.Biol. Chem.
, vol.284
, pp. 13296-13300
-
-
Chakrabarti, P.1
Kandror, K.V.2
-
15
-
-
43449097534
-
Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor
-
Choi N.H., Kim J.G., Yang D.J., Kim Y.S., Yoo M.A. Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor. Aging Cell 2008, 7:318-334.
-
(2008)
Aging Cell
, vol.7
, pp. 318-334
-
-
Choi, N.H.1
Kim, J.G.2
Yang, D.J.3
Kim, Y.S.4
Yoo, M.A.5
-
16
-
-
78650918920
-
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
-
Demontis F., Perrimon N. FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell 2010, 143:813-825.
-
(2010)
Cell
, vol.143
, pp. 813-825
-
-
Demontis, F.1
Perrimon, N.2
-
17
-
-
84862004148
-
FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c
-
Deng X., Zhang W., O-Sullivan I., Williams J.B., Dong Q., Park E.A., Raghow R., Unterman T.G., Elam M.B. FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c. J.Biol. Chem. 2012, 287:20132-20143.
-
(2012)
J.Biol. Chem.
, vol.287
, pp. 20132-20143
-
-
Deng, X.1
Zhang, W.2
O-Sullivan, I.3
Williams, J.B.4
Dong, Q.5
Park, E.A.6
Raghow, R.7
Unterman, T.G.8
Elam, M.B.9
-
18
-
-
84872899284
-
FOXOs: signalling integrators for homeostasis maintenance
-
Eijkelenboom A., Burgering B.M. FOXOs: signalling integrators for homeostasis maintenance. Nat. Rev. Mol. Cell Biol. 2013, 14:83-97.
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 83-97
-
-
Eijkelenboom, A.1
Burgering, B.M.2
-
19
-
-
11244320393
-
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
-
Essers M.A., Weijzen S., de Vries-Smits A.M., Saarloos I., de Ruiter N.D., Bos J.L., Burgering B.M. FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J. 2004, 23:4802-4812.
-
(2004)
EMBO J.
, vol.23
, pp. 4802-4812
-
-
Essers, M.A.1
Weijzen, S.2
de Vries-Smits, A.M.3
Saarloos, I.4
de Ruiter, N.D.5
Bos, J.L.6
Burgering, B.M.7
-
20
-
-
0036584593
-
Genetic analysis of insulin signaling in Drosophila
-
Garofalo R.S. Genetic analysis of insulin signaling in Drosophila. Trends Endocrinol. Metab. 2002, 13:156-162.
-
(2002)
Trends Endocrinol. Metab.
, vol.13
, pp. 156-162
-
-
Garofalo, R.S.1
-
21
-
-
69149110896
-
Remote control of insulin secretion by fat cells in Drosophila
-
Géminard C., Rulifson E.J., Léopold P. Remote control of insulin secretion by fat cells in Drosophila. Cell Metab. 2009, 10:199-207.
-
(2009)
Cell Metab.
, vol.10
, pp. 199-207
-
-
Géminard, C.1
Rulifson, E.J.2
Léopold, P.3
-
22
-
-
3142749712
-
Long-lived Drosophila with overexpressed dFOXO in adult fat body
-
Giannakou M.E., Goss M., Jünger M.A., Hafen E., Leevers S.J., Partridge L. Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 2004, 305:361.
-
(2004)
Science
, vol.305
, pp. 361
-
-
Giannakou, M.E.1
Goss, M.2
Jünger, M.A.3
Hafen, E.4
Leevers, S.J.5
Partridge, L.6
-
23
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J., Tuncman G., Chang L., Görgün C.Z., Uysal K.T., Maeda K., Karin M., Hotamisligil G.S. A central role for JNK in obesity and insulin resistance. Nature 2002, 420:333-336.
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Görgün, C.Z.4
Uysal, K.T.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.S.8
-
24
-
-
2942563805
-
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
-
Hwangbo D.S., Gershman B., Tu M.P., Palmer M., Tatar M. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 2004, 429:562-566.
-
(2004)
Nature
, vol.429
, pp. 562-566
-
-
Hwangbo, D.S.1
Gershman, B.2
Tu, M.P.3
Palmer, M.4
Tatar, M.5
-
25
-
-
62649089279
-
Insulin and JNK: optimizing metabolic homeostasis and lifespan
-
Karpac J., Jasper H. Insulin and JNK: optimizing metabolic homeostasis and lifespan. Trends Endocrinol. Metab. 2009, 20:100-106.
-
(2009)
Trends Endocrinol. Metab.
, vol.20
, pp. 100-106
-
-
Karpac, J.1
Jasper, H.2
-
26
-
-
66149160390
-
JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila
-
Karpac J., Hull-Thompson J., Falleur M., Jasper H. JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila. Aging Cell 2009, 8:288-295.
-
(2009)
Aging Cell
, vol.8
, pp. 288-295
-
-
Karpac, J.1
Hull-Thompson, J.2
Falleur, M.3
Jasper, H.4
-
27
-
-
79958181684
-
Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage
-
Karpac J., Younger A., Jasper H. Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage. Dev. Cell 2011, 20:841-854.
-
(2011)
Dev. Cell
, vol.20
, pp. 841-854
-
-
Karpac, J.1
Younger, A.2
Jasper, H.3
-
28
-
-
0033966768
-
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
-
Kido Y., Burks D.J., Withers D., Bruning J.C., Kahn C.R., White M.F., Accili D. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J.Clin. Invest. 2000, 105:199-205.
-
(2000)
J.Clin. Invest.
, vol.105
, pp. 199-205
-
-
Kido, Y.1
Burks, D.J.2
Withers, D.3
Bruning, J.C.4
Kahn, C.R.5
White, M.F.6
Accili, D.7
-
30
-
-
0345447590
-
Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
-
Libina N., Berman J.R., Kenyon C. Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 2003, 115:489-502.
-
(2003)
Cell
, vol.115
, pp. 489-502
-
-
Libina, N.1
Berman, J.R.2
Kenyon, C.3
-
31
-
-
0030657540
-
Daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
-
Lin K., Dorman J.B., Rodan A., Kenyon C. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 1997, 278:1319-1322.
-
(1997)
Science
, vol.278
, pp. 1319-1322
-
-
Lin, K.1
Dorman, J.B.2
Rodan, A.3
Kenyon, C.4
-
32
-
-
0033659210
-
Properties and function of pancreatic lipase related protein 2
-
Lowe M.E. Properties and function of pancreatic lipase related protein 2. Biochimie 2000, 82:997-1004.
-
(2000)
Biochimie
, vol.82
, pp. 997-1004
-
-
Lowe, M.E.1
-
34
-
-
33846515971
-
Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation
-
Luo X., Puig O., Hyun J., Bohmann D., Jasper H. Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation. EMBO J. 2007, 26:380-390.
-
(2007)
EMBO J.
, vol.26
, pp. 380-390
-
-
Luo, X.1
Puig, O.2
Hyun, J.3
Bohmann, D.4
Jasper, H.5
-
35
-
-
0037473115
-
An inhibitory function for JNK in the regulation of IGF-I signaling in breast cancer
-
Mamay C.L., Mingo-Sion A.M., Wolf D.M., Molina M.D., Van Den Berg C.L. An inhibitory function for JNK in the regulation of IGF-I signaling in breast cancer. Oncogene 2003, 22:602-614.
-
(2003)
Oncogene
, vol.22
, pp. 602-614
-
-
Mamay, C.L.1
Mingo-Sion, A.M.2
Wolf, D.M.3
Molina, M.D.4
Van Den Berg, C.L.5
-
37
-
-
31444452338
-
Evidence that stem cells reside in the adult Drosophila midgut epithelium
-
Micchelli C.A., Perrimon N. Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature 2006, 439:475-479.
-
(2006)
Nature
, vol.439
, pp. 475-479
-
-
Micchelli, C.A.1
Perrimon, N.2
-
38
-
-
0033636523
-
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
-
Michael M.D., Kulkarni R.N., Postic C., Previs S.F., Shulman G.I., Magnuson M.A., Kahn C.R. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol. Cell 2000, 6:87-97.
-
(2000)
Mol. Cell
, vol.6
, pp. 87-97
-
-
Michael, M.D.1
Kulkarni, R.N.2
Postic, C.3
Previs, S.F.4
Shulman, G.I.5
Magnuson, M.A.6
Kahn, C.R.7
-
39
-
-
79955815135
-
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis
-
Mihaylova M.M., Vasquez D.S., Ravnskjaer K., Denechaud P.D., Yu R.T., Alvarez J.G., Downes M., Evans R.M., Montminy M., Shaw R.J. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell 2011, 145:607-621.
-
(2011)
Cell
, vol.145
, pp. 607-621
-
-
Mihaylova, M.M.1
Vasquez, D.S.2
Ravnskjaer, K.3
Denechaud, P.D.4
Yu, R.T.5
Alvarez, J.G.6
Downes, M.7
Evans, R.M.8
Montminy, M.9
Shaw, R.J.10
-
40
-
-
33845914051
-
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
-
Niedernhofer L.J., Garinis G.A., Raams A., Lalai A.S., Robinson A.R., Appeldoorn E., Odijk H., Oostendorp R., Ahmad A., van Leeuwen W., et al. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 2006, 444:1038-1043.
-
(2006)
Nature
, vol.444
, pp. 1038-1043
-
-
Niedernhofer, L.J.1
Garinis, G.A.2
Raams, A.3
Lalai, A.S.4
Robinson, A.R.5
Appeldoorn, E.6
Odijk, H.7
Oostendorp, R.8
Ahmad, A.9
van Leeuwen, W.10
-
41
-
-
52449112590
-
14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila
-
Nielsen M.D., Luo X., Biteau B., Syverson K., Jasper H. 14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila. Aging Cell 2008, 7:688-699.
-
(2008)
Aging Cell
, vol.7
, pp. 688-699
-
-
Nielsen, M.D.1
Luo, X.2
Biteau, B.3
Syverson, K.4
Jasper, H.5
-
42
-
-
84874271499
-
ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy
-
O'Rourke E.J., Kuballa P., Xavier R., Ruvkun G. ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev. 2013, 27:429-440.
-
(2013)
Genes Dev.
, vol.27
, pp. 429-440
-
-
O'Rourke, E.J.1
Kuballa, P.2
Xavier, R.3
Ruvkun, G.4
-
43
-
-
84872166765
-
Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
-
Odegaard J.I., Chawla A. Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science 2013, 339:172-177.
-
(2013)
Science
, vol.339
, pp. 172-177
-
-
Odegaard, J.I.1
Chawla, A.2
-
44
-
-
0030659557
-
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
-
Ogg S., Paradis S., Gottlieb S., Patterson G.I., Lee L., Tissenbaum H.A., Ruvkun G. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 1997, 389:994-999.
-
(1997)
Nature
, vol.389
, pp. 994-999
-
-
Ogg, S.1
Paradis, S.2
Gottlieb, S.3
Patterson, G.I.4
Lee, L.5
Tissenbaum, H.A.6
Ruvkun, G.7
-
45
-
-
15444371989
-
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
-
Oh S.W., Mukhopadhyay A., Svrzikapa N., Jiang F., Davis R.J., Tissenbaum H.A. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc. Natl. Acad. Sci. USA 2005, 102:4494-4499.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 4494-4499
-
-
Oh, S.W.1
Mukhopadhyay, A.2
Svrzikapa, N.3
Jiang, F.4
Davis, R.J.5
Tissenbaum, H.A.6
-
46
-
-
31444444485
-
The adult Drosophila posterior midgut is maintained by pluripotent stem cells
-
Ohlstein B., Spradling A. The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature 2006, 439:470-474.
-
(2006)
Nature
, vol.439
, pp. 470-474
-
-
Ohlstein, B.1
Spradling, A.2
-
47
-
-
0037306190
-
Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control
-
Oldham S., Hafen E. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol. 2003, 13:79-85.
-
(2003)
Trends Cell Biol.
, vol.13
, pp. 79-85
-
-
Oldham, S.1
Hafen, E.2
-
48
-
-
0035940416
-
A conditional tissue-specific transgene expression system using inducible GAL4
-
Osterwalder T., Yoon K.S., White B.H., Keshishian H. A conditional tissue-specific transgene expression system using inducible GAL4. Proc. Natl. Acad. Sci. USA 2001, 98:12596-12601.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 12596-12601
-
-
Osterwalder, T.1
Yoon, K.S.2
White, B.H.3
Keshishian, H.4
-
49
-
-
0042161896
-
Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway
-
Puig O., Marr M.T., Ruhf M.L., Tjian R. Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev. 2003, 17:2006-2020.
-
(2003)
Genes Dev.
, vol.17
, pp. 2006-2020
-
-
Puig, O.1
Marr, M.T.2
Ruhf, M.L.3
Tjian, R.4
-
50
-
-
84871830937
-
Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila
-
Rera M., Clark R.I., Walker D.W. Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila. Proc. Natl. Acad. Sci. USA 2012, 109:21528-21533.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 21528-21533
-
-
Rera, M.1
Clark, R.I.2
Walker, D.W.3
-
51
-
-
84875902181
-
Organ-specific mediation of lifespan extension: more than a gut feeling?
-
Rera M., Azizi M.J., Walker D.W. Organ-specific mediation of lifespan extension: more than a gut feeling?. Ageing Res. Rev. 2013, 12:436-444.
-
(2013)
Ageing Res. Rev.
, vol.12
, pp. 436-444
-
-
Rera, M.1
Azizi, M.J.2
Walker, D.W.3
-
52
-
-
33645888693
-
Nutrition and aging: changes in the regulation of energy metabolism with aging
-
Roberts S.B., Rosenberg I. Nutrition and aging: changes in the regulation of energy metabolism with aging. Physiol. Rev. 2006, 86:651-667.
-
(2006)
Physiol. Rev.
, vol.86
, pp. 651-667
-
-
Roberts, S.B.1
Rosenberg, I.2
-
53
-
-
0037052544
-
Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
-
Rulifson E.J., Kim S.K., Nusse R. Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 2002, 296:1118-1120.
-
(2002)
Science
, vol.296
, pp. 1118-1120
-
-
Rulifson, E.J.1
Kim, S.K.2
Nusse, R.3
-
54
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
Saltiel A.R., Kahn C.R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001, 414:799-806.
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
55
-
-
84857861919
-
Mechanisms for insulin resistance: common threads and missing links
-
Samuel V.T., Shulman G.I. Mechanisms for insulin resistance: common threads and missing links. Cell 2012, 148:852-871.
-
(2012)
Cell
, vol.148
, pp. 852-871
-
-
Samuel, V.T.1
Shulman, G.I.2
-
56
-
-
33745294013
-
The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes
-
Schoenborn V., Heid I.M., Vollmert C., Lingenhel A., Adams T.D., Hopkins P.N., Illig T., Zimmermann R., Zechner R., Hunt S.C., Kronenberg F. The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes. Diabetes 2006, 55:1270-1275.
-
(2006)
Diabetes
, vol.55
, pp. 1270-1275
-
-
Schoenborn, V.1
Heid, I.M.2
Vollmert, C.3
Lingenhel, A.4
Adams, T.D.5
Hopkins, P.N.6
Illig, T.7
Zimmermann, R.8
Zechner, R.9
Hunt, S.C.10
Kronenberg, F.11
-
57
-
-
0033636780
-
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
-
Shimomura I., Matsuda M., Hammer R.E., Bashmakov Y., Brown M.S., Goldstein J.L. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol. Cell 2000, 6:77-86.
-
(2000)
Mol. Cell
, vol.6
, pp. 77-86
-
-
Shimomura, I.1
Matsuda, M.2
Hammer, R.E.3
Bashmakov, Y.4
Brown, M.S.5
Goldstein, J.L.6
-
58
-
-
70449774815
-
The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila
-
Sieber M.H., Thummel C.S. The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila. Cell Metab. 2009, 10:481-490.
-
(2009)
Cell Metab.
, vol.10
, pp. 481-490
-
-
Sieber, M.H.1
Thummel, C.S.2
-
59
-
-
84855422546
-
Coordination of triacylglycerol and cholesterol homeostasis by DHR96 and the Drosophila LipA homolog magro
-
Sieber M.H., Thummel C.S. Coordination of triacylglycerol and cholesterol homeostasis by DHR96 and the Drosophila LipA homolog magro. Cell Metab. 2012, 15:122-127.
-
(2012)
Cell Metab.
, vol.15
, pp. 122-127
-
-
Sieber, M.H.1
Thummel, C.S.2
-
60
-
-
47049101814
-
Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster
-
Skorupa D.A., Dervisefendic A., Zwiener J., Pletcher S.D. Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster. Aging Cell 2008, 7:478-490.
-
(2008)
Aging Cell
, vol.7
, pp. 478-490
-
-
Skorupa, D.A.1
Dervisefendic, A.2
Zwiener, J.3
Pletcher, S.D.4
-
61
-
-
79959559276
-
DFOXO-independent effects of reduced insulin-like signaling in Drosophila
-
Slack C., Giannakou M.E., Foley A., Goss M., Partridge L. dFOXO-independent effects of reduced insulin-like signaling in Drosophila. Aging Cell 2011, 10:735-748.
-
(2011)
Aging Cell
, vol.10
, pp. 735-748
-
-
Slack, C.1
Giannakou, M.E.2
Foley, A.3
Goss, M.4
Partridge, L.5
-
62
-
-
22944479314
-
JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3
-
Sunayama J., Tsuruta F., Masuyama N., Gotoh Y. JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3. J.Cell Biol. 2005, 170:295-304.
-
(2005)
J.Cell Biol.
, vol.170
, pp. 295-304
-
-
Sunayama, J.1
Tsuruta, F.2
Masuyama, N.3
Gotoh, Y.4
-
63
-
-
78649513976
-
Diabetes and insulin in regulation of brain cholesterol metabolism
-
Suzuki R., Lee K., Jing E., Biddinger S.B., McDonald J.G., Montine T.J., Craft S., Kahn C.R. Diabetes and insulin in regulation of brain cholesterol metabolism. Cell Metab. 2010, 12:567-579.
-
(2010)
Cell Metab.
, vol.12
, pp. 567-579
-
-
Suzuki, R.1
Lee, K.2
Jing, E.3
Biddinger, S.B.4
McDonald, J.G.5
Montine, T.J.6
Craft, S.7
Kahn, C.R.8
-
64
-
-
43549122104
-
Insulin-like signaling, nutrient homeostasis, and life span
-
Taguchi A., White M.F. Insulin-like signaling, nutrient homeostasis, and life span. Annu. Rev. Physiol. 2008, 70:191-212.
-
(2008)
Annu. Rev. Physiol.
, vol.70
, pp. 191-212
-
-
Taguchi, A.1
White, M.F.2
-
65
-
-
0037470501
-
The endocrine regulation of aging by insulin-like signals
-
Tatar M., Bartke A., Antebi A. The endocrine regulation of aging by insulin-like signals. Science 2003, 299:1346-1351.
-
(2003)
Science
, vol.299
, pp. 1346-1351
-
-
Tatar, M.1
Bartke, A.2
Antebi, A.3
-
66
-
-
72449195397
-
Molecular mechanisms of metabolic regulation by insulin in Drosophila
-
Teleman A.A. Molecular mechanisms of metabolic regulation by insulin in Drosophila. Biochem. J. 2010, 425:13-26.
-
(2010)
Biochem. J.
, vol.425
, pp. 13-26
-
-
Teleman, A.A.1
-
67
-
-
33846030099
-
Impaired genome maintenance suppresses the growth hormone-insulin-like growth factor 1 axis in mice with Cockayne syndrome
-
van der Pluijm I., Garinis G.A., Brandt R.M., Gorgels T.G., Wijnhoven S.W., Diderich K.E., de Wit J., Mitchell J.R., van Oostrom C., Beems R., et al. Impaired genome maintenance suppresses the growth hormone-insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol. 2007, 5:e2.
-
(2007)
PLoS Biol.
, vol.5
-
-
van der Pluijm, I.1
Garinis, G.A.2
Brandt, R.M.3
Gorgels, T.G.4
Wijnhoven, S.W.5
Diderich, K.E.6
de Wit, J.7
Mitchell, J.R.8
van Oostrom, C.9
Beems, R.10
-
68
-
-
39149139982
-
DFOXO regulates transcription of a Drosophila acid lipase
-
Vihervaara T., Puig O. dFOXO regulates transcription of a Drosophila acid lipase. J.Mol. Biol. 2008, 376:1215-1223.
-
(2008)
J.Mol. Biol.
, vol.376
, pp. 1215-1223
-
-
Vihervaara, T.1
Puig, O.2
-
69
-
-
17044408768
-
JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
-
Wang M.C., Bohmann D., Jasper H. JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 2005, 121:115-125.
-
(2005)
Cell
, vol.121
, pp. 115-125
-
-
Wang, M.C.1
Bohmann, D.2
Jasper, H.3
-
70
-
-
55849101681
-
Fat metabolism links germline stem cells and longevity in C. elegans
-
Wang M.C., O'Rourke E.J., Ruvkun G. Fat metabolism links germline stem cells and longevity in C. elegans. Science 2008, 322:957-960.
-
(2008)
Science
, vol.322
, pp. 957-960
-
-
Wang, M.C.1
O'Rourke, E.J.2
Ruvkun, G.3
-
71
-
-
79955802436
-
A hormone-dependent module regulating energy balance
-
Wang B., Moya N., Niessen S., Hoover H., Mihaylova M.M., Shaw R.J., Yates J.R., Fischer W.H., Thomas J.B., Montminy M. A hormone-dependent module regulating energy balance. Cell 2011, 145:596-606.
-
(2011)
Cell
, vol.145
, pp. 596-606
-
-
Wang, B.1
Moya, N.2
Niessen, S.3
Hoover, H.4
Mihaylova, M.M.5
Shaw, R.J.6
Yates, J.R.7
Fischer, W.H.8
Thomas, J.B.9
Montminy, M.10
-
73
-
-
84857473501
-
Insulin signaling regulates fatty acid catabolism at the level of CoA activation
-
Xu X., Gopalacharyulu P., Seppänen-Laakso T., Ruskeepää A.L., Aye C.C., Carson B.P., Mora S., Orešič M., Teleman A.A. Insulin signaling regulates fatty acid catabolism at the level of CoA activation. PLoS Genet. 2012, 8:e1002478.
-
(2012)
PLoS Genet.
, vol.8
-
-
Xu, X.1
Gopalacharyulu, P.2
Seppänen-Laakso, T.3
Ruskeepää, A.L.4
Aye, C.C.5
Carson, B.P.6
Mora, S.7
Orešič, M.8
Teleman, A.A.9
-
74
-
-
14744301343
-
JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage
-
Yoshida K., Yamaguchi T., Natsume T., Kufe D., Miki Y. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat. Cell Biol. 2005, 7:278-285.
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 278-285
-
-
Yoshida, K.1
Yamaguchi, T.2
Natsume, T.3
Kufe, D.4
Miki, Y.5
-
75
-
-
84872143888
-
Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators
-
Zhang P., Judy M., Lee S.J., Kenyon C. Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators. Cell Metab. 2013, 17:85-100.
-
(2013)
Cell Metab.
, vol.17
, pp. 85-100
-
-
Zhang, P.1
Judy, M.2
Lee, S.J.3
Kenyon, C.4
|