Modulation of A2B adenosine receptor by 1-Benzyl-3-ketoindole derivatives

European Journal of Medicinal Chemistry

Volumn 69, Issue , 2013, Pages 331-337

  Taliani, Sabrina ^a   Trincavelli, Maria Letizia ^a   Cosimelli, Barbara ^b   Laneri, Sonia ^b   Severi, Elda ^b   Barresi, Elisabetta ^a   Pugliesi, Isabella ^a   Daniele, Simona ^b   Giacomelli, Chiara ^b   Greco, Giovanni ^b   Novellino, Ettore ^b   Martini, Claudia ^a   Da Settimo, Federico ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

1 Benzyl 3 ketoindole derivatives; A2B adenosine receptor; GPCR modulators; Ligand receptor interaction; Negative modulators; Positive modulators

Indexed keywords

1 (1 BENZYL 1H INDOL 3 YL) 2 (FURAN 2 YL)ETHANE 1,2 DIONE; 1 (1 BENZYL 1H INDOL 3 YL) 2 (THIOPHEN 2 YL)ETHANE 1,2 DIONE; 1 (1 BENZYL 1H INDOL 3 YL) 2 PHENYLETHANE 1,2 DIONE; 1 BENZYL 1H INDOLE; 1 BENZYL N PHENYL 1H INDOLE 3 CARBOXAMIDE; 2 (1 BENZYL 1H INDOL 3 YL) 2 OXO N PHENYLACETAMIDE; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2B RECEPTOR; INDOLE DERIVATIVE; N BENZYL 2 (1 BENZYL 1H INDOL 3 YL) 2 OXOACETAMIDE; N,1 DIBENZYL 1H INDOLE 3 CARBOXAMIDE; UNCLASSIFIED DRUG; ADENOSINE DEAMINASE; ADENOSINE RECEPTOR; CYCLIC AMP;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; DRUG SCREENING; DRUG STRUCTURE; HUMAN; HUMAN CELL; 1-BENZYL-3-KETOINDOLE DERIVATIVES; 2-CHLORO-N(6)-(3-IODOBENZYL)-ADENOSINE-5′-N-METHYLURONAMIDE; 3′,5′-CYCLIC ADENOSINE MONOPHOSPHATE; 4-DIMETHYLAMINOPYRIDINE; [(125)I]4-AMINOBENZYL-5′-N-METHYLCARBOXAMIDOADENOSINE; [(125)I]AB-MECA; [(3)H]5′-N-ETHYLCARBOXAMIDEADENOSINE; [(3)H]8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE; [(3)H]DPCPX; [(3)H]NECA; A(2B) ADENOSINE RECEPTOR; ADA; ANIMAL; AR; CHEMICAL STRUCTURE; CHEMISTRY; CHINESE HAMSTER OVARY; CHO; CHO CELL LINE; CL-IBMECA; CRICETULUS; DMAP; DMEM; DOSE RESPONSE; DULBECCO'S MODIFIED EAGLE MEDIUM; G-PROTEIN COUPLED RECEPTORS; GPCR MODULATORS; GPCRS; LIGAND-RECEPTOR INTERACTION; METABOLISM; NEGATIVE MODULATORS; POSITIVE MODULATORS; SCANNING ELECTRON MICROSCOPY; STANDARD ERROR OF MEAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

1-BENZYL-3-KETOINDOLE DERIVATIVES; 2-CHLORO-N(6)-(3-IODOBENZYL)-ADENOSINE-5′-N-METHYLURONAMIDE; 3′,5′-CYCLIC ADENOSINE MONOPHOSPHATE; 4-DIMETHYLAMINOPYRIDINE; [(125)I]4-AMINOBENZYL-5′-N-METHYLCARBOXAMIDOADENOSINE; [(125)I]AB-MECA; [(3)H]5′-N-ETHYLCARBOXAMIDEADENOSINE; [(3)H]8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE; [(3)H]DPCPX; [(3)H]NECA; A(2B) ADENOSINE RECEPTOR; ADA; ADENOSINE DEAMINASE; ADENOSINE RECEPTOR; AR; CAMP; CHINESE HAMSTER OVARY; CHO; CL-IBMECA; DMAP; DMEM; DULBECCO'S MODIFIED EAGLE MEDIUM; G-PROTEIN COUPLED RECEPTORS; GPCR MODULATORS; GPCRS; LIGAND-RECEPTOR INTERACTION; NEGATIVE MODULATORS; POSITIVE MODULATORS; SEM; STANDARD ERROR OF MEAN;

ANIMALS; CHO CELLS; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INDOLES; MOLECULAR STRUCTURE; RECEPTOR, ADENOSINE A2B; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84884481729     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.09.001     Document Type: Article

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