-
1
-
-
0029992789
-
Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes
-
Barwick JL, Quattrochi LC, Mills AS, Potenza C, Tukey RH, and Guzelian PS (1996) Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes. Mol Pharmacol 50:10-16.
-
(1996)
Mol Pharmacol
, vol.50
, pp. 10-16
-
-
Barwick, J.L.1
Quattrochi, L.C.2
Mills, A.S.3
Potenza, C.4
Tukey, R.H.5
Guzelian, P.S.6
-
2
-
-
13144260727
-
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
-
Bertilsson G, Heidrich J, Svensson K, Asman M, Jendeberg L, Sydow-Backman M, Ohlsson R, Postlind H, Blomquist P, and Berkenstam A (1998) Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci US A 95:12208-12213.
-
(1998)
Proc Natl Acad Sci US A
, vol.95
, pp. 12208-12213
-
-
Bertilsson, G.1
Heidrich, J.2
Svensson, K.3
Asman, M.4
Jendeberg, L.5
Sydow-Backman, M.6
Ohlsson, R.7
Postlind, H.8
Blomquist, P.9
Berkenstam, A.10
-
3
-
-
0032532134
-
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
-
Blumberg B, Sabbagh W Jr, Juguilon H, Bolado J Jr, van Meter CM, Ong ES, and Evans RM (1998) SXR, a novel steroid and xenobiotic-sensing nuclear receptor.Genes Dev 12:3195-3205.
-
(1998)
Genes Dev
, vol.12
, pp. 3195-3205
-
-
Blumberg, B.1
Sabbagh Jr, W.2
Juguilon, H.3
Bolado Jr, J.4
van Meter, C.M.5
Ong, E.S.6
Evans, R.M.7
-
4
-
-
1642498178
-
Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor
-
Chen Y, Ferguson SS, Negishi M, and Goldstein JA (2004) Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. J Pharmacol Exp Ther 308:495-501.
-
(2004)
J Pharmacol Exp Ther
, vol.308
, pp. 495-501
-
-
Chen, Y.1
Ferguson, S.S.2
Negishi, M.3
Goldstein, J.A.4
-
5
-
-
0034827301
-
Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes
-
Drocourt L, Pascussi JM, Assenat E, Fabre JM, Maurel P, and Vilarem MJ (2001) Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes. Drug Metab Dispos 29:1325-1331.
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 1325-1331
-
-
Drocourt, L.1
Pascussi, J.M.2
Assenat, E.3
Fabre, J.M.4
Maurel, P.5
Vilarem, M.J.6
-
7
-
-
0036173085
-
Adenovirus vector-mediated reporter system for in vivo analyses of human CYP3A4 gene activation
-
Furukawa M, Okubo T, Ogino M, Yamazaki T, Shimada M, Nagata K, and Yamazoe Y (2002) Adenovirus vector-mediated reporter system for in vivo analyses of human CYP3A4 gene activation. J Biochem 131:71-78.
-
(2002)
J Biochem
, vol.131
, pp. 71-78
-
-
Furukawa, M.1
Okubo, T.2
Ogino, M.3
Yamazaki, T.4
Shimada, M.5
Nagata, K.6
Yamazoe, Y.7
-
8
-
-
0035805536
-
Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
-
Geick A, Eichelbaum M, and Burk O (2001) Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 276:14581-14587.
-
(2001)
J Biol Chem
, vol.276
, pp. 14581-14587
-
-
Geick, A.1
Eichelbaum, M.2
Burk, O.3
-
9
-
-
0026651273
-
Human cytochromes P450: Problems and prospects
-
Gonzalez FJ (1992) Human cytochromes P450: problems and prospects. Trends Pharmacol Sci 13:346-352.
-
(1992)
Trends Pharmacol Sci
, vol.13
, pp. 346-352
-
-
Gonzalez, F.J.1
-
10
-
-
0032702726
-
The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module
-
Goodwin B, Hodgson E, and Liddle C (1999) The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol Pharmacol 56:1329-1339.
-
(1999)
Mol Pharmacol
, vol.56
, pp. 1329-1339
-
-
Goodwin, B.1
Hodgson, E.2
Liddle, C.3
-
11
-
-
0021749262
-
Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma
-
Herbomel P, Bourachot B, and Yaniv M (1984) Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma. Cell 39:653-662.
-
(1984)
Cell
, vol.39
, pp. 653-662
-
-
Herbomel, P.1
Bourachot, B.2
Yaniv, M.3
-
12
-
-
0038798874
-
Drug-activated nuclear receptors CAR and PXR
-
Honkakoski P, Sueyoshi T, and Negishi M (2003) Drug-activated nuclear receptors CAR and PXR. Ann Med 35:172-182.
-
(2003)
Ann Med
, vol.35
, pp. 172-182
-
-
Honkakoski, P.1
Sueyoshi, T.2
Negishi, M.3
-
13
-
-
17744375160
-
The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution
-
Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, Tomkinson NC, LeCluyse EL, Lambert MH, Willson TM, et al. (2000) The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol Endocrinol 14:27-39.
-
(2000)
Mol Endocrinol
, vol.14
, pp. 27-39
-
-
Jones, S.A.1
Moore, L.B.2
Shenk, J.L.3
Wisely, G.B.4
Hamilton, G.A.5
McKee, D.D.6
Tomkinson, N.C.7
LeCluyse, E.L.8
Lambert, M.H.9
Willson, T.M.10
-
14
-
-
0028918996
-
Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit,and human hepatocytes
-
Kocarek TA, Schuetz EG, Strom SC, Fisher RA, and Guzelian PS (1995) Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit,and human hepatocytes. Drug Metab Dispos 23:415-421.
-
(1995)
Drug Metab Dispos
, vol.23
, pp. 415-421
-
-
Kocarek, T.A.1
Schuetz, E.G.2
Strom, S.C.3
Fisher, R.A.4
Guzelian, P.S.5
-
15
-
-
0028063131
-
CYP3A gene expression in human gut epithelium
-
Kolars JC, Lown KS, Schmiedlim-Ren P, Ghosh M, Fang C, Wrighton SA, Merion RM, and Watkins PB (1994) CYP3A gene expression in human gut epithelium.Pharmacogenetics, 4:247-259.
-
(1994)
Pharmacogenetics
, vol.4
, pp. 247-259
-
-
Kolars, J.C.1
Lown, K.S.2
Schmiedlim-Ren, P.3
Ghosh, M.4
Fang, C.5
Wrighton, S.A.6
Merion, R.M.7
Watkins, P.B.8
-
16
-
-
0032169485
-
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
-
Lehmann JM, McKee DD. Watson MA, Willson TM, Moore JT, and Kliewer SA (1998) The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest 102:1016-1023.
-
(1998)
J Clin Invest
, vol.102
, pp. 1016-1023
-
-
Lehmann, J.M.1
McKee, D.D.2
Watson, M.A.3
Willson, T.M.4
Moore, J.T.5
Kliewer, S.A.6
-
17
-
-
8844228096
-
A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides
-
Lemaire G, de Sousa G, and Rahmani R (2004) A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides. Biochem Pharmacol 68:2347-2358.
-
(2004)
Biochem Pharmacol
, vol.68
, pp. 2347-2358
-
-
Lemaire, G.1
de Sousa, G.2
Rahmani, R.3
-
18
-
-
0030726508
-
Preclinical evaluation of drug-drug interaction potential: Present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction
-
Li AP, Maurel P, Gomez-Lechon MJ, Cheng LC, and Jurima-Romet M (1997) Preclinical evaluation of drug-drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction. Chem Biol Interact 107:5-16.
-
(1997)
Chem Biol Interact
, vol.107
, pp. 5-16
-
-
Li, A.P.1
Maurel, P.2
Gomez-Lechon, M.J.3
Cheng, L.C.4
Jurima-Romet, M.5
-
19
-
-
0035987895
-
CYP3A4 induction by drugs: Correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes
-
Luo G, Cunningham M, Kim S, Burn T, Lin J, Sinz M, Hamilton G, Rizzo C, Jolley S, Gilbert D, et al. (2002) CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes. Drug Metab Dispos 30:795-804.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 795-804
-
-
Luo, G.1
Cunningham, M.2
Kim, S.3
Burn, T.4
Lin, J.5
Sinz, M.6
Hamilton, G.7
Rizzo, C.8
Jolley, S.9
Gilbert, D.10
-
20
-
-
34247333430
-
Assessment of human pregnane X receptor involvement in pesticide-mediated activation of CYP3A4 gene
-
Matsubara T, Noracharttiyapot W, Toriyabe T, Yoshinari K, Nagata K, and Yamazoe Y (2007) Assessment of human pregnane X receptor involvement in pesticide-mediated activation of CYP3A4 gene. Drug Metab Dispos 35:728-733.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 728-733
-
-
Matsubara, T.1
Noracharttiyapot, W.2
Toriyabe, T.3
Yoshinari, K.4
Nagata, K.5
Yamazoe, Y.6
-
21
-
-
0031975185
-
Update: Clinically significant cytochrome P-450 drug interactions
-
Michalets EL (1998) Update: clinically significant cytochrome P-450 drug interactions. Pharmacotherapy 18:84-112.
-
(1998)
Pharmacotherapy
, vol.18
, pp. 84-112
-
-
Michalets, E.L.1
-
22
-
-
0034676513
-
Use of the nuclear receptor PXR to predict drug interactions
-
Moore JT and Kliewer SA (2000) Use of the nuclear receptor PXR to predict drug interactions. Toxicology 153:1-10.
-
(2000)
Toxicology
, vol.153
, pp. 1-10
-
-
Moore, J.T.1
Kliewer, S.A.2
-
23
-
-
0034691064
-
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
-
Moore LB, Goodwin B, Jones SA, Wisely GB, Serabjit-Singh CJ, Willson TM, Collins JL, and Kliewer SA (2000) St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Proc Natl Acad Sci USA 97:7500-7502.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 7500-7502
-
-
Moore, L.B.1
Goodwin, B.2
Jones, S.A.3
Wisely, G.B.4
Serabjit-Singh, C.J.5
Willson, T.M.6
Collins, J.L.7
Kliewer, S.A.8
-
24
-
-
0037068964
-
Clinical importance of the cytochromes P450
-
Nebert DW and Russell DW (2002) Clinical importance of the cytochromes P450. Lancet 360:1155-1162.
-
(2002)
Lancet
, vol.360
, pp. 1155-1162
-
-
Nebert, D.W.1
Russell, D.W.2
-
25
-
-
33744999916
-
Construction of several human-derived stable cell lines displaying distinct profiles of CYP3A4 induction
-
Noracharttiyapot W, Nagai Y, Matsubara T, Miyata M, Shimada M, Nagata K, and Yamazoe Y (2006) Construction of several human-derived stable cell lines displaying distinct profiles of CYP3A4 induction. Drug Metab Pharmacokinet 21:99-108.
-
(2006)
Drug Metab Pharmacokinet
, vol.21
, pp. 99-108
-
-
Noracharttiyapot, W.1
Nagai, Y.2
Matsubara, T.3
Miyata, M.4
Shimada, M.5
Nagata, K.6
Yamazoe, Y.7
-
26
-
-
33645809139
-
The human intestinal cytochrome P450 "pie
-
Paine MF, Hart HL, Ludington SS, Haining RL, Rettie AE, and Zeldin DC (2006) The human intestinal cytochrome P450 "pie". Drug Metab Dispos 34:880-886.
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 880-886
-
-
Paine, M.F.1
Hart, H.L.2
Ludington, S.S.3
Haining, R.L.4
Rettie, A.E.5
Zeldin, D.C.6
-
27
-
-
0027427551
-
Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes
-
Schuetz EG, Schuetz JD, Strom SC, Thompson MT, Fisher RA, Molowa DT, Li D, and Guzelian PS (1993) Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes. Hepatology 18:1254-1262.
-
(1993)
Hepatology
, vol.18
, pp. 1254-1262
-
-
Schuetz, E.G.1
Schuetz, J.D.2
Strom, S.C.3
Thompson, M.T.4
Fisher, R.A.5
Molowa, D.T.6
Li, D.7
Guzelian, P.S.8
-
28
-
-
0028237729
-
Interindi-vidual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
-
Shimada T, Yamazaki H, Mimura M, Inui Y, and Guengerich FP (1994) Interindi-vidual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 270:414-423.
-
(1994)
J Pharmacol Exp Ther
, vol.270
, pp. 414-423
-
-
Shimada, T.1
Yamazaki, H.2
Mimura, M.3
Inui, Y.4
Guengerich, F.P.5
-
29
-
-
0035038919
-
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
-
Synold TW, Dussault I, and Forman BM (2001) The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 7:584-590.
-
(2001)
Nat Med
, vol.7
, pp. 584-590
-
-
Synold, T.W.1
Dussault, I.2
Forman, B.M.3
-
30
-
-
16544364469
-
Differences in trans activation between rat CYP3A1 and human CYP3A4 genes by human pregnane X receptor
-
Takada T, Ogino M, Miyata M, Shimada M, Nagata K, and Yamazoe Y (2004) Differences in trans activation between rat CYP3A1 and human CYP3A4 genes by human pregnane X receptor. Drug Metab Pharmacokinet 19:103-113.
-
(2004)
Drug Metab Pharmacokinet
, vol.19
, pp. 103-113
-
-
Takada, T.1
Ogino, M.2
Miyata, M.3
Shimada, M.4
Nagata, K.5
Yamazoe, Y.6
-
31
-
-
0037515661
-
A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression
-
Wang H, Faucette S, Sueyoshi T, Moore R, Ferguson S, Negishi M, and LeCluyse EL (2003) A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. J Biol Chem 278:14146-14152.
-
(2003)
J Biol Chem
, vol.278
, pp. 14146-14152
-
-
Wang, H.1
Faucette, S.2
Sueyoshi, T.3
Moore, R.4
Ferguson, S.5
Negishi, M.6
LeCluyse, E.L.7
-
32
-
-
0141532282
-
Sex is a major determinant of CYP3A4 expression in human liver
-
Wolbold R, Klein K, Burk O, Nüssler AK, Neuhaus P, Eichelbaum M, Schwab M, and Zanger UM (2003) Sex is a major determinant of CYP3A4 expression in human liver. Hepatology 38:978-988.
-
(2003)
Hepatology
, vol.38
, pp. 978-988
-
-
Wolbold, R.1
Klein, K.2
Burk, O.3
Nüssler, A.K.4
Neuhaus, P.5
Eichelbaum, M.6
Schwab, M.7
Zanger, U.M.8
-
33
-
-
0033638960
-
Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR
-
Xie W, Barwick JL, Simon CM, Pierce AM, Safe S, Blumberg B, Guzelian PS, and Evans RM (2000) Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes Dev 14:3014-3023.
-
(2000)
Genes Dev
, vol.14
, pp. 3014-3023
-
-
Xie, W.1
Barwick, J.L.2
Simon, C.M.3
Pierce, A.M.4
Safe, S.5
Blumberg, B.6
Guzelian, P.S.7
Evans, R.M.8
|