3-Aryl-[1,2,4]triazino[4,3-a ]benzimidazol-4(10 H)-one: A novel template for the design of highly selective A2B adenosine receptor antagonists

Journal of Medicinal Chemistry

Volumn 55, Issue 4, 2012, Pages 1490-1499

  Taliani, Sabrina ^a   Pugliesi, Isabella ^a   Barresi, Elisabetta ^a   Simorini, Francesca ^a   Salerno, Silvia ^a   La Motta, Concettina ^a   Marini, Anna Maria ^a   Cosimelli, Barbara ^b   Cosconati, Sandro ^c   Di Maro, Salvatore ^b   Marinelli, Luciana ^b   Daniele, Simona ^d   Trincavelli, Maria Letizia ^a   Greco, Giovanni ^b   Novellino, Ettore ^b   Martini, Claudia ^a   Da Settimo, Federico ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

^d ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

10 BENZYL 3 PHENYL [1,2,4] TRIAZINO [4,3 A] BENZIMIDAZOL 4(10H) ONE; 10 BENZYL 3(2 FURYL) [1,2,4] TRIAZINO [4,3 A] BENZIMIDAZOL 4(10H) ONE; 10 METHYL 3 PHENYL [1,2,4] TRIAZINO [4,3 A] BENZIMIDAZOL 4(10H) ONE; 10(4 CHLOROPHENYL) 3 PHENYL [1,2,4] TRIAZINO [4,3 A] BENZIMIDAZOL 4(10H) ONE; 10(4 CHLOROPHENYL) 3(2 FURYL) [1,2,4] TRIAZINO [4,3 A] BENZIMIDAZOL 4(10H) ONE; 3 ARYL [1,2,4] TRIAZINO [4,3 A] BENZIMIDAZOL 4(10H) ONE; 3 PHENYL; 3 PHENYL 10(2 PHENYLETHYL) [1,2,4] TRIAZINO [4,3 A] BENZIMIDAZOL 4(10H) ONE; 3 PHENYL [1,2,4] TRIAZINO [4,3 A] BENZIMIDAZOL 4(10H) ONE; 3(2 FURYL) 10 METHYL [1,2,4] TRIAZINO [4,3 A] BENZIMIDAZOL 4(10H) ONE; 3(2 FURYL) 10 PHENYL [1,2,4] TRIAZINO [4,3 A] BENZIMIDAZOL 4(10H) ONE; 3(2 FURYL) 10(2 PHENYLETHYL) [1,2,4] TRIAZINO [4,3 A] BENZIMIDAZOL 4(10H) ONE; 3(2 FURYL) [1,2,4] TRIAZINO [4,3 A] BENZIMIDAZOL 4(10H) ONE; 3,10 DIPHENYL [1,2,4] TRIAZINO [4,3 A] BENZIMIDAZOL 4(10H) ONE; 7 CHLORO 3(2 FURYL) 10 PHENYL [1,2,4] TRIAZINO [4,3 A] BENZIMIDAZOL 4(10H) ONE; 7 CHLORO 3,10 DIPHENYL [1,2,4] TRIAZINO [4,3 A] BENZIMIDAZOL 4(10H) ONE; [1,2,4] TRIAZINO [4,3 A] BENZIMIDAZOL 4(10H) ONE DERIVATIVE; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; BENZIMIDAZOLE DERIVATIVE; CHLORINE; PHENYL GROUP; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR MODEL; RECEPTOR AFFINITY;

ADENOSINE A2 RECEPTOR ANTAGONISTS; ANIMALS; BENZIMIDAZOLES; CACO-2 CELLS; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A2B; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 84857395877     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201177b     Document Type: Article

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