Expression of inhibitory markers is increased on effector memory T cells during hepatitis C virus/HIV coinfection as compared to hepatitis C virus or HIV monoinfection

AIDS

Volumn 27, Issue 14, 2013, Pages 2191-2200

  Saha, Banishree ^a,b   Choudhary, Manish C ^a   Sarin, Shiv K ^a  

^a INSTITUTE OF LIVER AND BILIARY SCIENCES   (India)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Hepatitis C virus; HIV; Immunophenotyping; Infection; Memory T cells; T lymphocytes

Indexed keywords

BIOLOGICAL MARKER; GAMMA INTERFERON; INTERLEUKIN 2; MEMBRANE PROTEIN; PROGRAMMED DEATH 1 RECEPTOR; T CELL IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING MOLECULE 3; UNCLASSIFIED DRUG;

ARTICLE; CD3+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; HEPATITIS C; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOPHENOTYPING; MAJOR CLINICAL STUDY; MEMORY T LYMPHOCYTE; MIXED INFECTION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE; UPREGULATION;

ADULT; ANTIGENS, CD; CELL PROLIFERATION; CELLS, CULTURED; COINFECTION; CYTOKINES; HEPATITIS C; HIV INFECTIONS; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; LEUKOCYTES, MONONUCLEAR; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PROGRAMMED CELL DEATH 1 RECEPTOR; T-LYMPHOCYTE SUBSETS; YOUNG ADULT;

EID: 84884500388     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32836285e4     Document Type: Article

References (48)

1. Mohsen AH, Easterbrook P, Taylor CB, Norris S. Hepatitis C and HIV-1 coinfection. Gut 2002; 51:601-608.
2. Hutin Y, Kitler ME, Dore GJ, Perz JF, Armstrong JF, Dusheiko G, et al. Global burden of disease (GBD) for hepatitis C. J Clin Pharmacol 2004; 44:20-29.
3. Alter MJ. Epidemiology of hepatitis C virus infection. World J Gastroenterol 2007; 13:2436-2441.
4. Hissar SS, Kumar M, Tyagi P, Goyal A, Suneetha PV, Agarwal S, et al. Natural history of hepatic fibrosis progression in chronic hepatitis C virus infection in India. J Gastroenterol Hepatol 2009; 24:581-587.
5. Lambotin M, Barth H, Moog C, Habersetzer F, Baumert TF, Stoll-Keller F, et al. Challenges for HCV vaccine development in HIV-HCV coinfection. Expert Rev Vaccines 2012; 11:791-804.
6. Lacombe K, Rockstroh J. HIV and viral hepatitis coinfections: advances and challenges. Gut 2012; 61 (Suppl 1):i47-i58.
7. Rehermann B. Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest 2009; 119:1745-1754.
8. Grakoui A, Shoukry NH, Woollard DJ, Han JH, Hanson HL, Ghrayeb J, et al. HCV persistence and immune evasion in the absence of memory T cell help. Science 2003; 302:659-662.
9. Shoukry NH, Grakoui A, Houghton M, Chien DY, Ghrayeb J, Reimann KA, et al. Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection. J Exp Med 2003; 197:1645-1655.
10. Bica I, McGovern B, Dhar R, Stone D, McGowan K, Scheib R, et al. Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection. Clin Infect Dis 2001; 32:492-497.
11. Naggie S, Sulkowski MS. Management of patients coinfected with HCV and HIV: a close look at the role for direct-acting antivirals. Gastroenterology 2012; 142:1324-1334.
12. Benhamou Y, Bochet M, Di Martino V, Charlotte F, Azria F, Coutellier A, et al. Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients. The Multivirc Group. Hepatology 1999; 30:1054-1058.
13. Fuster D, Planas R, Muga R, Ballesteros AL, Santos J, Tor J, et al. Advanced liver fibrosis in HIV/HCV-coinfected patients on antiretroviral therapy. AIDS Res Hum Retroviruses 2004; 20:1293-1297.
14. Kim AY, Chung RT. Coinfection with HIV-1 and HCV: a onetwo punch. Gastroenterology 2009; 137:795-814.
15. Freel SA, Saunders KO, Tomaras GD. CD8 (R)T-cell-mediated control of HIV-1 and SIV infection. Immunol Res 2011; 49:135-146.
16. Shedlock DJ, Shen H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 2003; 300: 337-339.
17. Graham CS, Curry M, He Q, Afdhal N, Nunes D, Fleming C, et al. Comparison of HCV specific intrahepatic CD4+ T cells in HIV/HCV versus HCV. Hepatology 2004; 40:125-132.
18. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401:708-712.
19. Roe B, Coughlan S, Dean J, Lambert JS, Keating S, Norris S, et al. Phenotypic characterization of lymphocytes in HCV/HIV co-infected patients. Viral Immunol 2009; 22:39-47.
20. Seder RA, Ahmed R. Similarities and differences in CD4+ and CD8+ effector and memory T cell generation. Nat Immunol 2003; 4:835-842.
21. Joshi NS, Kaech SM. Effector CD8 T cell development: a balancing act between memory cell potential and terminal differentiation. J Immunol 2008; 180:1309-1315.
22. Dutoit V, Ciuffreda D, Comte D, Gonvers JJ, Pantaleo G. Differences in HCV-specific T cell responses between chronic HCV infection and HIV/HCVcoinfection. Eur J Immunol 2005; 35:3493-3504.
23. Thimme R, Oldach D, Chang KM, Steiger C, Ray SC, Chisari FV. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J ExpMed 2001; 194:1395-1406.
24. Radziewicz H, Ibegbu CC, Fernandez ML, Workowski KA, Obideen K, Wehbi M, et al. Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J Virol 2007; 81:2545-2553.
25. Benoît Callendret B, Walker C. A siege of hepatitis: immune boost for viral hepatitis. Nat Med 2011; 17:252-253.
26. Lechner F, Wong DK, Dunbar PR, Chapman R, Chung RT, Dohrenwend P, et al. Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med 2000; 191:1499-1512.
27. Gaudieri S, Rauch A, Pfafferott K, Barnes E, Cheng W, McCaughan G, et al. Hepatitis C virus drug resistance and immune-driven adaptations: relevance to new antiviral therapy. Hepatology 2009; 49:1069-1082.
28. Lopez F, Belloc F, Lacombe F, Dumain P, Reiffers J, Bernard P, et al. Modalities of synthesis of Ki-67 antigen during the stimulation of lymphocytes. Cytometry 1991; 12:42-49.
29. Wolint P, Betts MR, Koup RA, Oxenius A. Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells. J Exp Med 2004; 199:925-936.
30. Mahalingam M, Peakman M, Davies ET, Pozniak A, McManus TJ, Vergani D. T cell activation and disease severity in HIV infection. Clin Exp Immunol 1993; 93:337-347.
31. Graham CS, Wells A, Liu T, Sherman KE, Peters M, Chung RT, et al. Antigen-specific immune responses and liver histology in HIV and hepatitis C coinfection. AIDS 2005; 19:767-773.
32. Capa L, Soriano V, García-Samaniego J, Nuñez M, Romero M, Cascajero A, et al. Influence of HCV genotype and coinfection with human immunodeficiency virus on CD4+ and CD8+ T-cell responses to hepatitis C virus. J Med Virol 2007; 79: 503-510.
33. Lee SK, Xu Z, Lieberman J, Shankar P. The functional CD8 T cell response to HIV becomes type-specific in progressive disease. J Clin Invest 2002; 110:1339-1347.
34. Papagno L, Spina CA, Marchant A, Salio M, Rufer N, Little S, et al. Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol 2004; 2:E20.
35. Champagne P, Ogg GS, King AS, Knabenhans C, Ellefsen K, Nobile M, et al. Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature 2001; 410:106-111.
36. Fahey LM, Brooks DG. Opposing positive and negative regulation of T cell activity during viral persistence. Curr Opin Immunol 2010; 22:348-354.
37. Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 2006; 439:682-687.
38. Brooks DG, Trifilo MJ, Edelmann KH, Teyton L, McGavern DB, Oldstone MB. Interleukin-10 determines viral clearance or persistence in vivo. Nat Med 2006; 12:1301-1309.
39. Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, Reddy S, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006; 443:350-354.
40. Petrovas C, Casazza JP, Brenchley JM, Price DA, Gostick E, Adams WC, et al. PD-1 is a regulator of virus specific CD8+ T cell survival in HIV infection. J Exp Med 2006; 203:2281-2292.
41. Greenwal RJ, Freeman GH, Sharpe AH. The B7 family revisited. Annu Rev Immunol 2005; 23:515-548.
42. Golden-Mason L, Palmer BE, Kassam N, Townshend-Bulson L, Livingston S, McMahon BJ, et al. Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. J Virol 2009; 83:9122-9130.
43. Zajac AJ, Blattman JN, Murali-Krishna K, Sourdive DJ, Suresh M, Altman JD, et al. Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med 1998; 188:2205-2213.
44. Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol 2009; 10:29-37.
45. Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, Roederer M, et al. Sensitive and viable identification of antigenspecific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods 2003; 281:65-78.
46. Makedonas G, Banerjee PP, Pandey R, Hersperger AR, Sanborn KB, Hardy GA, et al. Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity. J Immunol 2009; 182:5560-5569.
47. Das A, Ellis G, Pallant C, Lopes AR, Khanna P, Peppa D, et al. IL-10-producing regulatory Bcells in the pathogenesis of chronic hepatitis B virus infection. J Immunol 2012; 189:3925-3935.
48. Miller MF, Haley C, Koziel MJ, Rowley CF. Impact of hepatitis C virus on immune restoration in HIV-infected patients who start highly active antiretroviral therapy: a meta-analysis. Clin Infect Dis 2005; 41:713-720.