-
1
-
-
47049092561
-
Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver
-
Bennett MK, Seo YK, Datta S, Shin DJ, and Osborne TF (2008) Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver. J Biol Chem 283:15628-15637.
-
(2008)
J Biol Chem
, vol.283
, pp. 15628-15637
-
-
Bennett, M.K.1
Seo, Y.K.2
Datta, S.3
Shin, D.J.4
Osborne, T.F.5
-
2
-
-
7244243931
-
Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism
-
Bhalla S, Ozalp C, Fang S, Xiang L, and Kemper JK (2004) Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism. J Biol Chem 279:45139-45147.
-
(2004)
J Biol Chem
, vol.279
, pp. 45139-45147
-
-
Bhalla, S.1
Ozalp, C.2
Fang, S.3
Xiang, L.4
Kemper, J.K.5
-
3
-
-
0037200017
-
Metabolism of 4 beta -hydroxycholesterol in humans
-
Bodin K, Andersson U, Rystedt E, Ellis E, Norlin M, Pikuleva I, Eggertsen G, Björkhem I, and Diczfalusy U (2002) Metabolism of 4 beta -hydroxycholesterol in humans. J Biol Chem 277:31534-31540.
-
(2002)
J Biol Chem
, vol.277
, pp. 31534-31540
-
-
Bodin, K.1
Andersson, U.2
Rystedt, E.3
Ellis, E.4
Norlin, M.5
Pikuleva, I.6
Eggertsen, G.7
Björkhem, I.8
Diczfalusy, U.9
-
4
-
-
0035914368
-
Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: Evidence for involvement of cytochrome P450 3A4
-
Bodin K, Bretillon L, Aden Y, Bertilsson L, Broomé U, Einarsson C, and Diczfalusy U (2001) Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome P450 3A4. J Biol Chem 276:38685-38689.
-
(2001)
J Biol Chem
, vol.276
, pp. 38685-38689
-
-
Bodin, K.1
Bretillon, L.2
Aden, Y.3
Bertilsson, L.4
Broomé, U.5
Einarsson, C.6
Diczfalusy, U.7
-
5
-
-
0030941803
-
The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
-
Brown MS and Goldstein JL (1997) The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89:331-340.
-
(1997)
Cell
, vol.89
, pp. 331-340
-
-
Brown, M.S.1
Goldstein, J.L.2
-
6
-
-
0035102719
-
CYP3A genetics in drug metabolism
-
Eichelbaum M and Burk O (2001) CYP3A genetics in drug metabolism. Nat Med 7:285-287.
-
(2001)
Nat Med
, vol.7
, pp. 285-287
-
-
Eichelbaum, M.1
Burk, O.2
-
7
-
-
0026651273
-
Human cytochromes P450: Problems and prospects
-
Gonzalez FJ (1992) Human cytochromes P450: problems and prospects. Trends Pharmacol Sci 13:346-352.
-
(1992)
Trends Pharmacol Sci
, vol.13
, pp. 346-352
-
-
Gonzalez, F.J.1
-
8
-
-
42249106086
-
Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription
-
Gonzalez FJ (2008) Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription. Drug Metab Pharmacokinet 23:2-7.
-
(2008)
Drug Metab Pharmacokinet
, vol.23
, pp. 2-7
-
-
Gonzalez, F.J.1
-
9
-
-
0037422578
-
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor
-
Goodwin B, Gauthier KC, Umetani M, Watson MA, Lochansky MI, Collins JL, Leitersdorf E, Mangelsdorf DJ, Kliewer SA, and Repa JJ (2003) Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. Proc Natl Acad Sci USA 100:223-228.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 223-228
-
-
Goodwin, B.1
Gauthier, K.C.2
Umetani, M.3
Watson, M.A.4
Lochansky, M.I.5
Collins, J.L.6
Leitersdorf, E.7
Mangelsdorf, D.J.8
Kliewer, S.A.9
Repa, J.J.10
-
10
-
-
0035860807
-
Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in cerebrotendinous xanthomatosis
-
Honda A, Salen G, Matsuzaki Y, Batta AK, Xu G, Leitersdorf E, Tint GS, Erickson SK, Tanaka N, and Shefer S (2001) Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in cerebrotendinous xanthomatosis. J Biol Chem 276:34579-34585.
-
(2001)
J Biol Chem
, vol.276
, pp. 34579-34585
-
-
Honda, A.1
Salen, G.2
Matsuzaki, Y.3
Batta, A.K.4
Xu, G.5
Leitersdorf, E.6
Tint, G.S.7
Erickson, S.K.8
Tanaka, N.9
Shefer, S.10
-
11
-
-
0036251153
-
SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
-
Horton JD, Goldstein JL, and Brown MS (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109:1125-1131.
-
(2002)
J Clin Invest
, vol.109
, pp. 1125-1131
-
-
Horton, J.D.1
Goldstein, J.L.2
Brown, M.S.3
-
12
-
-
0029113123
-
Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors
-
Jiang G, Nepomuceno L, Hopkins K, and Sladek FM (1995) Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors. Mol Cell Biol 15:5131-5143.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 5131-5143
-
-
Jiang, G.1
Nepomuceno, L.2
Hopkins, K.3
Sladek, F.M.4
-
13
-
-
0035124052
-
Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: A study using adenovirus-mediated antisense targeting
-
Jover R, Bort R, Gómez-Lechón MJ, and Castell JV (2001) Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting. Hepatology 33:668-675.
-
(2001)
Hepatology
, vol.33
, pp. 668-675
-
-
Jover, R.1
Bort, R.2
Gómez-Lechón, M.J.3
Castell, J.V.4
-
14
-
-
34848824067
-
Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA
-
Kamiyama Y, Matsubara T, Yoshinari K, Nagata K, Kamimura H, and Yamazoe Y (2007) Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA. Drug Metab Pharmacokinet 22:287-298.
-
(2007)
Drug Metab Pharmacokinet
, vol.22
, pp. 287-298
-
-
Kamiyama, Y.1
Matsubara, T.2
Yoshinari, K.3
Nagata, K.4
Kamimura, H.5
Yamazoe, Y.6
-
15
-
-
10844273426
-
Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription
-
Li T and Chiang JY (2005) Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription. Am J Physiol Gastrointest Liver Physiol 288:G74-G84.
-
(2005)
Am J Physiol Gastrointest Liver Physiol
, vol.288
-
-
Li, T.1
Chiang, J.Y.2
-
16
-
-
0027513694
-
The role of cytochrome P450 3A (CYP3A) isoform(s) in oxidative metabolism of testosterone and benzphetamine in human adult and fetal liver
-
Mäenpää J, Pelkonen O, Cresteil T, and Rane A (1993) The role of cytochrome P450 3A (CYP3A) isoform(s) in oxidative metabolism of testosterone and benzphetamine in human adult and fetal liver. J Steroid Biochem Mol Biol 44:61-67.
-
(1993)
J Steroid Biochem Mol Biol
, vol.44
, pp. 61-67
-
-
Mäenpää, J.1
Pelkonen, O.2
Cresteil, T.3
Rane, A.4
-
17
-
-
33744962967
-
Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha
-
Miao J, Fang S, Bae Y, and Kemper JK (2006) Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha. J Biol Chem 281:14537-14546.
-
(2006)
J Biol Chem
, vol.281
, pp. 14537-14546
-
-
Miao, J.1
Fang, S.2
Bae, Y.3
Kemper, J.K.4
-
18
-
-
0028917364
-
Transcriptional elements directing a liver-specific expression of P450/6 beta A (CYP3A2) gene-encoding testosterone 6 beta-hydroxylase
-
Miyata M, Nagata K, Yamazoe Y, and Kato R (1995) Transcriptional elements directing a liver-specific expression of P450/6 beta A (CYP3A2) gene-encoding testosterone 6 beta-hydroxylase. Arch Biochem Biophys 318:71-79.
-
(1995)
Arch Biochem Biophys
, vol.318
, pp. 71-79
-
-
Miyata, M.1
Nagata, K.2
Yamazoe, Y.3
Kato, R.4
-
19
-
-
0033638283
-
Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1
-
Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, and Spiegelman BM (2000) Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1. Mol Cell 6:307-316.
-
(2000)
Mol Cell
, vol.6
, pp. 307-316
-
-
Monsalve, M.1
Wu, Z.2
Adelmant, G.3
Puigserver, P.4
Fan, M.5
Spiegelman, B.M.6
-
20
-
-
33750027681
-
Cytochrome P450s and cholesterol homeostasis
-
Pikuleva IA (2006) Cytochrome P450s and cholesterol homeostasis. Pharmacol Ther 112:761-773.
-
(2006)
Pharmacol Ther
, vol.112
, pp. 761-773
-
-
Pikuleva, I.A.1
-
21
-
-
35649000891
-
Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c
-
Ponugoti B, Fang S, and Kemper JK (2007) Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c. Mol Endocrinol 21:2698-2712.
-
(2007)
Mol Endocrinol
, vol.21
, pp. 2698-2712
-
-
Ponugoti, B.1
Fang, S.2
Kemper, J.K.3
-
22
-
-
0032589689
-
Activation of PPARgamma coactivator-1 through transcription factor docking
-
Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, and Spiegelman BM (1999) Activation of PPARgamma coactivator-1 through transcription factor docking. Science 286:1368-1371.
-
(1999)
Science
, vol.286
, pp. 1368-1371
-
-
Puigserver, P.1
Adelmant, G.2
Wu, Z.3
Fan, M.4
Xu, J.5
O'Malley, B.6
Spiegelman, B.M.7
-
23
-
-
0242349197
-
Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): Requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis
-
Rhee J, Inoue Y, Yoon JC, Puigserver P, Fan M, Gonzalez FJ, and Spiegelman BM (2003) Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc Natl Acad Sci USA 100:4012-4017.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 4012-4017
-
-
Rhee, J.1
Inoue, Y.2
Yoon, J.C.3
Puigserver, P.4
Fan, M.5
Gonzalez, F.J.6
Spiegelman, B.M.7
-
24
-
-
0038514189
-
Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state
-
Shiraki T, Sakai N, Kanaya E, and Jingami H (2003) Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state. J Biol Chem 278:11344-11350.
-
(2003)
J Biol Chem
, vol.278
, pp. 11344-11350
-
-
Shiraki, T.1
Sakai, N.2
Kanaya, E.3
Jingami, H.4
-
25
-
-
0031043595
-
Catalytic characteristics of CYP3A4: Requirement for a phenolic function in ortho hydroxylation of estradiol and mono-O-demethylated methoxychlor
-
Stresser DM and Kupfer D (1997) Catalytic characteristics of CYP3A4: requirement for a phenolic function in ortho hydroxylation of estradiol and mono-O-demethylated methoxychlor. Biochemistry 36:2203-2210.
-
(1997)
Biochemistry
, vol.36
, pp. 2203-2210
-
-
Stresser, D.M.1
Kupfer, D.2
-
26
-
-
62149088599
-
Unveiling a new essential cis element for the transactivation of the CYP3A4 gene by xenobiotics
-
Toriyabe T, Nagata K, Takada T, Aratsu Y, Matsubara T, Yoshinari K, and Yamazoe Y (2009) Unveiling a new essential cis element for the transactivation of the CYP3A4 gene by xenobiotics. Mol Pharmacol 75:677-684.
-
(2009)
Mol Pharmacol
, vol.75
, pp. 677-684
-
-
Toriyabe, T.1
Nagata, K.2
Takada, T.3
Aratsu, Y.4
Matsubara, T.5
Yoshinari, K.6
Yamazoe, Y.7
-
27
-
-
0033977890
-
The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
-
Vega RB, Huss JM, and Kelly DP (2000) The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol 20:1868-1876.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1868-1876
-
-
Vega, R.B.1
Huss, J.M.2
Kelly, D.P.3
-
28
-
-
0032553439
-
SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4
-
Wang JC, Stafford JM, and Granner DK (1998) SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4. J Biol Chem 273:30847-30850.
-
(1998)
J Biol Chem
, vol.273
, pp. 30847-30850
-
-
Wang, J.C.1
Stafford, J.M.2
Granner, D.K.3
-
29
-
-
3142765079
-
Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice
-
Wiwi CA, Gupte M, and Waxman DJ (2004) Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice. Mol Endocrinol 18:1975-1987.
-
(2004)
Mol Endocrinol
, vol.18
, pp. 1975-1987
-
-
Wiwi, C.A.1
Gupte, M.2
Waxman, D.J.3
-
30
-
-
11144354399
-
SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes
-
Yamamoto T, Shimano H, Nakagawa Y, Ide T, Yahagi N, Matsuzaka T, Nakakuki M, Takahashi A, Suzuki H, Sone H, et al. (2004) SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes. J Biol Chem 279:12027-12035.
-
(2004)
J Biol Chem
, vol.279
, pp. 12027-12035
-
-
Yamamoto, T.1
Shimano, H.2
Nakagawa, Y.3
Ide, T.4
Yahagi, N.5
Matsuzaka, T.6
Nakakuki, M.7
Takahashi, A.8
Suzuki, H.9
Sone, H.10
-
31
-
-
0035855858
-
Control of hepatic gluconeogenesis through the transcriptional coaotivator PGC-1
-
DOI 10.1038/35093050
-
Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, et al. (2001) Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413:131-138. (Pubitemid 32867868)
-
(2001)
Nature
, vol.413
, Issue.6852
, pp. 131-138
-
-
Yoon, J.C.1
Puigserver, P.2
Chen, G.3
Donovan, J.4
Wu, Z.5
Rhee, J.6
Adelmant, G.7
Stafford, J.8
Kahn, C.R.9
Granner, D.K.10
Newgard, C.B.11
Spiegelman, B.M.12
-
32
-
-
33745427575
-
Hepatic CYP3A expression is attenuated in obese mice fed a high-fat diet
-
Yoshinari K, Takagi S, Yoshimasa T, Sugatani J, and Miwa M(2006) Hepatic CYP3A expression is attenuated in obese mice fed a high-fat diet. Pharm Res 23:1188-1200.
-
(2006)
Pharm Res
, vol.23
, pp. 1188-1200
-
-
Yoshinari, K.1
Takagi, S.2
Yoshimasa, T.3
Sugatani, J.4
Miwa, M.5
-
33
-
-
71749119309
-
Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5′-flanking region
-
Yoshinari K, Yoda N, Toriyabe T, and Yamazoe Y (2010) Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5′-flanking region. Biochem Pharmacol 79:261-269.
-
(2010)
Biochem Pharmacol
, vol.79
, pp. 261-269
-
-
Yoshinari, K.1
Yoda, N.2
Toriyabe, T.3
Yamazoe, Y.4
|