From the pharmacophore to the homology model of the benzodiazepine receptor: The indolyglyoxylamides affair

Current Topics in Medicinal Chemistry

Volumn 12, Issue 4, 2012, Pages 321-332

  Cosimelli, Barbara ^a   Cosconati, Sandro ^b   Marinelli, Luciana ^a   Novellino, Ettore ^a   Greco, Giovanni ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Benzodiazepine receptors; Binding modes; Docking; Homology modelling; Molecular modelling; Pharmacophore

Indexed keywords

BENZODIAZEPINE RECEPTOR; INDOLE DERIVATIVE;

BINDING AFFINITY; DRUG CONFORMATION; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; REVIEW; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION;

AMIDES; ANTI-ANXIETY AGENTS; BINDING SITES; BRAIN; GABA-A RECEPTOR AGONISTS; GABA-A RECEPTOR ANTAGONISTS; GLYOXYLATES; HUMANS; HYPNOTICS AND SEDATIVES; INDOLES; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN SUBUNITS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84856476533     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/156802612799078702     Document Type: Review

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